最新刊期
期 10 ， 2016
- 摘要：Through the clinical practice followed up with the physicians,medical cases analysis and literature study on the experience of the supervisor and his team,professor Tang Han-jun's academic thought and clinical experience on therapy of strengthening healthy energy in surgical diseases treatment were systematically summarized,which presented as the four aspects of “supplement,regulation,dredging and harmony”.关键词：therapy of strengthening healthy energy;academic thoughts;experience of prestigious physicians in TCM;Tang Han-jun
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发布时间：2022-08-31 - 摘要：Assorted and classified the related literature of syncope syndrome, this paper proposed the new concept of “pain syncope ”(syncope due to pain) and “ depression syncope ”(syncope due to depression syndrome), and mainly discussed the syndrome differentiation and treatment of “ depression syncope ”. It considered that syncope was one of the manifestations of depression syndrome. Person suffered from syncope that caused by the disturbance of qi-movement mediated by the emotional factors,which is called as syncope due to depression syndrome. Syncope due to depression syndrome includes syncope with qi excess,part syncope with blood-inverse and syncope with phlegm disorder. “Zhong e” ,as an important kind of syncope due to depression syndrome,is due to psychasthenia and mainly caused by the temperament endowment as “the internal emotional factors”. Qi adverseness is considered as the basic pathogenesis of syncope due to depression syndrome,which presented the syndrome of syncope with qi disorder and “Zhong e”. Bleeding due to qi reversed flow can be expressed as syncope with blood disorder,phlegm due to qi reversed flow can be expressed as syncope with phlegm disorder. Stagnant blood and phlegm clouding the clear orifices are also the important pathogenesis of syncope due to depression syndrome. Syncope due to depression syndrome show peculiar clinical features,and often accompanied by the manifestations of dominant and recessive depression syndrome. According to the importance and necessity,the therapy point of syncope due to depression syndrome is before syncope,after syncope and syncope in turn. The five treatment principles for syncope due to depression syndrome are soothing liver and regulating qi movement,invigorating heart to tranquilize mind,activating blood and dissolving stasis,removing phlegm and turbid,regulating viscera as well as yin and yang, qi and blood. Syncope due to depression syndrome can be regarded as psychological syncope and vasovagal syncope induced by psychological disorders in modern medicine.关键词：depression syndrome;syncope syndrome;“Zhong e”;emotional etiology and pathogenesis;treatment based on relieving depression;psychological syncope
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发布时间：2022-08-31 - 摘要：Syndrome differentiation system of six meridians established by Treatise on Febrile Diseases pay attention to the holistic concept and systematic syndrome differentiation. Based on this system,syndrome differentiation system of classical prescription was developed and presented the connotation of accurate syndrome differentiation. Accurate syndrome differentiation,the detailed and concrete kind of systematic syndrome differentiation,emphasize the demonstration and efficacy,and realize the integration of “prescription” and “syndrome” through the prescription and drug as the main carrier,which conform to the direction of medical science development.关键词：Treatise on Febrile Diseases;syndrome differentiation system;systematic syndrome differentiation;accurate syndrome differentiation
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发布时间：2022-08-31 - 摘要：Intermuscular adipose tissue(IMAT)is considered as an important factor that influence the insulin sensitivity of skeletal muscle. The paper analyzed the source and regulation factors of IMAT and its influence on insulin sensitivity,and explained the possible relationship between IMAT and insulin resistance from the TCM theory of “ spleen governs the muscle”.关键词：type 2 diabetes;intermuscular adipose tissue(IMAT);insulin resistance;“spleen governs the muscle”
