最新刊期
期 12 ， 2016
- 摘要：This paper introduced the medication thinking of professor Shen Xiaoheng in the treatment of tumor and experience medicine for common complications,such as scorpion,aspongopus,henon bamboo dried shoot,chen hulu and so on. The diagnosis and treatment emphasize the combination of traditional Chinese and western medicine,the integrated differentiation of disease and syndrome,the modification of basic prescription according to the syndrome.The common therapy methods include supplementing qi and strengthening the body resistance,protecting spleen and stomach,regulating qi and relieving depression,nourishing blood and increasing leukocytes,detoxification and eliminating stagnation. It pays attention to on the application of medicine and food dual-use products.This article also summarized the medication experience in the common complications of tumor such as pain,hydrothorax and ascites.关键词：tumor;clinical experience;Shen Xiao-heng
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发布时间：2022-08-31 - 摘要：This paper discussed the syndrome and therapy of dizziness due to depression syndrome and put forward the academic point that “without depression,there would be no dizziness”. The pathogenesis of dizziness due to depression syndrome include stagnation of liver-qi,phlegm-turbidity,deficiency of vital qi and blood stasis. All of these can be caused by emotional factors. Negative emotions can most easily lead to stagnation of liver-qi,and then transform into liver-fire,liver-yang and liver-wind. By analyzing the detailed illustration of Zhu Danxi’s point that “without phlegm,there would be no dizziness” and Zhang Jingyue’s point that “without deficiency,there would be no dizziness”,the fact that a part of dizziness closely related to phlegm syndrome and deficiency syndrome is actually aroused by depression. And some identifiable clinical manifestations of dizziness due to depression syndrome can be found. In terms of the treating principles of dizziness due to depression syndrome,regulating the liver and restoring the deficiency,dispelling phlegm and removing blood stasis can help to cure and relieve the symptom. And varying degrees of soothing liver and regulating qi,tranquilizing mind and soothing nerves,can be considered as routine treatment of multiple therapies. Dizziness due to depression syndrome mainly contains the area of psychological dizziness in modern medicine. If the coexistence of diseases and depression syndrome is contained,the dizziness due to depression syndrome may account for over half of clinical patients suffered from dizziness.关键词：depression syndrome;dizziness;etiology and pathogenesis;emotion;psychological dizziness
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发布时间：2022-08-31 - 摘要：The aging population results in the rapid expansion of high-risk patients with lung cancer,while the early diagnosis technology increases the proportion of patients with lung cancer at early stage. Early intervention on high-risk patients and postoperative patients to prevent the occurrence and metastasis of lung cancer is the key to improve the overall survival. Due to lack of effective means of intervention for this group in modern medicine,the guiding ideology and diagnosis and treatment concept of traditional Chinese medicine in the treatment of cancer are mainly based on patients at advanced stage. New theories and methods are urgently required to guide the intervention and treatment for this group.Based on the classical theory of traditional Chinese medicine on the understanding of human life activities,combined with the latest development of modern oncology,this paper puts forward and systematically elaborates that “ deficiency of vital qi and hidden toxin” is the core pathogenesis of lung cancer,which provides sound theoretical guidance for traditional Chinese medicine in the prevention and treatment of lung cancer. Meanwhile,it serves a meaningful attempt to realize the theoretical innovation of traditional Chinese medicine through combining with the latest development of modern medicine.关键词：lung cancer;deficiency of vital qi and hidden toxin;pathogenesis;theoretical innovation
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发布时间：2022-08-31 - 摘要：Objective:To establish the characteristic parameters of normal pulse,slippery pulse and taut pulse and the reference range of normal medical indicators based on single pulse graphs. Methods447 pulse graphs of non-disease population were studied,among which 171 cases were pulse graphs of normal pulse,118 cases were pulse graphs of slippery pulse,and 158 cases were pulse graphs of taut pulse. The characteristic parameters of pulse graphs such as amplitude and chronaxie were analyzed. The characteristic parameter indexes and distribution range of normal pulse,slippery pulse and taut pulse were discussed. Results:Comparison of any two kinds of pulse,the differences on the ratio of h1 and t1,h3 and h1,h4 and h1 were statistically significant(P<0.01). Comparison between normal pulse and slippery pulse,the difference on the ratio of w and t was not statistically significant(P>0.05). Comparison between normal pulse and taut pulse or taut pulse and slippery pulse,the differences on the ratio of w and t was statistically significant(P<0.01). By measuring the index range of characteristic parameters of pulse graphs,the reference range of normal medical indexes of characteristic parameters in the three types of pulse were established simultaneously. Conclusion: The criteria for pulse graphs differentiation of normal pulse,slippery pulse and taut pulse can be established based on h3/h1,h4/h1,w/t and pulse shape as the core index parameters.关键词：pulse graphs;normal pulse;slippery pulse;taut pulse;index parameters
