Anti-hyperglycemic effect of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes

TANG Shan; HE Zhong-mei; REN Shen; YIN Chun-mei

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Anti-hyperglycemic effect of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes

更新时间：2022-08-31

- Anti-hyperglycemic effect of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 8, Pages: 86-89(2016)
- 作者机构：
  
  1. 吉林农业大学中药材学院,吉林,长春,130118
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TANG Shan, HE Zhong-mei, REN Shen, et al. Anti-hyperglycemic effect of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes. [J]. Shanghai Journal of Traditional Chinese Medicine 50(8):86-89(2016)
DOI：

TANG Shan, HE Zhong-mei, REN Shen, et al. Anti-hyperglycemic effect of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes. [J]. Shanghai Journal of Traditional Chinese Medicine 50(8):86-89(2016) DOI：

摘要

目的：考察不同比例人参皂苷Re与黄连素对2型糖尿病的降血糖作用。方法：采用均匀设计法对人参皂苷Re与黄连素进行不同比例配比,通过淀粉(6 mg/g)诱导小鼠高血糖模型,STZ(150 μg/g)和ALX(200 μg/g)法诱导大鼠2型糖尿病模型。观察人参皂苷Re与黄连素6种比例(2∶0、16∶1、1∶2、8∶4、0∶8、4∶16)(100 μg/g)对血糖的影响。结果：人参皂苷Re与黄连素1∶2组、8∶4组和4∶16组(100 μg/g)连续给药15天可显著降低淀粉(6 mg/g)诱导正常小鼠餐后血糖的升高(P<0.05,P<0.01)。其中,人参皂苷Re与黄连素1∶2组和4∶16组(100 μg/g)可显著抑制STZ所致糖尿病大鼠血糖水平(P<0.05,P<0.01)；而人参皂苷Re与黄连素4∶16组(100 μg/g)对ALX(200 μg/g)所致糖尿病大鼠血糖的升高也具有显著抑制作用(P<0.01),其效果类似降糖灵(100 μg/g)。此外,在STZ和ALX诱导大鼠高血糖模型中,人参皂苷Re与黄连素各比例之间进行比较发现,人参皂苷Re与黄连素4∶16(100 μg/g)对血糖的抑制作用要优于其他组(P< 0.05)。结论：人参皂苷Re与黄连素4∶16(100 μg/g)具有显著的降血糖作用。

Abstract

Objective:To investigate the anti-hyperglycemic effects of the compatibility of ginsenoside Re and berberine in different ratio on type 2 diabetes. MethodsThe different ratio of ginsenoside Re and berberine (2∶0, 16∶1, 1∶2, 8∶4, 0∶8, 4∶16) were matched by uniform design method. The hyperglycemia model in mice was induced by starch(6 mg/g), and the type 2 diabetes model in rats was induced by STZ(150 μg/g)and ALX(200 μg/g). The effects of different ratio of ginsenoside Re and berberine(100 μg/g) on blood sugar were observed. Results:postprandial blood glucose in starch induced mice treated with the ratio of ginsenoside Re and berberine at 1∶2(100 μg/g), 8∶4(100 μg/g), 4∶16(100 μg/g) significantly reduced(P<0.05 or P<0.01). the blood glucose level in STZ induced rats treated with the ratio of ginsenoside Re and berberine at 8∶4(100 μg/g)and 4∶16(100 μg/g) significantly inhibited(P<0.05 or P<0.01). The ratio of Ginsenoside Re and berberine at 4∶16 also showed significantly reverse effect on ALX-induced hyperglycemia in rats (P<0.01), and its hypoglycemic effect was similar to phenformin(100 μg/g). In addition, among the different ratio in the STZ and ALX induced models, the inhibition of blood glucose in the ratio of ginsenoside Re and berberine at 4∶16 was more effective than other groups(P<0.05). Conclusion:The ratio of ginsenoside Re and berberine at 4∶16(100 μg/g) showed significantly anti-hyperglycemic effect.

关键词

人参皂苷Re黄连素2型糖尿病降血糖作用

Keywords

ginsenoside Reberberinetype 2 diabetesanti-hyperglycemic effect

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