最新刊期
期 9 ， 2016
- 摘要：This paper introduced the unique clinical thinking and experience of professor Yan Shi-yun in the treatment of cardiac diseases. He considered the grouping of syndrome and elements as treatment ideas; the therapy was good at regulating Yin -Yang (especially Yin and Yang in kidney)and emotion,as well as qi-blood which suggested the tonifying Qi and activating blood as usual method. He emphasised the application of insect drugs and the strengthening of body resistance,especially spleen and stomach.For miscellaneous diseases,the treatment should combine with cold,heat,qi,blood,supplement and excretion.Some proven cases were recorded.关键词：cardiac diseases;clinical thinking of traditional Chinese medicine;experience of famous doctor;Yan Shiyun
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发布时间：2022-08-31 - 摘要：This paper discussed the therapy and syndrome of chest obstruction due to depression. Chest obstruction could be classified as the types of depression-related and depression-unrelated. Long before the modern medicine knowledge of cardiac neurosis and depression and anxiety disorders which show the symptoms of chest pain,chest congestion and shortness of breath,traditional Chinese medicine has already formed its own system of diagnosis and treatment of chest obstruction due to depression syndrome. This kind of chest obstruction is caused and influenced by emotional changes. Although the main symptoms of chest obstruction due to depression syndrome seem similar to chest obstruction of organic heart disease(type of depression-unrelated),there are inherent distinctions between two types in the aspects of degree,manifestations,lasting time,major and accompanied symptoms and the reactions to depression- relieving treatment and so on.关键词：depression syndrome;chest obstruction;psychological factors;emotion;etiology and pathogenesis;treatment based on relieving depression.
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发布时间：2022-08-31 - 摘要：The core theory and the key points of the treatment of lumbar disc herniation with spinal manipulation in traditional Chinese medicine was considered as the injury of bone seam and tendon groove. Based on this theory and correlation analysis combined with the pathological changes of lumbar disc herniation,the operation essential and core technical specification in the treatment of lumbar disc herniation with Lin’s orthopedic tuina were summarized, which could facilitate its further promotion and application.关键词：injury of bone seam and tendon groove;Lin’s orthopedic tuina;Tuina;lumbar disc herniation;technical specification
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发布时间：2022-08-31 - 摘要：This paper discussed the establishment and evaluation of rat model of diarrhea-predominant irritable bowel(D-IBS) syndrome with yang deficiency in spleen and kidney based on the combination of disease and syndrome. It was held that maternal separation,colorectal distention and water avoidance stress were the accepted methods for establishment of D-IBS model,as the animal model with yang deficiency in spleen and kidney was established by improper diet,diarrhea induced by bitter and cold herbs combined with overstrain and panic；model evaluation could be conducted in the following aspects as macroscopic sign,individual physicochemical index,drug reduction and model factors,which conform to the theory of Chinese medicine.关键词：irritable bowel syndrome;diarrhea;yang deficiency in spleen and kidney;animal model;combination of disease and syndrome
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发布时间：2022-08-31 - 摘要：Objective:To systematically assess the effects of safflow yellow on hemorheology of patients with acute cerebral infarction. MethodsA comprehensive search was preformed on relevant randomized controlled trials(RCTs)which investigated the effects of safflow yellow on hemorheology of patients with acute cerebral infarction.Systematic evaluational methods offered by Cochrane Library were used to evaluate those included literature. Then Meta-analysis and trial sequential analysis were performed by software RevMan 5.3 and TSA 0.9 respectively. Results:①Totally 9 RCTs which involved 780 participants were included in system evaluation. ②The Meta-analysis results well suggested that safflow yellow effectively reduced the plasma viscosity(PV),and improved the hematokrit(HCT). Sensitivity analysis and TSA sequential analysis confirmed the credibility of the results. ③There was no obvious difference on fibrinogen degree between groups,which needed further validation. Conclusion:Safflow yellow could improve the plasma viscosity and hematokrit of patients with acute cerebral infarction,which corrected the blood viscous state.关键词：safflow yellow;acute cerebral infarction;Hemorheology;system evaluation;Meta-analysis;trial sequential analysis
