最新刊期
期 5 ， 2017
- 摘要：This paper summarized professor Shi Qi’s experience in treating chronic musculoskeletal diseases with syndrome differentiation of eight principles.Syndrome differentiation of eight principles is an important method to analyze the common characteristics of diseases,which taken as the general principle of various syndrome differentiation methods.In the diagnosis and treatment of chronic musculoskeletal diseases,the holistic view and the theory of perpetual motion should be mastered under the guidance of syndrome differentiation of eight principles,and the therapy ideas of “three insights”(insight into the disease,patient and regularity)should be applied to explore the etiology and achieve the precise syndrome differentiation.As to understanding of the specific disease,it should pay attention to the combination of the targets of lesion,the surroundings of lesion and the overall syndrome characteristics,which would ensure more comprehensive understanding,more precise treatment and more prominent efficacy.The above ideas fully reveal the features and advantages of traditional Chinese medicine.关键词：chronic musculoskeletal diseases;syndrome differentiation of eight principles;experience of famous doctors;Shi Qi
- 5
- |
- 387
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced professor Lu Zhizheng’s clinical experience in treating chronic gout by regulating spleen and stomach. He considers that the disorder of spleen and stomach is the key factor of onset and repeated attack in chronic gout. He emphasizes the regulation of spleen and stomach as the method for treating root causes,and proposes the regulation of spleen and stomach and comprehensive therapy as the fundamental treatment of chronic gout. Meanwhile,invigorating the kidney should not be neglected,and the treatment should pay attention to promoting blood circulation for removing blood stasis and dissipating phlegm and resolving masses to eliminate pathogen and strengthen vital qi. The treatment can be applied combined with external therapy of Chinese materia medica.关键词：chronic gout;regulation of spleen and stomach;experience of famous doctor;Lu Zhizheng
- 5
- |
- 674
- |
- 0
发布时间：2022-08-31 - 摘要：This paper mainly discussed the therapy and syndromes of fever due to depression syndrome.Through a large number of ancient medical records,it finds that traditional Chinese medicine had long realized that internal injury caused by excess of seven emotions can induce the fever,and summarized the corresponding clinical features and treatment methods.Fever due to depression syndrome can be caused by emotional factors,such as panic,sadness,over-thinking,depression,anger and so on,which manifest as mild fever,tidal fever,intermittent fever with various accompanied symptoms.The pathogenesis of this kind of fever has the difference between deficiency syndrome and excess syndrome.Pathogenic fire derived from stagnation of liver qi,phlegm-dampness stagnation and internal stagnation of blood are the parts of excess syndrome.Deficiency syndrome ascribes the causes to deficiency of qi and blood as well as yin and yang,which is similar to prostration due to depression syndrome.Reinforcing deficiency and reducing excess is the basic therapy of this kind of fever.Reducing excess includes soothing liver and clearing fire,dispelling phlegm and removing stasis.Reinforcing deficiency includes tonifying qi and blood as well as yin and yang.Parts of functional fever in modern medicine which associated with the emotional factors,such as primary low fever,low fever after cured infection,seasonal(summer) fever,and physiological fever as well as fever of unknown origin,can be approximately classified into the category of fever due to depression syndrome.关键词：depression syndrome;fever;etiology and pathogenesis;treatment based on relieving depression
- 5
- |
- 447
- |
- 0
发布时间：2022-08-31 - 摘要：This paper compared the different views of directional reinforcing and reducing by straight pushing on five meridians in textbooks with different versions and related medical books,and analyzed the relationship between the school inheritance and it. Combined with the clinical trials which have been carried out and the theory of reinforcing and reducing by puncturing along and against the direction of meridians respectively,for the spleen,liver,heart and lung meridian,it considers that “Reinforcing method is straight pushing on finger pulps towards the finger root,and reducing method is straight pushing on finger pulps towards the finger tips”；for the kidney meridian,“Reducing method is straight pushing on finger pulps towards the finger root,and reinforcing method is straight pushing on finger pulps towards the finger tips”.关键词：five meridians;pediatric tuina;straight pushing;reinforce and reduce;reinforcing and reducing by puncturing along and against the direction of meridians respectively
- 5
- |
- 530
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced the development and application of an intelligent moxibustion equipment. According to the mechanism of hyperthermia in penetration moxibustion,based on modern computer and electronic technology combined with PID control algorithm,the precise and intelligent control of temperature and time in the process of moxibustion is achieved. The smoke treatment device avoids the stimulation from moxa smoke. The design of moxibustion box and the new production material solves the existing problems,such as the moxibustion box is easily fragile,not resistant to burn,hard to clean,easy to heat and so on. The humanization designs of equipment ensure the privacy of moxibustion operator. This equipment shows strong clinical practicability and popularization value,which can make the traditional moxibustion therapy play a greater role.关键词：moxibustion equipment;intelligent control;PID algorithm;moxibustion box