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发布时间：2022-08-31 - 摘要：Objective:To study the clinical characteristics and platelet parameters of different syndrome of TCM in senile hypertensive. MethodsA total of 127 cases of senile hypertensive patients were selected,among which 19 cases with yang excess and yin deficiency,25 cases with qi deficiency and blood stasis,38 cases with deficiency of both qi and yin,27 cases with phlegm and blood stasis,18 cases with yang deficiency in spleen and kidney. The clinical features and the platelet parameters in patients with different syndrome types were compared. Results:①Compared with other types, the levels of SBP, DBP, TC, LDL and ratio of cerebral infarction (89.5%) in patients with yang excess and yin deficiency were obviously increased(P<0.05). ② Compared with other types, the platelet distribution width (PDW) in patients with yang excess and yin deficiency was highest(P<0.05)and the mean platelet volume(MPV) was lowest(P<0.05)；there were no significant differences on PDW and MPV among the other syndrome types(P>0.05).Compared among the different syndrome types, the differences of platelet count (PLT), plateletcrit (PCT), platelet large cell ratio (P-LCR) were hot statistically significant (P>0.05). Conclusion:PDW and MPV are closely related to the senile hypertensive patients with yang excess and yin deficiency,which could be used as one of the objective reference basis for syndrome differentiation.关键词：senile hypertensive;syndrome type of TCM;platelet parameters
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发布时间：2022-08-31 - 摘要：Objective:To analyze Professor He Liren’s medication rules in the treatment of vertigo by using data mining method. MethodsThe medical data of 135 patients with vertigo(404 prescriptions) were collected to establish the database. The medication rules were analyzed in the herbal frequency and compatability. Results:①The frequently-used herbs included Stigmata maydis, Agrimony, Ligusticum wallichii, Semen coat glycines nigrum, White atractylodes rhizome, Rhizoma Gastrodiae, Sedum aizoon L., Giant knotweed rhizome, mulberry leaf, Radix puerariae, and so on. ②The common paired-herbs were Eclipta alba with Fructus Ligustri Lucidi, Radix sileris with Radix stephaniae tetrandrae, Radix Paeoniae Rubra with Radix Paeoniae Alba, Ganoderma lucidum grass with Sedum aizoon L., Cicada slough with Bombyx Batryticatus, and so on. ③The herbs against vertigo were mulberry leaf, Stigmata maydis, mulberry bark, Rhizoma Chuanxiong, and Rhizoma Polygoni cuspidate; the herbs against high pressure were Stephania tetrandra, Flastem Milkvetch Seed, Sophora flavescens, pollen Typhae, and Tribulus terrestris. Conclusion:Professor He usually treats vertigo condition by tonifying the kidney, invigorating the spleen, and nourishing the blood, with the assistance of calming the liver, promoting blood circulation and resolving dampness.关键词：vertigo;medication rule;data mining;He Liren
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Wang Xiuxia’s experience in the treatment of perimenopausal dysfunctional uterine bleeding. Professor Wang considered deficiency of spleen and kidney and damage of chong and ren meridians as the main pathogenesis of perimenopausal dysfunctional uterine bleeding. In the treatment she advocated the hemostasis combined with the treatment of root cause for arresting uterine hemorrhage,strengthening chong meridians to stop bleeding,invigorating spleen and tonifying kidney and supplementing qi and nourishing blood to restore. And surgeries should be assessed according to the condition of patients.关键词：perimenopausal dysfunctional uterine bleeding;cyclical treatment;experiences of famous doctor;Wang Xiuxia
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Zhu Huirong’s clinical experience in treating colorectal cancer based on the theory of“dredging function of six hollow organs”, including dredging the visible pathogenic factors,dissipating the potential pathogenic factors and relieving the emotional depression. Two proven cases of postoperative colorectal cancer were presented as examples.关键词：colorectal cancer;“dredging function of six hollow organs”;experience of famous physician;Zhu Huirong
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发布时间：2022-08-31 - 摘要：According to the classified method of six channels into nine parts,the affiliation of six channels in abdominal diseases was confirmed. Among them, there were three kinds in the typical diseases of six channels and five kinds in the non-typical diseases of six channels. For the latter,it could be recognized as a certain complicated disease and then identified the specific prescription and syndrome.关键词：classified method of six channels into nine parts;complicated disease;prescription and syndrome
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发布时间：2022-08-31 - 摘要：In recent years, there are many research about the theory of “Shaoyang governs the bone” in Neijing,but lack of systematic summary and review. This paper analyzed the ancient meaning and sorted the related literature of “Shaoyang governs the bone”. It founded that the interpretation of the disease associated with “Shaoyang governs the bone” was mainly divided into two parts as muscle rheumatism and bone paralysis by the current scholars. The possible relationship between “Shaoyang governs the bone” and biliary osteopathy was tried to discuss.关键词：Shaoyang governs the bone;muscular rheumatism;bone paralysis;biliary osteopathy
