最新刊期
期 4 ， 2017
- 摘要：Chronic musculoskeletal diseases as systemic and local syndromes are mainly caused by natural degeneration of human muscles and bones. Professor Shi Qi has led his team to carry out long-term clinical and basic research on spinal musculoskeletal disease,bone and joint musculoskeletal disease,bone inflammation,bone immune and bone tumor disease. They consider blood stasis due to qi deficiency,essence depletion due to kidney deficiency and bone damage due to marrow depletion as the important pathological basis of musculoskeletal degeneration,and create series technology and programs of prevention and treatment as “harmony therapy”(harmonizing qi and blood,invigorating liver and kidney)and “balance therapy”(regulating muscles and bones,restoring the balance). They establish the translational medicine mode of traditional Chinese medicine in prevention and treatment of chronic musculoskeletal diseases,and form the ideological system of traditional Chinese medicine in prevention and treatment of chronic musculoskeletal diseases.关键词：chronic musculoskeletal diseases;harmony therapy;balance therapy;therapy of traditional Chinese medicine;experience of famous physicians;Shi Qi
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发布时间：2022-08-31 - 摘要：This paper introduced Yao Naizhong’s experience in treating chronic idiopathic thrombocytopenic purpura with therapy of warming kidney and invigorating essence. Professor Yao considers that repeated hemorrhage is only the appearance of chronic idiopathic thrombocytopenic purpura,and the main pathogenesis is deficiency of kidney essence and kidney yang as root cause and blood stasis stagnation as manifestation,which belongs to the syndrome of asthenia in origin and pathogenic factors in superficiality.This disease locates in the kidney and the treatment should base on kidney. He emphasizes warming and recuperating kidney yang,strengthening and nourishing marrow and essence combined with promoting blood circulation for removing blood stasis and hemostasis.关键词：therapy of warming kidney and invigorating essence;chronic idiopathic thrombocytopenic purpura;Yao Naizhong
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发布时间：2022-08-31 - 摘要：This paper discussed the therapy and syndromes of fatigue due to depression syndrome. Ancient literatures of traditional Chinese medicine had realized early that in addition to physical tiredness,the fatigue manifestations include mental fatigue and energy deficiency,which can be taken as the representation form of depression syndrome. Fatigue due to depression syndrome seems to be caused by the deficiency of qi and blood,but actually result from emotional factors,such as sadness,over-thinking,depression and so on. Heart controls mental activities,so overworked mind can lead to fatigue. Liver controls conveyance and dispersion and is the root of physical stamina. Spleen governs the limbs and muscle,thoughtfulness can influence spleen’s function of transforming the essence of food and water. So the treatments for fatigue due to depression syndrome,include drug and/or non-drug therapy,should pay attention to the significance of regulation of the mind and spirit.关键词：depression syndrome;fatigue;emotional etiology and pathogenesis;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：Syndrome,disease and symptom of traditional Chinese medicine(TCM) are all summarization of some continuous events(event family)in panorama of single or composite cause and effect event induced by pathogeny. According to this theoretical framework,we can make the general judgment on the core reference range of disease,syndrome and symptom and the logical relationship between them. The scope of TCM syndrome roughly corresponds to the range of allostatic load described in western medicine,syndrome describes the pattern of allostatic load. All kinds of theories about syndrome in TCM history,actually have the inherent unity. They are aimed at the different stages of the continuous process of the whole body adjustment on adaptive responses and accompanied damage. TCM itself has two traditions as disease differentiation and syndrome differentiation,and seek the best combination of the two aspects. The primary significance of this paper is to point out the field described by TCM syndrome and the characteristics of this field,which holds significant meaning to the scientific research and clinical application of syndrome,understanding of relationship between disease and syndrome,formation of the novel medical paradigm.关键词：syndrome;disease;allostatic load;integration of disease and syndrome;pattern
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发布时间：2022-08-31 - 摘要：Objective:To analyze the medication rule of traditional Chinese medicine in treating plasma cell mastitis based on data mining. Methods The relevant literatures of traditional Chinese medicine in treating plasma cell mastitis which published in the past 20 years were searched in the main Chinese literature database. After screening by relevant standards,the medication information of related prescriptions were collected to establish the database. The association rules,frequency analysis and other methods were used to perform data mining for compound recipes of Chinese materia medica,and the main drugs,the medication rule of couplet medicines and medicine group in the treatment of plasma cell mastitis were investigated. Results: ①In the literatures of“recipes for general treatment”,Radix Bupleuri is the highest frequent used herb,followed by Herba Taraxaci,Radix Paeoniae Rubra. Medicine for clearing heat and removing toxicity and