最新刊期
期 1 ， 2017
- 摘要：Mr. Shi Xiaoshan,the third generation of Shi’s traumatology,was a famous scholar,physician and educator of traditional Chinese medicine (TCM) in our country. He had profound knowledge in traditional Chinese medicine with great attainments in treating wounds and bone-setting specially,and accumulated abundant clinical experience and built the complete theoretical system of Shi Xiaoshan’s traumatology academic thoughts. Professor Shi Qi,Mr. Shi Xiaoshan’s direct disciple,made great effort to enrich and develop Shi’s traumatology and insisted on the inheritance and innovation by keeping faith with Mr. Shi Xiaoshan’s academic thoughts and experience.关键词：Shi’s traumatology;Shi Xiaoshan;Shi Qi;academic experience;inheritance and innovation
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Zhu Bangxian’s clinical experience in treating IgA nephropathy with methods of ascending the clear and descending the turbid, removing poison and reinforcing the kidney. He considers that the pathogenesis of this disease is disturbance of ascending and descending and disorder of clear and turbid. Organs damage and toxin obstruction is mutual manifestation and root for each other. Based on the corresponding of prescription and syndrome and combination formula and complex therapy,the treatments make good use of methods of ascending the clear and descending the turbid,removing poison and dispelling evil combined with drugs pungent in flavor and warm in property to rise and support qi movement,and tonifying the kidney and nourishing the essence to restore the organs. One proven case was recorded.关键词：IgA nephropathy;ascending the clear and descending the turbid;clearing and detoxifying the toxin;reinforcing the kidney and recovering the essence;corresponding of prescription and syndrome;experience of famous doctor
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发布时间：2022-08-31 - 摘要：This paper investigated the therapy and syndromes of consumptive disease due to depression syndrome. Consumptive disease is a general term for chronic deficiency diseases due to consumption of yin,yang,qi and blood in viscera. A part of consumptive disease,which is caused by emotional factors,always manifests as ordinary deficiency syndrome, but actually belongs to the deformation of depression syndrome. The reasons include the facts that five excessive minds influence the five viscera especially the heart,seven emotions such as anger,sadness,over-thinking and fear lead to psychological diseases,changes in life circumstances cause the consumption of ying qi and loss of essence,and the emotional upset of the girls and boys at puberty,the divorced and nuns can arouse consumptive disease. Consumptive disease due to depression syndrome contains two forms as dominant depression syndrome and recessive depression syndrome. As for the treatments,besides of nourishing therapy,the principles of relieving depression,tranquilizing the mind and regulating qi should also be taken seriously. In addition to medication,regulation of mind and spirit is also essential to avoid consumptive diseases. Combination of these two aspects is very important for the prevention and treatment of consumptive disease due to depression syndrome.关键词：depression syndrome;consumptive disease;etiology and pathogenesis;emotion;treatment based on relieving depression;regulation of mind and spirit
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发布时间：2022-08-31 - 摘要：Western medicine was developed from “religious medicine” “machine medicine” “biomedicine” to the current stage of “biological-psychological-social medicine” model. Although there has been considerable progress, but the understanding for human is still limited in the biological vision,and it is lack of sufficient attention to the important role of “consciousness” and “nature” in human life activities. At present,mode of integrated traditional Chinese and western medicine is combined but not integrated in the theory,and only reflected as the“technical complementation”rather than organic“integration”in clinical practice. It considered that more complete and new model of “human medicine” should be reshaped based on the “human medicine” model of traditional Chinese medicine and combined with the research results of modern quantum mechanics.关键词：medicine mode;mode of integrated traditional Chinese and western medicine;“human medicine” mode;priori genes differernce
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发布时间：2022-08-31 - 摘要：Objective:To study the parametric feature of ambulatory blood pressure in elderly patients with hypertension of yin deficiency and yang excess syndrome. Methods114 cases of elderly patients with hypertension were selected,among 50 cases were of yin deficiency and yang excess syndrome,64 cases were without the syndrome of yin deficiency and yang excess. 