最新刊期
期 8 ， 2016
- 摘要：This article introduced professor Wang Lingtai’s experience in the treatment of primary biliary cirrhosis(PBC,or cholangitis). It was recommended that the main pathogenesis of PBC was the healthy energy deficiency as essence with the disharmony of spleen, liver and kidney and the evil excess as syndrome with dampness, hot and blood stasis throughout the whole. Professor Wang proposed the therapeutic method of regulating spleen, liver and kidney, clearing heat,removing dampness, alleviating blood stasis and jaundice,and the corresponding herb application. One proven case was recorded.关键词：primary biliary cirrhosis(cholangitis);immune liver disease therapy of;traditional Chinese medicine;experience of famous physician
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发布时间：2022-08-31 - 摘要：By analyzing the large account of therapeutic prescriptions and herbs,TCM emotional etiology and pathogenesis of palpitation,mechanisms of functional heart diseases in modern medicine,the morphology of depression syndrome including “diseases induced by depression syndrome” and “depression syndrome induced by diseases” and clinical recognization and so on,this article demonstrated the existence of “palpitation due to depression syndrome” and explored its clinical manifestations. Furthermore,this paper put forward the classifications of palpitation as “palpitation due to depression syndrome” and “palpitation unrelated with depression syndrome”.Connected with typical TCM patterns of palpitation,the former mainly refers to the patterns of timidity due to deficiency of heart qi,deficiency of both heart and spleen,deficiency of the heart-yin,devitalization of heart yang,deficiency of liver-yin and kidney-yin and a part of blockade of phlegm-turbidity and stagnation of the heart blood.The latter refers to the patterns of fluid retention invading heart,pathogenic poison invading heart,blockade of phlegm-turbidity and stagnation of the heart blood. Identifying and differentiating these two patterns will not only contribute to the inheritance and development of TCM,but also to the better implement of precision medicine.关键词：depression syndrome;palpitation;“palpitation due to depression syndrome”;cardiac neurosis
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发布时间：2022-08-31 - 摘要：Under the regulation of the hypothalamic pituitary ovary axis (HPOA), the related hormones in the female body present periodic dynamic change and physiological balance, which regulate menstrual cycle and other normal physiological activities through the influence on cyclical changes of the endometrium. This dynamic change and physiological balance mode is consistent with the theory of yin and yang in Traditional Chinese Medicine. The combination of the neuroendocrine system regulated by HPOA and the theory of yin and yang could promote the syndrome differentiation based on the general principle of yin and yang,and better guide for the clinical treatment of gynecological diseases.关键词：sex hormone;Yin-Yang theory;hypothalamus pituitary ovary axis
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发布时间：2022-08-31 - 摘要：Objective:To explore the change characteristics of serum kidney biomarker cystatin C(CysC) and neutrophil gelatinase-associated lipocalcin(NGAL) in adriamycin(ADR) and gentamicin(GM) -induced kidney injury in rats and the significance of the combined detection. MethodsWistar rats were randomly divided into the drug and the control group,and the kidney injury models of glomerular and renal tubular type were established respectively.The contents of serum blood urea nitrogen(BUN) and creatinine(Scr) were detected by means of biochemical analyzer.The concentrations of serum CysC and NGAL were measured by enzyme-linked immunosorbent assay(ELISA).The morphological changes of renal pathology were observed by light microscopy.The curve areas of various serum biomarkers and the combinations were compared by receiver operating characteristic curve(ROC curve) and logistic regression analysis based on renal pathology as positive diagnosis criteria. Results:①The significant changes of CysC and NGAL in both types of injury were earlier than the changes of morphology and BUN and