最新刊期
期 11 ， 2016
- 摘要：This paper introduced professor Chu Lixi’s experience in the treatment of delayed union of fracture. He considered the pathogenesis of this disease as asthenia in origin and pathogenic factors in superficiality. The asthenia in origin was caused by blood stasis and stagnation after trauma,the pathogenic factors in superficiality was due to insufficiency of liver-kidney and deficiency of qi-blood. The therapeutic principles emphasized the balance of whole and part treatment,integration of internal and external treatment,equality of ligament and bone treatment,complementation of static and dynamic treatment. In medication,he made good use of medicine compatibility of eliminating the pathogenic factors in superficiality and nourishing the asthenia in origin. One proven case was presented.关键词：delayed union of fracture;experience of famous doctor;Chu Lixi
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发布时间：2022-08-31 - 摘要：This paper discussed the syndrome and therapy of spontaneous sweating and night sweating due to depression syndrome. It indicates that apart from the insecurity of defense-exterior Qi and Qi deficiency of lung-spleen syndrome,depression syndrome can also lead to spontaneous sweating by disturbing the heart spirit,including panic,angry,timidity,worry and depression. Another,as yin deficiency with effulgent fire and heart-blood deficiency syndromes do,depression syndrome can also cause night sweating by the overconsumption of yin-blood induced by seven emotions such as joy,anger,panic,fear and excessive worry and thought. This article analyzed and demonstrated the common syndrome and treatments of spontaneous sweating caused by yin deficiency with effulgent fire and heart-blood deficiency,which could belong to the category of syndrome differentiation for depression syndrome. Spontaneous sweating and night sweating due to depression syndrome is concealed by the general sweating,which accompanied by a wide variety of clinical manifestation and presented the characteristics of masked depression syndrome and/or general depression syndrome. The treatment of spontaneous sweating and night sweating due to depression syndrome should be based on depression,including soothing liver and regulating qi to relieve depression,enriching yin and clearing heat to purge fire,tonifying qi and blood to nourish heart,sedation and tranquilization to stable mind,coordinating heart and kidney,tonifying liver and nourishing heart,soothing liver and strengthening spleen,tonifying spleen and heart,and other multiple treatment principles and methods. Modern medicine has confirmed that spontaneous sweating and night sweating due to depression syndrome are affected by psychological factors and mostly caused by dysfunction of autonomic nervous system.关键词：depression syndrome;spontaneous sweating;night sweating;autonomic nervous system dysfunction;treatment from the aspect of depression
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发布时间：2022-08-31 - 摘要：Chinese medicinal dispensing granule is an important topic in the reform of dosage form of Chinese medicine and the modernization of traditional Chinese medicine,which meets the convenience requirements of modern society and special diseases for the preparation of traditional Chinese medicine prescription. Through the overview of domestic and foreign development status of Chinese medicinal dispensing granule and the analysis of problems existing at present in our country,Chinese medicinal dispensing granule should be developed based on the experience of foreign countries and follow the pattern of clinical diagnosis and treatment of Chinese medicine and market requirements. The development could be in mode of couplet medicines granule as primary and single medicinal dispensing granule as subsidiary. Scientific and high quality basic studies and clinical research should be further carried out to obtain the systematic and propagable achievements.关键词：Chinese medicinal dispensing granule;traditional decoction;basic research;clinical trial;couplet medicines
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发布时间：2022-08-31 - 摘要：Objective:To investigate the medication and compatibility of traditional Chinese medicine prescriptions in the treatment of lung cancer based on complex systems entropy network method(CSENM). MethodsTraditional Chinese medicine prescriptions recorded in the great dictionary of prescription for tumor and indeed used in the treatment of lung cancer were selected. Correlation of traditional Chinese medicine was assessed by mutual information method based on random permutation test. On this basis complex network was established. The core couplet medicines and prescription and the compatibility rule of four properties,five tastes and channel tropism were explored through the central information of computer network. Results:Totally 323 prescriptions were selected which involved 407 herbal medicine. Among,20 herbs that