最新刊期
期 2 ， 2017
- 摘要：Professor Shi Qi, as the morality model for his students, devoted himself to TCM education more than fifty years. During long-term exploration of high-level personnel graduates and inheritating graduates training mode and method of TCM, he put forward the new teaching mode, “One body with two wings approaches, six pairs of key element” and summarized his education experience:building personality cultivation as the foundation, “six emotion” education as the guidance, “three roads” as the pathway. He promoted that subject development should pay attention to personnel training and scientific research should closely centre on three points, “clinical difficulties, discipline hotspots, characteristics of traditional Chinese medicine”. He was also good at feeding back education based on the results of the study and paying attention to the two-way transformation.关键词：education and teaching;one body with two wings;inheritation and innovation;Shi Qi
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发布时间：2022-08-31 - 摘要：This paper mainly discussed the syndromes and treatment of forgetfulness due to depression syndrome. This kind of forgetfulness due to depression syndrome mainly covers depression,anxiety and neurosal hypomnesis in modern medicine,but it dose not generally include the memory loss caused by organic diseases,age-associated memory impairment,cognitive impairment and various dementia. It is mainly caused by emotional factors,the pathogenesis in traditional Chinese medicine include deficiency of heart and spleen,disharmony between heart and kidney,stagnation of liver qi,blood stasis and phlegm turbidity. Also,the clinical features and the medicine treatment in ancient and modern for forgetfulness due to depression syndrome were analyzed.关键词：forgetfulness;depression syndrome;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：Syndrome,disease and symptom of traditional Chinese medicine(TCM) are all summarization of some continuous events(event family)in panorama of single or composite cause and effect event induced by pathogeny. According to this theoretical framework,we can make the general judgment on the core reference range of disease,syndrome and symptom and the logical relationship between them. The scope of TCM syndrome roughly corresponds to the range of allostatic load described in western medicine,syndrome describes the pattern of allostatic load. All kinds of theories about syndrome in TCM history,actually have the inherent unity. They are aimed at the different stages of the continuous process of the whole body adjustment on adaptive responses and accompanied damage. TCM itself has two traditions as disease differentiation and syndrome differentiation,and seek the best combination of the two aspects. The primary significance of related discussion is to point out the field described by TCM syndrome and the characteristics of this field,which holds significant meaning to the scientific research of syndrome and clinical application,understanding of relationship between disease and syndrome,formation of the novel medical paradigm.关键词：syndrome;disease;allostatic load;integration of disease and syndrome;pattern
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发布时间：2022-08-31 - 摘要：The method of central degeneration and crushing and drainage in solid tumor was studied in this paper. The degeneration and necrosis of tumor central tissue was caused by radio-frequency ablation,and then the degenerated and necrotic tissue was washed after crush and drained out,which reduce the leakage caused by thermal denaturation and the harmful substance released by necrotic tissue. Because of the formation of tumor cavity,the tumor lose the support for outward expansion and instead inward collapse to achieve organizational reconstruction,and then Chinese and western medicine with low temperature can be given into the cavity for composite treatment plan and whole comprehensive treatment. For larger tumors,above treatment can be repeated in order to gradually reduce the tumor volume and finally cure disease. In addition,the indications,the key technical problems that solved and to be solved and the technical advantages of this method were also illustrated in this paper.关键词：hepatocellular carcinoma;tumor;solid tumors central denaturation,smashing and drainage;radio-frequency ablation;crushing;drainage
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发布时间：2022-08-31 - 关键词：treatment for cancer;therapy of traditional Chinese medicine;clinical experience;Hong Shanyi
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发布时间：2022-08-31 - 摘要：This paper discussed Dong’s Jinsu Pill in the prevention and treatment of febrile convulsion in children from etiology and pathogenesis, syndrome differentiation and treatment. It considers that Jinsu Pill has the effects of suppressing hyperactive liver and nourishing yin,arresting convulsion for tranquillization. It also summarizes that the treatments for this disease focus on invigorating spleen to consolidate defensive qi and prevention of recurrence. Two proven cases were recorded.关键词：febrile convulsion;Jinsu Pill;clinical experience;Dong Tingyao