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发布时间：2022-08-31 - 摘要：Objective:To summarize and analyze the characteristics of four diagnostic information about pungent-warm medicinal formulas in the treatment of sore throat with Yin syndrome. Methods69 cases that met the inclusion criteria were collected. After standardized processing,related information were exported into EXCEL in the form of structured data. These data was analyzed by the Fisher exact probability test and association rules Apriori algorithm analysis and formed the result reports. Results:①Mahuang Fuzi Xixin decoction,Fuzi Ganjiang decoction,pinellia powder or decoction, Sini decoction were used as common prescription for sore throat with Yin syndrome. ②In the inspection of tongue picture,pale and moist tongue with saliva and white fur were often observed,which showed the local characteristics of throat as hyperemia and antiadoncus and whole state of mental sluggishness. In the pulse feeling and palpation,deep or thready or weak pulse and cold of hands and feet were often presented. In the auscultation and olfaction,the hoarse voice of patients could be found,with common accompanied symptoms of throat infarction, aversion to cold, dry throat and cough at the same time. ③In the medical history,patients often suffered wind-cold and poorly responsed to the prescription of clearing-heat and detoxifying,antibiotics and drugs of nourishing yin and clearing-heat,or even got worse. ④There were certain correlation among the cause of suffering cold-wind,the history characteristic of poor response to conventional treatment and the formation of typical tongue and pulse.⑤For the four diagnostic information of“red complexion ,frequent urination,enlarged and teeth-marked tongue with white coating”,types of prescription with aconite and dried ginger,as well as ephedra vulgaris and cassia twig,could be applicated with statistical significance(P<0.05). For the distinction between the two types prescription,the information of “angina light in day and heavy in night ,pharynx hyperemia,dislike drinking and like hot-drinking”was not statistically significant(P>0.05). Conclusion:In sore throat with Yin syndrome,there were certain correlation among the cause,the history characteristic,the common symptom and the formation of typical tongue and pulse,connected through body constitution. For the four diagnostic information of“red complexion ,frequent urination,enlarged and teeth-marked tongue”,type of prescription with aconite and dried ginger could be applicated；for“tongue with white coating”,type of prescription with ephedra vulgaris and cassia twig could be applicated.关键词：swelling and pain in throat;Yin syndrome;laryngalgia;tonsillitis;pungent-warm medicinal formulas;four diagnostic information;type of prescription with aconite and dried ginger;type of prescription with ephedra vulgaris and cassia twig
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发布时间：2022-08-31 - 关键词：dysuria;atmospheric theory;modified Shengxian drink;experience of famous doctor;Dr.Gu Wei-chao
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发布时间：2022-08-31 - 关键词：Sini Powder;Yinchenhao Decoction;Danggui Shaoyao Powder;Wuling Powder;intrahepatic cholestasis of pregnancy;postpartum urinary retention;postpartum lochia;classic prescription of traditional Chinese medicine;treatment based on syndrome differentiation
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发布时间：2022-08-31 -
- 摘要：Law of entropy, the second law of thermodynamics, provides scientific explanation for biological phenomena. Li Dong-yuan, a famous physician in period of Jin and Yuan who inherited and developed the academic thoughts of Inner Canon of Yellow Emperor, founded the theory of Vital Qi and the theory of Yin Fire during medical practice.Based on the analysis of his points and theory, this paper suggested that his academic thoughts mainly agreed with the law of entropy. Thus, Li’s thinking methods of clinic and health preservion could be annotated by the law of entropy.关键词：Li Dong-yuan;theory of spleen and stomach;law of entropy;Vital Qi;Yin fire;theory of dissipative structure
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发布时间：2022-08-31 - 摘要：This paper presented the clinical features of the disease due to dampness accumulation and the relationship between spleen-stomach and dampness accumulation,which implemented the preventive treatment of diseases by regulating the spleen and stomach to dissipate and dry dampness.