mainly nourishing Yin and tonifying Qi were used with high frequency,41 core triples combinations and 26 couplet medicines were founded. Meanwhile 13 basic prescriptions that based on medicine of nourishing Yin and tonifying Qi as main and medicine of reducing phlegm and resolving masses and clearing heat and detoxification as supplement were digged out. The herbal medicine mostly presented cold or warm in property,bitter or hot in taste,and the majority were distributed to lung,spleen,1iver,stomach and large intestine in channel tropism. Conclusion:CSENM is an effective method for the discovery of prescriptions and medicine in the treatment of lung cancer. The therapeutic principles emphasize the combination of cold and heat,the complementation of Yin and Yang,the coordination of exterior and interior. Medication is based on nourishing Yin and tonifying Qi as main and eliminating pathogenic factors as supplement.关键词：lung cancer;prescription;medication rule;complex network
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发布时间：2022-08-31 - 摘要：Vertigo diseases were put forward in Inner Canon of Huangdi. The understandings of vertigo from ancient physicians were of different emphasis. Combined with the clinical experience for many years and the theory of “all wind with vertigo and shaking is ascribed to liver”,“dizziness must be caused by phlegm”,“dizziness must be due to deficiency”,professor Chen Chonggao put forward the theory of “dizziness must be induced by stasis”. The prescription medication emphasized the combination of treatment based on liver,phlegm,deficiency and stasis,which obtained good curative effect.关键词：vertigo;treatment based on stasis;clinical experience;Chen Chonggao
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发布时间：2022-08-31 - 摘要：This paper discussed professor Chen Jinli’s experience in the treatment of perimenopausal syndrome. He considered the main pathogenesis of perimenopausal syndrome as deficiency of kidney,hyperactivity of heart-fire and imbalance between heart and kidney. The treatment should be based on clearing heart-fire,combined with strengthening spleen and stomach to nourish the weaken kidney qi,so as to reconstruct the balance of normal physiological coordination between heart and kidney and thus pass the perimenopausal period safely.关键词：perimenopausal syndrome;therapy of traditional Chinese medicine;clinical experience;Chen Jinli
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发布时间：2022-08-31 - 摘要：This paper introduced the clinical experience of Qu Xiaolu in differentiation and treatment of diabetic nephropathy. She considered the deficiency of qi and yin as the pathogenic factors and the blood stasis and phlegm as the symptom. This disease presented asthenia in origin and excess in superficiality,and she proposed that the therapy of supplementing qi and nourishing yin,activating blood circulation to dissipate blood stasis and eliminating turbidity should be throughout the whole treatment. Based on the method of yin and yang interaction which advocated by physician Zhang Jingyue in Ming dynasty and the formula of Zuogui Piu,prescription named ShenqiⅠwas developed to supplement qi and activat blood circulation,nourish yin and tonify kidney.关键词：diabetic nephropathy;“ShenqiⅠ”;clinical experience
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发布时间：2022-08-31 - 摘要：This article applied the therapeutic principle of Shaoyin diseases to the differentiation and treatment of nephrotic syndrome. Sini Decoction and associated prescriptions were mainly used in the method of restoring and reversing yang for the treatment of deficiency of yin and yang.Zhenwu Decoction and associated prescriptions were mainly used in the method of warming yang and dispeling dampness for the treatment of yin excess and yang deficiency syndrome with dampness.Prescriptions as Huanglian Ejiao Decoction,Zhuling Decoction,Zhufu Decoction and Kujiu Decoction were used in the method of nourishing yin and clearing fire for the treatment of heat-conversion syndrome of Shaoyin.关键词：nephrotic syndrome;Shaoyin disease;clinical application
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发布时间：2022-08-31 - 摘要：Gastrointestinal syndrome of intermingled cold and heat was put forward in Inner Canon of Huangdi. This paper researched the differentiation and treatment of gastrointestinal syndrome of intermingled cold and heat combined with the related discussion and clinical application. Gastrointestinal syndrome of intermingled cold and heat in Inner Canon of Huangdi were divided into 3 types as cold in stomach and heat in intestines,heat in stomach and cold in intestines,heat and cold in stomach. The corresponding therapeutic principals and medication should be applied flexibly under the guide of regulation of Sanli. Today the understanding of gastrointestinal syndrome of intermingled cold and heat in Inner Canon of Huangdi still has higher value of guidance for the clinical differentiation and treatment of spleen and stomach disease.关键词：Inner Canon of Huangdi;intermingled cold and heat in gastroenterology;treatment based on syndrome differentiation
