Clinical research on the influence of Dan’e Fukang Decocted Extract on the life quality and inflammatory factors in patients with endometriosis

LIU Xi; ZHONG Yi-cun

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Clinical research on the influence of Dan’e Fukang Decocted Extract on the life quality and inflammatory factors in patients with endometriosis

更新时间：2022-08-31

- Clinical research on the influence of Dan’e Fukang Decocted Extract on the life quality and inflammatory factors in patients with endometriosis
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 11, Pages: 52-54(2016)
- 作者机构：
  
  1. 上海交通大学医学院附属仁济医院妇产科,上海,200127
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LIU Xi, ZHONG Yi-cun. Clinical research on the influence of Dan’e Fukang Decocted Extract on the life quality and inflammatory factors in patients with endometriosis. [J]. Shanghai Journal of Traditional Chinese Medicine 50(11):52-54(2016)
DOI：

LIU Xi, ZHONG Yi-cun. Clinical research on the influence of Dan’e Fukang Decocted Extract on the life quality and inflammatory factors in patients with endometriosis. [J]. Shanghai Journal of Traditional Chinese Medicine 50(11):52-54(2016) DOI：

摘要

目的：观察丹莪妇康煎膏治疗子宫内膜异位症的临床疗效。方法：将174例子宫内膜异位症患者随机分为治疗组和对照组,每组87例。对照组予米非司酮治疗,治疗组予丹莪妇康煎膏治疗。两组疗程均为3个月经周期,观察临床疗效,比较生存质量、SAS、SDS评分,以及血清糖类抗原(CA125)、肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的变化情况。结果：①治疗组、对照组临床总有效率分别为93.10%和81.61%；组间临床疗效比较,差异有统计学意义,治疗组优于对照组(P<0.05)。②治疗前后组内比较,两组痛经程度积分差异均有统计学意义(P<0.05)；组间治疗前后痛经程度积分差值比较,差异有统计学意义,治疗组缓解痛经作用明显优于对照组(P<0.05)。③组间治疗后比较,生存质量、SDS及SAS评分差异有统计学意义,治疗组明显优于对照组(P<0.05)。④组间治疗后比较,CA125、TNF-α及IL-6水平差异有统计学意义,治疗组明显低于对照组(P<0.05)。结论：丹莪妇康煎膏治疗子宫内膜异位症的疗效满意,可有效改善临床症状,减轻抑郁焦虑,抑制机体炎症因子的释放。

Abstract

Objective:To observe the clinical efficacy of Dan’e Fukang Decocted Extract in the treatment of endometriosis(EM). Methods174 patients with EM were randomly divided into treatment group and control group, 87 cases in each group. The control group was treated with mifepristone while the treatment group was treated with Dan’e Fukang Decocted Extract,with a course of three menstrual cycles. The clinical efficacy were observed,the scores of life quality, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and the level of serum carbohydrate antigen (CA125),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were compared. Results:①The total effective rate was 93.10% in the treatment group and 81.61% in the control group,with statistically significant difference (P<0.05). The effect of the treatment group was better than that of the control group. ②Comparison of the treatment before and after, the difference on the score of dysmenorrhea degree in both groups was statistically significant (P<0.05). Comparison between the treatment group and control group,the difference on the score of dysmenorrhea degree was statistically significant,and the effect on relieving dysmenorrhea in the treatment group were obviously better than that in the control group (P<0.05). ③ After treatment, there were statistically significant differences on the scores of life quality,SDS and SAS between the two groups,and the effects of the treatment group were obviously better than those of the control group (P<0.05). ④ After treatment,there were statistically significant differences on the level of CA125,TNF-α and IL-6 between the two groups,and the levels of the treatment group were obviously lower than those of the control group (P<0.05). Conclusion:Dan’e Fukang Decocted Extract shows good effect in the treatment of endometriosis,which could effectively improve clinical symptoms,alleviate depression and anxiety,inhibit the release of inflammatory factors.

关键词

子宫内膜异位症丹莪妇康煎膏痛经炎症因子

Keywords

endometriosisDan’e Fukang Decocted Extractdysmenorrheainflammatory factors

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Department of Traditional Chinese Medicine， Jingshan Union Hospital， Huazhong University of Science and Technology

Department of Integrated Traditional Chinese and Western Medicine， Union Hospital， Tongji Medical College， Huazhong University of Science and Technology

Obstetrics and Gynecology Department of Xuzhou Central Hospital

The First Department of Gynecology， The First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Graduate School of Heilongjiang University of Traditional Chinese Medicine

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