drugs with cold and cool in nature are the most commonly used. The couplet medicines with higher confidence include “Herba Ephedrae-Radix Rehmanniae Preparata”,“Fructus Trichosanthis-Flos Lonicerae”,the medicine group with higher confidence include“Radix Salviae Miltiorrhizae-Radix Paeoniae Rubra-Herba Taraxaci”and so on. The couplet medicines with higher reliability include“Radix Bupleuri-Radix Paeoniae Rubra”,“Radix Bupleuri-Herba Taraxaci”,the medicine group with higher reliability include“Radix Paeoniae Rubra-Herba Taraxaci-Radix Angelicae Sinensis”and so on. ②In the literatures of “treatment by stages”,in lump period Radix Bupleuri is the highest frequent used herb,followed by Herba Taraxaci,Herba Hedyotis；in abscess period Flos Lonicerae is the highest frequent used herb,followed by Herba Taraxaci,Radix Angelicae Sinensis；in fistula period Radix Angelicae Sinensis is the highest frequent used herb,followed by Radix Astragali seu Hedysari,Radix Salviae Miltiorrhizae；in perioperative period Radix Angelicae Sinensis is the highest frequent used herb,followed by Radix Paeoniae Rubra,Radix Bupleuri. Drugs with cold and cool in nature are the most commonly used through all periods,medicine for clearing heat and removing toxicity is the most commonly used in the periods of lump,abscess,fistula,while blood-supplementing medicine is the most commonly used in perioperative period. The couplet medicines with higher confidence include “Radix Curcumae-Radix Bupleuri”in lump period,“Herba Taraxaci-Radix Paeoniae Rubra”in abscess period,“Semen Sinapis Albae-roasted ginger”in fistula period,“Radix Paeoniae Rubra-Radix Angelicae Sinensis”in perioperative period；the medicine group with higher confidence include “Rhizoma Corydalis-Herba Taraxaci-Radix Bupleuri”in lump period,“Radix Salviae Miltiorrhizae-Radix Paeoniae Rubra-Herba Taraxaci” in abscess period,“Herba Hedyotis-Radix Salviae Miltiorrhizae-Radix Angelicae Sinensis”in fistula period,“Radix Bupleuri-Radix Paeoniae Rubra-Radix Angelicae Sinensis”in perioperative period. The couplet medicines with higher reliability include“Herba Hedyotis-Herba Taraxaci”in lump period,“Fructus Trichosanthis-Spina Gleditsiae”in abscess period,“Radix Salviae Miltiorrhizae-Radix Angelicae Sinensis”in fistula period,“Radix Angelicae Sinensis-Radix Paeoniae Rubra”,“Radix Bupleuri-Radix Paeoniae Rubra”in perioperative period；the medicine group with higher reliability include “Herba Hedyotis-Herba Taraxaci-Radix Bupleuri” in lump period,“Radix Paeoniae Rubra-Herba Taraxaci-Radix Salviae Miltiorrhizae”in abscess period,“Herba Hedyotis-Radix Salviae Miltiorrhizae-Radix Angelicae Sinensis”in fistula period,“Radix Bupleuri-Radix Paeoniae Rubra-Radix Angelicae Sinensis”in perioperative period. Conclusion: The commonly used methods of treatment include dispersing stagnated liver qi for cooling blood and clearing heat-toxicity,Radix Bupleuri and Chinese materia medica for clearing heat and removing toxicity are essential for the treatment of this disease. The data mining explores the synergy characteristics of compound recipes in traditional Chinese medicine at the macro level,which has certain guiding significance for the prescriptions in the clinical syndrome differentiation and treatment of traditional Chinese medicine.关键词：plasma cell mastitis;mastitis;data mining;compound recipes of Chinese materia medica;medication rules
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Xu’s experience in treating lung cancer with ancient prescriptions. He proposes the therapy of tonifying kidney for marrow production in the treatment of myelo suppression,the therapy of benefiting qi for nourishing essence and detoxification for resolving stasis in the treatment of advanced lung cancer and other academic viewpoints. He summarizes the application of different prescriptions in the treatment of radiotherapy and chemotherapy in late period and distant metastasis of lung cancer. He emphasizes nursing and protecting lung,spleen and kidney,and strengthening the foundation of acquired constitution.关键词：lung cancer;ancient prescriptions;experience of physicians;Xu Zhenye
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发布时间：2022-08-31 - 关键词：hyperlipidemia;fatty liver;turbid lipid theory;liver regulation;Liu Yongnian
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发布时间：2022-08-31 - 关键词：restless legs syndrome;erbai acpoint(EX-UE2);clinical experience;Zhao Jianguo
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发布时间：2022-08-31 - 摘要：This paper analyzed and summarized the syndrome and treatment rules of Xiaochaihu Decoction in Treatise on Cold Pathogenic and Miscellaneous Diseases. Radix Bupleuri and Radix Glycyrrhizae are the basic herbs in Xiaochaihu Decoction. The formula shows the effects of strengthening vital qi to eliminate pathogenic factors and diaphoresis to relieve superficies syndrome,and the indications include exogenous diseases,miscellaneous diseases and gynecological diseases. The application should pay attention to the identification of similar syndromes,transformation of prescription and syndrome,drug withdrawal after recovery.关键词：Xiaochaihu Decoction;Treatise on Cold Pathogenic and Miscellaneous Diseases;syndrome and treatment
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发布时间：2022-08-31 - 摘要：From the study and research status of Treatise on Cold Pathogenic Diseases,the author puts forward some personal views on some common sense and concepts in this paper,for example,what is exogenous cold disease？How is Treatise on Cold Pathogenic Diseases produced？How to understand six meridians and classical prescriptions？What’s the relationship between exogenous cold disease and febrile disease？And the misunderstanding of exogenous cold disease were analyzed and interpreted.关键词：Treatise on Cold Pathogenic Diseases;exogenous cold disease;febrile disease;six meridians;classical prescriptions