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发布时间：2022-08-31 - 摘要：This paper introduced Wang Xu’s experience in differentiating and treating Hashimoto’s thyroiditis. It considers that the liver,spleen and kidney are closely related to this disease,and the basic pathogenesis is“stagnation of liver and qi,spleen injury induced by liver-qi,kidney deficiency by long time”. This disease can be divided into the early,middle and late period. In the treatment,it emphasizes the thought of “preventive treatment of disease”关键词：Hashimoto’s thyroiditis;therapy of traditional Chinese medicine;Professor Wang Xu
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发布时间：2022-08-31 - 摘要：This paper discussed the clinical experience of Professor He Xinhui in treating spleen and stomach diseases. She considers the disorder of ascending and descending in spleen or stomach caused by various factors as the basic pathogenesis of this disease. She puts forward the viewpoint that multifarious diseases of spleen and stomach should be treated with reconciliation method,which means regulating ascending-descending,qi-blood,cold-heat,deficiency-excess to improve the discord and paying attention to the liver regulation to achieve spleen-stomach harmony and recover middle-jiao to “Zhonghe”status according to the physiological properties of spleen and stomach. Hewei Qinghua Decoction is made and used in the treatment of chronic gastritis,which modified according to the syndrome. Two proven cases were presented.关键词：spleen and stomach diseases;reconciliation method;clinical experience;He Xinhui
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发布时间：2022-08-31 - 摘要：This paper introduced Li Yongmei’s experience in treating chloasma with herbal pastes. She considers that the incidence of this disease is associated with liver,spleen and kidney. The generation and transformation of qi and blood lack of source and can not up to the surface,which is considered as the main pathogenesis. Through the differentiation and treatment with herbal pastes,the generation and transformation of qi and blood are ordered and the yin and yang in viscera are balanced in order to nourish facial appearance and remove ecchymoses. One proven case was presented.关键词：chloasma;herbal paste;clinical experience;Li Yongmei
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发布时间：2022-08-31 - 摘要：This paper introduced the application of Xiaochaihu Decoction in the treatment of common cold including the therapeutic method,experience,pediatric usage,typical cases and matters needing attention and so on. The main contents described as Xiaochaihu Decoction classic prescription,treating cold with original Xiaochaihu Decoction,treating fever and body cold combined with Cassia Twig(Guizhi),treating dry cough without phlegm combined with Rhizoma Zingiberis(Ganjiang)and Schisandra Chinensis(Wuweizi),treating cough with sputum or tonsillitis combined with Platycodon Grandiflorum(Jiegeng)and Forsythia(Lianqiao),treating body pain combined with Cassia Twig(Guizhi)and Radix Paeoniae Alba(Baishao),treating body weakness and spontaneous sweating after cold combined with Astragalus(Huangqi) and Angelica(Danggui),treating anorexia after cold combined with dried orange peel(Chenpi),hawthorn(Shanzha)and Malt(Maiya), as well as the choice of prescription and pieces,the identification of similar syndrome and treatment stop. Corresponding cases were presented to illustrate.关键词：Xiaochaihu Decoction;common cold;clinical application
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发布时间：2022-08-31 - 摘要：Based on the doctrine on Yunqi,Wang Kentang’s differentiation and treatment for diseases had made contribution in internal medicine,surgery,pediatrics,gynecology,ophthalmology and otorhinolaryngology. The features of clinical application include 5 aspects as synthesis of views in Neijing and collection of various theories; illustration combined with pictures and words and explanation of the mechanism of Yunqi；analogy of clinical syndrome based on Zhongyun；demonstration of the relationship between disease mechanism and doctrine on Yunqi and analysis of monarch fire and ministerial fire. Wang’s abundant experience in diagnosis and treatment of disease based on doctrine on Yunqi are worth learning,which provide important reference for modern Chinese medicine in the profound understanding of the value of doctrine on Yunqi.关键词：Wang Kentang;syndrome differentiation and treatment;doctrine on Yunqi
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发布时间：2022-08-31 - 摘要：This paper summarized the characteristics of Ye Tianshi’ treatment of liver disease from clinical practice guide with medical record. It is described as nourishing water and wood,including nourishing lower energizer,suppressing yang and nourishing yin,warming kidney and cooling liver；regulating liver and stomach,including supporting stomach-yin to treat liver-yang,supporting stomach-yin to nourish liver-yin,supplying jue-yin and yang-ming,slowing down the emergency with sugariness and reinforcing spleen for liver；supporting gold to suppress wood,including nourishing lung for liver,clearing away the lung-heat to treat liver；removing heat and purging fire from liver,nourishing liver and activating meridians,relieving convulsion and spasm.关键词：Ye Tianshi;clinical practice guide with medical record;liver;characteristics