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发布时间：2022-08-31 - 摘要：There are 26 passages about acupuncture and moxibustion in the Treatise on Febrile Disease,but only 7 passages clearly record the specific acupuncture points as follow:Fengchi(GB20),Fengfu(GV16),Dazhui(GV14),Feishu(BL13),Ganshu(BL18),Qimen(LR14) and Guanyuan (CV4),among which only 6 are clearly pointed the needling. These points are specific points, and physician Zhang Zhong jing emphasized the specific points,the selected points were fewer but better with a wide range of treatment.关键词：Treatise on Febrile Piseases;acupoints;clinical application
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发布时间：2022-08-31 - 关键词：Qingying decoction;Yingfen syndrome;syndrome differentiation of wei-qi-ying-blood
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of electro-acupuncture based on syndrome differentiation of Yin and Yang in treating stroke patients with hemiplegia in community. MethodsAccording to the multi-center stratified block randomization,120 stroke patients with hemiplegia were divided into the treatment and control groups,60 in each group. The control group was treated with routine rehabilitation therapy,the treatment group was treated with electro-acupuncture based on syndrome differentiation of Yin and Yang on the basis of treatment for control group, with a course of 8 weeks. The changes of simplified Fugl-Meyer Assessment (FMA), modified Barthel Index(BI) and modified Rankin Scales (mRS) were observed and compared. Results:①Finally 112 patients completed the trail with 56 in each group, 8 cases fell off. ② After treatment, there was statistically significant difference on the level of FMA between the two groups,which suggested that the effect of the treatment group on improving the motor function was obviously better than that of the control group(P<0.05).③After treatment, there was statistically significant difference on the level of BI between the two groups,which suggested that the effect of the treatment group on improving the activities of daily living was obviously better than that of the control group(P<0.05). ④After treatment, there was statistically significant difference on the level of mRS between the two groups,which suggested that the effect of the treatment group on improving the dysfunction was obviously better than that of the control group(P<0.05). Conclusion:Electro-acupuncture based on syndrome differentiation of Yin and Yang shows good effect in treating stroke patients with hemiplegia in community,which is worthy of popularization and application in community.关键词：stroke;hemiplegia;acupuncture therapy;Yin syndrome;Yang syndrome;community rehabilitation
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of “Shenling Baizhu Powder” on serum gastrointestinal hormones and electrogastrogram in children with functional dyspepsia of spleen deficiency and qi stagnation. MethodsOne hundred and twenty subjects were divided into the observation group and control group, 60 cases in each group. The control group was given Mosapride, and the observation group was given “Shenling Baizhu Powder” and Mosapride, with a course of two weeks. The changes of serum motilin(MTL), neuropeptide Y(NPY)5-serotonin(5-HT) and electrogastrogram were observed before and after treatment in both groups. Results:①After treatment, in both groups, the levels of NPY and MTL increased(P<0.05) and 5-HT decreased (P<0.05), with more significant improvement in the observation group than in the control group(P<0.05). ②After treatment, the electrogastrogram in gastric corpus and antrum were all improved in both groups(P<0.05), with more significant improvement in the observation group than in the control group(P<0.05). Conclusion:“Shenling Baizhu Powder” acts to treat functional dyspepsia of spleen deficiency and qi stagnation by improving gastrointestinal motility.关键词：functional dyspepsia;spleen deficiency and qi stagnation;“Shenling Baizhu Powder”;children
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of “Pingni Decoction” in the treatment of reflux esophagitis with syndrome of stagnated heat in liver and stomach. Methods60 patients reflux esophagitis with syndrome of stagnated heat in liver and stomach were randomized into the treatment group and control group,30 cases in each group. The treatment group was treated with “Pingni Decoction”,and the control group was treated with omeprazole capsule,with a course of 8 weeks. The clinical efficacy,endoscope change and the scores of TCM syndrome were observed. Followed up for 3 months, the recurrence was observed. Results:①The total effective rate of TCM syndrome and endoscope in the treatment group were 93.33% and 93.33%,and in the control group were 86.67% and 90% respectively, and the efficacy in the treatment group was better than the control group (P<0.05). ②After treatment, the scores of TCM syndrome in both groups were significantly decreased (P<0.05),compared between the two groups, the difference on score of TCM syndrome between before and after treatment was statistically significant (P<0.05). ③The recurrence rate was 7.14% in the treatment group and 73.08% in the control group,and the difference was statistically significant(P<0.05). Conclusion:“Pingni Decoction” shows effect in the treatment of reflux esophagitis with syndrome of stagnated heat in liver and stomach,which could improve the symptoms significantly and repair the endoscopic mucosal injury with low relapse rate after drug withdraw.