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发布时间：2022-08-31 - 摘要：This paper initially analyzed the guidance of theory of twelve meridians branch in clinical acupuncture. The twelve meridians all have its main vein and branches,which also belong to the meridians and can be used in guiding the clinical practice. Because the branches can reach the part that the main vein not touch,clinical diagnosis and treatment should pay attention to the cycle routes of the branches and the acupoints located in the branches so as to obtain better effect.关键词：twelve meridians;branch;clinical significance
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发布时间：2022-08-31 - 摘要：One case of chronic renal failure treated with Buzhong Yiqi Decoction was recorded. The treatment was based on the insufficiency of primordial qi and emphasized the effect of rise and supplement of primordial qi and ascending lucidity and descending turbidity in the treatment of chronic renal failure,which was novel and worth learning.关键词：Buzhong Yiqi Decoction;chronic renal failure;medical record
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Yiqi Tongluo Recipe combined with routine western medicines on coronary slow flow phenomenon. MethodsFifty-nine patients with coronary slow flow phenomenon were randomly divided into the treatment group (30 cases) and control group(29 cases). The control group was treated with routine western medicines,while the treatment group was treated with Yiqi Tongluo Recipe additionally based on the treatment for the control group. The therapeutic course of both groups was three months. The clinical efficacy and electrocardiogram were observed,and the changes of high sensitive C reactive protein (hs-CRP),flow-mediated dilation(FMD),positive rate of treadmill exercise test (TET),correct TIMI frame count(CTFC)were compared. Results:①The total effective rate of the treatment group and the control group were 93.33% and 75.86% respectively. There was statistically significant difference on the clinical efficacy between the two groups,and the effect of the treatment group was better than that of the control group(P<0.05). ②The total effective rate of electrocardiogram in the treatment group and the control group were 90.00% and 72.41% respectively. There was statistically significant difference on the electrocardiogram efficacy between the two groups,and the effect of the treatment group was better than that of the control group(P<0.05). ③After treatment,there were statistically significant differences on the level of hs-CRP,FMD,CTFC and TET between the two groups,and the effects of the treatment group were significantly better than those of the control group(P<0.05). Conclusion:Yiqi Tongluo Recipe combined with routine western medicines shows good effects in the treatment of coronary slow flow phenomenon.关键词：coronary slow flow phenomenon;Yiqi Tongluo Recipe;myocardial microcirculation;vascular endothelial protection
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Baiyu Shenjing Maitong Decoction combined with conventional western medicine on serum adiponectin in patients with coronary heart disease of phlegm and blood stasis syndrome. MethodsSixty patients with coronary heart disease of phlegm and blood stasis syndrome were randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with conventional western medicine,and the treatment group was treated with Baiyu Shenjing Maitong Decoction combined with conventional western medicine,with a course of 2 months. The clinical efficacy was observed and the changes of TCM syndrome scores,blood lipid indexes and adiponectin level were compared. Results:①The total effective rate in the treatment group and control group was 90.0% and 70.0% respectively；there was statistically significant difference on the clinical efficacy between the two groups (P<0.05). ②Comparison of treatment before and after,there were statistically significant differences on the palpitations, shortness of breath, chest epigastric fullness, body weakness and total score in the treatment group(P<0.05),there were statistically significant differences on the chest pain, shortness of breath, chest epigastric fullness and total score in the control group(P<0.05). Comparison between the two groups,there were statistically significant differences on the chest epigastric fullness, body weakness and total score after treatment (P<0.05). ③Comparison of treatment before and after,the differences on the blood lipid indexes in both groups were not statistically significant(P>0.05),but there was statistically significant difference on the adiponectin in both groups(P<0.05). Comparison between the two groups,there was statistically significant difference on the adiponectin after treatment (P<0.05). Conclusion:Baiyu Shenjing Maitong Decoction combined with conventional western medicine can effectively alleviate the clinical symptoms of coronary heart disease patients with phlegm and blood stasis syndrome,and shows a certain effect of up-regulation of serum adiponectin.关键词：coronary heart disease;phlegm and blood stasis syndrome;therapy of integrated traditional Chinese and western Medicine;Baiyu Shenjing Maitong Decoction;adiponectin