Scr. ②ROC analysis showed that the area under curve(AUC)of CysC and NGAL were 0.866,0.691 in ADR model and 0.632,0.698 in GM model respectively,which higher than that of BUN or Scr.BUN+Scr combined with CysC or NGAL showed higher efficiency for glomerular and renal tubular injury,respectively.The combination of CysC and NGAL had certain value for two types of renal injury,which AUC,sensitivity and specificity were all more than 0.7. Conclusion:The significant changes of CysC and NGAL were earlier than morphological changes and traditional serum markers, which can predict the occurrence and development of renal injury in a certain degree. BUN+Scr combined with CysC or NGAL had higher efficiency for glomerular and renal tubular injury,respectively.Combination CysC+NGAL can be used to evaluate different types of drug-induced renal injury.关键词：kidney injury;model;Adriamycin;gentamicin;CysC;NGAL;ROC curve analysis
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发布时间：2022-08-31 - 摘要：This paper introduced the experience of Wang Guosan in the treatment of constipation after anal fistula surgery by dealing with deficiency. He advocated that the treatment should pay attention to supplement for the deficiency of spleen and stomach,and protect Yang and Qi as well as Yin and Jin. Proven cases were further illustrated.关键词：constipation;supplement for unblocking treatment;clinical experience;Wang Guo san
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发布时间：2022-08-31 - 关键词：diminished ovarian reserve;reinforcing kidney and invigorating spleen;clinical experience;Qi Cong
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发布时间：2022-08-31 - 摘要：This paper summarized professor Que Huafa’s experience in the treatment of upper extremity lymphedema after breast cancer surgery. Professor Que recommended the blood stasis and water retention as the main pathogenesis. He advocated that the main therapeutic method included promoting blood circulation and excreting water with dredging collaterals,replenishing and regulating qi.In early stage,blood stasis combined with dampness, the treatment focused on draining dampness and alleviating edema.In advanced stage,blood stasis combined with phlegm,the treatment focused on resolving phlegm and softening hardness,warming yang and dissipating mass. He emphasized the combination of syndrome differentiation,disease differentiation and constitution differentiation. The principle of treatment as reinforcing healthy qi and eliminating pathogen and treating branch or root should be flexible used. One proven case was recorded.关键词：postoperative breast cancer;upper extremity lymphedema;blood stasis and water retention;promoting blood circulation and excreting water;Que Huafa
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发布时间：2022-08-31 - 关键词：dysmenorrhea;classical prescriptions;clinical experience
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发布时间：2022-08-31 - 摘要：This paper analyzed and summarized the experience of professor Wu in the treatment of pelvic lymphatic cyst.He recommended the blood stasis combined with dampness and heat as main pathogenesis. Treatment should be used to strengthen the spleen and resolve the phlegm,clear heat and remove dampness,eliminate the mass and relieve swelling. Typical cases were described.关键词：pelvic lymph cyst;abdominal mass;clinical experience;Wu Kunlun
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发布时间：2022-08-31 - 摘要：This paper discussed the treatment of fever based on four points method. The diagnosis and treatment of typhoid was the source and basis of the fever treatment. The treatment of fever based on four points method was in favor of holding the basic principles and rules of clinical diagnosis and treatment. Four points method included routine treatment of six meridians of exogenous fever,treatment of accompanied symptom in miscellaneous diseases,diagnosis and treatment identification of the disease with the type of exogenous fever, take care and recovery from exogenous fever,which suggested the each position of exogenous fever,Jin Kui and febrile disease and reflected the unification of exogenous fever and febrile disease and exogenous and internal injuries in clinic.
