最新刊期
期 3 ， 2017
- 摘要：Professor Shi Qi considers that chronic musculoskeletal diseases belong to the category of “arthromyodynia” and are syndrome of asthenia in origin and pathogenic factors in superficiality. Disorder of nutrient qi and defensive qi and deficiency of qi and blood are the inner factors of the diseases,while invasion of outer pathogen is the external factor. The root cause of this disease is the deficiency of liver, spleen, and kidney. The treatment principle of chronic musculoskeletal diseases is strengthening body resistance and eliminating pathogenic factors.关键词：chronic musculoskeletal diseases;arthromyodynia;syndrome differentiation and treatment;Shi Qi
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发布时间：2022-08-31 - 摘要：This article introduced Professor Sun Shidao’s clinical experience in the treatment of chronic urticaria. He considers that the syndrome differentiation of chronic urticaria belongs to“asthenia in origin and pathogenic factors in superficiality”,“interaction between wind and dampness-heat”,“evil in Shaoyang”and “errhysis outside the vessels”. The therapy emphasize treating both manifestation and root cause of disease,reconciling Shaoyang,hemostasis with astringents and medication combined with modern pharmacological research. One proven case was presented.关键词：chronic urticaria;experience of famous doctor;Sun Shidao
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发布时间：2022-08-31 - 摘要：Somnolence is one of the manifestations of depression syndrome. Somnolence due to depression syndrome include but are not limited to the deficiency of heart qi,it can be caused by emotional factors such as sadness,over-thinking,depression,anger and so on. The pathogenesis are mainly related to functional dysfunction of zang-fu viscera such as heart,spleen,liver,gall bladder and dampness-phlegm and blood stasis. The treatment medicine in ancient and modern time can confirm the existence of somnolence due to depression syndrome,mainly including nourishing the heart,tranquilizing the mind and stabilizing the spirits,resuscitation and awaking consciousness,soothing liver and regulating qi to resolve depression,promoting blood circulation and removing blood stasis,dispelling phlegm and transforming turbidity. The psychological mechanisms of narcolepsy and antidepressive therapy in modern medicine also can be considered as the circumstantial evidence for the existence of somnolence due to depression syndrome.关键词：depression syndrome;somnolence;syndrome of deficiency of heart qi;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：Syndrome,disease and symptom of traditional Chinese medicine(TCM) are all summarization of some continuous events(event family)in panorama of single or composite cause and effect event induced by pathogeny. According to this theoretical framework,we can make the general judgment on the core reference range of disease,syndrome and symptom and the logical relationship between them. The scope of TCM syndrome roughly corresponds to the range of allostatic load described in western medicine,syndrome describes the pattern of allostatic load. All kinds of theories about syndrome in TCM history,actually have the inherent unity. They are aimed at the different stages of the continuous process of the whole body adjustment on adaptive responses and accompanied damage. TCM itself has two traditions as disease differentiation and syndrome differentiation,and seek the best combination of the two aspects. The primary significance of this paper is to point out the field described by TCM syndrome and the characteristics of this field,which holds significant meaning to the scientific research and clinical application of syndrome,understanding of relationship between disease and syndrome,formation of the novel medical paradigm.关键词：syndrome;disease;allostatic load;integration of disease and syndrome;pattern
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发布时间：2022-08-31 - 摘要：Objective:To objectively describe the influence of lifting manipulation in neck on the length and angle of cervical spine,and provide data support for the quantitative features of lifting manipulation. Methods30 cases of male patients aged 18-36 years old with cervical spondylosis of neck type were selected. The lifting manipulation in neck was implemented by the same senior massage physician. The changes of length and angle of cervical spine in subjects during the lifting manipulation process were collected by high speed motion capture test system for infrared light spot. Results:At the lifting moment,the mean stretched length of cervical spine in subjects was 10.39 mm,and the average angle of flexion and extension was 5.81°. The average angle of lateral flexion was 2.92°and the average angle of rotation was 13.03°. Conclusion:The angles change of cervical spine in subjects at the lifting moment are a complex process including flexion and extension,lateral flexion and rotation. The lifting manipulation in neck is a kind of manipulative reduction to mainly solve the movement limitation of sagittal and coronal planes in cervical spine.关键词：lifting manipulation;cervical spine;length;angle;kinematic parameters