关键词：reflux esophagitis;syndrome of stagnated heat in liver and stomach;Pingni Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect and possible mechanism of “Cupai Decoction” in patients of polycystic ovarian syndrome (PCOS) with insulin resistance (IR). MethodsEighty cases of PCOS with IR were randomly divided into the treatment group and control group, 40 cases in each group. The treatment group was orally treated with “Cupai Decoction”,and the control group was orally treated with Diane-35. Both groups were treated for three months and follow-up for three months. The clinical effect was observed and the index changes in endocrine and sex hormone were compared. Results:①During the trial,two cases among all 80 patients fell off. Finally 78 patients completed the trial,39 cases in each group. ②The total effective rate in the treatment group and control group was 74.36 % and 51.28 %,respectively,the difference was statistically significant and the treatment group was better than the control group(P<0.05). ③Comparison of before and after treatment,the difference on the level of serum homocysteine(Hcy) in the treatment group was statistically significant (P<0.05),but no statistically significant difference in the control group(P>0.05). After treatment,the level of Hcy in the treatment group was obviously decreased compared with the control group,with statistically significant difference (P<0.05). After 3 months follow-up, there was no rebound in the level of Hcy in the treatment group, which was significant decreased compared with treatment before and the control group (P<0.05). ④Comparison of before and after treatment,the differences on the level of LH, LH/FSH in the treatment group and LH,T,LH/FSH in the control group were statistically significant (P<0.05)；After 3 months follow-up, the levels of LH,T,LH/FSH in the control group were rebounded obviously(P<0.05). After 3 months follow-up, the level of LH/FSH in the treatment group was significant lower than that in the control group (P<0.05). Conclusion:Cupai Decoction shows good effect in the treatment of PCOS with IR. Its mechanism may be achieved by reducing the level of Hcy effectively and continuously and controlling the levels of LH, LH/FSH stably.关键词：polycystic ovarian syndrome;insulin resistance;Cupai Decoction;homocysteine;cardiovascular risk
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of Wenzhen Yunqi recipe in treating patients of chronic fatigue syndrome with negative emotion . Methods153 subjects were randomly divided into the health group(50 cases),treatment group(51 cases) and control group(52 cases). The health group was received any treatment,the treatment group was treated with Wenzhen Yunqi Recipe and the control group was treated with Chinese patent medicine Xiaoyao pill,with a course of 3 months. The score changes of fatigue scale-14 (F-14),Hamilton anxiety scale (HAMA),Hamilton depression scale (HAMD) and health status questionnaire (SF-36) score were observed,as well as the regulating effect on hydrogen proton magnetic resonance spectroscopy (1H-MRS) in bilateral hippocampal area. Results:①3 cases fell off during the trial(1 case in the treatment group and 2 cases in the control group)；finally 150 cases completed the trial,50 cases in each group. ②Comparison of before and after treatment,the differences on the score of F-14,HAMD and HAMA in both groups were statistically significant(P<0.05)；after treatment,the differences on the score of F-14,HAMD and HAMA between groups were statistically significant,and the effects on fatigue and negative emotion in the treatment group were better than those in the control group(P<0.05) ③Comparison of before and after treatment,the differences on the five dimensions scores in SF-36(body function,general health,life vitality,emotional role and psychological health) in the treatment groups were statistically significant(P<0.05)；the differences on the two dimensions scores(life vitality,psychological health)in the control groups were statistically significant(P<0.05).After treatment,the differences on the five dimensions scores in SF-36(body function,general health,life vitality,emotional role and psychological health)between groups were statistically significant(P<0.05). ④Before treatment,there were statistically significant difference on the ratio of NAA/Cr and Cho/Cr in the left and right hippocampus in the treatment and control groups compared with the