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发布时间：2022-08-31 - 摘要：Combined with the medical record,this paper introduced the Ding ganren’s four methods of treating spleen-stomach diseases from liver,including the method of supplying yin and nourishing yang,checking and descending upward rebellious qi,supporting gold and restraining wood,dispelling wind and soothing liver.关键词：Ding ganren;spleen-stomach disease;treatment based on liver
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Zhenjing Xiehuo Granule on mild-to-moderate anxiety with internal disturbance of phlegm-heat. Methods100 cases of mild-to-moderate anxiety with internal disturbance of phlegm-heat were randomly divided into the treatment group and control group,50 cases in each group. The treatment group was given Zhenjing Xiehuo Granule, and the control group was treated with the placebo granule,with a course of 2 months. The Hamilton anxiety(HAMA)scale,self-rating anxiety scale (SAS) score,Pittsburgh sleep quality index (PSQI) score,TCM syndrome score and medication safety were observed. Results:①93 patients completed the trials in the end,among which 48 in the treatment group and 45 in the control group,7 cases fell off. ②Comparison between the two groups after treatment, there were statistically significant differences on the HAMA and SAS scores,and the scores of the treatment group were decreased more significantly than those of the control group (P<0.05). ③Comparison between the treatment before and after within group,there were statistically significant differences on the PSQI scores in both groups,and the scores were both significantly decreased in the two groups(P<0.05). Comparison of the difference before and after treatment,there were statistically significant differences on the PSQI scores between the two group,and the scores of the treatment group were decreased more significantly than those of the control group (P<0.05). ④Comparison between the treatment before and after within group,there were statistically significant differences on the TCM syndrome scores in both groups,and the scores were both significantly decreased in the two groups(P<0.05). Comparison of the difference before and after treatment,there were statistically significant differences on the TCM syndrome scores between the two group,and the scores of the treatment group were decreased more significantly than those of the control group (P<0.05). ⑤ There was no statistically significant difference on the incidence rate of side effects between the two groups (P>0.05). Conclusion: Zhenjing Xiehuo Granule shows good efficacy on mild-to-moderate anxiety with internal disturbance of phlegm-heat,which can effectively reduce the anxiety degree of patients and improve the sleep quality.关键词：generalized anxiety disorder;internal disturbance of phlegm-heat;Zhenjing Xiehuo;randomized, double-blind, parallel controlled trial;placebo
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy and the mechanism of Bushen YiXin Tablet combined with western medicine on hypertension with erectile dysfunction(ED). Methods80 male patients of primary hypertension on grade 2 with ED were randomly divided into the control group and the treatment group,40 cases in each group. Both groups were received conventional treatment of western medicine,and the treatment group was received Bushen Yixin Tablet additionally,with a course of 3 months. The mean systolic and diastolic blood pressure within 24h,ED classification and indexes(IIEF-5)and the adverse reaction were observed and compared before and after treatment. Results:①Comparison between the treatment before and after within group,the mean systolic blood pressure(SBP)and diastolic blood pressure(DBP)within 24h were up to the standards,and significantly decreased after treatment in both groups(P<0.05). Comparison of difference before and after treatment,there was statistically significant difference on the SBP between the two groups,and the SBP in the treatment group was decreased more significantly than that in the control group(P<0.05). But there was no statistically significant difference on the DBP between the two groups(P>0.05). ②Comparison between the treatment before and after within group,the differences of ED classification and IIEF-5 in the treatment group were statistically significant(P<0.05),while those in the control group were not statistically significant(P>0.05). Compared between the two groups after treatment,the differences of ED classification and IIEF-5 were statistically significant,which suggested that the effects of the treatment group on the improvement of sexual function were better than those of the control group(P<0.05). ③Comparison between the treatment before and after within group,the level differences of NO and ET-1 were statistically significant in both groups,the NO level was significantly increased and the ET-1 level was significantly decreased(P<0.05). Comparison of the difference of the treatment before and after between the two groups,the serum levels of NO and ET-1 changed more significantly in the treatment group than the control group(P<0.05). ④There were no adverse reaction in both groups during the treatment. Conclusion: Bushen Yixin Tablet combined with western medicine can be used in the treatment of hypertension with erectile dysfunction,which effectively reduce the blood pressure and improve the erectile function. Regulation of vascular endothelial function may be one of its mechanisms.关键词：primary hypertension;erectile dysfunction;Bushen Yixin;removing heat from liver and alleviating water retention;Epimedium;Plantago