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发布时间：2022-08-31 - 关键词：Wu’s Xiaoliu Powder;liver cancer;treating different diseases with same method;medical case
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发布时间：2022-08-31 - 摘要：This paper introduced Cao Yemin’s clinical experience in treating thromboangiitis obliterans. He considers yang-deficiency in constitution and exogenous pathogenic factors invasion as the basic pathogenesis of this disease,and points out that the method of strengthening yang and consolidating body resistance should be applied throughout the treatment. He emphasizes syndrome differentiation and treatment by stages,which means eliminating pathogenic factors first in acute stage and combination of clearing and supplementing in stable stage. Mahuang Fuzi Xixin Decoction is usually taken as the basic prescription in clinic and modified according to symptoms. One proven case was presented.关键词：thromboangiitis obliterans;strengthening yang and consolidating body resistance;gangrene of digit;therapy of traditional Chinese medicine;experience of famous doctor
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发布时间：2022-08-31 - 摘要：This paper discussed the clinical experience of Xiao Zhaocen in treating cough with medicine of calming endogenous wind for relieving spasm. This medicine can calm endogenous wind for relieving spasm. The nature is cold in common,which can clear heat for resolving convulsion and dredge the channels and activate the collaterals. Animal medicine are salty and pungent in flavour,which show the effects of dredging the collaterals and dispersing by pungent taste. Two proven cases were presented.关键词：cough;medicine of calming endogenous wind for relieving spasm;experience of physicians
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发布时间：2022-08-31 - 关键词：Radix Puerariae;Radix Puerariae associated prescriptions;medicine and syndrome;prescription and syndrome
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发布时间：2022-08-31 - 摘要：Treatise on Cold Pathogenic Diseases and Synopsis of Golden Chamber were interpreted from the point of hemorrhagic fever. The original text was made an overall understanding of the specific disease,and analyzed from the aspects of clinical symptom,pathological mechanism and main treatment methods,which contrasted ancient and modern and provided insights and reference for the study of clinical classics.关键词：exogenous febrile disease;hemorrhagic fever;symptom;pathogenesis;treatment method
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发布时间：2022-08-31 - 摘要：Through the literature analysis on the recordation of pericardial membrane,collaterals,Danzhong and heart in Inner Canon of Huangdi,the category of pericardium,pericardial membrane,Danzhong and heart was clarified. It considers that pericardium is the abbreviated form of“pericardial membrane and collaterals”,which originally belongs to the vascular of “heart”.Danzhong and pericardial membrane together constitute the “heart”. The function of pericardial membrane belongs to the yin nature of “heart”function,which defines the scope of heart function and understand the state of heart spirit. The function of Danzhong belongs to the yang nature of “heart”function and achieves the coordination of qi and emotional activities between five zang viscera together with pericardial membrane,which is deposited in the body cavity mediated by pectoral qi.关键词：heart;pericardial membrane;Danzhong;pericardium
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发布时间：2022-08-31 - 摘要：Wu Jutong,a famous physician of epidemic febrile diseases in Qing Dynasty,made good use of the theory of five evolutive phases and six climatic factors and made comprehensive discussion on diagnosis and treatment of epidemic febrile diseases in Detailed Analysis of Epidemic Warm Diseases. In this paper,Wu Jutong’s idea of five evolutive phases and six climatic factors in differentiating and treating epidemic febrile diseases was deeply discussed. It puts forward that the cold and warm of epidemic diseases are different depended on the difference of five evolutive phases and six climatic factors,the differentiation and treatment of epidemic infectious disease should pay attention to the warm and cool,the insidious summer-heat evil is easily induced by host climatic qi and sovereign fire,the pox syndrome belongs to the epidemic warm diseases and its key treatments lie on the root cause. These views are of the important value and significance for the present research of five evolutive phases and six climatic factors on the diagnosis and treatment of warm diseases and comprehensive understanding of Wu Jutong’s academic thoughts.关键词：five evolutive phases and six climatic factors;Wu Jutong;Detailed Analysis of Epidemic Warm Diseases;epidemic febrile diseases