关键词：dampness accumulation;spleen-stomach;preventive treatment of disease;therapy of traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Yiqi Yangyin Huoxue Qufeng Therapy” in the treatment of diabetic nephropathy in stage Ⅲwith qi-yin deficiency and blood-stasis. MethodsSixty subjects were randomized into two groups (30 cases in each group).All were received conventional modalities and controlled the blood lipid and glucose. The treatment group was given “Yiqi Yangyin Huoxue Qufeng”decoction and the control group was given losartan, with a course of 12 weeks. The clinical efficacy, syndrome score of Traditional Chinese Medicine(TCM), urinary albumin within 24 hours, urine ACR, Cysc, GFR, FPG, HbA1C, TC, TG and TNF-α were observed and compared. Results:①The total effective rate was 86.67% in the treatment group and 53.33% in the control group, and the efficacy in the treatment group was better than that in the control group(P<0.05);②After treatment, the syndrome score of TCM in the treatment group significantly decreased compared with before treatment(P<0.01), and was lower than that in the control group(P<0.01);③After treatment, the levels of Cysc, urine ACR and urine albumin within 24 h all decreased in both groups compared with before treatment(P<0.05,P<0.01), and those in the treatment group were lower than those in the control group(P<0.05, P<0.01);④After treatment, the levels of FPG, HbA1c, TC, TG and TNF-α in the treatment group decreased compared with before treatment(P<0.05, P<0.01), and was lower than those in the control group(P<0.05,P<0.01). Conclusion:“Yiqi Yangyin Huoxue Qufeng Therapy”can reduce the level of the urine protein and TNF-α, and improve the metabolism of glucose and lipid in the patients with diabetic nephropathy in stage Ⅲ.关键词：diabetic nephropathy;“Yiqi Yangyin Huoxue Qufeng Therapy”;therapy of traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Qinggan Jiangzhi Decoction” in the treatment of nonalcoholic steatohepatitis with spleen-deficiency and phlegm-stasis. MethodsOne hundred and twenty-five subjects were randomly divided into two groups:the treatment group in which 62 cases were treated with “Qinggan Jiangzhi Decoction”and the control group in which 63 cases were treated with polyene phosphatidylcholine tablet and Dangfei Liganning Capsule, with a course of 24 weeks. The syndrome score of TCM, liver function, blood lipid, body weight, BMI, B-ultrasonic results of the liver were observed and compared before and after treatment. Results:①After treatment, the syndrome scores of TCM significantly decreased in both groups compared with before treatment(P<0.01), but with no statistical difference between the two groups(P>0.05); ②After treatment, the levels of ALT, AST, TC, TG and γ-GT significantly decreased in both groups compared with before treatment(P<0.01), but with no statistical difference between the two groups(P>0.05); ③After treatment, the body weight and BMI significantly decreased in both groups compared with before treatment(P<0.05, P<0.01), but with no statistical difference between the two groups(P>0.05);④After treatment, the B-ultrasonic results of the liver were improved in both groups(P<0.01), and the efficacy in the treatment group was better than that in the control group(P<0.01). Conclusion:“Qinggan Jiangzhi Decoction” could be used in the treatment of nonalcoholic steatohepatitis with spleen-deficiency and phlegm-stasis,which significantly improved clinical symptoms and liver functions, especially alleviates the severity of fatty liver.关键词：“Qinggan Jiangzhi Decoction”;nonalcoholic steatohepatitis;spleen deficiency;phlegm-stasis
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of Shegan mixture in the treatment of infantile cough. Methods285 children with cough were randomly divided into the treatment group A, treatment group B and control group, 90 cases in each group. Based on conventional therapy, the treatment group A was treated with Shegan mixture, treatment group B were treated with Xuanfei Zhike mixture, while the control group was treated with oral lipid of ambrocol,additionally,with a course of 7 days. The clinical effects and the changes of TCM syndromes were observed. Results:①15 cases were dropped totally and the expulsion rate was 5.26%(＜10%)during the experiment.Finally, 270 cases were finished, 90 cases in each group. ②The clinical total effective rate of the treatment group A, treatment group B and control group was 91.11%, 80% and 77.78%,respectively.The difference of clinical curative effect between groups was statistically significant, the effect in the treatment group A was significantly better than that in the treatment group B and control group(P<0.05).③Compared within group before and after treatment,the difference of TCM syndrome score in each group was statistically significant(P<0.05). Compared between groups after treatment,the difference of TCM syndrome score was statistically significant(P<0.05)；among,the reduction of TCM syndrome score in the treatment group A was significantly lower than that in the treatment group B and the control group(P<0.05)；there was no significant difference on the reduction of TCM syndrome score between the treatment group B and control group(P>0.05). Conclusion:The curative effect of Shegan mixture in the treatment of infantile cough was significant,which obviously alleviated the clinical symptoms.