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发布时间：2022-08-31 - 摘要：This paper summarized the therapy of regulating yin and yang in Treatise on Febrile Diseases from 4 aspects, including “Qi deficiency when the evil raised”, “receding its excess and supplementing its deficiency”,“nourish yin when yang excess,and warm yang when yin excess”,“focus on yin and yang to except its balance”. It was put forward that regulating yin and yang is not only supplying deficiency and expelling excess simply depending on patient’s cold-heat and deficiency-excess. The basic reason of imbalance of yin and yang through the surface should be estimated. Treatment should pay attention to flexible regulation of the degree on supporting healthy energy and eliminating evils,and supplying deficiency and expelling excess.关键词：Treatise on Febrile Diseases;regulating yin and yang;therapeutical principle
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of the “Ganfuan” decoction on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory. Methods102 HBV-infected patients(chronic hepatitis and liver cirrhosis) with abnormal iron metabolism were divided into the treatment group(n=48) treated with “Ganfuan” decoction ,and control group (n=54) treated with conventional drugs(antivirus, hepatoprotectants),with a course of 36 months. The degree of iron deposition on liver, serum markers of iron metabolism, liver function,HBV level,immune cell counts and abnormal ratio were measured and compared. Results:①There was significant difference in hepatic iron deposition between the treatment group and control group on the 24th and 36th month(P<0.05),and the treatment group was more effective. ②There were significant differences in concentration and abnormal ratio of SF,SI and TRF between the treatment and control group after 36 months(P<0.05).Compared with the control group, the degree of the SI、SF reduction in the treatment group was more significant and the abnormal rate was lower. ③There were significant differences in ALT,HBsAg, CD3+ and abnormal ratio of CD3+ and CD4+/CD8+ between the treatment and control group after treatment(P<0.05),and the treatment group was more effective. Conclusion:“Ganfuan” decoction based on Fuxie theory could renormalize the iron metabolism dysregulation effectively, recover the immune function, depress the virus replication, and alleviate the liver injury.关键词：chronic hepatitis B;liver iron overload;Fuxie;Ganfuan
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Qutan Dingxian Decoction” in the treatment of intractable epilepsy. MethodsSixty-one subjects were randomized into the treatment group(30 cases) and control group(31 cases), which all treated with routine modalities; besides, the treatment group was also given “Qutan Dingxian Decoction”, with a course of 12 weeks. The efficacy on frequency of epileptic seizures and abnormal electroencephalogram was observed before and after treatment. Results:①For the frequency of epileptic seizures, the effective rate was 73.33% in the treatment group and 41.93% in the control group, the efficacy in the treatment group was than better the control group(P<0.01). ②After treatment, the abnormal electroencephalogram was obviously improved in both groups(P<0.05, P<0.01), with more significant improvement in the treatment group than in the control group(P<0.05). Conclusion:“Qutan Dingxian Decoction” could be used in the treatment of intractable epilepsy which reduced epileptic seizure and improved electroencephalography.关键词：“Qutan Dingxian Decoction”;intractable epilepsy;electroencephalogram
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发布时间：2022-08-31 - 摘要：Objective:To discuss the clinical efficacy of Yangxin Shugan Decoction combined with the psychotherapy of systematic desensitization in the treatment of primary premature ejaculation. Methods80 patients with primary premature ejaculation were randomly divided into the treatment group and control group, 40 cases in each group. Psychotherapy of systematic desensitization was conducted in both groups,and the treatment group was given Yangxin Shugan Decoction additionally,with a course of 2 months. The change of premature ejaculation diagnostic tool(PEDT),intravagina ejaculation latency time(IELT),self-rating anxiety scale(SAS)and chinese index of sexual function for premature ejaculation(CIPE)-Q6/Q7 were observed. Results:The total effective rate of the treatment group and control group were 72.22% and 61.11% respectively,and there was statistically significant difference between the two groups (P<0.05). Within group,compared with before treatment,there were statistically significant differences in the scores of PEDT, SAS, CIPE-Q6, CIPE-Q7 and IELT in both groups after treatment (P<0.05); After treatment, there were significant differences in the scores and IELT between the two groups (P<0.05). Conclusion:Yangxin Shugan Decoction combined with the psychotherapy of systematic desensitization showed good effect on primary premature ejaculation,which could improve the symptoms of premature ejaculation, prolong the IELT, relieve anxiety and improve the satisfaction of sexual life.关键词：premature eiaculation;integrated therapy of chinese and western medicine;Yangxin Shugan Decoction;behavioral therapy;psychotherapy;systematic desensitization