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发布时间：2022-08-31 - 关键词：Treatise on Cold Pathogenic Diseases;main symptoms;syndrome differentiation
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发布时间：2022-08-31 - 摘要：This paper discussed the influence of “harmony” thoughts of pre-Qin Taoism and Confucianism on the theory of health maintenance in Inner Canon of Huangdi. Inner Canon of Huangdi was written in the Qin and Han dynasties,and the theory construction of health maintenance was greatly influenced by “harmony” thoughts of pre-Qin Taoism and Confucianism. “Harmony” thoughts of Taoism emphasize “harmony and equality in the development”“benevolent governance and solidarity to conform to social development”“mutual support of body and spirit”. Confucian theory put forward that “harmony” is a balanced relationship between human and nature and “harmony” is an efficient management for society and politics. On the basis of these theories,Inner Canon of Huangdi summarized the theories of health maintenance that harmony between human and nature,harmony between persons and things,harmony between body and spirit.关键词：harmony thoughts;Inner Canon of Huangdi;theory of health maintenance
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发布时间：2022-08-31 - 摘要：Through the analysis of his academic work, Li Biliu’s academic experience and characteristics of classical prescriptions application were explored. It finds that Li Biliu,a famous physician of exogenous febrile diseases in the south of the Five Ridges,emphasizes the homage to the classics,practice verification for experience and flexible application,and makes good use of classical prescriptions in the treatment of severe and acute diseases.关键词：exogenous febrile diseases;academic experience;Li Biliu
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发布时间：2022-08-31 - 摘要：According to related literature,this paper discussed “clearing heat of yingfen to qifen”. The nature lies in dispersing and regulating qi activities. Through clearing heat in yingfen,dispersing the depression and blockage,eliminating the stagnation in qifen and yingfen,the stagnated heat is circulated in the body and dissipated in the outer. In recent years,physicians have deeply research on “clearing heat of yingfen to qifen”,and the ideas of dispersing and regulating qi activities and dispelling the evil fully embody the essence of “clearing heat of yingfen to qifen”.关键词：epidemic febrile diseases;clearing heat of yingfen to qifen;mechanism;clinical application
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the effects of Kechuan Liuwei Mixture on the lung function and life quality of severe COPD patients with syndrome of deficiency of kidney yang. Methods 108 patients with severe COPD in stabilization period were randomly divided into the control group(36 cases)and the treatment group(72 cases). The control group was treated with Seretide inhalation at conventional dose,the treatment group was treated with Kechuan Liuwei Mixture combined with Seretide inhalation at small dose,with a course of 3 months. The clinical efficacy was observed,and the changes of lung function,6min walking distance,St. George’s respiratory questionnaire score and life quality score were compared before and after treatment. Results:The total effective rate was 84.72% in the treatment group and 58.33% in the control group,the clinical efficacy of the treatment was better than that of the control group(P<0.01). After treatment,the FEV1% in both groups was increased compared with the treatment before(P<0.05),but there was no statistically significant difference between the two groups(P>0.05). After treatment,the 6min walking distance and the scores of St. George’s respiratory questionnaire and life quality were increased in both group compared with the treatment before(P<0.01),and the increase in the treatment group were more significant than those in the control group(P<0.05). Conclusion: Kechuan Liuwei Mixture can enhance the clinical efficacy of COPD and improve the lung function and life quality of patients.关键词：Kechuan Liuwei Mixture;chronic obstructive pulmonary disease;pulmonary function;life quality