关键词：infantile cough;Shegan mixture;positive control drug;Shegan Mahuang Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of electroacupuncture on postoperative recovery of patients with laparoscopic cholecystectomy compared with patient-controlled intravenous analgesia with morphine. Methods90 patients undergoing laparoscopic cholecystectomy were randomly divided into the treatment group A, treatment group B and control group C,30 case in each group. Patients in treatment group A was treated with electroacupuncture, whereas morphine in the form of patient-controlled intravenous analgesia (PCIA) was used in the treatment group B. The control group was only received nursing care；each group was intramuscular injected with pethidine for analgesia when necessary. The course of treatment in all groups was 24 h, followed up to 72 h. The visual analogue score(VAS)of postoperative pain, postoperative nausea and vomiting(PONV)within 24 h,first time of flatus and defecation and observe assessment of alertness/sedation(OAA/S)score were observed and compared. Results:①Compared with the control group at each timepoint, the difference of VAS score in the treatment group A and B at T2-T5 was statistically significant, and the VAS score in these two groups significantly deoreased(P<0.05)；there was no statistically significant difference on VAS score between the treatment group A and B(P>0.05). ②Within 24 hours,the incidence of PONV of the treatment group A, B and control group were 30.00%, 50.00% and 16.67%,respectively；Among,the incidence of PONV of the treatment group B was the highest(P<0.05),the difference between the treatment group A and control group was not statistically significant(P>0.05). There was no statistically significant difference on the incidence of PONV among groups (P>0.05). ③The first exhaust time and defecation time in the treatment group A was the earliest, the control group followed, and the treatment group B was latest (P<0.05). ④Compared at T1 and T2, the OAA/S score grade in the treatment group B was the lowest and the effect of sedation was the most significant(P<0.05),there was no significant difference on the OAA/S score grade between the treatment group A and control group (P>0.05)；compared between T1 and T2,the OAA/S score grade in the treatment B was statistically significant (P<0.05). Conclusion:Electroacupuncture could effectively relieve postoperative pain and promote the recovery of gastrointestinal function after operation,which reduced the incidence of PONV without excessive sedation.关键词：laparoscopic cholecystectomy;electroacupuncture;morphine;analgesia;postoperative recovery
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of Tianmen acupoint massage on the treatment of preoperative anxiety in patients with uterine myoma. MethodsSixty cases of uterine myoma patients with anxiety were randomly divided into the intervention and control groups.Patients in control group received routine nursing criteria and patients in intervention group were treated with Tianmen acupoint massage in addition to routine nursing.The treatment of both groups were continued until 1 day before operation, the assessment score of anxiety,heart rate and blood pressure (systolic blood pressure and diastolic blood pressure) were observed and measured. Results:①After treatment, there was statistically significant difference on assessment score of anxiety between groups, and the score in the intervention group was significantly lower than that in the control group (P<0.05).②After treatment, there were statistically significant difference on heart rate,systolic blood pressure and diastolic blood pressure between groups, and the indexes in the intervention group was significantly lower than those in the control group (P<0.05). Conclusion:Tianmen acupoint massage could improve the preoperative anxiety status of patients with uterine myoma, which benefit for surgery and postoperative rehabilitation.关键词：uterine myoma;preoperative anxiety;acupoint massage;nursing of traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect on upper limb swelling following surgery of distal radius fracture treated with external application of mirabilite. Methods60 patients with swelling following surgery of distal radius fracture were randomly divided into the treatment and control group,30 cases in each group. Based on conventional rehabilitation training after surgery, sodium aescinate was intravenously injected in the control group, while the treatment group was treated with external application of mirabilite additionally, with a course of 28 days. The diameter of wrist joint, visual analogue scale (VAS) of pain and Gartland-Werley (G-W) scores of wrist were recorded and compared in both group. Results:①Compared within group before and after treatment,the difference of the diameter of wrist joint in both groups was statistically significant (P<0.05)；compared between groups before and after treatment,the difference of the diameter of wrist joint was statistically significant,and the reduction of diameter in the treatment group was more significant than that in the control group(P<0.05).②Compared within group before and after treatment,the difference of VAS of pain and G-W scores of wrist in both groups were statistically significant (P<0.05)；while compared between groups before and after treatment,these differences were not statistically significant (P>0.05). Conclusion:There was significant effect on upper limb swelling following surgery of distal radius fracture treated with external application of mirabilite. Meanwhile it avoided the side effects and adverse reactions of intravenous administration.关键词：distal radius fracture;postoperative swelling;external application of mirabilite;intravenous administration;adverse effect