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发布时间：2022-08-31 - 摘要：Objective:To observe the preventive effects of “Zifei Sanjie Decoction” on castrate resistant prostate cancer(CRPC). MethodsTotal 110 subjects with non-CRPC were randomized into two group:the control group in which 55 cases were treated with castration and endocrine therapy,and the treatment group in which 55 cases were treated with “Zifei Sanjie Decoction” additionally, with a course of 3 months. At the end of follow up, the incidence of castration resistance, hematuria and bone metastases, and terminal events were observed, the doubling of prostate specific antigen (PSA) was compared. Results:①Up to March 2016,the follow up time for all patients ranged from 12~36 months. Median time was 24 months. ②The incidence of CRPC in the treatment group and control group were 10.91% and 69.09% respectively, the difference was statistically significant, and the treatment group was significantly lower than that of the control group (P<0.05). ③There were statistically significant differences in the doubling of PSA,hematuria and bone metastases and terminal events between two groups,and those in treatment group was significantly lower than the control group (P<0.05). Conclusion:“Zifei Sanjie Decoction” could inhibit the CRPC to a certain extent and decrease the hematuria and bone metastasis, which improve the life quality of patients and prolong the survival time.关键词：prostatic cancer;type of castration resistant;“Zifei Sanjie Decoction”;bone metastasis;preventive treatment
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Yiqi Huoxue Huayu Therapy” in treatment of ovarian cyst and its effects on serum sex hormones. MethodsOne hundred and sixty-five cases of ovarian cyst were randomized into the observation group (84 cases) and control group (81 cases), and respectively treated with “Yiqi Huoxue Huayu Therapy” and “Guizhi Fuling Pills” respectively, with a course of two months. The syndrome scores, serum sex hormones testosterone(T), follicle stimulating hormone(FSH), progesterone(LH), estradiol(E2), progesterone(P) and the size of ovarian cyst were detected before and after treatment. Results: ①After treatment, the syndrome scores diminished and the size of ovarian cyst reduced in both groups(P<0.05), with better efficacy in the observation group than in the control group(P<0.05). ②After treatment, the levels of P and E2 decreased and the levels of FSH and LH increased in both groups(P<0.05), with more significant improvement in the observation group than in the control group(P<0.05). Conclusion:“Yiqi Huoxue Huayu Therapy” was quite effective in the treatment of ovarian cyst by regulating serum sex hormones.关键词：ovarian cyst;“Yiqi Huoxue Huayu Therapy”;sex hormone
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of abdominal acupuncture with low frequency electric stimulation combined with pelvic floor muscle training in the treatment of female stress urinary incontinence. Methods65 patients with female stress urinary incontinence were randomly divided into 2 groups. The control group (32 cases) were treated only with pelvic floor muscle training；the treatment group (33 cases) were treated with abdominal acupuncture combined with low frequency electric stimulation additionally,with a course of 2 months. Clinical efficacy in both groups was observed. The urine pad test results within 1h, the scores of incontinence advisory committee on international questionnaire summary table (ICI-Q-SF) and health survey profiles (SF-36) integral situation were compared. Results:①The total effective rate in the treatment and control group was 81.82% and 71.88% respectively. There was statistically significant difference in clinical efficacy between two groups(P<0.05),and the treatment group was more effective. ②There were statistically significant differences in the urine pad test results within 1h,the scores of ICI-Q-SF and SF-36 between two groups(P<0.05),and the treatment group was more effective. Conclusion:Abdominal acupuncture with low frequency electric stimulation combined with pelvic floor muscle training could be used for the treatment of female stress urinary incontinence,which effectively improved the symptoms of urinary incontinence and life quality of patients.关键词：stress urinary incontinence;female;abdominal acupuncture therapy;low frequency electric stimulation;pelvic floor muscle training