health group(P<0.05),but the difference on the ratio of NAA/Cr and Cho/Cr between the treatment and control groups was not statistically significant(P>0.05). Comparison of before and after treatment,the ratio of NAA/Cr in the left and right hippocampus in the treatment group was significantly increased,the ratio Cho/Cr in the left hippocampus was significantly decreased(P<0.05),the difference on the ratio Cho/Cr in the right hippocampus was not statistically significant(P>0.05)；the differences on the ratio of NAA/Cr and Cho/Cr in the left and right hippocampus in the control group were not statistically significant(P>0.05). After treatment,the increase of the NAA/Cr in the left and right hippocampus in the treatment group was more significant than that in the control group,and the decrease of the ratio Cho/Cr in the left hippocampus was more significant than that in the control group(P<0.05). Conclusion:Wenzhen Yunqi Recipe shows effect in the treatment of chronic fatigue syndrome,which significantly ameliorate the negative emotional and physical fatigue of the patients and improve the quality of life. Its mechanism may be related to regulation of functional metabolism(NAA/Cr、Cho/Cr)in the central hippocampus.关键词：chronic fatigue syndrome;negative emotion;Wenzhen Yunqi Recipe;central action mechanism;hippocampus
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发布时间：2022-08-31 - 摘要：Objective:To observe the immediate curative effect of short and strong stimulation on neck shoulder point in the treatment of neck-shoulder syndrome. Methods96 cases of neck-shoulder syndrome were randomly divided into the treatment group,control group and placebo group,32 in each group. The placebo group was treated with comfort massage,the control group was treated with conventional massage and the treatment group was treated with short and strong stimulation on neck shoulder point. All groups were treated only once and then the effect was observed immediately. The changes of pain visual analogue scale (VAS),University of California at Los Angeles(UCLA)scoring system and clinical evaluation scale of cervical vertebra were compared. Results:①4 cases in the placebo group fell off during the trial,and finally 92 cases completed the trial,32 in the treatment group,32 in the control group and 28 in the placebo group. ②Comparison of before and after treatment,the difference of VAS score in all groups was statistically significant(P<0.05)；comparison among the three groups,the difference of VAS score was statistically significant,and the score decrease in the treatment group was more significant than that in the control and placebo group(P<0.05),the difference between the control and placebo group was not statistically significant(P>0.05). ③Comparison of before and after treatment,the difference of UCLA score in all groups was statistically significant(P<0.05)；comparison among the three groups,the difference of UCLA score was statistically significant,and the score increase in the treatment group was more significant than that in the control and placebo group(P<0.05),the difference between the control and placebo group was not statistically significant(P>0.05). ④Comparison of before and after treatment,the difference on score of clinical evaluation scale of cervical vertebra in all groups was statistically significant(P<0.05)；comparison among the three groups,the difference on score of clinical evaluation scale of cervical vertebra was statistically significant,and the score increase in the treatment group was more significant than that in the control and placebo group(P<0.05),the difference between the control and placebo group was not statistically significant(P>0.05). Conclusion:The therapy of short and strong stimulation on neck shoulder point shows good immediate curative effect,which significantly improve the discomfort of neck and shoulder.关键词：neck-shoulder syndrome;neck shoulder point;immediate effect;special point for special disease;mechanism of neurohumor
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发布时间：2022-08-31 - 摘要：This paper introduced the experience in the treatment of ankylosing spondylitis from the syndrome of yin deficiency and dampness-heat. The important influence of yin deficiency on the pathogenesis was discussed from the etiology, pathogenesis, clinical prognosis and other aspects. The formation causes of dampness-heat and its significance in the development of the disease were analyzed. Kidney deficiency and dampness-heat stasis were considered as the important pathogenesis of ankylosing spondylitis. Yin deficiency in kidney was the basis of the disease,while the dampness-heat was not only the pathogenic factors but also the main pathological product that throughout the disease. The therapy of nourishing yin and tonifying kidney and clearing and reducing dampness-heat shows good clinical effect in the treatment of ankylosing spondylitis.