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发布时间：2022-08-31 - 摘要：This paper discussed the connotation,denotation and clinical significance of “You Gu Wu Yun” theory. The original meaning of “You Gu Wu Yun” theory refers to drugs with effects of drastic purgation,relaxing bowels,breaking blood and expelling stasis,qi consumption can be properly and rationally used in pregnant woman under critical conditions (“Daji Daju” syndrome) to achieve therapeutic purpose. Its denotative meaning emphasizes the accurate and flexible application of drugs in clinical practice. As long as the drugs are consistent with the syndromes,they can be boldly applied,even toxic medicine. “You Gu Wu Yun” theory is not only suitable for gynecology,but also instructive for the treatment of malignant tumor and miscellaneous diseases.关键词：“You Gu Wu Yun”theory;connotation;denotation;tumor
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发布时间：2022-08-31 - 摘要：This paper discussed the meridian theory of rising and falling of qi-blood. The existing theories about rising and falling of qi-blood include yin yang theory,zang-fu viscera theory,pulse theory,channels circulation theory,five phases and eight diagrams theory and so on. On the existing basis,the rising and falling of qi-blood of meridian is interpreted from the theory of correspondence between manifestation and root cause,in order to supplement the relevant theory and provide the basis for better clinical application of meridian theory of rising and falling of qi-blood.关键词：meridian and collateral;rising and falling of qi-blood;theory of manifestation,root cause and medial qi
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发布时间：2022-08-31 - 关键词：intestinal disharmony can worsen diseases;catharsis and expelling turbidity;medical cases
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Akebia Fruit seed (AFS) extract on morphology of different hepatocellular carcinoma cells. Methods By the comprehensive application of cell biology, scanning electron microscopy(SEM) and transmission electron microscopy(TEM),the effects of alcohol extract of AFS on the morphological characteristics of HepG2, Huh 7, and SMMC7721 were observed. Results: Untreated HepG2 cells show overlapping growth and the surfaces are fully covered with villus. After the treatment with AFS extract, the partial cell villus atrophied and disappeared, the cells became irregular and even collapsed, and rough endoplasmic reticulum(ER) expanded to different degrees. Spontaneous apoptosis could form in Huh 7 cells. After the treatment with AFS extract, the irregular villus, cell shrinking, a lot of apoptotic bodies, and numerous vacuoles caused by endoplasmic reticulum stress were observed in cells. Untreated SMMC-7721 cells are fully covered with longer villus. After the treatment with AFS extract, abnormal morphology could be detected. The cell body expansion with irregular round shape were observed,some regions on the surface of cells collapsed or upheaved,the surface of some cells collapsed due to severe endoplasmic reticulum stress, and a large number of heavily expanded endoplasmic reticulum were commonly found. Conclusion: These three kinds of hepatocellular carcinoma cell lines exhibit various morphological characteristics, but serious ER stress with different degrees can be induced after the treatment with Akebia Fruit seed extract,which may be one way of Akebia Fruit seed acting on liver cancer.关键词：hepatocellular carcinoma cells;Akebia Fruit seed;SEM;TEM;endoplasmic reticulum stress
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发布时间：2022-08-31 - 摘要：Objective:To preliminarily discuss the mechanism of Liushen Pill on reversing doxorubicin resistant human colon cancer cell line Lovo/Dox. MethodsThe control group,doxorubicin group,Liushen Pill group and combination group were divided. The effects of Liushen Pill on drug-resistant human colon cancer cell lines (Lovo/Dox,HCT116/L-OHP,Caco2/Dox)were detected by Cell Counting Kit-8(CCK-8). The expressions of P-gp, BCRP and related apoptosis proteins caspase-3, caspase-9, Cytochrome C and tumor suppressor protein p53 in human colon cancer cell line Lovo/Dox were determined by Western blot. The fluorescence expression of P-gp was detected by immunofluorescence assay. Results:After the intervention of Liushen Pill for 24 hours,the CCK-8 showed that Liushen Pill could inhibit the activities of the three drug-resistant human colon cancer cell lines,among the inhibiting effects on doxorubicin resistant human colon cancer cell line Lovo/Dox were most significant. The treatment of Liushen Pill combined with doxorubicin could up-regulate the protein expression of caspase-3,caspase-9 and p53 and decrease the protein and fluorescence expression of P-gp. Conclusion:Liushen Pill can reverse the expression of P-gp in doxorubicin resistant human colon cancer cell line Lovo/Dox, which may be related to the activation of the related apoptosis pathway and tumor suppressor protein.关键词：human colon cancer cell line;Liushen Pill;apoptosis mechanism;protein expression;doxorubicin;reversing drug-resistance