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the clinical efficacy of “Qinghua Tanshi Decoction” in the treatment of acne mastitis with phlegm-dampness syndrome. MethodsOne hundred and four subjects were randomized into the observation group and control group(52 cases in each group), and treated with topical herbal ointment; besides, the observation group was orally given “Qinghua Tanshi Decoction” and control group was given cefaclor capsules, with a course of two weeks. The clinical efficacy and symptoms scores were assessed. Results:①The total effective rate was 94.2% in the observation group and 13.5% in the control group, with better efficacy in the observation group than in the control group(P<0.01); ②After treatment, the symptoms scores and total score reduced obviously(P<0.05, P<0.01), with lower symptoms scores and total score in the observation group than in the control group(P<0.05). Conclusion:“Qinghua Tanshi Decoction” was quite effective on the acne mastitis with phlegm-dampness syndrome.关键词：acne mastitis;phlegm-dampness syndrome;“Qinghua Tanshi Decoction”
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发布时间：2022-08-31 - 摘要：Objective:To observe the efficacy of modified Jiubaowan in the treatment of post-infection cough in child with anemogenous phlegm accumulated in lung. MethodsAccording to the degree of cough severity, 200 subjects were randomized into the treatment group with mild symptom, control group with mild symptom, treatment group with severe symptom, control group with severe symptom. Modified Jiubaowan was applied in the two treatment groups,while leukotriene receptor antagonist in the two control groups,with a course of 14 days. The clinical efficacy was observed and the scores of TCM syndrome were compared. Results:①Among the patients who complete the whole test,there were 47 patients in the treatment group with mild symptom and 46 patients in the control group with mild symptom;44 patients in the treatment group with severe symptom and 44 patients in the control group with severe symptom.②The total effective rate of treatment group with mild symptom was 85.11%,and control group with mild symptom was 86.96%. There was no statistically significant difference in clinical efficacy between these two groups (P>0.05). The total effective rate of treatment group with severe symptom was 75%,and control group with severe symptom was 56.82%. There was statistically significant difference in clinical efficacy between these two groups (P<0.05). ③In the two groups of mild symptom,compared with before treatment within groups,there was statistically significant difference in the score of TCM syndrome in both group after treatment (P<0.05); compared between groups after treatment,there was no statistically significant difference in the score of TCM syndrome(P>0.05). In the two groups of severe symptom,compared with before treatment within groups,there was statistically significant difference in the score of TCM syndrome in both group after treatment (P<0.05); compared between groups after treatment,there was statistically significant difference in the score of TCM syndrome(P<0.05). Conclusion:Modified Jiubaowan showed good efficacy in the treatment of post-infection cough in child,which relieved cough symptoms, and it was more effective on severe cogh children.关键词：child;post-infection cough;anemogenous phlegm accumulated in lung;Jiubaowan;shaoyang disease
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发布时间：2022-08-31 - 摘要：This paper introduced the treatment of cystic acne. The common pathological state was recognized as accumulation of heat and toxic and stagnation of Qi and blood. Skin lesion morphology was similar to sore and furuncle. Two methods “xiao”and “tuo” should be used in the treatment of this type. According to the characteristics of young adults, the treatment of cystic acne by clearing poison and expelling pus was put forward. A homemade prescription “Qingjin Tuodu Decoction” was used for treatment,which can clear away heat and toxic,promote blood circulation and remove blood stasis and cure the cystic acne.关键词：cystic acne;the method of clearing poison and expelling pus;Qingjin Tuodu Decoction;clinical experience
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发布时间：2022-08-31 - 摘要：This article summarized the medical properties, attributions and indications of Herba Asari, as well as the application of flexible compatibility in the treatment of rheumatism. As a commonly used traditional Chinese medicine for treating rheumatism, it was often combined with other herbs,such as radix aconiti carmichaeli for warming yang and dispeling cold,angelica sinensis for nourishing blood and warming meridians,scutellaria baicalensis and radix rehmanniae for regulating yin and yang,gypsum fibrosum for relieving dizziness and dredging collaterals,radix angelicae tuhuo for regulating and nourishing liver and kidney. The appropriate dosage and proper use could reflect the flexibility of its clinical practice.关键词：Herba Asari;rheumatism;compatibility