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Chu’s Shuwei Recipe in the treatment of precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of blood stasis and heat. Methods130 patients of precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of blood stasis and heat were randomly divided into the treatment group and control group,65 cases in each group. The treatment group was treated with Chu’s Shuwei Recipe and the control group was treated with Weifuchun tablets,with a course of 3 months. The TCM syndrome scores,the pathological scores of mucous membrane under the gastroscopy and the pepsinogen(PGI and PGII)were observed and compared. Results:①For the comparison between groups after treatment,the improvement on TCM syndrome(including anorexia,marasmus,abdominal swelling,abdominal pain,loose stool,weakness,belching and so on)in the treatment group was significantly better than that in the control group(P<0.05). ②For the comparison between groups after treatment,the differences on the pathological scores of atrophy,intestinal metaplasia,chronic inflammation and activity were statistically significant(P<0.05). ③For the comparison between groups after treatment,the differences on the levels of PGI and PGI/PGII were statistically significant,and the effect of the treatment on pepsinogen was significantly better than that of the control group(P<0.05). Conclusion:Chu’s Shuwei Recipe shows good effects in the treatment of precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of blood stasis and heat. Regulation on serum protein level of PGI and PGII may be one of action mechanisms.关键词：Shuwei Recipe;precancerous lesions;strengthening spleen,clearing heat and removing blood stasis;therapy of traditional Chinese medicine;action mechanism
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “treating the same disease with analogous methods” in the treatment of myelodysplastic syndrome(MDS). Methods88 patients with MDS were divided into the treatment group(48 cases)and the control group(40 cases). Both groups were treated with basic treatment of western medicine,the treatment group was received the therapy of “treating the same disease with analogous methods” and the control group was received the therapy of “treatment based on syndrome differentiation”additionally,with a course of 6 months. The clinical efficacy and the related indexes of blood test were observed and compared. Results:The effective rate of hemoglobin was 75.00% in the treatment group and 77.50% in the control group,the effective rate of platelet was 66.70% in the treatment group and 65.00% in the control group,the effective rate of neutrophil was 70.83% in the treatment group and 72.50% in the control group. There was no statistically significant difference on the clinical efficacy between the treatment group and the control group (P>0.05). Conclusion:Compared with the therapy of “treatment based on syndrome differentiation”,the therapy of “treating the same disease with analogous methods” show the equivalent efficacy in the treatment of MDS. It is mastered and generalized more easily.关键词：myelodysplastic syndrome;treating the same disease with analogous methods;treating the same disease with different methods;the same disease with analogous patterns;hematology improvement
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发布时间：2022-08-31 - 摘要：Objective:To discuss the influence of Zhuyu Shenggu Decoction on early osteolysis of periprosthetic femoral after total hip replacement (THA) in elderly patients. Methods60 elderly patients who received THA were randomly divided into the combination group and control group,30 cases in each group. The control group was orally treated with alendronate after surgery, the combination group was treated with alendronate and Zhuyu Shenggu Decoction,with a course of 6 months. The changes of bone mineral density (BMD) of periprosthetic femoral, bone metabolism state and inflammatory cytokines were observed and compared. Results:①After treatment, the BMD was significantly decreased at the region of interest(ROI)1-7 in the control group(P<0.05) and at ROI 7 in the combination group(P<0.05).Except ROI 4,the BMD of the combination group at other regions were all significantly higher than those of the control group(P<0.05). ②After treatment, the levels of total pro-collagen type I N-terminal peptide (TP I NP) and C-telopeptide β cross link of type I collagen(CTX-β)in both groups were significantly decreased compared with treatment before(P<0.05),and the levels in the combination group were significantly lower than those in the control group(P<0.05). ③After treatment, the levels of interleukin-6(IL-6),C-reactive protein (CRP) and tumor necrosis factor-α(TNF-α) in both groups were significantly decreased compared with treatment before(P<0.05),and the levels in the combination group were significantly lower than those in the control group(P<0.05). Conclusion:Zhuyu Shenggu Decoction can effectively inhibit the inflammatory reaction in elderly patients after THA,prevent bone loss in periprosthetic femoral and delay the osteolysis.关键词：total hip replacement;osteolysis;Zhuyu Shenggu Decoction;gerontism