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of Tiaoxin Recipe on the learning and memory ability of APP/PS1 transgenic AD mice and synapse and neuronal structure and synapse number in hippocampal CA1 region. MethodsFifty-four APP/PS1 double transgenic AD mice with three months old were randomly divided into the model group,Tiaoxin Recipe group and donepezil hydrochloride group,and 18 wild C57BL/6J mice with the same age and sex were taken as the normal group. Corresponding intervention were given in each group. After intragastric administration for 12 weeks,the behavioral test was performed by Morris water maze,and the synapse and neuronal structure and synapse number in hippocampal CA1 region were observed by transmission electron microscopy. Results:①Compared with the normal group,the escape latency of mice in the model group was significantly prolonged (P<0.01),the number of platform crossing was significantly reduced (P<0.05),the stay time in the original platform quadrant was significantly decreased(P<0.01). The neuronal nuclear in hippocampus CA1 region showed pyknosis,the nuclear membrane was shrunk and thickened and the perinuclear empty halo was found. Some regions near the cell membrane were stained deeply,and there were heterochromatin and swelling mitochondria. The rough surfaced endoplasmic reticulum showed expansion as vesicle shape,the number of synapses in the neuropil was decreased significantly(P<0.01),and large axoplasmic vacuoles were found in synaptic structures. ②Compared with the model group,the escape latency of mice in the Tiaoxin Recipe group was significantly shortened (P<0.01),the number of platform crossing was significantly increased (P<0.01),the stay time in the original platform quadrant was significantly increased(P<0.05). The neuronal nucleus in hippocampus CA1 region were round with clear and complete nuclear membrane and obvious nucleolus. The chromatin was fine and smooth,the mitochondrial cristae was clearly visible and parts of mitochondria were slightly swollen. The rough surfaced endoplasmic reticulum and ribosomes were normal,the synapse structure was clear and the number of synapses was significantly increased (P<0.01),and the organelles lesion were alleviated. Conclusion:Tiaoxin Recipe can improve the learning and memory ability of APP/PS1 transgenic AD mice,and improve the degeneration of neuron and synapse structure and reduction of synapses number,which shows protective effects on cognition and synapse.关键词：Tiaoxin Recipe;Morris water maze;hippocampus CA1 region;synapse;neuron;electron microscope
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of red coral (Corallium rubrum) on the healing of experimental rat fracture. Methods 12 rats were randomly selected as the blank group from sixty Wistar rats with SPF grade,and the radius fracture model on left forelimb was established in the other rats and verified by X-ray fluoroscopy. The successful modeling rats were randomly divided into the model group,positive drug group(150 μg/g),red coral groups with low-dose(150 μg/g) and high-dose(300 μg/g),12 rats in each group. From the second day after modeling,the drugs were given to the corresponding group by intragastric administration,once a day. After administration for 10,0,30 days,the fracture sites of rats in each group were evaluated by X-ray fluoroscopy and the histopathological changes were observed after HE staining. The serum contents of alkaline phosphatase (ALP), calcium (Ca) and phosphorus (P) were detected by enzyme linked immunosorbent assay(ELISA). Results: The X-ray image showed that the edge line of fracture became blurred in the red coral group with high-dose after administration for 10 days；when administration for 20 days,the callus increased in the broken end of fracture and the density increased,the edge almost disappeared；when administration for 30 days,the callus filled with the fracture defect and complete healing was found. The HE staining of the fracture site showed that more fibrous tissue was found in the red coral group with high-dose,the callus formation rate was faster than that in the other groups,and the fracture healing time was shorter than that in the other groups. The serum levels of Ca and P were gradually increased in the red coral group with high-dose,and significantly higher than those in the model group,with statistical differences(P< 0.05). The content of ALP was increased first and then decreased in the red coral group with high-dose,and this change was more earlier and significant than that in the other groups, with statistical difference(P< 0.05). Conclusion: The red coral can regulate the serum levels of ALP,Ca and P,accelerate calcium salt deposition,promote the increase of fibrous tissue in the fracture site of rats,accelerate the callus formation,shorten the healing period of fracture,which shows promotion effects on the healing and repair of fracture.关键词：mongolian medicine;red coral;fracture healing
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发布时间：2022-08-31 - 摘要：Objective:To establish the high-speed counter-current chromatography (HSCCC) method for isolation and purification of Asperosaponin Ⅵ from Dipsacus asper Wal.. Methods Dried root of Dipsacus asper Wal. is taken as raw material. The ethanol extracts are first treated with AB-8 macroporous resin to enrich target substances. Then Asperosaponin Ⅵ is isolated and purified by semi preparative HSCCC. A mixture of ethyl acetate-n-Butanol-water (3∶1∶4,v/v) is used as the two phase solvent system,which the light phase is the stationary phase and the heavy phase is the mobile phase with flow rate of 3.0 ml/min. The speed of apparatus is 800 r/min. The evaporative light scattering detector (ELSD) was used as the detector. Results: After enrichment by macroporous adsorption resin and isolation by HSCCC,75 mg Asperosaponin Ⅵ is obtained from 200 mg extract of Dipsacus asper Wal. . The purity is 98.5 % by HPLC detection. Conclusion: This method is quick and simple with good repeatability,which provides reference for mass production of Asperosaponin Ⅵ.关键词：HSCCC;Dipsacus asper Wal.;Asperosaponin Ⅵ