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Weikangning prescription in the treatment of chronic atrophic gastritis (CAG) of spleen deficiency and cold-heat stagnation pattern accompanied with precancerous lesion of gastric carcinoma (PLGC)and regulation mechanism on COX-2 protein. MethodsNinety cases with CAG of spleen deficiency and cold-heat stagnation pattern accompanied with PLGC were randomly divided into the treatment group and control group,45 cases in each group.The treatment group was orally treated with Weikangning prescription and the control group was orally treated with Weifuchun tablets,with a course of 12 weeks.The clinical efficacy and pathological changes were observed and the changes of TCM syndrome scores and COX-2 protein in gastric mucosa were compared between the two groups. Results:① The total effective rate in the treatment group and control group was 93.3% and 57.6% respectively；there was statistically significant difference on the clinical efficacy between the two groups (P<0.05).②Comparison of treatment before and after,there were statistically significant differences on the inflammation, atrophy,intestinal metaplasia and total score in both groups (P<0.05). Comparison between the two groups,there were statistically significant differenceson the inflammation, atrophy,intestinal metaplasia and total score after treatment (P<0.05).③Comparison of treatment before and after,there were statistically significant differences on the stomach pain, abdominal fullness, noisy, fatigue, anorexia andtotal score in both groups (P<0.05). Comparison between the two groups,there were statistically significant differences on the stomach pain, abdominal fullness, anorexia andtotal score after treatment (P<0.05).④Comparison of treatment before and after,there was statistically significant difference on the COX-2 in the treatment group (P<0.05). Comparison between the two groups,there was statistically significant difference on the COX-2 after treatment (P<0.05). Conclusion:Weikangning prescription shows good effects in the treatment of chronic atrophic gastritis with precancerous lesions of spleen deficiency and cool heat stagnation pattern,which significantly improve the clinical symptoms of patients,relieve inflammation in gastric mucosa and reverse gastric mucosal atrophy and intestinal metaplasia. Reducing the protein expression of COX-2 in gastric mucosa may be one of the mechanisms.关键词：Weikangning;method of acrid openning and bitter descending;chronic atrophic gastritis;precancerous lesion of gastric carcinoma;clinical efficacy;mechanism research
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of laparoscopy combined with Penyan Prescription on tubal infertility. MethodsSixty patients with tubal infertility were randomly divided into the control group and treatment group,30 cases in each group. The control group was treated with laparoscopy combined with hydrotubation,and the treatment group was received Penyan Prescription treatment on the basis of operation. The total course of treatment in both groups was 3 months and 1 years follow-up. The changes of pregnancy rate and patency rate of fallopian tube were observed and the levels of serum interleukin-6 (IL-6),tumor necrosis factor-α(TNF-α),intercellular adhesion molecule-1 (ICAM-1) were compared. Results:①1 year after treatment, the numbers of intrauterine pregnancy in the treatment group and control group were 19 and 10 cases respectively. There was statistically significant difference on the rate of intrauterine pregnancy between the two groups,and the rate of intrauterine pregnancy in the treatment group was significantly higher than that in the control group(P<0.05).②After treatment, there was statistically significant difference on the patency rate of fallopian tube between the two groups,and the patency rate in the treatment group was significantly higher than that in the control group(P<0.05).③Comparison of treatment before and after,there were statistically significant differences on the serum level of IL-6,TNF-α and ICAM-1 in both groups(P<0.05).After treatment, there were statistically significant differences on the serum level of IL-6,TNF-α and ICAM-1 between the two groups(P<0.05). Conclusion:Laparoscopic combined with Penyan Prescription shows good effect in the treatment of tubal infertility. The mechanism may be related to the regulation of the expression of serum IL-6,TNF-α and ICAM-1.关键词：tubal infertility;laparoscope;integrated traditional Chinese and western medicine;Penyan prescription;pregnancy rate