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of transcutaneous electrical acupoint stimulation(TEAS)on asthenospermia patients with deficiency of kidney essence. MethodsAsthenospermia patients with deficiency of kidney essence who met the inclusion criteria were randomly divided into the treatment group, placebo group and acupuncture group. Patients in the treatment group were treated with TEAS at the frequency of 2 Hz, patients in the placebo group were treated with TEAS on ineffective stimulative frequency, patients in the in acupuncture group were treated with routine acupuncture with reinforcing method. All patients were treated once a day,30 times in one course and 3 courses in total. The TCM syndrome scores of all patients were assessed before and after treatment. The sperm motility, serum hormone and anti mullerian hormone (AMH) in seminal plasma were detected. Results:Compared with treatment before, the TCM syndrome scores of patients in the treatment group and acupuncture group were obviously decreased after treatment,the percentage of forward movement sperm (PR), sperm vitality (PR+NP) and seminal plasma AMH were obviously increased (P<0.05), the serum follicle stimulating hormone (FSH) were obviously reduced (P<0.05).The effects in the two groups were significantly better than those in the placebo group(P<0.05),but there were no statistically significant differences between the treatment group and acupuncture group(P>0.05).Compared with treatment before,the serum luteinizing hormone (LH) and testosterone (T) in the treatment group were significantly improved after treatment (P<0.05), but there were no obviously changes in the acupuncture group and placebo group (P>0.05). Conclusion:The therapy of TEAS can improve the clinical symptom of asthenospermia patients with deficiency of kidney essence,as well as the sperm motility and serum hormone levels.关键词：transcutaneous electrical acupoint stimulation;deficiency of kidney essence;asthenospermia;sperm vitality;sexhormone
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of oral medication of Yiqi Qingli Huayu Prescription combined with footbath of Huayu Jiangzhuo Prescription in the treatment of chronic kidney disease of kidney-spleen deficiency. MethodsSeventy-four cases of chronic kidney disease with kidney-spleen deficiency were randomly divided into the control group(34 cases)and treatment group(40 cases). Both groups were received the conventional treatment of western medicine,the treatment group was treated with oral medication of Yiqi Qingli Huayu Prescription combined with footbath of Huayu Jiangzhuo Prescription additionally,with a course of 2 months. The clinical efficacy in both groups were observed,as well as the changes of TCM syndrome scores and renal function before and after the treatment. Results:The total effective rate of the treatment group was 85.0 %, and the total effective rate of the control group was 55.9%. The clinical efficacy of the treatment group was better than that of the control group(P<0.05). After treatment,the TCM syndrome scores in the treatment group were significantly decreased compared with the treatment before(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05). After treatment,the levels of serum creatinine,urea nitrogen and urinary protein in both groups were decreased compared with the treatment before(P<0.05,P<0.01),and the glomerular filtration rate was increased compared with the treatment before(P<0.05). The effects of the treatment group on improving the renal function indexes were better than those of the control group(P<0.05,P<0.01). Conclusion: Oral medication of Yiqi Qingli Huayu Prescription combined with footbath of Huayu Jiangzhuo Prescription can significantly improve the clinical symptoms and renal function of patients with chronic kidney disease.关键词：chronic kidney disease;deficiency of kidney-spleen;Yiqi Qingli Huayu Prescription;Huayu Jiangzhuo Prescription
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of blood-promoting and water-disinhibiting therapy on neurological function of massive cerebral infarction patients following decompressive hemicraniectomy. MethodsSixty subjects were randomly divided into the treatment group and control group (30 cases in each group), and treated with routine therapies of western medicine. The treatment group was additionally given the prescription herbs of blood-promoting and water-disinhibiting, with a course of 14 days. The NIH stroke scales (NIHSS), and the serum levels of superoxide dismutase (SOD) and lipid peroxides (LPO) were observed before and after treatment. Results:After treatment, the NIHSS was decreased in both groups compared with the treatment before(P<0.05,P<0.01), and that in the treatment group was lower than that in the control group(P<0.01). The level of LPO was decreased in both groups compared with the treatment before (P<0.01), and that in the treatment group was lower than that in the control group (P<0.01). The level of SOD were increased in both groups compared with the treatment before (P<0.01), and that in the treatment group was higher than that in the control group (P<0.01). Conclusion: The blood-promoting and water-disinhibiting therapy may improve neurological function of postoperative patients with cerebral infarction through anti-oxidation and scavenging oxygen free radicals.关键词：cerebral infarction;blood-promoting and water-disinhibiting therapy;neurological deficit;superoxide dismutase(SOD);lipid peroxides(LPO)
