Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal

HE Zhong-mei; LI Chao-hua; SUN Ya-nan; ZHANG Jing; WANG Yi

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Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal

更新时间：2022-08-31

- Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 9, Pages: 97-100(2016)
- 作者机构：
  
  1. 吉林农业大学中药材学院,吉林,长春,130118
  2. 北京市中医药防治重大疾病基础研究重点实验室,中国中医科学院医学实验中心,北京,100700
- 作者简介：
- 基金信息：
- DOI：
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HE Zhong-mei, LI Chao-hua, SUN Ya-nan, et al. Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal. [J]. Shanghai Journal of Traditional Chinese Medicine 50(9):97-100(2016)
DOI：

HE Zhong-mei, LI Chao-hua, SUN Ya-nan, et al. Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal. [J]. Shanghai Journal of Traditional Chinese Medicine 50(9):97-100(2016) DOI：

摘要

综述动物类中药中蛋白多肽成分的口服吸收机制及其研究进展。通过查阅国内外文献总结蛋白多肽类物质主要是通过载体转运、胞饮作用和 M细胞途径、细胞旁路、谷胱甘肽(GSH)转运系统这4种方式进行吸收转运,并分析了临床疗效显著的蛇毒、水蛭素、蚓激酶、鹿茸这4种动物类来源蛋白口服吸收入血途经及部分相关机制,对开发口服动物来源蛋白多肽类药物具有极大的应用价值和推广意义。

Abstract

This article reviewed the mechanism research progress on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal. By consulting and summarizing the domestic and foreign literature, it suggested that the absorption and transportion of protein peptides were mainly performed through the carrier transport, pinocytosis and M cell pathway, cell bypass and glutathione (GSH) transport system.Meanwhile the process of oral absorption into the blood and relevant mechanisms of venom, hirudin, lumbrokinase, pilose antler,4 kinds of protein from animal source with significant clinical effect were analyzed,which showed great application value and significance for the development of protein polypeptide drugs from animal source.

关键词

动物类中药蛋白多肽吸收机制口服给药综述

Keywords

Chinese traditional medicine from animalprotein polypeptideabsorption mechanismoral administrationreview

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