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Jiaji acpoint (EX-B2) injection of safflower injection on the inflammatory factors in patients with lumbar disc herniation. Methods80 cases of lumbar disc herniation were randomly divided into the observation group and control group,40 cases in each group. The control group was treated with routine western medicine,the observation group was treated with safflower injection for Jiaji acpoint (EX-B2) injection based on the treatment for the control group,with a course of 2 weeks. The clinical efficacy was observed,and the visual analogue scale (VAS) score,Japanese orthopaedic association(JOA)score and the levels of IL-6,NO were compared before and after treatment. Results:The total effective rate was 97.5% in the observation group and 70.0% in the control group. The clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,the VAS score was decreased(P<0.05)and the JOA score was increased(P<0.05)in both groups compared with treatment before. The improvement on the scores in the observation group was better than that of the control group(P<0.05). After treatment,the levels of IL-6 and NO were decreased in both groups compared with treatment before(P<0.05),and the levels in the observation group was lower than those in the control group(P<0.05). Conclusion:The Jiaji acpoint injection of safflower injection in the treatment of lumbar disc herniation can effectively reduce the release of inflammatory factors, and further alleviate the pain.关键词：lumbar disc herniation;Safflower Injection;IL-6;NO
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Taijiquan exercise combined with acupuncture in the treatment of knee osteoarthritis. MethodsTotally 92 cases of knee osteoarthritis were randomly divided into the treatment group and control group,46 cases in each group. The control group was treated with acupuncture,and the treatment group was treated with acupuncture and Taijiquan exercise,with a course of one month. The clinical efficacy was observed,the scores of Western Ontario and McMaster University (WOMAC) Osteoarthritis Index and the walking time for 10 meters were compared. Results:①The total effective rate was 93.48% in the treatment group and 73.91% in the control group,the clinical efficacy of the treatment was significantly better than that of the control group(P<0.05). ②For the comparison between groups after treatment,the differences on the scores of knee pain,stiffness,functional limitation were statistically significant(P<0.05). ③For the comparison between groups after treatment,the walking time for 10 meters in the treatment group was significantly less than that in the control group(P<0.05). Conclusion:Taijiquan exercise combined with acupuncture can be used in the treatment of knee osteoarthritis,which can effectively relieve the knee pain,stiffness and movement limitation,improve the walking ability.关键词：knee osteoarthritis;Taijiquan;acupuncture;combination therapy;motor muscle group;joint function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Honglu Mixture combined with Longqing Capsule in the treatment of chronic nonbacterial prostatitis with syndrome of stagnant dampness-heat. Methods84 cases of chronic nonbacterial prostatitis with syndrome of stagnant dampness-heat were randomly divided into the treatment group and the control group,42 patients in each group. The treatment group was treated with Honglu Mixture combine with Longqing Capsule, while the control group was treated with tamsulosin hydrochloride sustained-release capsule,with a course of one month. The clinical efficacy was observed,the changes of National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI)and routine indexes of prostatic fluid were compared. Results:①The total effective rate was 92.96% in the treatment group and 69.01% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison of treatment before and after within group,there were statistically significant differences on the scores of pain,urination and life quality and the total score of CPSI in both groups(P<0.05)；for the comparison between the two groups after treatment,there were statistically significant differences on the score of pain and the total score of CPSI(P<0.05). ③For the comparison of treatment before and after within group,there were statistically significant differences on the levels of white blood cell(WBC)and small particle of lecithin(SPL)in both groups(P<0.05)；for the comparison between the two groups after treatment,the improvement on the levels of WBC and SPL in the treatment group was significantly better than that of the control group(P<0.05). Conclusion:Honglu Mixture combined with Longqing Capsule can be used in the treatment of chronic nonbacterial prostatitis with syndrome of stagnant dampness-heat,which significantly relieve the symptoms such as pain,frequent urination,urgent urination,and improve the function of the prostate.关键词：chronic nonbacterial prostatitis;Honglu Mixture;Longqing Capsule;dampness-heat;blood stasis;microcirculation