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Bai’s Huzhang ointment on wound healing after low anal fistuletomy. Methods150 patients with low anal fistulectomy were randomly divided into the treatment group A, treatment group B and control group,50 cases in each group. The treatment group A was treated with Bai’s Huzhang ointment on the gauze.The treatment group B were treated with Hongyou ointment on the gauze. The control group was treated with vaseline on the gauze,with a course of 21 days. The wound healing progress, weekly wound healing rate, postoperative pain and exudate were observed and compared. Results:①The wound healing time in the treatment group A was significantly less than that in the treatment group B and control group (P<0.05). There was no statistically significant difference between the treatment group B and control group (P>0.05). ②In the first two weeks, the wound healing rate in the treatment group A was significantly higher than that in the treatment group B and control group (P<0.05). In the third week,the wound healing rate in the treatment group A was significantly higher than that in the control group(P<0.05), but the difference of wound healing rate between treatment group A and B showed no statistical significance (P>0.05).③Compared within group after operation,the pain and exudate grading on the 7th,14th,21th day were statistically significant compared with those on the 2nd day (P<0.05). The pain and exudate grading in the treatment group A were significantly lighter than those in the treatment group B and control group on the 7th and 14th day after operation (P<0.05). Conclusion:Bai’s Huzhang ointment could obviously accelerate wound healing and improve pain and exudate after low anal fistulectomy.关键词：low anal fistula;postoperative recovery;wound healing;Bai’s Huzhang ointment
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发布时间：2022-08-31 - 摘要：This paper introduced six particulars in the application of Chinese herbs, including herbal dosage form, herbal tropism, herb-foci distance, administration route, herbal modalities and therapeutic collaboration.关键词：clinical herbal application;dosage form;herbal tropism;herb-foci distance;administration route;herbal modality;therapeutic collaboration
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发布时间：2022-08-31 - 摘要：This article summarized the mechanism and compatibility of Cornu bubali in the clinical treatment of headache. The curative effect of Cornu bubali on headache was discussed based on TCM syndrome differentiation and treatment and modern medicine pharmacology. It suggested that its mechanisms were related to anti-inflammation,analgesic and sedation,suppression of excessive immunity,maintenance of cerebral blood circulation patency and protection of brain tissue.关键词：Cornu bubali;headache;Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To investigate the repair effect of Panax notoginseng flower saponins hydrogel on skin wound. MethodsAnimal model of acute mechanical skin damage was formed by incisions of full skin in rats. Recombinant bovine basic fibroblast growth factor hydrogel (rb-bFGF) was used as a positive drug. Panax notoginseng flower saponins hydrogel(10g/L,25g/L,50g/L)was administrated by coating the wound surface,once a day and a course of 10 days. The effects of different treatments on wound healing time, wound healing rate, wound angiogenesis and wound histology were compared. Results:Panax notoginseng flower saponins hydrogel improved wound healing rate and reduced the infection reaction of infected wound with the time and dose increasing. Pathology results showed that Panax notoginseng flower saponins hydrogel significantly promoted the absorption of wound inflammatory exudate,formation of granulation tissue and epidermal hyperplasia. Conclusion:Panax notoginseng flower saponins hydrogel could promote the repair of skin wounds in rats.关键词：Panax notoginseng flower saponins hydrogel;hydrogel;skin wounds;healing;angiogenesis
