Objective,2,To control the internal quality of Shichangpu （Acori Tatarinowii Rhizoma） formula granules， the overall characteristic chromatogram by ultra-performance liquid chromatography （UPLC） and the characteristic chromatogram of water-soluble components by high-performance liquid chromatography （HPLC） were established， and the content of uridine， a nucleic acid component， was determined by HPLC.,Methods,2,The overall UPLC characteristic chromatogram was determined on a Waters ACQUITY UPLC BEH C,18, column （2.1 mm×100 mm， 1.7 μm） with a gradient elution of methanol and 0.1% phosphoric acid aqueous solution as mobile phases at a flow rate of 0.4 mL/min， detection wavelength of 280 nm， column temperature of 35 ℃， and injection volume of 1 μL. The HPLC characteristic chromatogram of water-soluble components and content determination were performed on a SHIMADZU Shim-pack GIST C,18,-AQ column （4.6 mm×250 mm， 5 μm） with a gradient elution of methanol and 0.1% phosphoric acid aqueous solution as mobile phases at a flow rate of 1 mL/min， detection wavelength of 260 nm， column temperature of 35 ℃， and injection volume of 10 μL.,Results,2,The overall characteristic chromatogram of Acori Tatarinowii Rhizoma formula granules was established with 9 characteristic peaks， among which 4 peaks were identified as asarylaldehyde （peak 3）， ,N,-,trans,-feruloyltyramine （peak 4）， ,β,-asarone （peak 6）， and ,α,-asarone （peak 9）， with similarities of 10 bathes of samples ranging from 0.994 to 1.000. The water solubility characteristic chromatogram Acori Tatarinowii Rhizoma formula granules was established with 8 characteristic peaks， among which 5 component peaks were identified as adenine （peak 1）， uridine （peak 2）， adenosine （peak 3）， guanosine （peak 5）， and ,L,-phenylalanine （peak 7）， with similarities of 23 batches of samples ranging from 0.931 and 0.972. According to the quantitative analysis， the concentration of uridine had a good linear relationship with the peak area in the linear range of 2.086 to 104.300 mg/L （,R,2,=1.000 0）， the mean spiked recovery was 100.16%， the ,RSD, value was 2.02%， and the uridine content of 23 batches of Acori Tatarinowii Rhizoma formula granules ranged from 0.037% to 0.061%， showing the stable quality of the formulation granules.,Conclusion,2,The established characteristic chromatograms and content determination methods are simple， reproducible， and specific， and can be used for the quality control of Acori Tatarinowii Rhizoma formula granules.