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发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on chemical constituents and pharmacological actions of Polyporus Umbellatus in recent years.The main chemical components include polysaccharides, steroids, proteins, amino acids, vitamins and trace inorganic elements. The pharmacological actions include diuretic effect, anti-tumor, anti-inflammation, antioxidation, immunoregulation, hepatoprotection, antibacterial,promoting hair growth and so on.关键词：Polyporus Umbellatus;polysaccharide;ergosterol;pharmacological actions;review
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发布时间：2022-08-31 - 摘要：The paper reviewed the research progress on pharmacological activities of arctiin.As a kind of lignans compound isolated from the dry seeds of Arctium lappa L. (Asteraceae),it has a variety of biological activities,such as anti-tumor,anti-inflammation,anti-oxidation,anti diabetes,anti-influenza,anti-bacteria,nerve protection and so on.关键词：arctiin;anti-tumor;anti-inflammation;anti diabetes
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发布时间：2022-08-31 -
One proven case of nephropathy treated by Gao Ji’ning with syndrome differentiation of six meridians
关键词：chronic nephritis;hematuria;syndrome differentiation of six meridians;clinical experience;Gao Ji’ning- 5
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Yiqi Yangyin Jiedu Formula on advanced non-small cell lung cancer related immune indexes and serum sB7-H3,and explore the related mechanism based on the influence of costimulatory molecules on T lymphocyte immune response. Methods 60 patients with advanced non-small cell lung cancer who identified as the pattern of qi-yin deficiency in traditional Chinese medicine(TCM) syndrome differentiation were randomly divided into the treatment group and control group,30 cases in each group. The control group was only treated with chemotherapy,the treatment group was treated with Yiqi Yangyin Jiedu Formula additionally based on the treatment for the control group. All the treatments were given with a course of two cycles and one cycle was 21 days. The scores of TCM syndrome and eastern cooperative oncology group performance status(ECOGPS)were observed,and the levels of immune indexes(CD3+,CD4+,CD8+,IL-2)and serum soluble costimulatory molecules sB7-H3 were detected and compared. Results: ①For the comparison between the treatment before and after,the differences on the each and total score of TCM syndrome in the treatment group were all statistically significant(P<0.05),the differences on the single score of cough,expectoration,chest tightness,dry mouth and the total score of syndrome in the control group were statistically significant(P<0.05). For the comparison after treatment,there were statistically significant differences on the single score of chest pain,fatigue,anorexia,insomnia and the total score of syndrome between the two groups(P<0.05). ②For the comparison between the treatment before and after,the difference on the ECOGPS score in the treatment group was statistically significant(P<0.05),but the difference on the ECOGPS score in the control group was not statistically significant(P>0.05). For the comparison after treatment,there was statistically significant difference on the ECOGPS score between the two groups(P<0.05). ③For the comparison between the treatment before and after,the differences on the levels of IL-2 and sB7-H3 in the treatment group were statistically significant(P<0.05),but the differences on the levels of all indexes in the control group were not statistically significant(P>0.05). For the comparison after treatment,there were statistically significant differences on the levels of CD4+,IL-2,sB7-H3 between the two groups(P<0.05). Conclusion: Yiqi Yangyin Jiedu Formula can improve the syndrome of qi-yin deficiency in patients with lung cancer,increase the proportion of CD4+ cells and the level of IL-2,reduce the serum level of sB7-H3.关键词：non-small cell lung cancer;Yiqi Yangyin Jiedu Formula;sB7-H3
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Chuankezhi(CKZ)Injection with continuous airway humidification on mechanical ventilation function of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). MethodsEighty AECOPD patients with artificial airway were randomly divided into the treatment group and control group,40 cases in each group. Both groups were treated with conventional therapy (including mechanical ventilation). Meanwhile,the control group was treated with 0.45% normal saline for airway humidification and the treatment group was treated with CKZ for continuous airway humidification by micro pump injection,with a course of 7 days. The clinical efficacy was observed,the changes of respiratory mechanics indexes that included pulmonary static compliance (Cst),pulmonary dynamic compliance (Cdyn),peak airway pressure (PIP),platform pressure (Pplat) and airway resistance (Raw),and the incidence of complications were compared before and after treatment. Results:①The clinical total effective rate was 95.0% in the treatment group and 82.5% in the control group. The clinical efficacy of the treatment group was better than that of the control group(P<0.05). ②The improvement on all respiratory mechanics indexes in the treatment group was significantly better than that in the control group(P<0.05).③The incidence of complications such as related pneumonia and sputum scab formation in the treatment group was significantly lower than that in the control group(P<0.01). Conclusion:The treatment with Chuankezhi Injection for continuous airway humidification by micro pump injection can significantly improve the respiratory mechanics in AECOPD patients of mechanical ventilation,reduce the complications and ultimately reduce the time of mechanical ventilation.关键词：chronic obstructive pulmonary disease;mechanical ventilation;airway humidification;respiratory mechanics;Chuankezhi Injection