- 5
- |
- 524
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced professor Wang Longhui’s experience in treating infertility of polycystic ovarian syndrome. He considers that the main pathogenesis of this disease are dysfunction of kidney,spleen and liver and changes of qi stagnation,blood stasis and phlegm dampness. The therapy of tonifying kidney and regulating menstruation can be applied,which means nourishing yin and blood combined with enhancing yang in postmenstrua period,invigorating kidney for activating blood circulation and enhancing yang to promote ovulation in intermenstrual period,activating blood circulation for regulating menstruation to eliminate blood stasis in menstrual period.关键词：polycystic ovarian syndrome;therapy of tonifying kidney and regulating menstruation;experience of famous doctors;Wang Longhui
- 5
- |
- 277
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced the clinical experience of Dai Yiquan in the treatment of insomnia with anxiety by Baihe Zhuyu Decoction. He considers that this disease is mainly caused by deficiency of zang-fu viscera,emotional disorder,depression and blockage of qi movement,disharmony of qi and blood,malnutrition of heart spirit,which result in blood deficiency and blood stasis for a long time. He uses Baihe Zhuyu Decoction to nourish yin for promoting blood circulation and tranquillize for sedating mind,which shows exact efficacy.关键词：Baihe Zhuyu Decoction;insomnia;anxiety;clinical experience
- 6
- |
- 227
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discussed professor Huang Guihua’s clinical experience in treating drug-induced liver injury with classical prescriptions. He considers that this disease can be treated according to syndrome differentiation based on the theory of syndrome differentiation of six meridians,which associated with “jaundice” in Treatise on Cold Pathogenic Diseases. One proven case was presented.关键词：drug-induced liver injury;classical prescriptions;clinical experience;Huang Guihua
- 5
- |
- 250
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discussed Zheng Qin’an’s thoughts of spleen and stomach. Through the research on Zheng Qin’an’s medical books,it finds that Zheng’s discussion on innate qi,primordial yin and primordial yang all focus on the spleen and stomach. Zheng’s thoughts of spleen and stomach permeate all aspects of his medical ideas. He inherited his teacher Liu Yuan ’s thoughts of spleen and stomach,combined with Inner Canon of Huangdi and Treatise on Cold Pathogenic and Miscellaneous Diseases,drew lessons from the theory of nature and nurture in yi-ology,and put forward the thoughts of spleen and stomach concerning“interdependence between nature and nurture,spleen and stomach as key of acquired foundation”. The principle method,prescription,medication all pay attention to the treatment of spleen and stomach.关键词：Zheng Qin’an;thoughts of spleen and stomach;invigorating spleen and hiding fire;interdependence of nature and nurture
- 5
- |
- 330
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discussed the differences between five phases theory in Han medicine and seven phases theory in Hui medicine. Seven phases theory in Hui medicine is innovated and developed based on five phases theory in Han medicine. Although the two theories show something in common,there are great differences on concept connotation,zang-fu viscera attachment,four seasons,orientation induction between them. This paper analyzed and compared the differences between the two,in order to deepen the understanding of the two medical theories, learn from each other and make the theoretical system more perfect.关键词：Hui medicine;seven phases;Han medicine;five phases;differences
- 5
- |
- 161
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discussed the application of supporting yang therapy in the treatment of ankylosing spondylitis. From the aspects such as the importance of yang qi,the circulation of channels and collaterals,etiology and pathogenesis,cases analysis and so on,the necessity of supporting yang was expounded,and the specific application of supporting yang therapy in the treatment of ankylosing spondylitis were elaborated.关键词：ankylosing spondylitis;spinal pain;kidney governor channel;supporting yang
- 5
- |
- 196