关键词：ankylosing spondylitis;yin deficiency with damp-heat;treatment based on syndrome differentiation;therapy of traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Discussed the syndrome and treatment of Guizhi(cassia twigin)in Prescriptions of Intergrating Chinese and Western Medicine combined with the exploration of the clinical application from the classic original texts in Treatise on Febrile and Miscellaneous Diseases and Shennong’s Classic of Materia Medica,this paper introduced Zhang Xichun’s experience on the application of Guizhi(cassia twigin)from 3 aspects of its effects as expelling pathogenic factors from muscles and keeping ying and wei qi in balance,ascending and descending of functional activity of qi,warming and activating meridian and blood vessels.关键词：Zhang Xichun;prescriptions of intergrating Chinese and Western medicine;Guizhi(cassia twigin)
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发布时间：2022-08-31 - 摘要：Objective:To explore the mechanism of Xiaoying Mixture on autoimmune thyroiditis in view of factor associated suicide / factor associated suicide ligand(Fas/FasL). MethodsFor 58 rats,10 rats were divided into the normal group,and rat model of experimental autoimmune thyroiditis was established in the other 48 rats. Then the successful modeling rats were divided into the model group,tripterygium glycosides group as positive control and Xiaoying Mixture groups with low- and high-does. The level of serum thyroid globulin antibody (TgAb) was detected by radioimmunoassay (RIA); and the expression of Fas and FasL in thyroid epithelial cells were detected by immunohistochemistry. Results:Compared with the normal group,the level of TgAb in the model group was increased(P<0.05);compared with the model group,the level of TgAb in the tripterygium glycosides group and Xiaoying Mixture group with high-dose was significant decreased(P<0.05). The difference on the positive area of Fas and FasL expression between the normal group and model group was statistically significant (P<0.01); compared with the model group, the expression of Fas and FasL in the treatment groups was decreased with statistically significant difference (P<0.05, P<0.01). For the effect on reducing the expression of Fas,the difference between the tripterygium glycosides group and Xiaoying Mixture groups with low- and high-dose was statistically significant (P<0.01). For the effect on reducing the expression of FasL,the difference between the tripterygium glycosides group and Xiaoying Mixture group with high-dose was not statistically significant (P>0.05); the difference between the tripterygium glycosides group and Xiaoying mixture group with low-dose was statistically significant (P<0.01). Conclusion:The mechanism of Xiaoying Mixture on cell apoptosis in the treatment of autoimmune thyroiditis may be related to reducing the expressions of Fas and FasL in thyroid epithelial cells关键词：Xiaoying Mixture;autoimmune thyroiditis;Fas;FasL
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Jianpi Jiedu Decoction on the mRNA expression of Bax and Bcl-2 in subcutaneous transplanted tumor of nude mice. MethodsHCT8/V cells were subcutaneously injected into the nude mice to establish model. Then 32 successful modeling mice were randomly divided into four groups and 8 in each group. The blank group was treated with intraperitoneal injection of 0.9% NaCl, the chemotherapy group was treated with intraperitoneal injection of vincristine, the Chinese medicine group was given Jianpi Jiedu Decoction by means of intragastric administration, the combination group was given vincristine with intraperitoneal injection and Jianpi Jiedu decoction with intragastric administration. The tumor weight and inhibition rate of subcutaneous transplanted tumor in each group were measured, the pathological changes of tumor tissues were observed by light microscope, and the mRNA expression of Bax and Bcl-2 were determined by Real-time PCR. Results:Compared with the blank group, the tumor weight of the chemotherapy group, Chinese medicine group and combination group was significantly reduced, with statistically significant difference(P<0.01); compared with the chemotherapy group, the tumor weight of the Chinese medicine group and combination group was significantly reduced, with statistically significant difference(P<0.01); compared with the blank group, the inhibition rate of tumor in the chemotherapy group, Chinese medicine group and combination group were 22.84%, 38.44%, 51.53% respectively, and the effect of the combination group was best. Compared with the blank group, the Bax mRNA expression of the chemotherapy group, Chinese medicine group and combination group was increased significantly (P<0.05, P<0.01) and the Bcl-2 mRNA expression was significantly decreased (P<0.01); compared with the chemotherapy group, the relative expression level of Bax mRNA in the Chinese medicine group and the combination group was higher than that in the chemotherapy group(P<0.05,P<0.01), the relative expression level of Bcl-2 mRNA in the Chinese medicine group and the combination group was lower than that in the chemotherapy group (P<0.01). Conclusion:Jianpi Jiedu Decoction promote the apoptosis of colorectal cancer cells by up-regulating the mRNA expression of Bax and down-regulating the mRNA expression of Bcl-2, which shows synergistic effect with chemotherapy drug.关键词：colorectal cancer;Jianpi Jiedu Decoction;Bax;Bcl-2;cell apoptosis