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effect of indigo on Hashimoto’s thyroiditis and possible mechanism through comparison of the changes of thyroid globulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), interleukin-10 (IL-10) and interferon-γ(IFN-γ) in experimental autoimmune thyroiditis rats before and after treatment. Methods After adaptive feeding for 1 week,30 SD female rats were randomly divided into the normal control group(10 rats)and modeling group(20 rats). The modeling group was treated with iodine at high concentration, and the normal control group was given distilled water. From 4th week,the modeling group was treated with porcine thyroglobulin (pTG) of complete Freund’s adjuvant (CFA) and the successful modeling rats were randomly divided into the model control group (10 rats) and treatment group of traditional Chinese medicine (10 rats). The treatment group were treated with indigo decoction,with a course of 42 days. The levels of serum TGAb、TPOAb、INF-γ and IL-10 in all groups were tested by ELISA. And the pathological sections of thyroid gland tissue were observed by light microscopy. Results:After treatment, the serum levels of TPOAb and TGAb in the treatment group were decreased compared with the model control group (P<0.01). Compared with the normal control group, the serum IL-10 levels of all modeling groups were decreased (P<0.01), and the levels of IL-10 in the traditional Chinese medicine treatment group were increased compared with the model control group after treatment (P<0.01). Compared with the normal control group, the level of IFN-γ in the model control group and the traditional Chinese medicine treatment group were significantly increased (P<0.01); compared with the model control group, the IFN-γ level of traditional Chinese medicine treatment group was decreased (P<0.01). Conclusion:Indigo regulated the level of TGAb, TPOAb, IL-10 and IFN-γ in model rats,which improved Hashimoto’s thyroiditis.关键词：Indigo;Hashimoto’s thyroiditis;animal experiment;rats;T cell immunity
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of “Yangxin Decoction” on the serum levels of brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) in rats with chronic heart failure(CHF). Methods60 SD male rats were chose. Among which 10 rats were randomly selected as blank control group,the remaining 50 rats were treated with adriamycin by intraperitoneal injection at the dose of 4 μg/g/week. After 6 weeks the heart function of all rats were measured,and the model of CHF was established successfully with LVEF≤60%. The successful model rats were randomly divided into the model control group, Yangxin decoction group and captopril group, 14 in each group. Yangxin Decoction group was treated with Yangxin decoction extract at the dose of 2.34 g·kg-1·d-1; the captopril group was treated with captopril at the dose of 2.25 μg·g-1·d-1,and the blank control group and model control group were treated with equal volume of distilled water. After 4 weeks,the level of LVEF and serum BNP of all rats were measured,the morphology of myocardial tissue was observed by Hematoxylin-Eosin (HE) staining. Results:For BNP and LVEF,the differences between the blank control and model control group were statistically significance (P<0.01); the differences between the model control and Yangxin Decoction group or captopril group were statistically significance (P<0.01)；there were no statistically significant difference between the Yangxin decoction and captopril group (P>0.05). HE staining showed that in the blank control group myocardial cell morphology,ransverse longitudinal lines and cytoplasm were normal,muscle fibers arranged in neat,cytoplasm was homogeneous and no inflammatory cell infiltration and cell proliferation were in the myocardium; while in model group myocardial cells are wavy and the gap widened and swelled,inflammatory cell infiltration,part of the vacuole degeneration,myocardial fiber arrangement disorder, interstitial edema and even bleeding were observed. It can be seen mild myocardial fiber granular degeneration in the Yangxin decoction and captopril group,and there was no obvious difference between two groups. Conclusion:“Yangxin Decoction” could reduce the level of serum BNP and improve LVEF of rats with CHF,the efficacy was comparable with captopril.关键词：Yangxin Decoction;brain natriurotic peptide;left ventricular ejection fraction;chronic heart failure;Adriamycin
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发布时间：2022-08-31 - 摘要：Objective:To investigate and compare the protective effect of two kinds of aqueous extractive of Penis et Testis Cervi against cisplatin(CDDP)-induced acute kidney injury in mice and discuss the possible mechanism. Methods64 mice were evenly and randomly divided into the control group,CDDP model group, aqueous extract of penis cervi of Cervus nippon and Cervus elaphus with low-,mid- and high- dose(100,0,400 mg/kg respectively)groups,8 mice in each group. The different groups of Penis et Testis Cervi were intragastrical administrated with corresponding aqueous extract for 7 days, the mice(except the control group)were intraperitoneally injected with CDDP(20 μg/g)to induce acute kidney injury on fifth day 1h after administration. After modeling 48 h, the index level of renal function in serum and kidney tissue was measured and the pathological change was observed by HE staining. Results:Compared with CDDP model group,the groups treated with two kinds of aqueous extract of Penis et Testis Cervi against with different dose were all improved the index level of renal function and renal damage,and the effect of penis cervi in Cervus nippon was better than Cervus elaphus. It showed the most significant effect in the group treated with penis cervi of Cervus nippon at high dose,which the contents of BUN,CRE and MDA significantly decreased(P<0.01)and the activity of SOD and GSH significantly increased(P<0.01). It obviously improved the degeneration and necrosis of renal tubule,but not recovered. Conclusion:These two kinds of aqueous extract of Penis et Testis Cervi effectively protected mice from the acute kidney injury induced by cisplatin. It may be closely related to cleaning out radicals and anti-oxidative stress.