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Yan’s Wenyang Huoxue Recipe in the prevention and treatment of restenosis after percutaneous coronary intervention. Methods 60 patients who had received the percutaneous coronary intervention were randomly divided into the treatment group and control group,30 cases in group. The control group was treated with the routine therapy of western medicine, the treatment group was treated with Yan’s Wenyang Huoxue Recipe based on the treatment for the control group,with a course of 3 months. During the follow-up,the cardiovascular events and the restenosis occurrence were observed,the angina-related scores, TCM syndrome scores of blood stasis and chest painful impediment were compared. Results: ①The incidence rate of restenosis in the treatment group and the control group was 3.33 % and 20.00 %, respectively. The incidence rate of restenosis in the treatment group was significantly lower than that in the control group(P<0.05). ②For the comparison between the two groups after treatment,the differences on the occurrence frequency, duration, pain degree, NTG dosage, grading score of angina and the total score were statistically significant,the improvement on angina symptoms in the treatment group was better than that in the control group(P<0.05). ③For the comparison between the two groups after treatment,the differences on the syndrome scores of chest pain, dark purple tongue with ecchymosis, dark purple lips and gums, sublingual varicose vein and the total score were statistically significant,the improvement on blood stasis syndrome in the treatment group was better than that in the control group(P<0.05). ④For the comparison between the two groups after treatment,the differences on the syndrome scores of oppression in chest,palpitation,fear of cold and cold in limbs,breath shortness and weakness,white complexion and pale lips and the total score were statistically significant,the improvement on syndrome of chest painful impediment was better than that in the control group(P<0.05). Conclusion: Yan’s Wenyang Huoxue Recipe can be used in the prevention and treatment of restenosis after percutaneous coronary intervention,which significantly decrease the incidence rate of restenosis and improve the clinical symptoms of patients.关键词：restenosis after coronary intervention;coronary heart disease;method of warming yang and promoting blood circulation;Yan Dexin;recurrence rate
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of catgut implantation at acupoint in the treatment of insomnia with syndrome of qi and blood deficiency. Methods123 cases of insomnia with syndrome of qi and blood deficiency were randomly divided into the catgut implantation group,acupuncture group and drug group,41 cases in each group. The catgut implantation group was treated with the therapy of catgut implantation at acupoint,the acupuncture group was treated with acupuncture at the same acupoint,the drug group was orally treated with estazolam,with a course of 30 days. The clinical efficacy was observed,and the pittsburgh sleep quality index (PSQI)scores and sleep time were compared. Results:①Finally 40 cases in the catgut implantation group,39 cases in the acupuncture group and 38 cases in the drug group completed the trial.②At the end of the treatment,the total effective rate of the catgut implantation group,acupuncture group and drug group was 95.00%,87.18% and 65.79% respectively.For the comparison of clinical efficacy between groups,the effect of the catgut implantation group was significantly better than that of the drug group(P<0.05),and equivalent to that of the acupuncture group(P>0.05).When followed-up,the total effective rate of the catgut implantation group,acupuncture group and drug group was 80.00%,61.54% and 39.74% respectively.Compared with the efficacy at the end of treatment,there was a certain degree of recurrence in each group. For the comparison of clinical efficacy between groups,the effect of the catgut implantation group was significantly better than that of the acupuncture group and drug group(P<0.05),but the effect of the acupuncture group was better than that of the drug group(P<0.05).③For the comparison between groups after treatment,the total score of PSQI in the catgut implantation group was equivalent to that of the acupuncture group(P>0.05),and the total score in these two groups was significantly lower than that in the drug group(P<0.05). For the comparison of each sleep-related factor,there were no significant differences between the catgut implantation group and acupuncture group(P>0.05),the scores on sleep quality,fall sleep time, sleep time,sleep efficiency,sleep disorders and daytime function in the catgut implantation group were significantly better than those of the drug group(P<0.05),the scores on sleep quality,fall sleep time,sleep disorders and daytime function in the acupuncture group were significantly better than those of the drug group(P<0.05).