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xu’s Zhenzhu Dingchuan Prescription in the treatment of bronchial asthma with heat syndrome. Methods80 cases of bronchial asthma with heat syndrome were randomly divided into the treatment group and control group,40 cases in each group. The treatment group was treated with Xu’s Zhenzhu Dingchuan Prescription,and the control group was treated with compound methoxyphenamine capsules and budesonide powder inhalation,with a course of 7 days. The clinical efficacy was observed,the scores of TCM single symptom(dyspnea,cough,expectoration etc.)and the indexes related to lung function as forced vital capacity (FVC),forced expiratory volume in the first second (FEV1) and peak expiratory flow (PEF) were compared. Results: ①The clinical total effective rate was 87.50% in the treatment group and 67.50% in the control group,the clinical efficacy in the treatment group was obviously better than that in the control group(P<0.05). ②For the comparison between groups after treatment,the differences on the scores of dyspnea and cough were statistically significant(P<0.05),and the differences on the scores of other symptoms were not statistically significant(P>0.05). ③There were statistically significant differences on the levels of FEV1 and PEF between the two groups after treatment(P<0.05),but no obvious change of FVC was found(P>0.05). Conclusion: Xu’s Zhenzhu Dingchuan Prescription shows good effects in the treatment of bronchial asthma with heat syndrome,which can significantly relieve the clinical symptoms of patients and improve the pulmonary ventilation function.关键词：bronchial asthma;asthma with heat syndrome;Zhenzhu Dingchuan Prescription;Xu Xiaopu;Xu Zhongcai;ventilation function
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发布时间：2022-08-31 - 摘要：Objective:To observe the pathological effect,the traditional Chinese medicine(TCM) syndrome efficacy and the mechanism of Weifuchun in treating gastric intestinal metaplasia of chronic atrophic gastritis. Methods 48 patients with chronic superficial gastritis(CSG)and 110 patients with gastric intestinal metaplasia(GIM)were divided into the CSG and GIM group respectively. Then the patients in the GIM group were randomly divided into the GIM-control and GIM-treatment group according to the different expression of sonic hedgehog (Shh) and Wnt signaling pathway protein (Wnt3A),55 cases in each group. The GIM-control group was orally treated with folic acid tablets,and the GIM-treatment group was orally treated with Weifuchun and folic acid tablets,with a course of 6 months. The pathological grade of GIM,TCM syndrome efficacy and expression of Shh and Wnt3A in the two groups were compared. Results: ①During the trial,21 cases fell off in the GIM group and no case fell off in the CSG group,a total of 89 cases finally completed the test. ②Before the intervention, the Shh was weakly expressed in the GIM group, but strongly expressed in the CSG group,with statistically significant difference(P<0.05). Before the intervention, the Wnt3A expression in the GIM group was obviously higher than that in the CSG group,with statistically significant difference(P<0.05). ③For the comparison between groups after treatment,the GIM grade of the GIM-treatment group was obviously improved compared with the GIM-control group(P<0.05). ④The total effective rate of TCM syndrome was 85.42% in the GIM-treatment group and 36.59% in the GIM-control group. For the comparison of the TCM syndrome efficacy between groups,the effects of the GIM-treatment group were significantly better than those of the GIM-control group(P<0.05). For the comparison between groups after treatment,the total score of TCM syndrome in the GIM-treatment group was obviously lower than that in the GIM-control group(P<0.05). ⑤For the comparison between groups after treatment,the Shh expression in the GIM-treatment group was significantly higher than that in the GIM-control group,while the Wnt3A expression in the GIM-treatment group was significantly lower than that in the GIM-control group(P<0.05). Conclusion: Weifuchun can improve TCM syndromes of GIM patients and alleviate the pathological grade. The mechanism may be associated with the regulation of Hh-Wnt signaling pathway.关键词：gastric intestinal metaplasia(GIM);Weifuchun;TCM syndrome;Hedgehog/Wnt gene signaling pathway;sonic hedgehog(Shh)
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the effects of modified Xiaotan Decoction in the prevention of polyp recurrence one year after colorectal polypectomy(spleen deficiency with blood stasis syndrome). Methods There were 149 patients of colorectal polypectomy with complete medical data,who were identified as spleen deficiency with blood stasis syndrome in Chinese medicine and reviewed by colonoscopy one year after operation. Among,79 cases who had regularly taken Xiaotan Decoction for one year were divided into the treatment group,and 70 cases who had not taken any drugs were divided into the non-treatment group. The recurrence one year after colorectal polypectomy and the traditional Chinese medicine(TCM)syndrome in both groups were compared. Results: ① One year after colorectal polypectomy,the recurrence rate in the treatment group was 18.99%(15 cases),which was lower than 38.57% in the non-treatment group(27 cases)(P<0.05). Among,the recurrence rate of adenomatous colorectal polyps and non-adenomatous polyps was 20.75% and 15.38% in the treatment group and 42.86% and 32.14% in the non-treatment group respectively,there was statistically significant difference on the recurrence rate of adenomatous polyps between the two groups(P<0.05). ② The obvious change of fear of cold in the treatment was not found(P>0.05),but other single syndrome were all improved in the treatment group(P<0.05). Conclusion: The modified Xiaotan Decoction shows certain effects in the prevention of polyp recurrence after colorectal polypectomy(spleen deficiency with blood stasis syndrome),and improves the TCM syndrome of patients to some extent.关键词：colorectal polyps;spleen deficiency with blood stasis syndrome;postoperative recurrence;Xiaotan Decoction;retrospective study