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency. Methods60 patients of non-small cell lung cancer with syndrome of qi and yin deficiency were randomly divided into the treatment group and control group,30 case in each group. The control group was treated with platinum chemotherapy,and the treatment group was treated with Sanqi Decoction additionally based on chemotherapy. The chemotherapy course of both groups were 6 weeks,and Sanqi Decoction was given one week in advance(a course of 7 weeks in the treatment group).The incidence and classification of myelosuppression were observed,and the serum level of granulocyte macrophage colony stimulating factor (GM-CSF) and Karnofsky performance scores(KPS)were compared. Results:①The incidence rate of myelosuppression in the treatment group was significantly lower than that in the control group(P<0.05).The incidence rates of toxic reaction with I,II degree on white blood cell (WBC),red blood cell (RBC),platelet (PLT) and neutrophil(NEUT) were significantly lower than those in the control group(P<0.05). ②After treatment,the level of GM-CSF in the treatment group was significantly higher than that in the control group(P<0.05). ③After treatment,the improvement and stability of KPS in the treatment group were significantly better than those in the control group(P<0.05). Conclusion:Sanqi Decoction shows significant efficacy in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency,which can regulate the related cytokine concentration and improve the life quality of patients.关键词：non small cell lung cancer;chemotherapy;myelosuppression;syndrome of qi and yin deficiency;Sanqi Decoction;reducing toxicity and enhancing efficacy;He Chengzhi
- 5
- |
- 202
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xiapu Fuling Decoction in the treatment of functional dyspepsia with syndrome of spleen and stomach deficiency. Methods70 patients of functional dyspepsia with syndrome of spleen and stomach deficiency were randomly divided into the treatment group (36 cases)and control group(34 cases). The control group was treated with domperidone tables,and the treatment group was treated with Xiapu Fuling Decoction,with a course of one month. The clinical efficacy was observed,the TCM syndrome scores were compared,and the efficacy persistence during follow-up was evaluated. Results:①The clinical total effective rate was 88.89% in the treatment group and 73.53% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison after treatment,the improvement on the scores of abdominal distention and fullness,loss of appetite,fatigue and weakness,nausea and vomiting,loose stool and the total score in the treatment group were more significant than those in the control group(P<0.05). ③For the comparison between withdrawal for 3 months and 6 months,the difference on TCM syndrome score in the treatment group was not statistically significant(P>0.05),while this difference in the control group was statistically significant(P<0.05). When withdrawal for 3 months and 6 months,the TCM syndrome scores in the treatment group were significantly lower than those in the control group(P<0.05). Conclusion:Xiapu Fuling Decoction can be used in the treatment of functional dyspepsia with syndrome of spleen and stomach deficiency,which can significantly relieve the clinical symptoms of patients with longer persistent efficacy.关键词：Xiapu Fuling Decoction;Waitai Fuling Decoction;functional dyspepsia;distention and fullness syndrome;deficiency of spleen and stomach;follow-up efficacy
- 4
- |
- 222
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To evaluate the clinical efficacy and safety of Ruanmai Decoction that has the effects of tonifying kidney and invigorating qi in the treatment of carotid atherosclerosis with syndrome of kidney essence deficiency. MethodsA total of 98 patients of carotid atherosclerosis with syndrome of kidney essence deficiency were randomly divided into the treatment group and control group,49 cases in each group. The control group was treated with the conventional therapy of western medicine,and the treatment group was treated with Ruanmai Decoction based on the treatment for the control group,with a course of 6 months. The efficacy and safety indexes such as carotid intima-media thickness (IMT),plaque area and endpoints incidence were compared in both groups before and after treatment. Results:After treatment,the IMT of the treatment group was decreased(P<0.01),while the IMT of the control group was increased(P<0.01). The IMT difference of treatment before and after in the treatment group was greater than that in the control group(P<0.01). After treatment,the plaque area of the treatment group was decreased(P<0.05),and the plaque area difference of treatment before and after in the treatment group was greater than that in the control group(P<0.01). The incidence rates of cumulative endpoints and secondary endpoints in the treatment group were lower than those in the control group (P<0.05). Conclusion:Ruanmai Decoction combined with conventional therapy of western medicine can inhibit the thickening of carotid atherosclerosis,delay the progress of plaque area and reduce the incidence rate of clinical endpoints.关键词：Ruanmai Decoction;atherosclerosis;carotid ultrasound
- 5
- |
- 139