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Dan’e Fukang Decocted Extract in the treatment of endometriosis(EM). Methods174 patients with EM were randomly divided into treatment group and control group, 87 cases in each group. The control group was treated with mifepristone while the treatment group was treated with Dan’e Fukang Decocted Extract,with a course of three menstrual cycles. The clinical efficacy were observed,the scores of life quality, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and the level of serum carbohydrate antigen (CA125),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were compared. Results:①The total effective rate was 93.10% in the treatment group and 81.61% in the control group,with statistically significant difference (P<0.05). The effect of the treatment group was better than that of the control group. ②Comparison of the treatment before and after, the difference on the score of dysmenorrhea degree in both groups was statistically significant (P<0.05). Comparison between the treatment group and control group,the difference on the score of dysmenorrhea degree was statistically significant,and the effect on relieving dysmenorrhea in the treatment group were obviously better than that in the control group (P<0.05). ③ After treatment, there were statistically significant differences on the scores of life quality,SDS and SAS between the two groups,and the effects of the treatment group were obviously better than those of the control group (P<0.05). ④ After treatment,there were statistically significant differences on the level of CA125,TNF-α and IL-6 between the two groups,and the levels of the treatment group were obviously lower than those of the control group (P<0.05). Conclusion:Dan’e Fukang Decocted Extract shows good effect in the treatment of endometriosis,which could effectively improve clinical symptoms,alleviate depression and anxiety,inhibit the release of inflammatory factors.关键词：endometriosis;Dan’e Fukang Decocted Extract;dysmenorrhea;inflammatory factors
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of chiropractic intervention on premature and low birth weight infants. Methods160 cases of premature and low birth weight infants were randomly divided into the treatment group and control group, 80 cases in each group. The control group was received routine treatment and nursing of western medicine, while the treatment group was given extra chiropractic therapy on the basis of treatment for the control group. The course of treatment for the two groups were both duration of hospital stay. The changes of weight at discharge, oral feeding time and hospitalization time,level of total bilirubin,white blood cell and C reactive protein were observed. Results:① After treatment, there were statistically significant differences on the weight at discharge, oral feeding time and hospitalization time between the two groups,the weight at discharge of the treatment group was significantly heavier than that of the control group,and the oral feeding time and hospitalization time of the treatment group were significantly less than those of the control group(P<0.05). ②Comparison between postnatal and discharge time within group,there were statistically significant differences on the level of total bilirubin and white blood cell in the treatment group(P<0.05),there were statistically significant differences on the level of total bilirubin,white blood cell and C reactive protein in the control group(P<0.05).At discharge time,there were statistically significant differences on the level of total bilirubin,white blood cell and C reactive protein between the two groups,and those of the treatment group were significantly lower than those of the control group(P<0.05). Conclusion:Chiropractic intervention on premature and low birth weight infants could promote the growth and development, shorten the hospitalization time and oral feeding time and prevent the neonatal jaundice.关键词：preterm low birth weight infant;chiropractic;oral feeding;neonatal jaundice
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of contralateral acupuncture at Jiantong point in the treatment of shoulder periarthritis. MethodsEighty subjects were randomly divided into two groups:the treatment group in which 40 cases were treated with acupuncture at the contralateral Jiantong point, and the control group in which 40 cases were treated with conventional electroacupuncture,with a course of 2 weeks. The clinical efficacy and the scores of shoulder pain and motion were observed and compared before and after treatment. Results:The total effective rate was 95.0% in the treatment group and 75.0% in the control group；the clinical efficacy of the treatment group was better than that of the control group (P<0.05). After treatment, the scores of shoulder pain and motion in both groups were obviously increased compared with treatment before(P<0.01), and the scores in the treatment group were higher than those in the control group (P<0.01). Conclusion:Acupuncture at contralateral Jiantong point can reduce shoulder pain and improve shoulder motion in the treatment of shoulder periarthritis.关键词：shoulder periarthritis;Jiantong point;contralateral acupuncture