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发布时间：2022-08-31 - 摘要：Objective:To observe the intervention effects of Yiqi Huayu Recipe on the hypercoagulability in patients after hip arthroplasty. Methods 60 patients after hip arthroplasty were randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with low molecular weight heparin,and the treatment group was treated with Yiqi Huayu Recipe based on the treatment for the control group,with a course of 7 days. The D-dimer(D-D),fibrin degradation product (FDP),prothrombin time(PT) and partial thromboplastin time(APTT) were observed and compared. Results: ①The levels of D-D and FDP on 7th day after operation were both significantly decreased in the two groups compared with 1st day after operation,with statistically significant differences(P<0.05). For the comparison between operation before and 7th day after operation within group,the differences on the levels of D-D and FDP were not statistically significant(P>0.05). On 7th day after operation,the decrease of D-D and FDP levels in the treatment were more significant than those in the control group(P<0.05). ②For the comparison between operation before and 1st and 7th day after operation within group,the differences on the PT and APTT were not statistically significant(P>0.05). For the comparison between groups on 7th day after operation,the differences on the PT and APTT were not statistically significant(P>0.05). Conclusion: Yiqi Huayu Recipe can significantly improve the hypercoagulability in patients after hip arthroplasty,and prevent deep vein thrombosis with slight side effect.关键词：hip arthroplasty;anticoagulation;Yiqi Huayu Recipe;deep vein thrombosis
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xi’s cortex erythrinae Decoction with external wash in the treatment of varicose ulcer of lower extremity (ecthyma). Methods 60 patients with ecthyma were randomly divided into the treatment group and control group,30 cases in each group. The control group was received the conventional treatment,the treatment group was treated with Xi’s cortex erythrinae Decoction for external wash based on the treatment for the control group,with a course of 30 days. The clinical efficacy was observed,the scores of clinical symptoms and signs(the size,depth,quantity,color of ulcer and so on)and inflammation related indicators white blood cell(WBC),high sensitivity C-reactive protein(hs-CRP)were compared. Results: ①The clinical cure rate and total effective rate in the treatment group were 42.86% and 95.24% respectively,those in the control group were 33.33% and 88.89%. There were statistically significant differences on the clinical efficacy between the two groups,and the effect of the treatment group was significantly better than that of the control group(P<0.05). ②Compared with the control group after treatment, the size of ulcer was significantly reduced and the depth and color of ulcer was obviously improved in the treatment group, the quantity of ulcer and exudant were decreased obviously, and the neonatal granulation tissue and neonatal epithelial tissue were significantly increased, and the degree of pain was significantly relieved(P<0.05). ③For the comparison of treatment before and after within group,the levels of WBC and hs-CRP were significantly decreased in the two groups,with statistically significant differences(P<0.05). For the comparison between groups after treatment,the decrease of WBC and hs-CRP levels in the treatment were more significant than those in the control group(P<0.05). Conclusion: Xi’s cortex erythrinae Decoction with external wash can be used in the treatment of varicose ulcer of lower extremity (ecthyma),which significantly improve the clinical symptoms and signs of patients and accelerate ulcer healing.