关键词：aqueous extract of Penis et Testis Cervi;cisplatin;acute kidney injury;protective effect;oxidative stress
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发布时间：2022-08-31 - 摘要：Objective:To optimize the ultrasonic-assisted extraction process of Curcumae Rhizoma based on response surface methodology and desirability function. MethodsBased on the experiment of single factor,and taken the extraction contents of furanodiene and β-elemene from Curcumae Rhizoma as evaluation index, the effect of the ratio of liquid to solid, ethanol concentration and ultrasound time on extraction amount of furanodiene and β-elemene were investigated by using response surface methodology. Combined with the desirability function,best ultrasonic assisted extraction process was optimized. Results:The value of overall desirability as 1.00 was obtained when the ratio of liquid to solid was 7 ml·g-1, the concentration of ethanol was 75% and the ultrasonic time was 19 min. Under the optimizated extraction conditions, the actual extraction contents of furanodiene and β-elemene were 137.1 μg·g-1 and 122.4 μg·g-1, and the relative deviations between the measured and predicted value were 0.65% and 0.73%,respectively. Besides,compared to the extraction method of steam distillation recorded in the monogragh of Curcumae Rhizoma in Chinese Pharmacopoeia,the optimized condition demonstrated higher extraction efficiency. It displayed that the surface structures of the sonicated herbal materials were fluffy and irregular by the field emission scanning electron microscope. Conclusion:The ultrasonic-assisted extraction technique of Curcumae Rhizoma optimized by response surface methodology and desirability function was stable and feasible.关键词：Curcumae Rhizoma;ultrasonic;response surface methodology;desirability function
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发布时间：2022-08-31 - 摘要：This article reviewed the mechanism research progress on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal. By consulting and summarizing the domestic and foreign literature, it suggested that the absorption and transportion of protein peptides were mainly performed through the carrier transport, pinocytosis and M cell pathway, cell bypass and glutathione (GSH) transport system.Meanwhile the process of oral absorption into the blood and relevant mechanisms of venom, hirudin, lumbrokinase, pilose antler,4 kinds of protein from animal source with significant clinical effect were analyzed,which showed great application value and significance for the development of protein polypeptide drugs from animal source.关键词：Chinese traditional medicine from animal;protein polypeptide;absorption mechanism;oral administration;review
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发布时间：2022-08-31 - 摘要：This article reviewed the experimental research progress on traditional Chinese medicine in the diagnose and treatment of precancerous lesions of chronic atrophic gastritis based on toxin in recent years. Considering toxin as important factor of precancerous lesions of chronic atrophic gastritis(CAG),detoxification is important therapy for the block or even reverse precancerous lesions of CAG. The experimental research progress on traditional Chinese medicine in the treatment of precancerous lesions of CAG based on toxin were analyzed and summarized from the following aspects:intervention on injury repair of gastric mucosal, regulation of gastrointestinal hormones, effect on free radical metabolism and cancer gene expression, regulation of cell proliferation and apoptosis.关键词：chronic atrophic gastritis;precancerous lesions;detoxification;therapy of traditional Chinese medicine;experimental study;review
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- 389
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发布时间：2022-08-31 - 摘要：This paper reviewed the clinical efficacy and mechanisms of Kuntai capsule the treatment of female infertility and perimenopausal symptoms due to diminished ovarian reserve and premature ovarian failure.关键词：diminished ovarian reserve;Kuntai Capsule;infertility;perimenopausal symptom;premature ovarian failure
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- 411
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发布时间：2022-08-31
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