24 hours ambulatory blood pressure monitoring was performed in all patients. The differences of ambulatory blood pressure parameters were compared between the two groups. Results:①The systolic blood pressure(SBP)and cerebral infarction rate in the group with syndrome of yin deficiency and yang excess were higher than those in the group without this syndrome(P<0.05). There were no statistically significant differences on the blood lipid,blood glucose and liver and renal function between the two group(P>0.05). ②Comparison between the two group,the values of 24 h average systolic blood pressure (24 hASBP),daytime average systolic blood pressure (dASBP),24 h mean pulse pressure (24 hMPP),daytime mean pulse pressure (dMPP),daytime mean arterial pressure (dMAP),24 h systolic blood pressure variability (24 hSBPV),24 h diastolic blood pressure variability (24 hDBPV),daytime systolic blood pressure variability (dSBPV),24 h systolic blood pressure load(24 hSBPL),24 h diastolic blood pressure load(24 hDBPL),daytime systolic blood pressure load(dSBPL) and morning blood pressure peak (MBPP) in the group with syndrome of yin deficiency and yang excess were higher than those in the group without this syndrome(P<0.05). ③Comparison of circadian rhythm of blood pressure between the two groups,the constituent ratio of dipper in the group with syndrome of yin deficiency and yang excess was higher than that in the group without this syndrome(P<0.05),the constituent ratio of reverse-dipper in the group with syndrome of yin deficiency and yang excess was lower than that in the group without this syndrome(P<0.05). ④Spearman correlation analysis results showed that there were correlation between the existence of yin deficiency and yang excess syndrome and the descend rate of SBP,complicated cerebral infarction,24 hASBP,dASBP,24 hMPP,dMPP,dMAP,24 hSBPV,24 hDBPV,dSBPV,24 hSBPL,24 hDBPL,dSBPL,MBPP,night systolic blood pressure(nSBP)(P<0.05).⑤Binary logistic regression analysis results showed that dASBP was the independent factor for elderly hypertension of yin deficiency and yang excess syndrome. Conclusion:①The parameters changes of ambulatory blood pressure in elderly patients with hypertension of yin deficiency and yang excess syndrome were mainly presented as the increase of systolic blood pressure parameters,and the diastolic blood pressure parameters were not obviously changed,which accompanied by the large blood pressure variability,the increased blood pressure load,the prominent morning peak and the circadian rhythm disorders. ②In all the differential factors,dASBP was most closely related to elderly hypertension of yin deficiency and yang excess syndrome,which may be used as the characteristic index. Clinical application should pay attention to the ambulatory blood pressure monitoring for patients with yin deficiency and yang excess syndrome,and implement the treatment according to syndrome differentiation as well as individualized treatment,so as to reduce the complications and damage of target organs,improve the clinical efficacy and life quality of patients.关键词：hypertension;elderly people;syndrome of yin deficiency and yang excess;ambulatory blood pressure
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Li Qizhong’s clinical experience in differentiating and treating acute and chronic cough and asthma. Under the guidance of theories of Zhang Jingyue and Cheng Zhongling,he emphasizes the nature of lung as Jiao-zang and the property of purifying and descending. The medication should be gentle for lung diseases. The treatments for cough and asthma concentrate on dispersing and descending and convergence. Proper balance in ventilating and descending of lung qi is critical to treatment. Concurrence of liver and lung diseases can be treated with Sini Powder. Lung diseases affected by the stomach dysfunction can be treated with Baohe Pill. Damage of both lung and kidney can be treated by recovering the lung function of astringing and improving the kidney function of receiving qi.关键词：cough and asthma;clinical experience;Li Qizhong
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Tong Xiaolin’s new interpretation of cold-dryness caused by internal disorder. He considers that cold-dryness is not simply dry but dues to deficiency of yang qi,which is difficult to steam fluid to distribute and moist the whole body,and consequently forms dryness symptoms in the skin,mucous membranes and five sense organs,especially common in middle-aged and elderly patients with yang deficiency. Followed the treatment principles of traditional Chinese medicine as“homotherapy for heteropathy based on the pathogenesis”,Professor Tong applies the main prescriptions such as Shengyang Yiwei Decoction,Huangqi Guizhi Wuwu Decoction,Wutou Decoction,Gegen Decoction,Erxian Decoction,Zhenwu Decoction,Mahuang Fuzi Xixin Decoction in the treatment of cold-dryness syndrome to warm yang,disperse cold and dredge collaterals.关键词：cold-dryness syndrome;combination of status and target;clinical experience
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发布时间：2022-08-31 - 摘要：This paper discussed Professor Cui Yun’s experience in treating varicocele infertility. Professor Cui considers that the basic pathogenesis of varicocele infertility is stagnation of liver-qi,meridian stasis and insufficiency of kidney essence,and proposes the methods of soothing the liver and dredging the channels and supplementing essence as the therapeutic principal of varicocele infertility.关键词：Cui Yun;varicocele;infertility;methods of soothing the liver and dredging the channels and supplementing essence