关键词：ecthyma;varicose ulcer of lower extremity;Xi’s cortex erythrinae Decoction;external wash of Chinese materia medica;inflammatory reaction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Zhixuean Mixture in treating hemorrhoids bleeding in elderly patients of damp-heat pouring downward syndrome. Methods 120 elderly patients with hemorrhoids bleeding were randomly divided into the treatment group and control group,60 cases in each group. The treatment group was orally treated with Zhixuean Mixture,the control group was orally treated with Huaijiao Pills,with a course of 2 weeks. The changes of hematochezia, bearing-down pain, hemorrhoids mucosa, hemorrhoidal node size and prolapse in both groups were observed before and after treatment and follow-up for 2 weeks. Results: After treatment,the integrals of hematochezia, bearing-down pain, hemorrhoids mucosa and hemorrhoidal node size were decreased in both groups compared with treatment before(P<0.05,P<0.01),and the integrals of hematochezia, hemorrhoids mucosa and hemorrhoidal node size in the treatment group were lower than those in the control group(P<0.05).When followed-up for 2 weeks,the integrals of hematochezia, bearing-down pain, hemorrhoids mucosa and hemorrhoidal node size were significantly decreased in both groups compared with treatment before and after(P<0.05),and the integrals of hematochezia and hemorrhoids mucosa in the treatment group were lower than those in the control group(P<0.05). Conclusion: Zhixuean Mixture shows good effects in the treatment of hemorrhoids bleeding in elderly patients.关键词：Zhixuean Mixture;hemorrhoids;bleeding;elderly patients
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Kangfuxin Liquid in the treatment of chronic periodontitis. Methods A total of 168 patients with chronic periodontitis were randomly divided into the observation group and control group, 84 cases in each group. The control group was treated with routine therapy(such as anti-infection)and chlorhexidine gargle, and the observation group was treated with routine therapy and Kangfuxin Liquid for gargle, with a course of 4 weeks. The clinical efficacy, probing depth, plaque index and gingival bleeding index, loss of periordontal attachment and tooth mobility during follow-up, and levels of inflammatory factors were observed in the two groups before and after treatment. Results: ①The total effective rate was 96.4% in the observation group and 76.2% in the control group, the efficacy in the observation group was better than that in the control group (P<0.05). ②After treatment, the paradental probing depth, plaque index and gingival bleeding index were significantly decreased in both groups compared with treatment before (P<0.05), and the indexes in the observation group were lower than those in the control group (P<0.05). ③In follow-up survey, the loss of periordontal attachment and tooth mobility were reduced in both groups compared with treatment before (P<0.05), with more significant reduction in the observation group than in the control group (P<0.05). ④After treatment, the levels of hs-CRP, TNF-α, IL-8 and IL-10 were obviously improved in both groups compared with treatment before (P<0.05), with more significant improvement in the observation group than in the control group (P<0.05). Conclusion: Kangfuxin Liquid combined with routine therapy can relieve the clinical symptoms and improve the levels of inflammatory factors in the treatment of chronic periodontitis.
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发布时间：2022-08-31 - 摘要：The theory of “hundreds of diseases resulting from qi disorder”clearly points out that the qi disorder is the important mechanism of disease. Spleen and stomach is the source of qi and blood and the pivot of rising and falling of qi,which closely related to the movement of qi. Gastralgia is common in diseases of spleen and stomach,in the treatment process it should pay attention to the regulation of qi movement. Chaiping Decoction has the effects of eliminating dampness and regulating the middle-warmer and qi movement,which shows significant efficacy in the treatment of gastralgia.关键词：hundreds of diseases resulting from qi disorder;gastralgia;Chaiping Decoction
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发布时间：2022-08-31 - 摘要：This paper made an analysis on the trichosanthes-oyster couplet medicines from three parts as clearing heat and promoting fluid production,promoting urination,softening and resolving hard mass. Clearing heat and promoting fluid production is chiefly used in hyperthyroidism,menopausal syndrome,type II diabetes mellitus and those identified as syndrome of hyperactivity of fire due to yin deficiency in Chinese medicine. Promoting urination,which means inducing diuresis without impairment of yin,is generally used in ascites due to liver cirrhosis in decompensated status,edema and those identified as syndrome of asthenia in origin and pathogenic factors in superficiality in Chinese medicine. Softening and resolving hard mass is mainly used in thyromegaly,tumor and those identified as syndrome of hyperactivity of fire due to yin deficiency and turbidity and accumulation of phlegm in Chinese medicine.关键词：trichosanthes;oysters;couplet medicines