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发布时间：2022-08-31 - 摘要：Objective:To explore the effective parts of Alisma orientalis(Samuel.) Juzep. associated with blood glucose decrease in type 2 diabetic mice. MethodsEthanol extracts from A. orientalis were obtained by ultrasonic extraction. Then, the ethanol extract was extracted and separated with petroleum ether, ethyl acetate, water saturated n-butanol and water respectively. After decompressing concentration, these solvent extractions were applied to type 2 diabetic mice model induced by intraperitoneal injection of streptozotocin and nicotine. After successful modeling,the mice were divided into the blank control group(without injection of streptozotocin and nicotine),model group of type 2 diabetes mellitus,positive control group and test drug groups,8 in each group. The blank control group and model group were treated with 0.9% NaCl at the dose of 10μl/g,the test drug groups were treated with corresponding extracts from different solvent extractions described above at the high-,mid-,low-dose of 100,50,25 μg/g respectively. The positive control group was treated with rosiglitazone at the dose of 10μg/g. The treatment course was 21 days for intragastric administration. The effective parts of Alisma orientalis(Samuel.) Juzep. associated with blood glucose decrease in type 2 diabetic mice were screened and then the effect of the screened effective part on the differentiation of 3T3-L1 pre-adipocyte was observed. Results:Compared with the model group,the blood glucose was decreased after the intragastric administration with ethyl acetate extract of A. orientalis at dose of 100μg/g for 21 days and the glucose tolerance during the oral glucose tolerance test (OGTT) was improved(P<0. 01). The differentiation of pre-adipocyte was promoted when the ethyl acetate extract of A. orientalis at the concentration of 1 mg/L and 10 mg/L. Conclusion:The ethyl acetate extract of A. orientalis reduced the blood glucose in type 2 diabetic mice and promoted the differentiation of 3T3-L1 pre-adipocytes, but the specific mechanism still need to be further studied.关键词：Alisma orientalis(Samuel.) Juzep.;type 2 diabetic mice;blood glucose;differentiation of 3T3-L1 pre-adipocytes
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Wenshen Jianpi Decoction on 5-hydroxytryptamine (5-HT), 5-HT3 receptor (5-HT3R), and 5-HT4 receptor (5-HT4R) in colon mucosa of rats with diarrhea-predominant irritable bowel syndrome (IBS-D). MethodsForty male Sprague-Dawley rats were divided randomly into four groups as the normal group, model group, Chinese medicine group, and western medicine group. Except the normal group,IBS-D model was copied in the other groups by an integrated approach which combined the AL-Chaer ED modeling method,intragastric administration with senna soup,tail tamping stimulation and constraint stress. After successful modeling,the normal and model group were administrated with 0.9% NaCl,the Chinese medicine group was treated with Wenshen Jianpi Decoction,and the western medicine group was treated with pinaverium bromide,with a course of two weeks for intragastric administration. The general situation of rats was observed, the score of abdominal withdrawal reflex(AWR)and the fecal moisture content in rats were measured. The colonic mucosa of rats were collected,the expression of 5-HT was determined by enzymelinked immunosorbent assay and the expression of 5-HT3R and 5-HT4R were determined by immunohistochemical assay. Results:Compared with the normal group, the rats in the model group appeared loose stool, dull color of fur and appetite loss, meanwhile the AWR scores of rats and fecal moisture content increased,the levels of 5-HT and the optical density of 5-HT3R and 5-HT4R in the colonic mucosa increased, with statistically significant differences (P<0.05, P<0.01). Compared with the model group,the AWR scores,fecal moisture content and expression of 5-HT,5-HT3R,5-HT4R in the colonic mucosa of the Chinese medicine group decreased,with statistically significant differences (P<0.05, P<0.01). Conclusion:The comprehensive effects of Wenshen Jianpi Decoction in the treatment of model rats with IBS-D may involve with the regulating 5-HT and its receptors,regulating enteric nervous system,reducing bowel movement and secretion, and decreasing intestinal visceral hypersensitivity.