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of optimized Gangyong Recipe on postoperative wound healing of high perianal abscess. MethodsTotally 70 patients with high perianal abscess were randomly divided into two groups. 35 patients in the control group were treated with surgery alone. The other 35 patients in the treatment group were orally treated with optimized Gangyong Recipe after surgery,with a course of 7 days. The clinical efficacy was observed in the two groups. The shedding time of wound slough,the disappearance time of wound edema and exudation,the time of wound healing in the two groups were compared. The change of pH value in wound was detected. Results:①The total effective rate was 97.14% in the treatment group and 91.43% in the control group. There was no statistical difference on the clinical efficacy between the two groups (P> 0.05). ②The shedding time of wound slough,the disappearance time of wound edema and exudation,the time of wound healing in the treatment group were all less than those in the control group(P<0.05).③In the treatment group,the wound pH value on the 7th day after surgery was lower than that on the 3rd day(P<0.01). Conclusion:Optimized Gangyong Recipe can significantly promote the wound healing after surgery for high perianal abscess.关键词：high perianal abscess;Gangyong Recipe;surgical treatment;wound healing
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发布时间：2022-08-31 - 关键词：acupuncture of fire needles at bones;bone and joint diseases;clinical application
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发布时间：2022-08-31 - 摘要：This paper discussed the disease characteristics,etiology and pathogenesis of menstrual diarrhea with syndrome of liver-spleen disharmony and prescription composition and compatibility of“Tongxie Yao Fang”(important formula for diarrhea with abdominal pain). Through the analysis of physiological and pathological features of women in menstrual period,combined with related ancient books and modern clinical research about diarrhea,it found that menstrual diarrhea with syndrome of liver-spleen disharmony was the most common form. “Tongxie Yao Fang” is a representative formula of invigorating spleen and restraining liver. Analyzing its prescription characteristics could provide reference for the clinical syndrome differentiation and treatment of menstrual diarrhea.关键词：menstrual diarrhea;“Tongxie Yao Fang”;syndrome of liver-spleen disharmony;invigorating spleen and restraining liver
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发布时间：2022-08-31 - 摘要：Objective:To investigate the intervention effects of Panax Notoginseng Saponins(PNS) on ACh-CaCl2 induced atrial fibrillation and proiosystole in rats. MethodsAnimal model of atrial fibrillation was established by acetylcholine (ACh)-calcium chloride (CaCl2) mixture for tail intravenous injection. After monitoring dynamic electrocardiogram for 24 hours, the rats with typical electrocardiogram of atrial fibrillation were screened out, and then randomly divided into the normal group, model group and PNS group. Each group was received the corresponding intervention. The dynamic electrocardiogram monitoring for 24 hours was applied in each group until the end of the experiment. The morphological changes of heart were observed by light microscope after hematoxylin and eosin (HE) and Masson’s thrichrome staining. The serum level of IL-17A was detected by enzyme linked immunosorbent assay (ELISA). Results:①Compared with the normal group, the duration of atrial fibrillation in the model group was significantly increased(P<0.05). Compared with the model group,the duration of atrial fibrillation in the PNS group was significantly decreased(P<0.05). ②Compared with the normal group, the proiosystole incidence in the model group was significantly increased(P<0.05). Compared with the model group,the proiosystole incidence in the PNS group was significantly decreased(P<0.05). ③Compared with the normal group, a large number of inflammatory cells infiltration and local necrosis in the myocardium and many collagen fibers were observed in the model group. Compared with the model group,the myocardial cells in the PNS group arranged in order, only a small amount of inflammatory cell infiltration and collagen deposition were found around the vessels(P<0.05). ④Compared with the normal group, the serum level of IL-17A in the model group was significantly increased(P<0.05). Compared with the model group,the serum level of IL-17A in the PNS group was significantly decreased(P<0.05). Conclusion:PNS can significantly inhibit the atrial fibrillation and proiosystole induced by ACh-CaCl2 in rats,and relieve the myocardial fibrosis induced by atrial fibrillation. Its mechanism may relate to the inhibition of inflammatory reaction.关键词：Panax Notoginseng Saponins;atrial fibrillation;proiosystole;IL-17A