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of wet-hot compress of traditional Chinese medicine combined with exercise therapy in the treatment of knee osteoarthritis with wind-cold obstruction. Methods90 subjects were randomly divided into the wet-hot compress group,exercise group and combination group,30 in each group. Each group was received the corresponding treatment,with a course of one month. The scores of pain,stiffness and daily function were observed and compared. Results:Compared with treatment before,the pain,stiffness,difficulty of daily activities and total score were significantly decreased in each group after treatment(P<0.05). After treatment,the differences on these index scores(except the difficulty of daily activities in the exercise group)between the combination group and other two groups were statistically significant(P<0.05)；there were no statistically significant differences on these index scores between the wet-hot compress group and exercise group(P>0.05). Conclusion:The therapy of wet-hot compress of traditional Chinese medicine combined with exercise can significantly alleviate clinical symptoms of knee osteoarthritis with wind-cold obstruction.关键词：knee osteoarthritis;wet-hot compress of traditional Chinese medicine;exercise therapy
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发布时间：2022-08-31 - 摘要：Treatment for blood vomiting used by Miao Xiyong was applied to the idiopathic thrombocytopenic purpura(ITP)in this article,and the concrete application of three methods of blood-stanching therapy,including blood-activating,liver-nourishing and qi-downbearing in the treatment of ITP was discussed.关键词：idiopathic thrombocytopenic purpura;bleeding disorder;three methods of blood-stanching therapy;Miao Xiyong
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Bushen Jianpi Formula on the ovarian response and reserve in naturally aged mice. MethodsForty-eight female C57BL/6J mice that 10months old were randomly divided into the model group, Bushen Jianpi Formula(BJSP) group and dehydroepiandrosterone(DHEA)group,and given the corresponding treatments. Meanwhile, young female C57BL/6J mice that 2-3 months old were set as the control group.Before and after intervention,the serum level of anti mullerianhormone(AMH),the changes of oocyte number, MII oocyte number,fertilized oocyte number,fertilization rate and ovarian follicle count were observed and compared. Results:①The serum AMH level in the BSJP group was higher than that in the model group and DHEA group(P<0.05); ②In vitro fertilization,the oocyte number, MII oocyte number, fertilized oocyte number, fertilization rate of the BSJP group were significantly higher than those of the model group and DHEA group(P<0.05); ③The number of mature follicle of the BSJP group was significantly increased compared with the model group and DHEA group (P<0.05). Conclusion:Bushen Jianpi Formula can improve the ovarian reserve and response in naturally aged mice.关键词：Bushen Jianpi Formula;ovarian response;ovarian reserve;fertilization in vitro
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发布时间：2022-08-31 - 摘要：Objective:To observe the dynamic effects of Guanxinkang on the molecule expression of hepatic cholesterol homeostasis in hyperlipidemia rats. Methods96 SD rats were randomly divided,among which 24 rats were set as the normal control group and treated with normal diet,72 rats were treated with high cholesterol diet to induce hyperlipidemia and then randomly divided into the model group, simvastatin group, Guanxinkang group. Rats were sacrificed at 4th,8th and 12th week. The levels of blood lipid were detected by biochemistry, the gene and protein expression levels of low-density lipoprotein receptor(Ldlr),scavenger receptor class B type 1(Srb1),HMG-CoA Reductase(Hmgcr) and sterol regulatory element-binding protein 2(Srebp2)were determined by real-time fluorescence quantitative PCR and Western-blot. Results:Compared with the model group, the serum levels of cholesterol and low density lipoprotein were decreased after the treatment with Guanxinkang for 4 weeks, 8 weeks and 12 weeks, but the difference was not statistically significant (P>0.05). Compared with the model group,Guanxinkang significantly up-regulated the gene and protein expression level of Ldlr in the liver of hyperlipidemia rat (P<0.05),and significantly up-regulated the gene and protein expression level of Srebp2 in the liver of hyperlipidemia rat after treatment for 4-8 weeks and 8-12 weeks(P<0.05),with a time-dependent manner. Conclusion:Guanxinkang can dynamically regulate the gene and protein expression of Ldlr in the liver of hyperlipidemia rats to control the blood lipid level,and may regulate the cholesterol homeostasis by adjusting the gene and protein level of Srebp2.关键词：cholesterol homeostasis;hyperlipidemia;Guanxinkang;Srebp2;LDLR