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Tangshen Shengqing Jiangzhuo Particles in treating diabetic nephropathy(DN)with proteinuria. Methods96 patients of DN with proteinuria were randomly divided into the treatment group and control group,48 cases in each group. Both groups were treated with the same conventional symptomatic treatment. The treatment group was orally treated with Tangshen Shengqing Jiangzhuo Particles and the control group was treated with Benazepril hydrochloride tablets additionally,with a course of 3 month. The clinical efficacy was observed,and the changes of TCM syndrome score,urinary microalbumin,24 h urine protein quantitation,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),serum creatinine (SCr),blood urine nitrogen (BUN),total cholesterol (TC) and triglyceride(TG) were compared. Results:①The clinical total effective rate was 85.42% in the treatment group and 66.67% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison of the difference between treatment before and after,the decrease of TCM syndrome score in the treatment group was more significant than that in the control group(P<0.05). ③After treatment,the decrease of urinary microalbumin and 24h urine protein quantitation in the treatment group were more significant than those in the control group(P<0.05). ④After treatment,there were no statistically significant differences on the levels of SCr and BUN between the two groups(P>0.05),while the levels of FPG,HbA1c,TC,TG in the treatment group were significantly lower than those in the control group(P<0.05). Conclusion:Tangshen Shengqing Jiangzhuo Particles can be used in the treatment of diabetic nephropathy with proteinuria,which can control blood glucose and protect renal function,reduce urine protein and improve lipid metabolism.关键词：diabetic nephropathy;proteinuria;ascending lucidity and descending turbidity;Shengjiang Powder
- 5
- |
- 248
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupoint application of Qin’s Daijiu Ointment in the treatment of ankylosing spondylitis(AS)with syndrome of kidney deficiency and governor vessel cold. Methods120 cases of AS with syndrome of kidney deficiency and governor vessel cold were randomly divided into the treatment group and control group. The control group was treated with conventional western medicine,and the treatment group was treated with acupoint application of Qin’s Daijiu Ointment,with a course of 3 months. The clinical efficacy and medication safety were observed,and the TCM syndrome score,related signs scores and biochemical indexes were compared. Results:①The total effective rate of the treatment group and the control group were 89.83% and 65.00%,respectively. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②The improvement on TCM syndrome score in the treatment group was significantly better than that in the control group(P<0.05). ③There were statistically significant differences on the scores of Bath AS functional index(BASFI)and Bath AS disease activity index(BASDAI),erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP),spine curvature and Schober distance between the two groups after treatment,the improvement in the treatment group were significantly better than those in the control group(P<0.05). ④There was no statistically significant differences on the incidence rate of adverse events between the two groups(P>0.05). Conclusion:Acupoint application of Qin’s Daijiu Ointment shows good efficacy in the treatment of ankylosing spondylitis with syndrome of kidney deficiency and governor vessel cold,which is simple,convenient and safe.关键词：ankylosing spondylitis;syndrome of kidney deficiency and governor vessel cold;Qin’s Daijiu Ointment;acupoint application
- 5
- |
- 229
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Compound ZijingXiaoshang Cataplasm combined with glucosamine sulfate capsules in the treatment of knee osteoarthritis(KOA). Methods109 patients with early KOA were randomly divided into the observation group (55 cases) and control group (54 cases). The control group was orally treated with glucosamine sulfate capsules,and the observation group was treated with Compound ZijingXiaoshang Cataplasm for external application based on the treatment for the control group,with a course of 4 weeks. The clinical efficacy was observed,and the Lysholm knee jointfunction score,Japan Orthopaedic Association (JOA) score and visual analogue scale (VAS) score in both groups were compared before and after treatment. Results:①The clinical total effective rate was 94.55% in the observation group and 81.48% in the control group. The overall clinical efficacy in the observation group was better than that in the control group(P<0.05). ②After treatment,the Lysholm score and JOA score in the observation group were increased compared with treatment before(P<0.05),the VAS score was decreased compared with treatment before(P<0.05). The Lysholm score and JOA score in the observation group were higher than those in the control group(P<0.05),and the VAS score in the observation group was lower than that in the control group(P<0.05). Conclusion:CompoundZijingXiaoshang Cataplasm can help to relieve the clinical symptoms and improve the knee joint function of patients with KOA.关键词：knee osteoarthritis;Compound ZijingXiaoshang Cataplasm;jointfunction
- 5
- |
- 175
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the effects of five mimic-animal exercise(wuqinxi) on muscular tension of waist and abdomen in the population of spinal degeneration at compensatory stable stage. Methods92 patients of spinal degeneration at compensatory stable stage were randomly divided into the exercise group(32 cases),manipulation group(30 cases)and control group(30 cases).The three groups were treated with five mimic-animal exercise,manipulation therapy and health education,respectively. The changes of muscular tension of waist and abdomen in all subjects were compared before treatment and after treatment for 5,10,30 times. Results:After treatment for 5,10,30 times,there were statistically significant differences on the muscular tension of bilateral erector spinae between the control group and exercise group or manipulation group(P<0.05). After treatment for 5,10,30 times,there were statistically significant differences on the muscular tension of bilateral erector spinae between the exercise group and manipulation group(P<0.05). Conclusion:Five mimic-animal exercise can decrease the muscular tension of bilateral erector spinae in patients of spinal degeneration at compensatory stable stage.关键词：five mimic-animal exercise(wuqinxi);Tuina manipulation;spinal degeneration;muscular tension