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qiangji Tongluo Granules in the treatment of ankylosing spondylitis with syndrome of kidney deficiency and phlegm stasis. Methods 60 patients of ankylosing spondylitis with syndrome of kidney deficiency and phlegm stasis were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with Qiangji Tongluo Granules,the control group was treated with compound granules(without Tripterygium Wilfordii),with a course of 3 months. The clinical efficacy was observed. The changes of related symptoms(the time of early morning stiffness,degree score of low back pain,score of total pain,swelling number of peripheral joint,overall symptom score of patients) and sign indexes(pillow-wall distance,finger-ground distance,erythrocyte sedimentation rate (ESR),C reactive protein(CRP),bath ankylosing spondylitis disease activity index(BASDAI),bath ankylosing spondylitis disease function index(BASDFI)),TCM syndrome scores were compared. Results: ①28 cases in the treatment group and 25 cases in the control group finally completed the trials. ②The total effective rate of the treatment group and the control group were 96.43% and 64.00% respectively. There was statistically significant difference on the clinical efficacy between the two groups,and the effect of the treatment group was better than that of the control group(P<0.05). ③Comparison between the two groups after treatment,there were statistically significant differences on the time of early morning stiffness,degree score of low back pain,score of total pain,swelling number of peripheral joint,overall symptom score of patients(P<0.05),which suggested that the clinical symptoms in the treatment group were significantly relieved compared with the control group. Comparison between the two groups after treatment,there were statistically significant differences on the levels of pillow-wall distance,finger-ground distance,ESR,CRP,BASDAI and BASDFI(P<0.05),which suggested that the signs recovery in the treatment group were more significant than those in the control group. ④Comparison of the difference before and after treatment,there was statistically significant difference on the TCM syndrome scores between the two groups(P<0.05). ⑤Before and after treatment, tests for blood, urine and stool and the liver and kidney function of subjects in the two groups were normal. During the trial, no adverse reactions were found in both groups. Conclusion: Qiangji Tongluo Granules can be used in the treatment of ankylosing spondylitis with syndrome of kidney deficiency and phlegm stasis,which significantly improve the clinical symptoms and signs of patients. Meanwhile,the effect was improved after adding Tripterygium Wilfordii to the compounds,and there was no adverse reaction in the short term.关键词：ankylosing spondylitis;kidney deficiency;phlegm stasis;Qiangji Tongluo;Tripterygium Wilfordii;reducing toxicity and enhancing efficacy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of modified Gualou Niubang Decoction in the treatment of early-stage acute mastitis during lactation. MethodsSixty subjects of early-stage acute mastitis during lactation were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with modified Gualou Niubang Decoction and the control group was treated with intravenous infusion of penicillin,both groups were received the manual massage to drain milk,with a course of 6 days. The clinical efficacy was observed and the time for defervesce and pain and lump disappearance and the adverse reactions were compared. Results:①The total effective rate of the treatment group and the control group were 96.67% and 100% respectively. There was no statistically significant difference on the clinical efficacy between the two groups,and the effect of the treatment group was similar to the control group(P>0.05). ②There was no statistically significant difference on the time for defervesce between the two groups(P>0.05)；there were statistically significant differences on the time for pain and lump disappearance between the two groups(P<0.05),which suggested that the relief of some symptoms in the treatment was faster than that in the control group. ③There was no statistically significant difference on the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The effects of modified Gualou Niubang Decoction in the treatment of early-stage acute mastitis during lactation may be equivalent to antibiotics,but it may be faster to relieve pain and lump.关键词：acute mastitis;early stage;lactation;Gualou Niubang Decoction;antibiotics
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of special acupoints massage in treating exogenous fever of children. Methods150 children with exogenous fever were randomly divided into the ibuprofen group,massage group and combination group,50 cases in each group. The ibuprofen group was treated with ibuprofen suspension,the massage group was treated with special acupoints massage,the combination group was treated with ibuprofen suspension and special acupoints massage at the same time,with a course of 4 hours. 