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发布时间：2022-08-31 - 摘要：Objective:To study the therapeutic effects and mechanism of Mahuang Lianqiao Chixiaodou Decoction in the treatment of IgA nephropathy in rats model. Methods60 male SD rats were divided into the normal group,model group,losartan potassium group, pseudoephedrine group and Mahuang Lianqiao Chixiaodou Decoction(Chinese medicine)group. Except the normal group, experimental IgA nephropathy model in SD rats was established by complex immunifaction of bovine serum albumin (BSA) plus lipopolysaccharide (LPS) plus carbon tetrachloride (CCl4) in the other groups. Each group was received the corresponding intervention. The changes of 24 hours protein quantitation, renal function and renal pathology in rats were observed, and the related cytokines were detected by ELISA and compared. Results:①There was statistically significant difference on the level of urine protein between the model group and pseudoephedrine group or Chinese medicine group or losartan potassium group(P<0.05),which suggested that pseudoephedrine,Mahuang Lianqiao Chixiaodou Decoction and losartan potassium could significantly reduce proteinuria in rats with IgA nephropathy. ②There were statistically significant differences on the serum levels of creatinine(Scr) and urea nitrogen(BUN) between the model group and pseudoephedrine group or Chinese medicine group(P<0.05),which suggested that pseudoephedrine and Mahuang Lianqiao Chixiaodou Decoction could significantly reduce the serum level of Scr and BUN in rats with IgA nephropathy. ③There was statistically significant difference on the level of IL-21 between the model group and pseudoephedrine group or Chinese medicine group or losartan potassium group(P<0.05),which suggested that pseudoephedrine,Mahuang Lianqiao Chixiaodou Decoction and losartan potassium could significantly reduce the serum level of IL-21 in rats with IgA nephropathy. ④The mild hyperplasia in glomerular mesangial cells,eosinophilic changes in renal tubules and swelling in renal tubular epithelial cells were observed in the model group. The pathological changes were improved in the Chinese medicine group,losartan potassium group and pseudoephedrine group. Conclusion:Mahuang Lianqiao Chixiaodou Decoction can significantly reduce proteinuria and serum levels of creatinine and urea nitrogen in rats with IgA nephropathy,and protect the renal function. Its mechanism is related to the decrease of serum IL-21 level in IgA nephropathy rats and the regulation of IL-21 involved immune response. Pseudoephedrine as the main effective components shows the same effects as this prescription.关键词：IgA nephropathy;Mahuang Lianqiao Chixiaodou Decoction;pseudoephedrine;Chinese materia medica;rats;experimental study
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发布时间：2022-08-31 - 摘要：Objective:To observe the influence of Jiedu Huayu Jianpi Formula on the expression of phosphatase and tensin homolog deleted on chromosome ten(PTEN) and E-cadherin(E-cad)in rats of chronic atrophic gastritis with dysplasia. MethodsRat model of chronic atrophic gastritis with dysplasia was established by N-methyl-N’-nitro-N-nitrosoguanidine(MNNG) integrated modeling method. Rats were randomly divided into the model group, western medicine group(retinoic acid)and Chinese medicine group(Jiedu Huayu Jianpi Formula),and the normal rats were taken as the normal control group. Drug intervention was carried out in the corresponding group. The expressions of PTEN and E-cad in mRNA and protein level were detected by RT-PCR and Western blot. Results:Compared with the normal control group,the expressions of PTEN and E-cad in mRNA and protein level were significantly decreased in the model group(P<0.01),there were no statistical differences on the expressions of E-cad in mRNA and protein level between the control group and Chinese medicine group(P>0.05). Compared with the model group,the expressions of PTEN and E-cad in mRNA and protein level were significantly increased in Chinese medicine group and western medicine group(P<0.05). Compared with the western medicine group,the expressions of PTEN and E-cad in mRNA level were significantly increased in Chinese medicine group(P<0.01),the protein expression of PTEN was decreased and the protein expression of E-cad was increased in Chinese medicine group(P<0.01). Conclusion:Jiedu Huayu Jianpi Formula can induce the increasing protein expressions of PTEN and E-cad in gastric mucosal cells and consequently treat the chronic atrophic gastritis with dysplasia and reverse the precancerous lesions of gastric cancer.