- 5
- |
- 360
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Hongteng Mixture combined with Huayu Sanjie Enema in the treatment of chronic pelvic inflammatory disease(CPID)with syndrome of stagnant dampness-heat. Methods61 patients of CPID with syndrome of stagnant dampness-heat were randomly divided into the treatment group(31 cases)and control(30 cases).The control group was treated with Hongteng Mixture,and the treatment group as treated with Hongteng Mixture combined with Huayu Sanjie Enema,with a course of 3 months. The clinical efficacy was observed,and the TCM syndrome score,gynecological examination score,effusion volume in pelvic cavity under B-mode ultrasonography and hemorrheological parameters were compared. Results:①The clinical total effective rate was 90.32% in the treatment group and 76.67% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison between groups after treatment,the decrease of TCM syndrome score and gynecological examination score in the treatment group were more significant than those in the control group(P<0.05). ③For the comparison between groups after treatment,the decrease of effusion volume in pelvic cavity in the treatment group was more significant than that in the control group(P<0.05). ④For the comparison between groups after treatment,the decrease of all hemorrheological parameters in the treatment group were more significant than those in the control group(P<0.05). Conclusion:Hongteng Mixture combined with Huayu Sanjie Enema shows good efficacy in the treatment of chronic pelvic inflammatory disease with syndrome of stagnant dampness-heat.关键词：chronic pelvic inflammatory disease;syndrome of stagnant dampness-heat;Hongteng Recipe;retention enema;both internal and external treatment
- 5
- |
- 246
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qizhen Ziyin Mixture in the treatment of late onset hypogonadism with syndrome of kidney-yin deficiency. Methods152 patients of late onset hypogonadism with syndrome of kidney-yin deficiency were randomly divided into the treatment group and control group,76 cases in each group. The treatment group was treated with Qizhen Ziyin Mixture,and the control group was treated with testosterone undecanoate,with a course of 8 weeks. The changes of TCM syndrome scores,symptomatic inventory for screening late onset hypogonadism(SILOH) scores, the serum level of total testosterone(TT)and body mass index(BMI)were observed. Results:①For the comparison of treatment before and after,the differences on the scores of soreness and weakness of waist and knees,spiritlessness and weakness,tidal fever and night sweating,insomnia and amnesia,asexuality and erectile dysfunction in both groups were statistically significant(P<0.05).For the comparison after treatment,the score of tidal fever and night sweating in the treatment group was lower than that in the control group(P<0.05),the score of erectile dysfunction in the control group was lower than that in the treatment group(P<0.05),and there were no statistically significant differences on the other scores between the two groups(P>0.05). ②For the comparison of treatment before and after,the differences on the SILOH scores of physical fitness,vasodilation and vasoconstriction symptoms,mental and psychological symptoms and sexual function symptoms in both groups were statistically significant(P<0.05). For the comparison after treatment,there was statistically significant difference on the score of sexual function symptoms between the two groups(P<0.05),and the differences on the other scores were not statistically significant between the two groups(P>0.05). ③For the comparison of treatment before and after,the difference on the testosterone level in both groups was statistically significant(P<0.05),the significant change of BMI was not found in both groups(P>0.05). For the comparison after treatment,there was statistically significant difference on the testosterone level between the two groups(P<0.05),and the differences on BMI was not statistically significant between the two groups(P>0.05). Conclusion:Qizhen Ziyin Mixture can improve the clinical symptoms in patients of late onset hypogonadism with syndrome of kidney-yin deficiency,which shows similar effects as hormone alternative therapy.关键词：late onset hypogonadism;Qizhen Ziyin Mixture;therapy of traditional Chinese medicine;alternative therapy
- 5
- |
- 133
- |
- 0
发布时间：2022-08-31 - 摘要：This paper elaborates the physiology,pathology and pathogenesis of gastroesophageal reflux disease(GERD). Combined with the epidemiological characteristics,it puts forward that the treatment of GERD should base on liver and gallbladder,and emphasizes that the liver and gallbladder have played an important role in the occurrence and development process of GERD.关键词：gastroesophageal reflux disease;treatment based on syndrome differentiation;treating from regulating liver;treating from regulating gallbladder.