④For the comparison of PSQI after treatment and follow-up,the differences on the total score and each sleep-related factor in all groups were statistically significant,which suggested that there was a certain degree of recurrence in each group(P<0.05). For the comparison between groups during follow-up,the total score in the catgut implantation group was significantly lower than that in the acupuncture group and drug group(P<0.05),while the total score in the acupuncture group was equivalent to that of the drug group(P>0.05).For the comparison of each sleep-related factor during follow-up,the scores on sleep quality,fall sleep time,sleep time,sleep efficiency and sleep disorders in the catgut implantation group were still significantly better than those of the drug group(P<0.05),while the scores on sleep quality,sleep time,sleep disorders in the catgut implantation group were significantly better than those of the acupuncture group(P<0.05).⑤For the comparison after treatment and follow-up,the differences on the sleep time in all groups were statistically significant(P<0.05),which suggested that there were recurrence in each group. For the comparison between groups after treatment,the sleep time in the catgut implantation group was significantly longer than that in the acupuncture group and drug group(P<0.05),and the sleep time in the acupuncture group was equivalent to that of the drug group(P>0.05). For the comparison between groups during follow-up,the sleep time in the catgut implantation group was significantly longer than that in the acupuncture group and drug group(P<0.05),and the sleep time in the acupuncture group was significantly longer than that in the drug group(P<0.05). Conclusion:Catgut implantation at acupoint shows good recent and sustained efficacy in the treatment of insomnia with syndrome of qi and blood deficiency,compared with traditional acupuncture or hypnotic drugs,this therapy is more easily accepted by patients due to the advantages of lower frequency and less time.关键词：insomnia;agrypnia;deficiency of qi and blood;catgut implantation at acupoint;long-term needling sensation
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Jiangzhi Recipe of medicinal tea combined with external application in the treatment of alcoholic fatty liver. Methods 120 cases of patients with alcoholic fatty liver were randomly divided into the observation group and control group,60 cases in each group. The observation group was treated with medicinal tea of Jiangzhi Recipe combined with external application of Jiangzhi Recipe at abdominal region of liver,the control group was treated with Xuezhikang capsule combined with tiopronin enteric-coated tablets,with a course of 3 months. The changes of liver function(serum ALT,AST),serum lipids(TC,TG),controlled attenuation parameters(CAP)of hepatic steatosis were observed and compared. Results: Compared with the treatment before,the levels of ALT,AST,TC,TG and CAP were significantly decreased in both groups after treatment(P<0.05)；there were statistically significant differences on all the indicators between the two groups after treatment(P<0.05). Conclusion: Jiangzhi Recipe of medicinal tea combined with external application shows good efficacy in the treatment of alcoholic fatty liver with no obvious adverse reaction.关键词：alcoholic fatty liver;Jiangzhi Recipe of medicinal tea;Jiangzhi Recipe of external application;therapy of traditional Chinese medicine;internal and external treatment
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Shi’s Tanyu Tongluo Decoction in the treatment of cervical spondylotic radiculopathy (CSR). MethodsOne hundred and twenty patients with CSR were randomly divided into the control group and treatment group,60 cases in each group.Patients in the control group were treated with diclofenac sodium sustained release tablets,while the others in the treatment group were treated with Shi’s Tanyu Tongluo Decoction,with a course of 28 days.The clinical efficacy was observed,and the symptoms and signs score of cervical spondylosis and visual analogue scale(VAS)score for pain were compared. Results: ①Finally 114 cases completed the clinical research,among which 59 cases in the treatment group and 55 cases in the control group. ②The total effective rates of the treatment group and control group were 91.53% and 72.73% respectively；there was statistically significant difference on the clinical efficacy between the two groups(P<0.05).③For the comparison between the treatment before and after,the differences on the symptoms and signs score of cervical spondylosis were statistically significant in both groups(P<0.01)；for the comparison after treatment,there were statistically significant differences on the symptoms and signs score of cervical spondylosis between the two groups(P<0.01).④For the comparison between the treatment before and after,the differences on the VAS score were statistically significant in both groups(P<0.01)；for the comparison between the two groups after treatment for one week,the difference on VAS score was not statistically significant(P>0.05)；but there were statistically significant differences on the VAS score between the two groups after treatment for two,three and four weeks(P<0.01). Conclusion: Shi’s Tanyu Tongluo Decoction can be used in the treatment of cervical spondylotic radiculopathy,which obviously relieve the pain and improve the clinical symptoms in patients.