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发布时间：2022-08-31 - 摘要：The theory connotation of Guizhi Qushaoyao Decoction was discussed from the prescriptions and syndrome, associated prescriptions and medication. It considered that Guizhi Qushaoyao Decoction should be applied when the syndrome were presented as fullness in the chest and intermittent pulse.关键词：Guizhi Qushaoyao Decoction;correspondence of prescription and syndrome;fullness in the chest;intermittent pulse
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发布时间：2022-08-31 - 摘要：This paper discussed and analyzed the academic thoughts of menstruation regulation in Fuke Bingjian. In diagnosis,it emphasizes the pulse and symptoms based on eight principles. Disorder in chong and ren channels and disharmony of spleen,stomach and emotion are considered as the pathogenesis of this disease. In syndrome differentiation,it is based on the five viscera combined with the essence and blood. In treatment,it concentrates on the regulation of blood and qi.关键词：Fuke Bingjian;menstruation regulation;academic thoughts;investigation
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发布时间：2022-08-31 - 摘要：This paper summarized and analyzed the relevant literatures of ancient medical books and recent clinical and experimental studies on acupuncture needle retaining time,and found that the length of retaining needle time played a direct and important role in acupuncture effects. There was optimal needle retaining time in the treatment. Physicians in past dynasties took the retaining needle seriously and modern research also confirmed and developed the ancient understanding of retaining needle in a certain extent. But the concrete retention time is still not consistent in the current study. In the future standardized scientific research work should be carried out to seek the best needle retaining time with high recognition and objectivity. Based on the disease,it should take into account the differences on illness,time,individual,meridian and points to determine needle retention time关键词：acupuncture;retention time;acupuncture effect
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发布时间：2022-08-31 - 摘要：This paper discussed the syndrome differentiation and classification and treatment on recurrent spontaneous abortion(RSA)caused by polycystic ovary syndrome(PCOS),and summarized that heart,liver,spleen and kidney were related to this disease,the syndrome differentiation was mainly kidney deficiency combined with phlegm dampness,stagnated fire and blood stasis. The therapy follows the principle of treatment by stages. Before pregnancy,the treatments emphasize the pre conditioning and removal of pathogens,and mainly concentrate on nourishing kidney and regulating chong meridian,combined with strengthening spleen and dispelling dampness,soothing liver and clearing away heart-fire,activating blood and resolving stasis. After pregnancy,the treatments insist on medication and concentrate on nourishing kidney and supplementing qi,reinforcing and supporting the fetus. Meanwhile,it encourages patients to adjust the life style and balance the diet,which reflect the diagnosis and treatment thoughts of “preventive treatment of disease” and “individuation” in traditional Chinese medicine.关键词：polycystic ovary syndrome;recurrent spontaneous abortion;differentiation and classification of syndrome;treatment by stages
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发布时间：2022-08-31 - 摘要：This paper discussed Chengqi Decoction associated prescriptions and clinical application by Wu Jutong.Wu Jutong inherited Sanchengqi Decoction that proposed by Zhang Zhongjing and made it flourish in Detailed Analysis of Epidemic Warm Diseases(Wenbing Tiaobian),which expanded clinical application category and enriched the differentiation and treatment system of fever. By making careful and detailed analysis and comparison on the Chengqi Decoction associated prescriptions and the modified formula in Detailed Analysis of Epidemic Warm Diseases,this paper discussed the inheritance and change of Wu’s Chengqi Decoction for Zhang Zhongjing’s purgative method,and summarized the mechanism and common used prescriptions,which aimed to investigate the medication rule and clinical application of Chengqi Decoction associated prescriptions.关键词：Detailed Analysis of Epidemic Warm Diseases(Wenbing Tiaobian);Chengqi Decoction;associated prescriptions;medication rule
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发布时间：2022-08-31 - 摘要：Objective:To investigate the anti-tumor effect of Qingre Jiedu(QRJD) Formula on transplanted hepatocellular carcinoma in mice and the influence on chemokine. MethodsMice models of CBRH-7919 orthotopic hepatocellular carcinoma were established,and the mice were randomly divided into the control group and Chinese medicine groups with low-,mid- and high-dose. The anti-tumor effect of QRJD Formula was observed. The differential genes (with at least 3 folds) among different dose groups were screened by the chemokine chip,and then the differential genes were verified by immunohistochemistry and Western blotting. Results:① QRJD Formula with different doses all showed anti-tumor effect in varying degree(P<0.01 compared with the control group),comparison among groups,the anti-tumor effect of high-dose group was more significant(P<0.01).② CXCL1, CXCL2, CXCL3, CXCR2 and IL-1β were screened as differential gene by the chemokine microarray detection,among,the gene expression of CXCL1, CXCL2, CXCL3 and IL-1β were down-regulated in the Chinese medicine intervention group and the gene expression of CXCR2 was up-regulated,which more significant in the high-dose group (P<0.05).③Above differential gene were verified by immunohistochemistry and Western blotting on the protein levels. Conclusion:QRJD Formula could significantly down-regulate the expression of chemotactic factors CXCL1, CXCL2, CXCL3 and IL-1β and up-regulate the chemotactic factor receptor CXCR2 in mice with transplanted hepatocellular carcinoma,which may be related to its mechanism on anti-tumor.关键词：Qingre Jiedu Formula;primary hepatocellular carcinoma;chemokine;chip technology