- 5
- |
- 219
- |
- 0
发布时间：2022-08-31 - 关键词：primary biliary cirrhosis;pruritus;Xijiao Dihuang Decoction
- 5
- |
- 207
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To evaluate the effects of Polyphyllin I on proliferation and apoptosis of circulating tumor cells (CTC) of lung cancer in vitro. MethodsThe CTC were intervened by Polyphyllin I at different concentrations for 24,8 and 72 hours. The cell proliferation was determined by CCK-8,and the cell apoptosis and cycle were detected by flow cytometry and confocal laser scanning microscopy. Results:Polyphyllin I could significantly inhibit the CTC proliferation in a concentration-dependent manner,and induce the significant morphological changes of CTC nucleus. The proportion of apoptotic cells was significantly increased,and the cells cycle was stagnated in G0/G1 phase. Conclusion:Polyphyllin I can induce CTC apoptosis and inhibit the cells differentiation from G0/G1 to S phase,which plays an anti-tumor effects.关键词：polyphyllin I;circulating tumor cells of lung cancer;cell proliferation;cell apoptosis;cell cycle
- 5
- |
- 369
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To evaluate the bacteriostatic and anti-inflammatory effects of Compound Tougucao Solution and explore the mechanism of anti-inflammation,provide the experimental basis for its clinical application. MethodsThe bacteriostatic effects of Compound Tougucao Solution on dermatophytes and saccharomycetes were observed by bacteriostatic experiment in vitro. The mice model of dimethylbenzene-induced ear edema and rat model of carrageenan-induced paw swelling were established to observe the anti-inflammatory effects of Compound Tougucao Solution and Dexamethasone Sodium Phosphate Injection with external application. 4 hours after the inflammation induced in rat paw,the levels of interleukin(IL)-1β and tumor necrosis factor(TNF)-α in the tissue were determined. Results:The bacteriostatic experiment in vitro showed that the minimum inhibitory concentration (MIC) of Compound Tougucao Solution against dermatophytes and saccharomycetes were 12.5% and 25.0% of original solution,respectively. Compound Tougucao Solution could reduce the swelling degree of dimethylbenzene-induced ear edema in mice,and there was significant difference between the Compound Tougucao Solution group with high-dose and negative control group(P<0.01). Compound Tougucao Solution could obviously alleviate the swelling degree of carrageenan-induced paw swelling in rats,and there were significant differences between the Compound Tougucao Solution groups with different doses and negative control group(P<0.01). Compound Tougucao Solution could decrease the level of IL-1β in the tissue of rat swelling paw,and there were significant differences on IL-1β level between the Compound Tougucao Solution groups with different doses and negative control group(P<0.05,P<0.01). Conclusion:Compound Tougucao Solution shows significant bacteriostatic and anti-inflammatory effects,and it plays a role in inhibiting the development of inflammation by decreasing the level of IL-1β in tissue.关键词：Compound Tougucao Solution;bacteriostasis;anti-inflammatory;IL-1β
- 5
- |
- 419
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To explore the effects of Qingre Lishi Recipe for external application (Rhizoma Polygoni Cuspidati,Herba Taraxaci,Radix Sophorae Flavescentis,Cortex Phellodendri) and polydatin on perianal wound healing in SD rats. MethodsSD rat model of perianal wound was established. The rats were randomly divided into the Qingre Lishi Recipe group,polydatin group,normal saline group,45 rats in each group. Interventions were given in the corresponding groups. 