1.上海市浦东新区浦兴社区卫生服务中心中医科(上海 200129)
2.上海中医药大学附属曙光医院肿瘤科(上海 201203)
3.上海中医药大学附属曙光医院肿瘤研究所(上海 201203)
杨燕青,男,硕士,副主任医师,主要从事中医药防治肿瘤临床研究工作
周利红,副研究员,硕士研究生导师; E-mail:zlhtcm@hotmail.com
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杨燕青,武鹏涛,陶莹,等.穴位埋线对结直肠腺瘤性息肉合并代谢综合征患者息肉术后复发及代谢水平的影响[J].上海中医药杂志,2022,56(10):53-56.
YANG Yanqing,WU Pengtao,TAO Ying,et al.Effect of acupoint catgut embedding on postoperative recurrence of polyps and metabolic level in patients with colorectal adenomatous polyps complicated with metabolic syndrome[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(10):53-56.
杨燕青,武鹏涛,陶莹,等.穴位埋线对结直肠腺瘤性息肉合并代谢综合征患者息肉术后复发及代谢水平的影响[J].上海中医药杂志,2022,56(10):53-56. DOI: 10.16305/j.1007-1334.2022.2206090.
YANG Yanqing,WU Pengtao,TAO Ying,et al.Effect of acupoint catgut embedding on postoperative recurrence of polyps and metabolic level in patients with colorectal adenomatous polyps complicated with metabolic syndrome[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(10):53-56. DOI: 10.16305/j.1007-1334.2022.2206090.
目的,2,观察穴位埋线对结直肠腺瘤性息肉合并代谢综合征患者息肉术后复发及代谢水平的影响。,方法,2,将80例结直肠腺瘤性息肉(术后)合并代谢综合征患者随机分为治疗组和对照组,每组40例。对照组给予对症治疗及健康管理,治疗组在对照组治疗措施的基础上加用穴位埋线治疗,两组均干预3个月。观察两组治疗后6个月、12个月的息肉复发情况及治疗安全性,比较治疗前后两组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)水平,以及体质量、体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、收缩压、舒张压的变化情况。,结果,2,①试验过程中,治疗组脱落3例,对照组脱落2例,最终完成试验者75例,其中治疗组37例、对照组38例。②治疗后6个月,两组息肉术后复发率比较,差异无统计学意义(,P,>,0.05);治疗后12个月,治疗组、对照组息肉术后复发率分别为13.5%、34.2%,差异有统计学意义(,P,<,0.05)。③治疗前后组内比较,治疗组血清LDL-C、HDL-C、FPG、HbA1c水平及收缩压、体质量、BMI、WC、WHR值降低(,P,<,0.05),对照组血清TC、LDL-C水平及WC、WHR值降低(,P,<,0.05);组间治疗后比较,治疗组血清LDL-C、FPG、HbA1c水平及收缩压、体质量、BMI、WC、WHR值低于对照组(,P,<,0.05)。④两组均未见安全性指标异常。,结论,2,穴位埋线可通过调节代谢水平预防结直肠腺瘤性息肉术后复发,有效防治高血压病、糖尿病、高脂血症等社区常见病,且安全性佳。
Objective,2,To observe the effect of acupoint catgut embedding on postoperative recurrence of polyps and metabolic level in patients with colorectal adenomatous polyps (CAP) complicated with metabolic syndrome (MS).,Methods,2,Eighty patients with CAP (postoperative) complicated with MS were randomly divided into a treatment group (,n,=40) and a control group (,n,=40). The control group was administered with symptomatic treatment and health management, while the treatment group was administered with acupoint catgut embedding besides the treatment measures of the control group. The treatment lasted 3 consecutive months. The recurrence of polyps in both groups was observed at 6 and 12 months after treatment,and the treatment safety was observed. The levels of serum total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c), as well as body mass, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), systolic blood pressure, and diastolic blood pressure were compared before and after treatment.,Results,2,①During the trial, there were 3 drop-out cases in the treatment group and 2 drop-out cases in the control group. Finally, 75 cases completed the trial, including 37 cases in the treatment group and 38 cases in the control group. ②At 6 months after treatment, there was no statistically significant difference in the postoperative recurrence rate of polyps between the two groups (,P,>,0.05). At 12 months after treatment, the postoperative recurrence rate of polyps was 13.5% in the treatment group and 34.2% in the control group, and the difference was statistically significant (,P,<,0.05). ③According to the intra-group comparison before and after treatment, the levels of serum LDL-C, HDL-C, FPG and HbA1c, as well as systolic blood pressure, body mass, BMI, WC and WHR decreased in the treatment group (,P,<,0.05); The levels of serum TC and LDL-C, as well as WC and WHR decreased in the control group (,P,<,0.05). After treatment, the levels of serum LDL-C, FPG and HbA1c, as well as systolic blood pressure, body mass, BMI, WC and WHR in the treatment group were lower than those in the control group (,P,<,0.05). ④No abnormal safety index was found in both groups.,Conclusions,2,Acupoint catgut embedding has certain popularization value as it can prevent the postoperative recurrence of colorectal adenomatous polyps by regulating metabolic levels, and effectively prevent and treat common community diseases such as hypertension, diabetes and hyperlipidemia. The safety of this treatment is good.
结直肠息肉癌前病变代谢综合征穴位埋线复发结直肠癌临床试验
colorectal polypsprecancerous lesionsmetabolic syndromeacupoint catgut embeddingrecurrencecolorectal cancerclinical trial
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