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发布时间：2022-08-31 - 摘要：Objective:To study the inhibitive effects of Lingmao Formula on cccDNA, pgRNA, sRNA and La-mRNA in HepG2.2.15 and HepAD38 cells, and discuss its mechanism on anti-hepatitis B virus(HBV). MethodsThe aqueous extract of Lingmao Formula was prepared. HepG2.2.15 and HepAD38 cells were intervened by the aqueous extract of Lingmao Formula at concentration of 500 and 1 000 mg/L respectively,the blank control group was treated with normal saline. The supernatant of culture medium was collected after 6 days and the levels of HBsAg and HBeAg were detected by ELISA. The cells were collected and the total RNA was extracted,the expression levels of cccDNA, pgRNA, sRNA and La mRNA were detected by RT-PCR. Results:Compared with the blank control group, the secretion levels of HBsAg and HBeAg in HepG2.2.15 and HepAD38 cells of the Lingmao Formula group were significantly decreased, the expression levels of intracellular cccDNA, pgRNA, sRNA and La mRNA were significantly decreased (P< 0.01). Conclusion:Lingmao Formula may promote the degradation of pgRNA, sRNA and cccDNA by inhibiting La protein expression in HepG2.2.15 and HepAD38 cells, and result in the inhibition of HBV replication.关键词：Lingmao Formula;HepG2.2.15;HepAD38;La protein;pgRNA;cccDNA;sRNA
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发布时间：2022-08-31 - 摘要：Objective:To study the efficacy of one-finger massage manipulation in the treatment of gastrocnemius muscle atrophy after sciatic nerve injury. Methods36 SD rats were randomly divided into the blank group,model group and massage group. In the model group and the massage group,the atrophy of gastrocnemius muscle induced by sciatic nerve injury was established according to reference literature,and the blank group received sham treatment. 7 days after modeling,the massage group was treated with one-finger massage manipulation,and 4 rats were sacrificed when the massage therapy for 10,0 and 30 times respectively. The wet weight of gastrocnemius muscle,the diameter of gastrocnemius muscle cells and the fibrillation potential amplitude of gastrocnemius muscle were measured. After therapy for 30 times,the gastrocnemius muscle of rats in the three groups were stained with HE,and its morphological changes were observed. Results:After therapy for 30 times,the one-finger massage manipulation could effectively increase the recovery rate of wet weight of gastrocnemius muscle, the difference between the treatment group and model group was statistically significant (P<0.05); the massage manipulation could effectively increase the diameter and cross-section area of the gastrocnemius muscle cells, the differences between the massage group and model group was statistically significant (P<0.05); the massage manipulation of one-finger scrubbing could effectively improve the fibrillation potential amplitude of gastrocnemius muscle, the difference between the massage group and model group was statistically significant (P<0.05). The morphological differences among the three groups were confirmed by HE staining. Conclusion:The one-finger massage manipulation can effectively relieve the atrophy of gastrocnemius muscle after sciatic nerve injury in rats.关键词：one-finger massage manipulation;sciatic nerve injury;gastrocnemius muscle atrophy
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Chinese medicine freckle cream on skin superoxide dismutase(SOD), malondialdehyde (MDA) and melanin granules in male brown guinea pigs. Methods40 male brown guinea pigs were randomly divided into the blank group, model group, positive control group, Chinese medicine freckle cream group, 10 in each group. All guinea pigs were received the hair removal treatment on the back skin in an area of 3cm × 3cm once every other day. Except the blank group,the other groups were treated with ultraviolet irradiation with a wavelength of 320 nm once a day for four consecutive weeks, each irradiation time was 60 minutes, the distance between the animal and the light source was 10 cm, the skin changes in the back hair removal area of guinea pigs in each group were observed continuously. After successful modeling,the guinea pigs in the Chinese medicine freckle cream group and the positive control group were treated with corresponding drugs for external application on the skin lesions once a day,and combined with massage for 5 minutes each time. After 4 weeks of continuous administration, the animals were sacrificed by cervical dislocation and the skin tissue after the hair removal was collected rapidly. The contents of