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Shugan Hewei Decoction on the expression of Ca2+/calmodulin-dependent protein kinaseⅡ(CaMKⅡ)in visceral hypersensitive rats. Methods32 healthy male SD rats were randomly divided into the model group,Shugan Hewei Decoction group,rabeprazole group and blank control group,eight rats in each group. The model of visceral hypersensitivity was established by the chicken ovalbumin combined with esophageal acid perfusion. The expression of CaMKⅡ in spinal cord and the number of positive neurons of rats in each group were observed by immunohistochemistry. Results:Compared with the blank control group,the expression of CaMKⅡ and the number of positive neurons in the model group were increased significantly (P<0.05); compared with the model group, the expression of CaMKⅡ and the number of positive neurons in the Shugan Hewei Decoction group and rabeprazole group were decreased significantly,and the differences were statistically significant(P<0.01). The number of positive neurons in the Shugan Hewei Decoction group was less than that in the control group(P<0.05). There was no statistically significant difference on the expression of CaMKⅡ between the Shugan Hewei Decoction group and rabeprazole group(P>0.05). Conclusion:Shugan Hewei Decoction could decrease the visceral hypersensitivity by the inhibition of CaMKⅡ expression.关键词：Shugan Hewei Decoction;visceral hypersensitivity;CaMKⅡ
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Qingfei Zhikeling syrup on pathology of lung tissue and serum IL-8 and TNF-α of rats with chronic bronchitis in acute attack. Methods40 Wistar rats(20 male and 20 female)were randomly divided into the blank group,positive drug group,model group,Chinese medicine group with low-and high-dose,8 rats in each group. Except the blank group,the model of chronic bronchitis in acute attack was established in the other rats by improved smoked method. The morphological changes of bronchus and lung tissue were observed under light microscope,and the serum contents of IL-8 and TNF-α were determined. Results:There were statistically significant differences on the serum contents of IL-8 and TNF-α between the blank group and model group(P<0.05). Compared with the blank group,the serum contents of IL-8 and TNF-α in the Chinese medicine group with low-and high-dose and positive drug group were all decreased(P<0.05). Pathological results showed that the morphological injuries of bronchus and lung tissue of rats with chronic bronchitis in acute attack were improved in various degrees after the treatment with Qingfei Zhikeling syrup with low-and high-dose and positive drug. Conclusion:Qingfei Zhikeling syrup shows repair and anti-inflammatory effect on lung tissue of rats with chronic bronchitis in acute attack,which may be related to reducing the serum contents of IL-8 and TNF-α.关键词：Qingfei Zhikeling syrup;chronic bronchitis in acute attack;pathological changes;IL-8;TNF-α
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effect of combined reagent of different particles of Compound Lizards Powder on the protein expression of myeloid differentiation factor88(MyD88) and tumor necrosis factor receptor-associated factor-6(TRAF6) that in TLRs/MyD88 signaling pathway and the content of downstream inflammatory factors tumor necrosis factor-α(TNF-α)in rat model of ulcerative colitis(UC),and discuss its mechanisms on UC. Methods84 male SD rats were randomly divided into six groups as the normal control group, model group, sulfasalazine tablets (SASP) treatment group, treatment groups of Compound Lizards Powder filtrated through 80 mesh ,100 mesh ,80+100 mesh equivalent mix respectively,14 rats in each group. The control group was received the enema treatment with 0.9%NaCl solution, and the other groups were received the enema treatment with three nitrobenzene sulfonic acid (TNBS) to establish the UC model. After successful modeling, the control and model group were administered intragastrically with 0.9%NaCl solution and the other groups were administered intragastrically with the corresponding drugs,with a course of 14 days. After treatment for 14 days,all rats were anesthetized and the blood were collected from abdominal aorta and preserved at low temperature after centrifugation. The lesion of colon tissue were obtained and embedded. The pathological changes of colonic mucosa were observed by HE staining. The situ protein expressions of MyD88 and TRAF6 in colon tissues were determined by immunohistochemistry. The level of serum TNF-α was detected by enzyme linked immunosorbent assay(ELISA). Results:Compared with the normal control group,the protein expression of MyD88 and TRAF6 and the level of TNF-α in the other groups were increased,with statistically significant