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发布时间：2022-08-31 - 摘要：Objective:To study the inhibitory effects of Yupingfeng Powder on thymic stromal lymphopoietin(TSLP)secreted in airway epithelial cells of asthma model mice. Methods Forty BALB/c mice were randomly divided into the blank control group, OVA model group, Yupingfeng Powder treatment group and dexamethasone treatment group. Corresponding interventions were taken in each group. The level of TSLP in lung homogenate was detected by ELISA, the mRNA expression of TSLP in lung tissue was determined by quantitative real-time PCR, and the expression of TSLP in lung was determined by immunohistochemistry. Results: The level of TSLP in lung homogenate of OVA-induced asthma model mice was not increased compared with the control group,and there was no statistically significant difference on the level of TSLP in lung homogenate among groups(P>0.05). The levels of interleukin-13(IL-13) and interleukin-17(IL-17) in the asthma model group were significantly increased compared with the control group,and Yupingfeng Powder and dexamethasone treatment could significantly reduce the levels of IL-13 and IL-17(P<0.05,P<0.01). The TSLP mRNA expression in the asthma model group was up-regulated compared with the control group(P<0.05). Yupingfeng Powder and dexamethasone treatment showed no inhibitory effects on the TSLP level and TSLP mRNA expression(P>0.05). Conclusion: Yupingfeng Powder can decrease the levels of IL-13 and IL-17 in lung of asthma model mice,but shows no inhibitory effects on the expression of TSLP.关键词：thymic stromal lymphopoietin (TSLP);asthma;Yupingfeng Powder;IL-13;IL-17
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of catalpol on myocardial hypertrophy induced by isoproterenol (ISO) in mice. Methods Mice were randomly divided into four groups:normal group, model group, metoprolol(60 μg/g)group and catalpol(90 μg/g) group. Except the normal group,myocardial hypertrophy model was established by subcutaneous injection with isoproterenol at the dose of 2 μg/g for consecutive 7 days in mice that in the other groups. After drug intervention for 7 days,the heart weight index (HWI) and left ventricular weight index (LVWI) were determined. The activities of total superoxide dismutase (T-SOD) and the levels of glutathione (GSH) and malondialdehyde (MDA) in myocardial tissue were measured by hydroxylamine method,DTNB method and TBA method,respectively. The contents of cyclic adenosine monophosphate(cAMP) and angiotensin II (AngII) in myocardium were detected by ELISA. Results: Compared with the normal control group, the HWI and LVWI were increased in the model mice of myocardial hypertrophy induced by ISO,and the contents of MDA,cAMP and AngII were increased and the GSH level was decreased(P<0.05,P<0.01). Catalpol treatment could significantly reduce the cardiac weight indexes and decrease the contents of MDA,cAMP and AngII in myocardium(P<0.05,P<0.01). Conclusion: Catalpol has the effects of inhibiting myocardial hypertrophy in experimental animals,which are associated with the elimination of free radicals and inhibition of the over excitation of neuroendocrine system.关键词：catalpol;isoproterenol;myocardial hypertrophy;mice
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Qinggan Huatan Huoxue Decoction on the expressions of aquaglyceroporin-7(AQP-7)and -9(AQP-9)in nonalcoholic steatohepatitis(NASH)rats. Methods Rats model was copied by the feeding of high fat diet. On the 8th week,5 rats in the normal group and 10 rats in the model group were sacrificed respectively. Then the remaining rats in the model group were divided into the high fat diet group,Yishanfu Tablet group and Qinggan Huatan Huoxue Decoction group. After administration for 5 weeks,the rats were sacrificed and the serum and liver tissue samples were collected. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triacylglycerol (TG), cholesterol (TC) and the expression of AQP-7,9 in liver tissue were detected. The pathological changes of liver tissues were observed by HE staining under light microscope. Results: On 8th week, there were significant differences on the degree of steatosis and score of inflammatory activity between the model group and normal group(P<0.01). On 13th week, there were significant differences on the degree of steatosis and score of inflammatory activity between the high fat diet group and normal group,western medicine group,Chinese medicine group(P<0.05,P<0.01). There were significant differences on the levels of AQP-7 and AQP-9 mRNA between the high fat diet group and normal group,western medicine group,Chinese medicine group(P<0.01). There were statistically significant differences on the degree of steatosis and score of inflammatory activity between the high fat diet group and Qinggan Huatan Huoxue Decoction group(P<0.05).Compared with the high fat diet group,the contents of AST, ALT, TG, TC in the Qinggan Huatan Huoxue Decoction group were significantly decreased(P<0.01),the level of AQP-7 in liver tissue was significantly increased(P<0.01)and the level of AQP-9 was significantly decreased(P<0.01). Conclusion: AQP-7,9 are associated with the pathogenesis of nonalcoholic steatohepatitis. Qinggan Huatan Huoxue Decoction may regulate the expression of AQP-7,9 and improve lipid metabolism of liver cells,which plays a role in the prevention and treatment of nonalcoholic steatohepatitis.关键词：nonalcoholic steatohepatitis;Qinggan Huatan Huoxue Decoction;aquaglyceroporin-7,9