SOD and MDA in the skin of guinea pig were detected,the positive expression of melanin granules in guinea pig model of chloasma was observed by HE staining and immunohistochemical staining. Results:The content of SOD in the Chinese medicine freckle cream group was obviously higher than that in the model group and positive control group (P< 0.05), while the content of MDA in the Chinese medicine freckle cream group was obviously lower than that in the model group and positive control group (P< 0.05), and the positive expression of melanin granules in the Chinese medicine freckle cream group was obviously lower than that in the model group and positive control group(P<0.05). Conclusion:Chinese medicine freckle cream can improve the skin SOD activity of guinea pig model of chloasma, decrease the MDA content and reduce the generation of melanin granules in skin.关键词：chloasma;animal experiments;guinea pig;superoxide dismutase(SOD);malondialdehyde(MDA);melanin granules
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发布时间：2022-08-31 - 摘要：Objective:To study the optimum process of ginsenoside Rg3 prepared by hydrolysis protopanaxadiol-type saponins by glutamic acid. MethodsTaken glutamic acid as catalyst and protopanaxadiol(PPD)-type saponins as raw material,the preparation condition of ginsenoside Rg3 was optimized by single factor investigation and orthogonal test,and the reaction products were quantitatively analyzed by HPLC. Results:The optimization results of orthogonal test showed that all PPD-type saponins were converted when PPD-type saponins (10 g/L) were hydrolyzed by glutamic acid (10 g/L) at 80℃ for 2 h,the conversion rate of ginsenoside Rg3 was 65.12%. Conclusion:The method is simple in operation,low in cost with no pollution to environment,and is a feasible method for rapid preparation of 20(S)-ginsenoside Rg3 and 20(R)-ginsenoside Rg3.关键词：ginsenoside Rg;3;glutamic acid;protopanaxadiol-type saponins;acid hydrolysis;orthogonal test
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发布时间：2022-08-31 - 摘要：Now Parkinson’s disease (PD) and Alzheimer’s disease (AD) are the most common neurodegenerative diseases with more and more higher incidence. Traditional Chinese medicine has played positive role in the clinical treatment. Combined and based on the literatures in recent years,this paper summarized and prospected the experimental study and clinical application of uncaria and its compound preparations in the treatment of this disease,in order to provide reference for the research and application of uncaria in neurodegenerative diseases in the future.关键词：uncaria;nervous protection;neurodegenerative disease;clinical application
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发布时间：2022-08-31 - 摘要：From extracts of Chinese medicine,single herb and Chinese herbal compound,this paper reviewed the regulation on biological behavior of bone marrow mesenchymal stem cells(BMSCs) by traditional Chinese medicine and the mechanism. BMSCs are ideal seed cells for tissue engineering, and the traditional Chinese medicine regulate the biological behaviors of its differentiation,hematopoiesis support, angiogenesis promotion, chemotactic migration and immune regulation by many ways.关键词：bone marrow mesenchymal stem cells;traditional Chinese medicine;biological behavior
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发布时间：2022-08-31 - 关键词：infertility;herbal paste;medical records
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发布时间：2022-08-31 - 摘要：Objective:To observe the influence of syndrome differentiation treatment of Weichang’an Prescription on the overall survival (OS) and the progression free survival (PFS) of patients with unresectable colorectal liver metastases. MethodsThe clinical data on a total of 131 patients with unresectable colorectal liver metastases were collected and divided into the integrated Chinese and western medicine group(65 cases)and western medicine group(66 cases)by the bidirectional cohort and concurrent control method.The database was established by Microsoft Excel and SPSS 21.0 software.The survival rates of patients within 1,2,3,4,5 years were counted by life-table method；the median OS and PFS were calculated by Kaplan-Meier method and then carried on the univariate analysis,the difference was compared between groups by Log-rank test；the factors with statistically significance in univariate analysis were enrolled in Cox regression analysis and conducted the multivariate analysis.The prognosis related factors of patients with unresectable colorectal liver metastases were screened out. Results:①The median OS of the western medicine group was 18.5 months and the median OS of the integrated therapy group was 23.2months. There was significant difference on the median OS between the two groups (P=0.006＜0.05). ②Within 1,2,3,4,5 years the survival rates of the western medicine group and integrated therapy group were 69.7% vs 87.2%, 33.3%vs 47.4%, 14.5%vs 28.4%, 1.3%vs 23.7%, 0%vs 0% respectively,which suggested that the survival rate of the integrated therapy group in 5 years was obviously better than that of the western medicine group(P<0.05).