differences(P<0.05). Compared with the model group,the levels of all indicators in each treatment group were decreased,with statistically significant differences(P<0.05). Comparison of SASP treatment group and treatment groups of Compound Lizards Powder,the treatment effects of the Compound Lizards Powder filtrated through 80+100 mesh equivalent mix were best,with statistically significant differences(P<0.05). There were no statistically significant differences on the effects between the SASP treatment group and treatment group of Compound Lizards Powder filtrated through 80 mesh or 100 mesh(P>0.05). Comparison of treatment groups of Compound Lizards Powder,the levels of all indicators were obviously decreased in the treatment group of Compound Lizards Powder filtrated through 80+100 mesh equivalent mix,with statistically significant differences(P<0.05). Conclusion:The combined reagent of different particles of Compound Lizards Powder could inhibit the protein expression of MyD88 and TRAF6 that in TLRs/MyD88 signaling pathway and decrease the level of downstream inflammatory TNF-α,which suggested that its main mechanism in the treatment of ulcerative colitis were blocking the inflammatory reaction,regulating immunity,restoring intestinal barrier,maintaining intestinal homeostasis and promoting intestinal mucosal repair.关键词：combined reagent of different particles of Compound Lizards Powder;ulcerative colitis;TLRs/MyD88 signaling pathways;myeloid differentiation factor88;tumor necrosis factor receptor-associated factor-6;tumor necrosis factor-α
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发布时间：2022-08-31 - 摘要：Objective:To observe the protective effects of Astragaloside IV on heart in rats with chronic heart failure from different perspective. MethodsChronic heart failure(CHF) model was established by abdominal aorta constriction (AAC) in 60 SD rats that without significant difference in baseline. 6 weeks after operation,cardiac ultrasound was conducted to determine whether the model was successful or not. After successful modeling,the CHF rats were divided into the model group,Astragaloside IV groups with low and high-dose and sham operation group,20 rats in each group. The rats in the Astragaloside IV groups were treated with Astragaloside IV at dose of 30 and 70 μg·g-1·d-1 as low and high dose respectively. The rats in sham operation group and model group were treated with 0.9%NaCl solution with equal volume. After treatment for 8 weeks,cardiac structure and function indexes of rats were determined by ultrasound. The hemodynamic indexes were measured after left ventricular intubation. The heart was collected and the left ventricular mass index (LVMI) and right ventricular mass index (RVMI) were detected. The morphologic changes of myocardial tissue were observed by Hematoxylin and eosin(HE)and Masson staining. The protective effects of Astragaloside IV on CHF rats were evaluated from cardiac structure and function,hemodynamics,ventricular remodeling and morphology. Results:Compared with the sham operation group,the LVMI,collagen volume fraction (CVF) and thickness of left ventricular posterior wall (LVPW) of rats in the model group were increased (P<0.05). After treatment with Astragaloside IV,the LVMI,CVF and thickness of LVPW of rats in the Astragaloside IV groups with low and high dose were decreased compared with the model group (P<0.05). Conclusion:The cardioprotective effects of Astragaloside IV may be associated with inhibiting myocardial fibrosis and decreasing left ventricular hypertrophy,improving hemodynamics of CHF rats.关键词：Astragaloside IV;chronic heart failure;cardioprotective effects;Sprague Dawley rats
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发布时间：2022-08-31 - 摘要：The research progress on the treatment of psychological diseases with Crocus sativus L.and its related mechanism were systematically summarized,including depression,anxiety,obsessive-compulsive disorder,schizophrenia,sexual dysfunction and premenstrual syndrome. The mechanism may be related to antioxidation, anti-inflammation, neuroendocrine and nerve protective effect.关键词：Crocus sativus L.;depression;anxiety;schizophrenia;sexual dysfunction;premenstrual syndrome
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发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on pharmacological effects and mechanism of Timosaponin AⅢ. Timosaponin AⅢ was one of the major active components from RhizomaAnemarrhenae. Studies showed that it had a wide range of pharmacological effects such as improvement of learning and memory deficits,inhibition of platelet aggregation and blood vessel expansion,anti-tumor,hypoglycemic effect,anti-hypertension,anti-inflammation,anti-oxidation,anti-radiation,anti-virus and antifungal activity.关键词：timosaponin AⅢ;pharmacological effects;action mechanism;research progress
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发布时间：2022-08-31
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