关键词：cervical spondylosis;radiculopathy;eliminating phlegm and resolving stasis;radicular pain;Shi’s traumatology;Fructus Arctii Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the influence of five mimic-animal exercise on knee-joint muscle strength and balance capacity in middle-aged and elderly women. Methods 56 middle-aged and elderly women volunteers were divided into the intervention group and control group by the methods of quasi-experiment,28 cases in each group. Five mimic-animal exercise were performed in the intervention group and stretching exercises were performed in the control group,with a course of 12 months. The indexes of isokinetic test in knee-joint and the scores of Berg balance scale were observed and compared. Results:①Comparison of different time points(T1 refers to treatment before,T2 and T3 refer to treatment for 6 and 12 months respectively)in the intervention group:For the comparison of peak torque/body weight(PW)in right knee extensors and left knee flexors,there were statistically significant differences between T1 and T2 (P<0.05)；for the PW comparison in extensors and flexors of left and right knee,there were no statistically significant differences between T2 and T3(P>0.05),there were statistically significant differences between T1 and T3(P<0.05).Comparison of different time points in the control group:for the PW comparison in extensors and flexors of left and right knee,there were no statistically significant differences between T1 and T2,T2 and T3,T1 and T3(P>0.05).②For the comparison in extensors of left and right knee at T3, there was statistically significant difference on PW between the two groups(P<0.05)；while for the comparison in flexors of left and right knee at T3,there was no statistically significant difference on PW between the two groups(P>0.05).③Comparison of different time points in the intervention group:there were statistically significant differences on Berg scores between T1 and T2,T2 and T3,T1 and T3(P<0.05). Comparison of different time points in the control group:there were statistically significant differences on Berg scores between T1 and T2,T1 and T3(P<0.05),but there was no statistically significant difference on Berg score between T2 and T3(P>0.05).There was statistically significant difference on Berg scores between the two groups at T3(P<0.05). Conclusion:Five mimic-animal exercise can improve the knee-joint muscle strength in middle-aged and elderly women,which slow down the muscle weakness and improve the balance capacity.关键词：fall;middle-aged and elderly women;five mimic-animal exercise;isokinetic muscle test;balance capacity
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发布时间：2022-08-31 - 摘要：Objective:To study whether the corresponding relationship between “needling point”and“body partition”is specific,that is,the specificity of the needling point in wrist-ankle acupuncture. Methods A randomized controlled trial was designed. Ninety patients with acute low-back pain (ALBP) were randomly divided into the specific needling point group and No.1 and 2 non-specific needling point groups, 30 cases in each group. All the subjects were treated with wrist-ankle acupuncture for one time with a retaining needle time of 30 minutes. The specific needling point group was treated with acupuncture at the needling points of lower 5 or 6 region according to the theory of “selecting needling point based on the body partition”, and No.1 and 2 non-specific needling point groups were treated with acupuncture at the needling points of lower 2 and upper 5 region,respectively. At the timepoints of 3 minutes before treatment and 5,0, 15,0 minutes in the treatment course,the short form McGill pain questionnaire (SF-MPQ) was used to evaluate the waist pain when the subjects exercised,the modified-modified Schober test (MMS) was used to observe the lumbar activity,the expected changes in the three groups before and after the treatment were analyzed by expectation and treatment credibility scale (ETCS). Results: Before the treatment,there were no statistically significant differences on the scores of all items in SF-MPQ,MMS and ETCS among the three groups (P>0.05). Compared with the treatment before,the scores of all items in SF-MPQ in the three groups were all decreased at the timepoints of 5,0, 15 and 30 minutes in the treatment course(P<0.05). For the comparison of treatment before and after,at the timepoint of 5,0, 15 minutes,the differences on the scores of all items in SF-MPQ (except PPI) in the specific needling point group were all greater than those in No.1 and 2 non-specific needling point groups(P<0.05)；at the timepoint of 30 minutes,the differences on the scores of all items in SF-MPQ in the specific needling point group were all greater than those in No.1 and 2 non-specific needling point groups(P<0.05). Compared with the treatment before,the scores of MMS in the three groups were all increased after treatment(P<0.05). For the comparison of treatment before and after,the differences on the score of MMS in the specific needling point group were all greater than those in No.1 and 2 non-specific needling point groups(P<0.05). Compared with the treatment before,the scores of all items in ETCS in the specific needling point group were all increased after treatment(P<0.05). For the comparison of treatment before and after,there were no statistically significant differences on the scores of all items in ETCS in No.1 and 2 non-specific needling point groups(P>0.05). Conclusion: The wrist-ankle acupuncture shows the analgesic effect on low-back pain and improves the lumbar flexion activity,which has certain specificity.关键词：wrist-ankle acupuncture;specific needling point;non-specific needling point;acute low-back pain;analgesic effect;randomized controlled trial
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发布时间：2022-08-31
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