5 minutes before treatment,5 minutes and 4 hours after treatment,the temperature change was observed and the scores of clinical symptom and sign were compared. Results:①During the trial,143 cases completed the test at last and 7 cases fell off,among which 46 cases in the ibuprofen group,52 cases in the massage group and 45 cases in the combination group. ②Comparison of the temperature 5 minutes before and after treatment,the difference in each group was significantly decreased with statistically significant difference(P<0.05). Comparison of the temperature 5 minutes after treatment,the temperature difference between the ibuprofen group and massage group was not statistically significant(P>0.05),but the temperature in the combination group was obviously higher than that in the ibuprofen group and massage group(P<0.05). Comparison of the temperature 5 minutes before and 4 hours after treatment,the temperature in the ibuprofen group appeared obvious rebound(P>0.05),but the temperature in the massage group and combination group showed further downward trend obviously without rebound(P<0.05). Comparison of the temperature 4 hours after treatment,the temperature in the massage group and combination group was obviously lower than that in the ibuprofen group(P<0.05),compared with the combination group,the temperature in the massage group was decreased more significantly(P<0.05). ③Comparison of the scores of clinical symptom and sign 4 hours after treatment,the scores in the massage group were obviously lower than those in the ibuprofen group and combination group(P<0.05),but there were no statistically significant differences on the scores between the ibuprofen group and combination group(P>0.05). Conclusion: Special acupoints massage show good short-term effects in the treatment of exogenous fever in children,which is not easy to rebound. Special acupoints massage combined with ibuprofen will affect the efficacy,rather than obviously synergistic effects.关键词：fever in children;exogenous pathogens;special acupoints massage;non-steroidal anti-inflammatory drug;natural therapy
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发布时间：2022-08-31 - 摘要：This paper discussed the traditional Chinese medicine therapy of chronic obstructive pulmonary disease(COPD) in stabilization period. It considered that there were syndrome transformation process from lung-qi deficiency,lung-spleen deficiency,lung-kidney deficiency syndrome to lung-spleen-kidney deficiency syndrome. Tonifying lung-spleen-kidney was the key of treatment. Quanzhen Yiqi Decoction could regulate lung-spleen-kidney together combined with tonifying yin and yang to coordinate earth-gold-water and their interaction,which was quite suitable for the pathogenesis of COPD.关键词：chronic obstructive pulmonary disease;tonifying lung-spleen-kidney;Quanzhen Yiqi Decoction
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发布时间：2022-08-31 - 摘要：Objective:To discuss the effects of Sijunzi Decoction on suppressing bacterial translocation and promoting bone repair in mice with bone injury. MethodsTen mice were taken as the control group from 100 healthy mice. After modeling the other 90 mice were randomly divided into the traditional Chinese medicine(TCM) group, antibiotic group and recovery group, 30 mice in each group. The antibiotic group was treated with penicillin and streptomycin by intraperitoneal injection,the TCM group was treated with Sijunzi Decoction based on the treatment for the antibiotic group, and the recovery group was treated with 0.9% normal saline by intragastric administration. 10 days after modeling, the bacterial translocation in the liver and the phagocytic function of macrophages were detected. The scar areas and bone volume fraction(BVF) of the TCM group,antibiotic group and recovery group were checked after 2 weeks, 4 weeks, 6 weeks and 8 weeks. Results:The rate of bacterial translocation and liver living bacteria count in the TCM group were significantly lower than those in the recovery group and antibiotic group (P<0.01); the phagocytic capacity of macrophages in the TCM group was significantly higher than that in the recovery group and antibiotic group (P<0.01); the scar areas reduced most quickly in the TCM group(P<0.01); the BVF in the TCM group at different time points were all higher than that in the recovery group and antibiotic group (P<0.01). Conclusion: Sijunzi Decoction can inhibit the bacterial translocation and improve the phagocytic function of macrophages to promote bone repair in bone damage mice.关键词：Sijunzi Decoction;bone injury;bacterial translocation
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发布时间：2022-08-31 - 摘要：Objective:To discuss the effects of Xiaotan Tongfu (XTTF) Decoction on protein expression of nuclear factor-κB(NF-κB)/ interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3)and activation induced cytidine deaminase(AICD)in colorectal mucosal epithelium of mice with colorectal precancerous lesions model. MethodsAccording to the random number table,ninety C57BL/6 mice were randomly divided into five groups:the control group,model group,western medicine group(Sulfasalazine group), traditional Chinese medicine group(XTTF Decoction group)and the combination group(Sulfasalazine and XTTF Decoction group). Except the control group,model was established in the other four groups by the AOM/DSS “four-step three-cycle method”. General condition of mice and pathological changes of colorectal mucosa epithelium in each group were observed. The rate of tumor formation of colorectal precancerous lesions was calculated. The protein expression of NF-κB/IL-6/STAT3 and AICD in colorectal mucosal epithelium of mice during the modeling process (6 weeks,14 weeks,18 weeks) were detected by Western Blotting. Results:After the treatment of XTTF Decoction,the general condition of mice were better than the mice in the model group. The rate of tumor formation in the combination group (33.33%) was lower than that in the model group (50.00%). After treatment for 14 and 18 weeks,compared with the western medicine group,the changes of NF-κB expression in the traditional Chinese medicine group and combination group were not significant,but the expression levels of IL-6,STAT3 and AICD were all significantly down-regulated. Compared with the traditional Chinese medicine group, the differences on the expression of IL-6 and STAT3 in the combination group were not significant,but the AICD expression was significantly lower than that in the traditional Chinese medicine group. Conclusion: XTTF decoction can improve the general condition of mice with colorectal precancerous lesion,decrease the incidence of colorectal precancerous lesions,down-regulate the protein expression of IL-6/STAT3 as well as AICD in colorectal mucosal epithelium. This may be one of its mechanisms on decreasing the incidence of colorectal precancerous lesions and preventing the occurrence of colorectal cancer.