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of JinFuKang Decoction(JFK) on clearing the “hidden pathogen”—circulating tumor cells(CTC) in patients with non-small cell lung cancer(NSCLC) and verify the hypothesis that JFK prevent metastasis through intervening CTC. MethodsThe CTC cell line from peripheral blood in patients with NSCLC were enriched and cultivated,then the CTC cells were intervened by JFK. The Cell proliferation and clone formation were detected by cell counting kit -8 (CCK-8). The Cell apoptosis and cycle were detected by flow cytometry and confocal laser scanning technique. Results:The CTC cell proliferation was significantly inhibited by JFK in time-dependent and concentration- dependent manner. The clone formation of CTC cell was significantly inhibited by JFK in a dose-dependent manner(P<0.05). JFK effectively induced the apoptosis of CTC cells (P<0.01); the CTC cell proliferation was blocked in the S phase in JFK group with high concentration(P<0.05). Conclusion:JFK could inhibit the CTC in patients with NSCLC, which indicated that interventing CTC may be the mechanism of JFK on prevention and treatment of the recurrence and metastasis in NSCLC.关键词：JinFuKang;circulating tumor cell;non-small cell lung cancer;hidden pathogen
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发布时间：2022-08-31 - 摘要：Objective:To observe the therapeutic effect of Baijinwan aqueous solvent in the treatment of hyperlipidemic mice. Methods48 mice were randomly divided into the control group, model group, Baijinwan group with high and low dose (6.4 g·kg-1,1.6 g·kg-1), Xuezhikang group (0.16 g·kg-1) and statin group (0.0026 g·kg-1), and 8 mice in each group. Except the control group, the rest groups were given high fat diet to establish the hyperlipidemia model. Four weeks later, mice in different groups were treated with corresponding drugs by means of intragastric administration,with a course of 15 days. The body weight,liver index,serum total cholesterol (TC) ,triglyceride (TG) ,low-density lipoprotein cholesterol(LDL-C) ,high-density lipoprotein cholesterol (HDL-C) ,the liver superoxide dismutase (SOD)and malondialdehyde (MDA) of mice were detected and compared. Results:Compared with the control group, body weight and liver index of the model group significantly increased (P<0.05). Compared with the model group, body weight and liver index of Baijinwan groups significantly decreased (P<0.05); TG of Baijinwan group with high-and low-dose significantly decreased (P<0.05), LDL of Baijinwan group with low-dose significantly decreased (P<0.05), HDL of Baijinwan group with high-and low-dose significantly increased. (P<0.05); MDA in liver homogenates of Baijinwan group with low-dose significantly decreased. (P<0.05), MDA in liver homogenates of Baijinwan group with high-dose significantly decreased (P<0.01). Compared with the model group, the activity of SOD in liver homogenates of atorvastatin group and Baijinwan group with low-dose increased significantly (P<0.05). Conclusion:Baijinwan aqueous solvents could significantly reduce body weight and liver index of hyperlipidemic mice,which regulated lipid metabolism by reducing TG,LDL-C and increasing HDL-C. Meanwhile ,it decreased MDA and increased the activity of SOD in liver.关键词：Baijinwan;hyperlipidemia;blood lipids;liver index
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发布时间：2022-08-31 - 摘要：Objective:To study the protective effects of “Buyang Huanwu Decoction” on the integrity of neurovascular unit after brain ischemia in rats. MethodsMCAO was established in rats and then the rats were randomized into the treatment group and control group. The treatment group was orally given “Buyang Huanwu Decoction” and the control group was orally given normal saline, with a course of seven days. The neurological score was used to test the behavioral performance, the TTC staining was used to determine the infarct area, the number of neuron and integrity of the neurovascular unit. was determined by immnuohischemstry ResultsCompared with the control group, NRSS score could reduced, the infarct area the number of neuron positive cells and the integrity of the neurovascular unit increased(P<0.05). Conclusion:“Buyang Huanwu Decoction” can promote the recovery following MCAO via improving the integrity of neuralvascular unit.关键词：“Buyang Huanwu Decoction”;cerebral ischemia;neurovascular unit;rat