③The Cox regression analysis suggested that resection of primary tumor (P=0.003) , chemotherapy (P=0.000) and syndrome differentiation treatment of Chinese medicine(P=0.004) were independent prognostic factors which affected the OS of patients with this disease. The hazard ratio of resection of primary tumorwas 0.433(95%CI:0.251-0.748),chemotherapy was 0.148(95%CI:0.060-0.365),administration with Chinese medicine was 0.532(95% CI:0.347-0.816). ④The median PFS of the western medicine group were 6.1 months,and the median PFS of the integrated therapy group were 9.2 months. There was significant difference on the median PFS between the two groups (P=0.049＜0.05). ⑤The Cox regression analysis suggested that resection of primary tumor (P=0.022) and local treatment of liver metastases(P=0.020) were independent prognostic factors which affected PFS of patients with this disease. The hazard ratio of resection of primary tumor was 0.466(95%CI:0.242-0.895), and local treatment of liver metastases was 0.576(95%CI:0.362-0.918). Conclusion:The syndrome differentiation treatment of traditional Chinese medicine based on Weichang’an Prescription are effectively protective factors of prognosis；integrated therapy of Chinese and western medicine show a certain advantage on prolonging OS and PFS of patients with unresectable colorectal liver metastases,which needs to be further evaluated by follow-up.关键词：colorectal cancer;liver metastases;unresectable;therapy of traditional Chinese medicine;syndrome differentiation treatment;overall survival;progression free survival
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy and influence of ginsenoside combined with temozolomide on the levels of HGF, TNF-α and IL-17 in cerebrospinal fluid of postoperative patients with brain glioma. Methods90 postoperative patients with brain glioma were divided into the treatment group and the control group,45 cases in each group. The control group was treated with temozolomide, the treatment group was treated with ginsenoside Rg3 based on the treatment for control group,with a course of 6 treatment cycles. The overall survival (OS), progression-free survival (PFS), and the levels of HGF, TNF-α and IL-17 in cerebrospinal fluid before and after treatment were compared. Results:After treatment,the OS and PFS in the treatment group were significantly longer than those in the control group (P<0.05); after treatment,the levels of HGF, TNF-α and IL-17 in cerebrospinal fluid of patients in both groups were significantly decreased compared with the treatment before(P<0.05, P<0.01), and the levels of HGF, TNF-α and IL-17 in the treatment group were significantly lower than those in the control group(P<0.05). Conclusion:Ginsenoside Rg3 combined with the temozolomide can inhibit the growth and proliferation of brain glioma and prolong the survival time of patients.关键词：brain glioma;ginsenoside;stem cell factor
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of modified Huangqi Guizhi Wuwu Decoction in the prevention and treatment of peripheral neurotoxicity induced by oxaliplatin. Methods68 cases of colorectal cancer and gastric cancer who received chemotherapy of improved FOLFOX plan were randomly divided into the control group and the treatment group,34 cases in each group. The control group was treated with chemotherapy plus mecobalamin tablets and the treatment group was treated with chemotherapy plus modified Huangqi Guizhi Wuwu Decoction. After 4 cycles of chemotherapy,the occurrence of peripheral neurotoxicity and the changes of T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+)were evaluated. Results:① In the treatment group,there were 6 cases of peripheral neurotoxicity in class I,3 cases in classⅡ,one case in class Ⅲ and no cases in class Ⅳ,the total incidence rate was 29.4％. In the control group,there were 11 cases of peripheral neurotoxicity in class I,5 cases in classⅡ,2 cases in class Ⅲ and no cases in class Ⅳ,the total incidence rate was 52.9％. Comparison of the total incidence rate between groups,the rate of the treatment group was obviously lower than that of the control group(P<0.05). ②Comparison of treatment before and after within group,there was no significant change in lymphocyte subsets in the treatment group,the levels of CD3+,CD4+,CD4+/CD8+ were significantly decreased in the control group with statistical differences(P<0.05)；after treatment,there were statistically significant differences on the levels of CD3+,CD4+,CD4+/CD8+ between the two groups(P<0.05). Conclusion:Modified Huangqi Guizhi Wuwu Decoction can effectively reduce the peripheral neurotoxicity induced by oxaliplatin,and improve the cellular immune function of patients.关键词：peripheral neurotoxicity;Huangqi Guizhi Wuwu Decoction;oxaliplatin;reducing toxicity and increasing effects