关键词：colorectal precancerous lesions;NF-κB;IL-6;STAT3;AICD;Xiaotan Tongfu Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the intervention of Babaodan capsule on liver fibrosis induced by dimethylnitrosamine(DMN)in rats. Methods90 Sprague-Dawley male rats were randomly divided into the normal group and modeling group. The rat model of hepatic fibrosis was established by intraperitoneal injection of 0.5 % DMN at the dose of 2 μl/g for 4 weeks. At the end of the fourth week,the rats in the modeling group were randomly divided into the model group,Babaodan capsule groups with high-,medium- and low-dose,Fuzheng Huayu group. Treatment drugs were orally given to the corresponding groups. The normal group and model group were treated with equivalent dose of 0.5% sodium carboxymethyl cellulose (CMC). The treatment course was 4 weeks. At the end of the 8th week,animals were sacrificed and the samples were collected. The serum levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),albumin (ALB),total bilirubin (TBIL) and the hepatic levels of hydroxyproline (Hyp) were detected. Pathological changes of liver tissue was observed by sirius red staining and HE staining. Results:Compared with the normal group,the serum levels of ALT, AST and TBIL in the model group were significantly increased (P<0.05),after drug intervention the serum levels of ALT,AST and TBIL were all decreased. HE staining showed that there were a large amount of inflammatory cell infiltration,swelling,degeneration and necrosis,significant bleeding phenomenon in the liver tissue of rats in the model group. Sirius red staining showed that there was obvious hyperplasia of liver collagen with false lobules in the model group. Compared with the normal group,the collagen area and hepatic Hyp content in the model group were significantly increased (P<0.01). After drug intervention,the degree of inflammation and fibrosis in liver tissue were all improved compared with the model group,and the hepatic Hyp content was decreased significantly. The collagen deposition in liver tissue in the Babaodan capsule groups with high- and medium-dose and Fuzheng Huayu group were significantly reduced compared with the model group(P<0.05), and there was no statistically significant difference between the Babaodan capsule group with high-dose and Fuzheng Huayu group. Conclusion: Babaodan capsule show better reversal effects on rat liver fibrosis induced by DMN. The intervention effects of Babaodan capsule with high-dose on hepatic fibrosis in rats are more prominent compared with the medium-and low-dose,which is similar to the effects of Fuzheng Huayu Capsule as positive control.关键词：Babaodan capsule;Fuzheng Huayu capsule;dimethylnitrosamine;liver fibrosis
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发布时间：2022-08-31 - 摘要：Objective:To study the antitussive,expectorant and antiasthmatic effects of Xijie Huatan Pingchuan Cataplasm. Methods50 Kunming mice(25 male and 25 female)were randomly divided into the blank control group,Xijie Huatan Pingchuan Cataplasm groups with high-,medium- and low-dose and Amidi group as positive control. One day before the experiment,the back hair of all the mice were shaved,and then corresponding drugs were applied externally on lung-shu point of mice in the treatment groups and positive control group. The antitussive and expectorant effects of Xijie Huatan Pingchuan Cataplasm were investigated by the methods of mice cough caused by concentrated ammonia water and mice tracheal phenol red excretion. 40 rats(20 male and 20 female)were treated with the same grouping and administration described previously. Rat model of asthma was replicated by the methods of ovalbumin(OVA) sensitization and excitation. The latent period of asthma induced by aerosol inhalation in rats was calculated. The contractile response of rat tracheal spiral strips to acetylcholine was observed. Results:For the antitussive test, compared with the blank control group,the cough times of mice were significantly inhibited in the Xijie Huatan Pingchuan Cataplasm groups with different doses and positive control group(P<0.05,P<0.01),the response latency of mice was significantly prolonged. There were statistically significant differences on the cough times and latent period between the Xijie Huatan Pingchuan Cataplasm group with low dose and Xijie Huatan Pingchuan Cataplasm groups with medium- and high-dose(P<0.05),which suggested that the effects presented in a dose-dependent manner. For the expectorant test,compared with the blank control group,the excretion of phenol red in mice airway in the Xijie Huatan Pingchuan Cataplasm groups with medium- and high-dose and positive control group was obviously increased(P<0.05,P<0.01),which suggested that Xijie Huatan Pingchuan Cataplasm showed expectorant effect. There were statistically significant differences on the excretion of phenol red between the Xijie