3,7,11 days after operation,the wound capillary permeability was observed by evans blue staining,the wound exudation,inflammation and healing were observed by naked eye and electron microscope,the tight junction of vascular endothelial cells and synthesis and distribution of collagen fibrils were observed by electron microscope. Results:On 3rd day after modeling,there was no difference on the leakage of evans blue between the Qingre Lishi group and polydatin group(P>0.05),but the leakage in these two groups was less than that in the normal saline group(P<0.05). On 7th and 11th day,there were no differences on the leakage of evans blue among the groups(P>0.05). The observation by naked eye showed that there were no differences on the wound exudation among the groups on 3rd,7th,11th day after modeling(P>0.0167). On 3rd,7th day after operation,the granulation hyperplasia and epithelial migration in the Qingre Lishi group were better than those in the normal saline group(P<0.0167),but there were no statistically significant differences on the granulation hyperplasia and epithelial migration between the Qingre Lishi group and polydatin group(P>0.0167)as well as the polydatin group and normal saline group(P>0.0167). On 11th day,there were no differences on the wound healing among the groups(P>0.0167). The light microscopy results showed that there was no obvious edema of granulation tissue in the Qingre Lishi group,the new capillaries were abundant and the fibroblasts arranged in order. The light microscopy observation in the polydatin group was similar to that in the Qingre Lishi group,and the wound healing in these two groups was better than that in the normal saline group. The electron microscopy results showed that there were tight junction of vascular endothelial cells and close fitting with adjacent cells in the Qingre Lishi group,the collagen fibrils distribution was compact and regular,the fiber bundle arranged closely. Conclusion:Qingre Lishi Recipe and polydatin can reduce the permeability of blood vessel and control the inflammatory exudation of wound,but Qingre Lishi Recipe can more effectively promote the epithelial migration and accelerate the regeneration of various components in granulation tissue.关键词：external treatment of Chinese medicine;anorectal surgery;postoperative;wound healing;Qingre Lishi Recipe;polydatin
- 5
- |
- 127
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To investigate the hypoglycemic activity of Sophora japonica L. extract in mice with type 2 diabetes mellitus. MethodsEthanol extract of Sophora japonica L. was acquired by ultrasonic extraction. Mice model of type 2 diabetes mellitus induced by nicotinamide and streptozotocin with intraperitoneal injection and 3T3-L1 preadipocytes differentiation model were established to determine the effects of ethanol extract of Sophora japonica L. on blood glucose and 3T3-L1 preadipocytes differentiation. Results:After treatment with ethanol extract of Sophora japonica L. by intragastric administration at the daily dose of 100 μg/g for continuous 3 weeks,the level of blood glucose in type 2 diabetic mice was reduced,and the glucose tolerance in oral glucose tolerance test(OGTT)was improved. Differentiation of 3T3-L1 preadipocytes was promoted by ethanol extract at the concentration of 0.4 and 0.8 mg/L. Conclusion:Ethanol extract of Sophora japonica L. can reduce the blood glucose in type 2 diabetic mice and promote the differentiation of 3T3-L1 preadipocytes. The specific mechanism needs further study.关键词：Sophora japonica L.(Leguminosae);type 2 diabetic mellitus;blood glucose;3T3-L1 preadipocytes;differentiation
- 5
- |
- 453
- |
- 0
发布时间：2022-08-31 - 摘要：This paper reviewed the research advance of effective components of Chinese materia medica on alleviating cisplatin-induced nephrotoxicity. The flavonoids,saponins and polysaccharides and other components in Chinese materia medica and some compound extractsshow unique advantages in alleviatingcisplatin-induced nephrotoxicity.关键词：Chinese materia medica;cisplatin-induced nephrotoxicity;renal protection;review
- 7
- |
- 643
- |
- 0
发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on the regulation of heat-clearing and supplementing Chinese medicine on innate immune molecules. The heat-clearing and supplementing prescriptions and drugs can induce or down-regulate the expression of innate immune molecules in inflammatory condition and diseases,and thus play a role in killing pathogens and regulating immune response,which may provide a new idea for clinical treatment of infectious diseases.关键词：innate immunity;innate immune molecules;heat-clearing medicines;supplementing medicines;review
- 5
- |
- 326
- |
- 0
发布时间：2022-08-31
- Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备13044091号
沪公网安备 31011502015228号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：70575 Visits Today：56
0