Clinical observation of the effects of “Ganfuan Decoction” on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory

ZHANG Jing; CUI Jian-wei; CHENG Wei-zhong; LIU Lin; CHEN Ju-ying; YIN Peng-ge; LU Min; YAN Fu-hua; ZHU Nai-yi; LIN Rui-min; TU Hong

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Clinical observation of the effects of “Ganfuan Decoction” on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory

更新时间：2022-08-31

- Clinical observation of the effects of “Ganfuan Decoction” on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 8, Pages: 38-42(2016)
- 作者机构：
  
  1. 上海市徐汇区大华医院中医肝科,上海,200237
  2. 上海交通大学医学院附属瑞金医院放射科,上海,200025
  3. 上海交通大学医学院附属仁济医院上海市肿瘤研究所癌基因及相关基因国家重点实验室,上海,200032
- 作者简介：
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ZHANG Jing, CUI Jian-wei, CHENG Wei-zhong, et al. Clinical observation of the effects of “Ganfuan Decoction” on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory. [J]. Shanghai Journal of Traditional Chinese Medicine 50(8):38-42(2016)
DOI：

ZHANG Jing, CUI Jian-wei, CHENG Wei-zhong, et al. Clinical observation of the effects of “Ganfuan Decoction” on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory. [J]. Shanghai Journal of Traditional Chinese Medicine 50(8):38-42(2016) DOI：

摘要

目的：观察基于“伏邪”说的肝复安治疗慢性乙型病毒性肝炎(简称慢乙肝)患者铁代谢异常的临床疗效。方法：将102例铁代谢异常相关性肝病(慢乙肝及肝硬化)患者分为治疗组(48例)与对照组(54例)。治疗组予中药“肝复安”辨证治疗,对照组予西医常规药物(抗病毒、保肝药)治疗。两组疗程均为36个月,观察肝脏铁质沉积疗效,比较血清铁代谢指标、肝功能、病毒及相关免疫指标等的变化情况。结果：①组间肝脏铁沉积疗效比较,第24个月、第36个月差异均有统计学意义,治疗组优于对照组(P,<,0.05)。②组间治疗后比较,血清铁(SI)、血清铁蛋白(SF)浓度及异常率差异有统计学意义,治疗组较对照组降低程度更显著、指标异常率更低(P,<,0.05)。组间治疗后比较,转铁蛋白(TRF)浓度及异常率差异有统计学意义,治疗组较对照组升高程度更显著、指标异常率更低(P,<,0.05)。③组间治疗后比较,治疗组丙氨酸氨基转移酶(ALT)水平较对照组降低更为明显,差异有统计学意义(P,<,0.05)；乙肝表面抗原(HBsAg)浓度差异有统计学意义,治疗组较对照组降低程度更显著(P,<,0.05)；CD3,+,水平及异常率差异有统计学意义,治疗组较对照组升高程度更显著、指标异常率更低(P,<,0.05)；CD4,+,/CD8,+,异常率差异有统计学意义(P,<,0.05)。结论：基于“伏邪”说的肝复安治疗慢乙肝患者铁代谢异常,能有效纠正铁代谢异常,恢复免疫功能,抑制病毒复制,减轻肝脏损伤。

Abstract

Objective:To observe the clinical effects of the “Ganfuan” decoction on the iron metabolism dysregulation in chronic viral hepatitis B patients based on Fuxie theory. Methods102 HBV-infected patients(chronic hepatitis and liver cirrhosis) with abnormal iron metabolism were divided into the treatment group(n=48) treated with “Ganfuan” decoction ,and control group (n=54) treated with conventional drugs(antivirus, hepatoprotectants),with a course of 36 months. The degree of iron deposition on liver, serum markers of iron metabolism, liver function,HBV level,immune cell counts and abnormal ratio were measured and compared. Results:①There was significant difference in hepatic iron deposition between the treatment group and control group on the 24th and 36th month(P,<,0.05),and the treatment group was more effective. ②There were significant differences in concentration and abnormal ratio of SF,SI and TRF between the treatment and control group after 36 months(P,<,0.05).Compared with the control group, the degree of the SI、SF reduction in the treatment group was more significant and the abnormal rate was lower. ③There were significant differences in ALT,HBsAg, CD3,+, and abnormal ratio of CD3,+, and CD4,+,/CD8,+, between the treatment and control group after treatment(P,<,0.05),and the treatment group was more effective. Conclusion:“Ganfuan” decoction based on Fuxie theory could renormalize the iron metabolism dysregulation effectively, recover the immune function, depress the virus replication, and alleviate the liver injury.

关键词

慢性乙型病毒性肝炎肝脏铁过载伏邪肝复安

Keywords

chronic hepatitis Bliver iron overloadFuxieGanfuan

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