Huatan Pingchuan Cataplasm group with low dose and Xijie Huatan Pingchuan Cataplasm groups with medium- and high-dose(P<0.05). For the asthma experiment,compared with the blank control group,the incubation period of asthma was obviously prolonged in the Xijie Huatan Pingchuan Cataplasm groups with different doses and positive control group(P<0.05),and the rats number of falling and shock was small. There was statistically significant difference on the incubation period of asthma between the Xijie Huatan Pingchuan Cataplasm group with low dose and high dose(P<0.05). Compared with the blank control group,the contraction of rat tracheal smooth muscle was all obviously suppressed in the Xijie Huatan Pingchuan Cataplasm groups with different doses and positive control group(P<0.05),which suggested that Xijie Huatan Pingchuan Cataplasm could suppress the contraction of airway smooth muscle,relax the airway smooth muscle and reduce airway responsiveness. There were statistically significant differences on the suppression of contraction of rat tracheal smooth muscle between the Xijie Huatan Pingchuan Cataplasm group with low dose and Xijie Huatan Pingchuan Cataplasm groups with medium- and high-dose(P<0.05). Conclusion: Xijie Huatan Pingchuan Cataplasm shows pharmacodynamic actions of antitussive, expectorant and antiasthmatic effects.关键词：cataplasm;antitussive;expectorant;antiasthmatic;pharmacodynamics
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发布时间：2022-08-31 - 摘要：Objective:To study the antidepressant effects of Gastrodia elata seeds and provide the basis for development and application. MethodsThe mice were randomly divided into the blank control group, model group, fluoxetine group, Gastrodia elata seeds groups with high-,medium- and low- dose. All drugs were orally given to mice for 28 days. Through the forced swimming test and tail suspension test in mice,the immobility time of swimming and tail suspension within 4min was observed. 24 hours after tail suspension test,each mouse was treated with tail suspension test for 5 minutes and then forced swimming test for 5 minutes,and after 30 minutes the blood were collected and the serum contents of adrenal stimulating hormone releasing hormone (CRH),adrenal cortical hormone (ACTH) and corticosterone (CORT) were detected. Results:Compared with the model group,the immobility time of forced swimming and tail suspension in all drug treatment groups were significantly decreased(P<0.05,P<0.01). Compared with the model group,serum CRH,ACTH and CORT contents of mice in the Gastrodia elata seeds groups with different dose were all decreased,the effects in the Gastrodia elata seeds group with high- and medium-dose were significant(P<0.05,P<0.01). The serum hormone levels of mice in the Gastrodia elata seeds group with high-dose were similar to those in the fluoxetine group. Conclusion: Gastrodia elata seeds has antidepressant effects,its mechanism may be associated with regulating the hormone levels of HPA axis.关键词：Gastrodia elata seeds;antidepressant effects;immobility time
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发布时间：2022-08-31 - 摘要：Objective:To optimize the extraction process of total flavonoids from Anchusa italica Retz. . Methods According to the extraction efficiency of total flavonoids and rutin and the extraction ratio, the process of refluxing extraction of Anchusa italica Retz. was optimized by two kinds of multi-index comprehensive score method and L9(34) repeated orthogonal design. Results:The methods of content determination for total flavonoids and rutin in the extracts were accordance with the requirements of methodology. The optimized refluxing extraction process of total flavonoids from Anchusa italica Retz. as follows:the ratio of material and liquid is 1∶20(w/v), extraction temperature is 100 ℃,the volume fraction of ethanol is 75%,twice extraction and each 2 hours. Conclusion: The validation test shows that the optimized extraction process is simple,reasonable and feasible,which provides the theory basis for the subsequent studies.关键词：Anchusa italica Retz.;reflux extraction;multi-index comprehensive score;repeated orthogonal design
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发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on noncoding RNA (ncRNAs) and traditional Chinese medicine(TCM),including miRNA and TCM syndrome and mechanism,lncRNA and TCM mechanism. ceRNA-miRNA-mRNA improve the mechanism network of ncRNA,which provide new perspective for TCM syndrome research and TCM mechanism elucidation. The academic significance of ncRNA and TCM research was also discussed.关键词：noncoding RNA;traditional Chinese medicine;research progress
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发布时间：2022-08-31 - 摘要：This paper reviewed the application status of anti-angiogenic effects of traditional Chinese medicine in tumor disease. The relevant literatures at home and abroad in recent years were summarized and analyzed. This article reviewed the relationship between tumor and angiogenesis and the underlying mechanism,the research progress on anti-angiogenic effects of single herb monomer and herbal compound of traditional Chinese medicine,and elaborated the potential features and advantages of traditional Chinese medicine in the research field of angiogenesis,as well as the action link and mechanism of traditional Chinese medicine in the process of angiogenesis.关键词：traditional Chinese medicine;angiogenesis;tumor;review
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发布时间：2022-08-31
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