Objective,2,To observe the clinical effect of Ganjiang Xiaochaihu Decoction on patients with mild infection of COVID-19 Omicron variant.,Methods,2,One hundred and forty-five patients with mild infection of COVID-19 Omicron variant were randomly divided into a treatment group （,n,=97） and a control group （,n,=48）. The control group was given basic routine treatment， while the treatment group was administered with Ganjiang Xiaochaihu Decoction and the basic routine treatment. After 5 days of treatment， the clinical effect was observed， and TCM syndrome scores， self-rating depression scale （SDS） scores， self-rating anxiety scale （SAS） scores and nucleic acid conversion time （NCT） were compared between the two groups.,Results,2,①During the trial， 1 case in the control group dropped out， and finally 97 cases in the treatment group and 47 cases in the control group completed the trial. ②The total effective rate of the treatment group was 99.0%， and that of the control group was 78.7%. The treatment group showed a better clinical effect compared with the control group （,P,<,0.05）. ③After 5 days of treatment， the TCM syndrome sub-item scores and total scores in both groups decreased， and the differences were statistically significant （,P,<,0.05）； After 5 days of treatment， the sub-item scores of pharyngeal discomfort， nasal obstruction and runny nose， loss of appetite， irritability， palpitation and the TCM syndrome total scores in the treatment group were lower than those in the control group， and the differences were statistically significant （,P,<,0.05）. ④The scores of SDS and SAS in the two groups decreased after 5 days of treatment compared with those before treatment， and the differences were statistically significant （,P,<,0.05）； After 5 days of treatment， the scores of SDS and SAS in the treatment group were lower than those in the control group， and the differences were statistically significant （,P,<,0.05）. ⑤There was no statistically significant difference between the two groups in terms of nucleic acid conversion time （,P,>,0.05）.,Conclusion,2,Ganjiang Xiaochaihu Decoction has achieved a satisfactory result in treating patients with mild infection of COVID-19 Omicron variant because it can effectively improve the patients’ TCM syndromes， relieve depression and anxiety， and has the effect of “simultaneous treatment of infection and depression”.