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of Qingnao Decoction combined with Shuxuetong Injection in the treatment of acute cerebral infarction and its mechanism. Methods60 cases of acute cerebral infarction were randomly divided into the treatment group and control group (30 cases in each group); both groups were received conventional treatment of western medicine, while the control group was treated with Shuxuetong Injection for intravenous infusion, the treatment group was treated orally with Qingnao Decoction based on the treatment for the control group, with a course of 14 days. The changes of National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI) in both groups were observed before and after treatment,and the changes of hyperhomocysteinemi(HCY) and D-dimer were detected. Results:①After treatment, the NIHSS score in both groups were significantly decreased compared with treatment before (P<0.01),and the score of the treatment group was lower than that of the control group (P<0.05);②After the treatment, the BI in both groups were significantly increased compared with treatment before (P<0.01),and the index of the treatment group was higher than that of the control group (P<0.05);③After treatment,the serum contents of HCY and D-dimer in both groups were decreased compared with treatment before(P<0.05,P<0.01),and the contents of the treatment group were lower than those of the control group (P<0.05). Conclusion:Qingnao Decoction combined with Shuxuetong Injection shows good effects in the treatment of acute cerebral infarction, its mechanism may be related to reducing the serum contents of HCY and D-dimer.关键词：acute cerebral infarction;Qingnao Decoction;Shuxuetong Injection;hyperhomocysteinemi;D-dimer
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Shijun Granule on minimal hepatic encephalopathy. Methods76 patients with minimal hepatic encephalopathy were randomly divided into the treatment group and the control group,38 cases in each group. The treatment group was treated orally with Shijun Granule,the control group was treated orally with lactulose syrup (Duphalac),with a course of one month. The related parameters of liver function (ALT, AST),blood ammonia,serum amino acids (aromatic,branched chain amino acid),number-connection test type A ( NCT-A) and digital symbol test(DST)were observed and compared. Results:① During the trial, totally 5 cases fell off and 71 cases completed the whole test,among which 36 cases in the treatment group and 35 cases in the control group.②Comparison between the treatment group and control group after treatment,the differences on the level of ALT and AST were statistically significant,the indicators decrease in the treatment group were more significant than those in the control group(P<0.05).③Comparison of the treatment before and after within group,the difference on the blood ammonia level in both groups was statistically significant (P<0.05)；comparison of the difference of blood ammonia before and after treatment,the difference between groups was statistically significant,the reduction in treatment group was more obvious than that in the control group(P<0.05).④There were no significant differences on the levels of phenylalanine and tyrosine between the treatment group and control group after treatment (P>0.05).Comparison between groups after treatment,the differences on the levels of leucine,isoleucine,valine were statistically significant (P<0.05),which suggested that the effect of the treatment group on metabolism regulation of branched chain amino acid was more obvious than that of the control group.⑤Comparison between the two groups after treatment,the time of the treatment group in the NCT-A was obviously shorter than that of the control group (P<0.05).The DST score in the treatment group was significantly higher than that in the control group (P<0.05). Conclusion:Shijun Granule shows good effect in the treatment of minimal hepatic encephalopathy,which is worthy of promotion and application in the early intervention of hepatic encephalopathy.关键词：minimal hepatic encephalopathy;Shijun Granule;Duphalac;intelligence test;blood ammonia;amino acid metabolism
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Professor Cao Renfa’s three-step massage in treating insomnia. Methods90 insomnia patients were randomly divided into the estazolam group, tuina group and combination group, 30 cases in each group. The patients were treated with estazolam tablets and /or Cao Renfa’s three-step massage respectively,with a course of 12 days. The clinical efficacy and the changes of pittsburgh sleep quality index(PSQI)score,athens insomnia scale(AIS)score and polysomnogram in the three groups before and after treatment were observed. Results:①The total effective rate was 83.3% in the estazolam group,80.0% in the tuina group and 93.3% in the combination group；the clinical efficacy of the combination group was better than that of the estazolam and tuina group(P<0.05). ②After treatment,the scores of PSQI and AIS in all groups were obviously decreased compared with treatment before(P<0.05),and the scores of the combination group were lower than those of the estazolam and tuina group(P<0.05). ③After treatment,the light and deep sleep time in all groups were significantly prolonged compared with treatment before(P<0.05),and the time of the combination group was longer than that of the estazolam and tuina group(P<0.05). Conclusion:Cao Renfa’s three-step massage can significantly improve the sleep quality of patients with insomnia.关键词：three-step massage;insomnia;pittsburgh sleep quality index(PSQI);athens insomnia scale(AIS);Cao Renfa