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Gutongling Prescription on the expression of monocyte chemoattractant protein-1(MCP-1) and nerve growth factor(NGF) in the spinal cord of mice with bone metastasis of lung cancer model,and discuss its potential mechanism on the treatment of bone cancer pain. MethodsThe mice model of lung cancer with bone metastasis was established by the injection of Lewis lung cancer cells into the bone marrow cavity of left leg tibia. 50 mice were randomly divided into five groups:sham-operation group, model group, Chinese medicine group, western medicine group, Chinese and western medicine combination group,10 in each mice. The Chinese medicine group was treated with decoction of Gutongling Prescription for intragastric administration,the western medicine group was treated with zoledronic acid for intraperitoneal injection,the combination group was treated with Gutongling Prescription and zoledronic acid. Before modeling and 6(7),13(14),20(21)days after modeling,the changes of paw withdrawal mechanical threshold(PWMT) and paw withdrawal thermal latency(PWTL) were observed by Von Frey hairs and heat stimulation test. The protein expressions of MCP-1 and NGF in the spinal cord were detected by enzyme linked immunosorbent assay (ELISA). Results: 3 weeks after modeling, the PWMT and PWTL of the three treatment groups were obviously higher than those of the model group(P<0.05),the PWMT of the combination group was higher than that of the Chinese medicine group and western medicine group,with statistically significant difference(P<0.05). Compared with the model group,the protein expression of MCP-1 in all the three treatment groups was obviously decreased(P<0.05),and the NGF expression was significantly increased(P<0.05). Conclusion: Gutongling Prescription can suppress the central sensitization by decreasing the protein expression of MCP-1 in the spinal cord,and repair the damaged neurons by promoting the protein expression of NGF,and consequently exert the analgesic effect.关键词：bone cancer pain;bone metastasis of lung cancer;Gutongling Prescription;MCP-1;NGF
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发布时间：2022-08-31 - 摘要：Objective:To investigate the regulating effect of serum containing Shoutai Pill on proliferation,invasion and migration of human first trimester trophoblastic cells. Methods Human first trimester trophoblastic cells were isolated and cultured in vitro, and then treated with serum containing Shoutai Pill at high-, medium-and low-dose respectively. Blank serum and serum containing dydrogesterone were taken as the control. The proliferation activity, cell cycle distribution, invasion and migration capacity of trophoblastic cells were detected by methyl thiazolyl tetrazolium (MTT) colorimetry,flow cytometry (FCM) and Transwell experiments respectively. Results: Compared with the control group treated with blank serum,after intervention of serum containing Shoutai Pill on the trophoblastic cells,the activity of cell proliferation and the capacity of invasion and migration were obviously enhanced,the cellular proportion in S period was increased and the cellular proportion in G2/M period was decreased(P<0.05). Compared with low-dose group of Shoutai Pill,the activity of cell proliferation and the capacity of invasion and migration were obviously enhanced in the trophoblastic cells treated with Shoutai Pill at medium-and high-dose,and the change of cell cycle distribution was more obvious(P<0.05). Conclusion: Serum containing Shoutai Pill can promote the activity of proliferation and the capacity of invasion and migration of human first trimester trophoblastic cells,and reduce cell apoptosis.关键词：Shoutai Pill;trophoblastic cells;proliferation;cell cycle;invasion;migration
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发布时间：2022-08-31 - 摘要：This paper reviewed the research advance on intervention of traditional Chinese and western medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence. Chemotherapy drugs can cause bone marrow suppression. At present,it is considered that the hematopoietic stem cell senescence is the key mechanism of bone marrow suppression,involving the main signaling pathway of p53-p21(Cip1/Waf1) pathway and p16Ink4a-RB pathway. It has confirmed that traditional Chinese medicine can effectively intervene on the hematopoietic stem cell senescence.关键词：chemotherapy;bone marrow suppression;hematopoietic stem cell senescence;signaling pathways
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发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on the pharmacological effects and mechanism of catalpol. Catalpol is one of the active components of Radix Rehmanniae,which has the effect of lowering blood sugar,protecting nerve and heart and anti-tumor.关键词：catalpol;pharmacological effect;mechanism
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发布时间：2022-08-31
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