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of electroacupuncture(EA) on depressive-like behavior and c-fos protein expression of habenular nucleus in the WKY rat model. Methods24 male WKY rats were randomly divided into the EA, sham and model groups,8 in each group.8 Wistar male rats were set as normal group. The behaviors were evaluated by open field test, sucrose preference test and force swimming test, the expression of c-fos was detected by immunofluorescence. Results:Compared with the control group , the behaviors of open field test and Sucrose preference test in model group decreased significantly (P<0.05),and the immobile time of force swimming test and c-fos expression of habenular nucleus increased significantly (P<0.05). Compared with sham group , the behaviors of open field test and Sucrose preference test in EA group increased significantly (P<0.05),and the immobile time of force swimming test and c-fos expression of habenular nucleus decreased significantly (P<0.05). Conclusion:Electroacupuncture cauld improve the depressive- like behaviors of WKY rats and decrease the expression of c-fos protein in habenular nucleus. It may be one of the mechanisms of electroacupuncture on depression.关键词：electroacupuncture;depression;habenular nucleus;c-fos
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发布时间：2022-08-31 - 摘要：Objective:To investigate the anti-hyperglycemic effects of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes. MethodsThe different ratio of ginsenoside Re and berberine (2∶0, 16∶1, 1∶2, 8∶4, 0∶8, 4∶16) were matched by uniform design method. The hyperglycemia model in mice was induced by starch(6 mg/g), and the type 2 diabetes model in rats was induced by STZ(150 μg/g)and ALX(200 μg/g). The effects of different ratio of ginsenoside Re and berberine(100 μg/g) on blood sugar were observed. Results:postprandial blood glucose in starch induced mice treated with the ratio of ginsenoside Re and berberine at 1∶2(100 μg/g), 8∶4(100 μg/g), 4∶16(100 μg/g) significantly reduced(P<0.05 or P<0.01). the blood glucose level in STZ induced rats treated with the ratio of ginsenoside Re and berberine at 8∶4(100 μg/g)and 4∶16(100 μg/g) significantly inhibited(P<0.05 or P<0.01). The ratio of Ginsenoside Re and berberine at 4∶16 also showed significantly reverse effect on ALX-induced hyperglycemia in rats (P<0.01), and its hypoglycemic effect was similar to phenformin(100 μg/g). In addition, among the different ratio in the STZ and ALX induced models, the inhibition of blood glucose in the ratio of ginsenoside Re and berberine at 4∶16 was more effective than other groups(P<0.05). Conclusion:The ratio of ginsenoside Re and berberine at 4∶16(100 μg/g) showed significantly anti-hyperglycemic effect.关键词：ginsenoside Re;berberine;type 2 diabetes;anti-hyperglycemic effect
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发布时间：2022-08-31 - 摘要：Objective:To determine the content of the 17 types of amino acids in the swine heart tissue. Methods17 types of amino acids in the cardiac tissue of swine were detected by the amino acid analyzer with ninhydrin post-column derivatization. Results:The correlation coefficient (r) of linear equation of these 17 types of amino acid were all above 0.9990 within the range of concentration. The average recoveries of glycine, tyrosine, phenylalanine and arginine were 99.0%, 99.6%, 101.7% and 97.9%(n=6), respectively, and RSD were all less than 2%. Conclusion:The method was simple and reliable that can be used to determine the content of amino acid in the swine heart tissue.关键词：swine heart;amino acids;content determination
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发布时间：2022-08-31 - 摘要：This paper summarized the research progress of protective effects of traditional Chinese medicine on endothelial function in hypertension. The role of endothelial dysfunction in the development of hypertension was explained from the perspectives of inflammation, oxidative stress, immune system, renin-angiotensin-aldosterone system, homocysteine, endothelial micro particles and other aspects,which suggested that traditional Chinese medicine played an important role in protecting the endothelial function in hypertension.关键词：hypertension;Chinese medicine therapy;endothelial dysfunction;review
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发布时间：2022-08-31 - 摘要：This paper reviewed the recent research on the clinical application and mechanism of Zishen Yutai pill. In the past it was used for the prevention of miscarriage and treatment of incipient abortion, irregular menstruation, ovarian dysfunction. In recent years clinical practice showed that it was more used in the assisted reproduction, which enhance embryo implantation rate and increase embryo number of good quality, repair the endometrial and improve the endometrial receptivity.关键词：Zishen Yutai pill;incipient abortion;infertility;premature ovarian failure;review
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发布时间：2022-08-31
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