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupuncture therapy with finger in the treatment of acute lumbar sprain. MethodsTotally 60 patients of acute lumbar sprain were randomly divided into the treatment group and control group according to the random number table,30 cases in each group. Patients in the treatment group were treated with acupuncture therapy with finger,and patients in the control group were treated with the conventional acupuncture therapy,the points include Weizhong(BL40),Jinmen(B63),Shenshu(BL23) and Daimai(GB26). Both groups were treated one time every other day and a total of six times. The clinical efficacy and the score change of brief pain inventory (BPI) were observed. Results:The total effective rate of treatment group and control group were 96.7% and 93.3% respectively. There was statistically significant difference on the clinical efficacy between the two groups(P<0.05). After treatment,the integral of pain degree and interference level were significantly decreased in both groups(P<0.05),and the integral of the treatment group was lower than that of the control group(P<0.05). Conclusion:The acupuncture therapy with finger can improve the symptoms of patients with acute lumbar strain,reduce the interference of pain on daily life,work and other matters.关键词：lumbar sprain;non-medication therapy;acupuncture therapy with finger
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Dong’s acupuncture and medicine in treating infantile anorexia. Methods4 050 children patients with anorexia were randomly divided into the Supi Liquid group,Shanmai group and Dong’s acupuncture and medicine group,1 350 cases in each group. The Supi Liquid group was treated with Dong’s Supi Liquid,the Shanmai group was treated with Shanmai Jianpi oral liquid,the Dong’s acupuncture and medicine group was treated with Dong’s Supi Liquid combined with acupuncture on Sifeng point(EX-UE 10). The clinical efficacy was observed,and the changes of onset time,TCM syndrome scores,body height,body weight and hemoglobin level were compared. Results:① 489 cases fell off during the trial,and 3 561 cases completed the whole test,among which 1 121 cases in the Supi Liquid group,1 117 cases in the Shanmai group and 1 323 cases in the Dong’s acupuncture and medicine group. ② The clinical total effective rate of Supi Liquid group,Shanmai group and Dong’s acupuncture and medicine group were 72.26%,70.01% and 90.02% respectively . The clinical efficacy of Dong’s acupuncture and medicine group was significantly better than that of the Supi Liquid and Shanmai group(P<0.05),there was no statistically significant difference on the clinical efficacy between the Supi Liquid group and Shanmai group(P>0.05).③ In the onset time,there were statistically significant differences among the three groups,the onset time in the Dong’s acupuncture and medicine group was significantly earlier than that in the other two groups(P<0.05),there was no statistically significant difference on the onset time between the Supi Liquid group and Shanmai group(P>0.05). ④ Comparison of treatment before and after within group,the difference of TCM syndrome scores in all groups were statistically significant(P<0.05)；comparison among groups,the difference of TCM syndrome scores between treatment before and after in the Dong’s acupuncture and medicine group was obviously higher than that in the other two groups(P<0.05),there was no statistically significant difference between the Supi Liquid group and Shanmai group(P>0.05).⑤ There were no statistically significant differences on the body height,body weight and hemoglobin level among the three groups after treatment(P>0.05). Conclusion:Dong’s acupuncture and medicine show good effect on infantile anorexia,which can significantly improve the appetite of children patients and increase the food intake. Rapid onset is its advantage.关键词：infantile anorexia;combination of acupuncture and medicine;Supi Liquid;Sifeng point (EX-UE 10);Dong Tingyao
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupuncture combined with western medicine in the treatment of mild to moderate obstructive sleep apnea hypopnea syndrome in children. Methods56 children patients were randomly divided into the treatment group and control group,28 cases in each group. Patients in the control group were treated with conventional western medicine,patients in the treatment group were treated with acupuncture combined with conventional western medicine,with a course of 3 months. The clinical efficacy in both groups were observed and the changes of apnea hyponea index(AHI)and night lowest oxygen saturation(SaO2)before and after treatment were compared. Results:The total effective rate was 89.2% in the treatment group and 53.5% in the control group；the clinical effect of the treatment group was better than that of the control group(P<0.01). After treatment, the AHI in both groups were decreased compared with treatment before(P<0.01),and the AHI in the treatment group was lower than that in the control group(P<0.05)；the night lowest SaO2 in both groups were increased compared with treatment before(P<0.01),and the night lowest SaO2 in the treatment group was higher than that in the control group(P<0.05). Conclusion:Acupuncture combined with western medicine can improve the sleep state of children patients with mild to moderate obstructive sleep apnea hypopnea syndrome.关键词：obstructive sleep apnea hypopnea syndrome;acupuncture;apnea hyponea index;children
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发布时间：2022-08-31
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