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发布时间：2022-08-31 - 摘要：Objective:To study the anti-inflammatory and analgesic effects of Chinese herbal compound Manpen Decoction. MethodsThe dimethylbenzene-induced ear edema model in mice and the egg white-induced paw swelling model in rats were used to study the anti-inflammatory effects of Manpen Decoction,with China root greenbrier(Jin Gang Teng) and aspirin as positive control. The writhing test induced by acetic acid and hot plate test in mice were used to observe the analgesic effects of Manpen Decoction,with China root greenbrier and ibuprofen as positive control. In each model experiment,mice were divided into the control group,model group,positive control group and treatment groups with low-,mid- and high- dose of Manpen Decoction,10 in each group. Each group was treated with the corresponding drug and the control and model groups were treated with distilled water. The anti-inflammatory and analgesic effects of Manpen Decoction were observed. Results:In the treatment groups with mid- and high- dose of Manpen Decoction,the swelling degree of ear edema in mice induced by dimethylbenzene was significantly suppressed(P<0.05). In the all treatment groups with low-,mid- and high-dose,the swelling degree of paw edema in rats induced by egg white was significantly reduced(P<0.05,P<0.01),and the group with high-dose was more effective. In addition, in the all treatment groups with different dose of Manpen Decoction,the pain reaction in writhing mice induced by acetic acid was significantly relieved(P<0.05,P<0.01),and the threshold of pain in hot plate test was increased(P<0.05,P<0.01). Conclusion:Chinese herbal compound Manpen Decoction shows good anti-inflammatory and analgesic effect,as well as the good application prospects in the treatment of chronic pelvic inflammatory disease.关键词：Manpen decoction;anti-inflammation;analgesia;chronic pelvic inflammatory disease;experimental study
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发布时间：2022-08-31 - 摘要：Objective:To study the therapeutic mechanisms of “Xiegan Liangxue Jiedu Decoction” in the treatment of psoriasis. MethodsThe guinea pigs were randomly divided into the control group, model group, “Xiegan Liangxue Jiedu Decoction” group(herb group) and acitretin group. Popranolol emulsion was applied on ears back of guinea pigs to induce the psoriasis-like lesions. Each group was given corresponding treatment for 4 weeks. The general situation of guinea pigs, pathological changes of skin lesions, and the TNF-α expressions in the local skin and blood were observed. Results:①The ear skin of the guinea pigs in the model group showed typical psoriatic lesions, which were obviously alleviated in herb group and acitretin group; ②Compared with the control group, the levels of TNF-α in the blood and local lesions were increased in the model group(P<0.05); compared with the model group, the levels of TNF-α in the blood and local lesions were decreased in the herb and acitretin groups(P<0.05); while there was no significant difference in the level of TNF-α between the herb and acitretin groups(P>0.05). Conclusion:“Xiegan Liangxue Jiedu Decoction” acts to treat psoriasis by reducing TNF-α in the blood and local lesions.关键词：“Xiegan Liangxue Jiedu Decoction”;psoriasis;TNF-α;guinea pig
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发布时间：2022-08-31 - 摘要：This paper reviewed the mechanism of occurrence and development of autophagy, and mainly discussed on the correlation between autophagy and the theory of traditional Chinese medicine and the research progress of the intervention of traditional Chinese medicine on autophagy. Autophagy is generally divided into 3 categories, the process of autophagy formation includes the induction stage, the formation stage and the mature degradation stage. At present, research found that autophagy was closely related to the theory of traditional Chinese medicine, such as “Qi deficiency and phlegm stasis”,“self-combination of Yin and Yang”,“liver controlling conveyance and dispersion”and so on. And a large number of studies indicated that traditional Chinese medicine showed regulatory effect on the level of autophagy.关键词：autophagy;traditional Chinese medicine;review
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发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on single compounds of Chinese herbs,single Chinese medicinal herb and Chinese herbal compound prescription which affect the expression of apoptosis related genes caspase, Bcl-2 and survivin. Various single compounds of Chinese herbs,single Chinese medicinal herb or Chinese herbal compound prescription show good effect on inhibiting tumor proliferation and inducing tumor apoptosis through the influence on the gene expression of caspase, Bcl-2 and survivin. Screening drugs that with the effect on inducing tumor apoptosis from traditional Chinese medicine, would be one of the important directions for the future research and development of antitumor drugs.关键词：traditional Chinese medicine;tumor;apoptosis gene;caspase;Bcl-2;survivin
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发布时间：2022-08-31
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