This paper introduces the clinical experience of professor Qi Guangchong in treating andrological diseases with modified Guizhi Longgu Muli Decoction. Developed from the Chinese classic formula – Guizhi Longgu Muli Deocoction， it is reformulated by changing Shengjiang （Zingiberis Rhizoma Recens） into Ganjiang （Zingiberis Rhizoma）， increasing the amount of Dazao （Jujubae Fructus）， and adding Lujiao （Cervi Cornu） and Fengfang （Vespae Nidus）. Therefore， modified Guizhi Longgu Muli Decoction has the effects of harmonizing yin and yang， warming and tonifying kidney yang. Prof. Qi advocates the combination of disease differentiation and syndrome differentiation. First select an appropriate formula based on disease differentiation， and then modify the formula based on syndrome differentiation. Modified Guizhi Longgu Muli Decoction can be applied to various andrological diseases such as impotence， premature ejaculation， and infertility， etc. Its clinical application is exemplified by three proven cases.