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of volatile oils extracted from Pericarpium Citri Reticulatae, Resina Liquidambaris, Myrrha and Radix Aucklandiae on the proliferation of human high metastatic ovarian cancer cell line HO-8910PM in vitro. MethodsThe HO-8910PM cells cultured in vitro were divided into the volatile oils group,positive control group,negative control group and control group,which treated with volatile oils,cyclophosphamide,DMSO and complete medium respectively. The inhibition effects of volatile oils of Pericarpium Citri Reticulatae, Resina Liquidambaris, Myrrha and Radix Aucklandiae with different concentrations and different time on HO-8910PM cells growth were evaluated by methyl thiazolyl tetrazolium (MTT) assay. The nuclei were stained by fluorescent staining Hoechst33258 and the morphological changes were observed by inverted microscope. The activity of lactate dehydrogenase (LDH) and Caspase-3 in cell culture medium were determined to evaluate the effects of four kinds of volatile oils on cell membrane structure and cell apoptosis. Results:All above volatile oils exhibited inhibitive effect on the proliferation of HO-8910PM cells in a time-dose dependent manner. The obvious morphological changes of apoptosis in nuclei were observed by Hoechst33258 fluorescence staining. After the treatment with each volatile oil at experimental concentration,the activity of LDH and Caspase-3 in cell culture medium were obviously increased,the differences were statistically significant compared with the control group and positive control group of cyclophosphamide(P<0.01). Conclusion: The volatile oils of Pericarpium Citri Reticulatae, Resina Liquidambaris, Myrrha and Radix Aucklandiae show the effects of proliferation inhibition and apoptosis promotion on HO-8910PM cells. The mechanism may be to destroy the cell membrane of tumor cells and activate Caspase-3 as the key enzyme in the pathway of apoptosis.关键词：volatile oil;HO-8910PM cancer cell;proliferation
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发布时间：2022-08-31 - 摘要：Objective:To study the protective effects of steamed Codonopsis lanceolata(SCL)on alcohol-induced acute liver injury in mice. MethodsMale ICR mice were randomly divided into the blank control group, model group, silymarin group, SCL groups with low-, medium-and high-dose. Except the blank control group, mice model of acute liver injury was established by alcohol in the other groups. Each group was received the corresponding intervention. The serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),triglyceride(TG)and the liver contents of reduced glutathione(GSH)and malondialdehyde(MDA)were determined by colorimetry. The pathological changes of liver tissue were observed and the histopathological scores were evaluated. Results:Compared with the blank control group,the serum levels of ALT,AST and TG were increased in the model group,and the content of MDA was increased and the activity of GSH was decreased in liver,with statistically significant differences(P<0.05). Compared with the model group,the serum levels of ALT,AST and TG were significantly decreased in mice treated with SCL,and the content of MDA was decreased and the activity of GSH was increased in liver,with statistically significant differences(P<0.05). The results of HE staining showed that the obvious liver injury was observed in the model group,which performed as the cells necrosis, fatty degeneration of adjacent hepatocytes and infiltration of lymphocytes. But no severe steatosis was observed in the SCL group with high-dose,and the liver injury and the fragmentation degree of liver structure was the slightest. Conclusion: Steamed Codonopsis lanceolata shows protective effects on alcohol-induced acute liver injury in mice. Its mechanism may be related to the improvement on lipid peroxidation.关键词：steamed Codonopsis lanceolata;alcohol-induced liver injury;histopathology
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发布时间：2022-08-31 -
Effects of ginsenoside Rb1 and ginsenoside Rg1 on central nervous system and the relevant mechanisms
摘要：This paper reviewed the pharmacological effects of ginsenoside Rb1 and Rg1 on central nervous system. Ginsenosides have many pharmacological effects,such as improving human immunity,promoting metabolism,anti-tumor,anti-fatigue,anti-aging and so on. Among all the components,the contents of glycol type ginsenoside Rb1 and triol type ginsenoside Rg1 are the highest and they mainly show the excitement and inhibition effects in the central nervous system diseases.关键词：ginsenosides Rb1;ginsenosides Rg1;central nervous system;degenerative diseases- 6
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发布时间：2022-08-31 - 摘要：This paper reviewed the mechanism of Chinese herbal monomers on reversing multidrug resistance gene 1 (MDR1) -induced tumor multidrug resistance. The mechanisms mainly include inhibiting the gene expression of MDR1, inhibiting the activity of P-gp, inhibiting ATP enzyme, reversing apoptosis, inhibit the activity of protein kinase and so on.关键词：tumor;multidrug resistance;MDR1;Chinese herbal monomers;reverse
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发布时间：2022-08-31
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