1.吉林农业大学中药材学院,省部共建生态恢复与生态系统管理国家重点实验室(吉林 长春 130118)
史帧婷,女,博士研究生,主要从事中药资源学研究工作
杨利民,教授,博士研究生导师;E-mail:ylmh777@126.com
扫 描 看 全 文
史帧婷,刘丽鸽,韩梅,等.代谢组学在人参研究中的应用进展[J].上海中医药杂志,2022,56(11):84-90.
SHI Zhenting,LIU Lige,HAN Mei,et al.Advances in application of metabolomics to research ofGinseng Radix et Rhizoma[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):84-90.
史帧婷,刘丽鸽,韩梅,等.代谢组学在人参研究中的应用进展[J].上海中医药杂志,2022,56(11):84-90. DOI: 10.16305/j.1007-1334.2022.2206040.
SHI Zhenting,LIU Lige,HAN Mei,et al.Advances in application of metabolomics to research ofGinseng Radix et Rhizoma[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):84-90. DOI: 10.16305/j.1007-1334.2022.2206040.
阐述代谢组学的定义和研究方法。从基源鉴定、生长环境、采收时期、炮制方法、药理活性几方面综述人参的代谢组学研究进展,并归纳总结代谢组学在人参研究中的问题及未来发展方向,为人参的深入研究提供思路。
The definition and research methods of metabolomics were explained. The advances in the application of metabolomics to the research of Renshen (Ginseng Radix et Rhizoma) were reviewed in terms of source identification, growth environment, harvesting time, processing methods and pharmacological activity. The problems and future development directions of metabolomics in the research of Renshen (Ginseng Radix et Rhizoma) were summarized to provide ideas for the in-depth research of Renshen (Ginseng Radix et Rhizoma).
人参人参皂苷代谢组学有效成分研究进展中药研究
Ginseng Radix et Rhizomaginsenosidesmetabonomicsactive ingredientresearch progresstraditional Chinese herbal medicine research
国家药典委员会. 中华人民共和国药典(2020年版):一部[M]. 北京:中国中医药科技出版社,2020.
石威. 不同生长期人参中化学成分及农药残留的研究[D]. 长春:吉林大学,2007.
RATAN Z A, YOUN S H, KWAK Y S, et al. Adaptogenic effects of Panax ginseng on modulation of immune functions[J]. J Ginseng Res, 2021, 45(1): 32-40.
YANG Z H, YU Y Y, SUN N N, et al. Ginsenosides Rc,as a novel SIRT6 activator,protects mice against high fat diet induced NAFLD[J/OL]. J Ginseng Res, 2020[2022-07-29]. https://doi.org/10.1016/j.jgr.2020.07.005https://doi.org/10.1016/j.jgr.2020.07.005.
PARK S K, HYUN S H, IN G, et al. The antioxidant activities of Korean red ginseng(Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials[J]. J Ginseng Res, 2021, 45(1): 41-47.
曹智,张燕娣,许永华,等. 人参有效成分及其药理作用研究新进展[J]. 人参研究,2012, 24(2): 39-43.
钟贵,王元忠,张霁,等. 人参属植物代谢组学研究进展[J]. 时珍国医国药,2013, 24(9): 2234-2237.
LEE H J, JEONG J, ALVES A C, et al. Metabolomic understanding of intrinsic physiology in Panax ginseng during whole growing seasons[J]. J Ginseng Res, 2019, 43(4): 654-665.
刘迪,陈佳伟,张聪,等. 组学技术在人参皂苷活性研究中的应用进展[J]. 食品工业,2019, 40(10): 285-288.
杨鹤,宋述尧,许永华,等. 人参三萜皂苷的研究进展及其生态学作用[J]. 中草药,2017, 48(8): 1692-1698.
刘妹芹,张世亮. 人参应用概述[J]. 实用中医内科杂志,2016, 30(1): 84-85.
GOODACRE R, VAIDYANATHAN S, DUNN W B, et al. Metabolomics by numbers: acquiring and understanding global metabolite data[J]. Trends Biotechnol, 2004, 22(5): 245-252.
EDWARDS D, BATLEY J. Plant bioinformatics: from genome to phenome[J]. Trends Biotechnol, 2004, 22(5): 232-237.
TWEEDDALE H, NOTLEY-MCROBB L, FERENCI T. Effect of slow growth on metabolism of Escherichia coli, as revealed by global metabolite pool(“metabolome”) analysis[J]. J Bacteriol, 1998, 180(19): 5109-5116.
尹恒,李曙光,白雪芳,等. 植物代谢组学的研究方法及其应用[J]. 植物学通报,2005, 22(5): 22-30.
辛萍,匡海学,李晓亮,等. 蛋白质组学技术及其在中药作用机制研究中的应用[J]. 中国中药杂志,2018, 43(5): 904-912.
张欣欣,张爱华,雷锋杰,等. 人参内生细菌F1对人参根系分泌物的化学趋向性响应[J]. 中国中药杂志,2019, 44(24): 5358-5362.
李乐乐. 应用植物代谢组学方法研究不同人参制品的化学成分差异[D]. 长春:长春中医药大学,2020.
CHUNG I M, KIM J W, SEGUIN P, et al. Ginsenosides and phenolics in fresh and processed Korean ginseng( Panax ginseng C. A. Meyer) : Effects of cultivation location, year,and storage period[J]. Food Chem, 2012, 130(1): 73-83.
GEOGRIEV M I, ALI K, ALIPIEVA K, et al. Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics[J]. Phytochemistry, 2011, 72(16): 2045-2051.
王雪洁,李震宇,薛水玉,等. 基于植物代谢组学技术的远志不同炮制品质量控制研究[J]. 中草药,2012, 43(9): 1727-1737.
KIM S, SHIN B K, LIM D K, et al. Expeditious discrimination of four species of the Panax genus using direct infusion-MS/MS combined with multivariate statistical analysis[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 1002: 329-336.
ZHAO H, XU J, GHEBREZADIK H, et al. Metabolomic quality control of commercial Asian ginseng, and cultivated and wild American ginseng using 1H NMR and multi-step PCA[J]. J Pharma Biomed Anal, 2015, 114: 113-120.
QIU S, YANG W Z, YAO C L, et al. Nontargeted metabolomic analysis and “commercial-homophyletic” comparison-induced biomarkers verification for the systematic chemical differentiation of five different parts of Panax ginseng[J]. J Chromatogr A, 2016, 1453: 78-87.
CHANG X W, ZHANG J J, LI D, et al. Nontargeted metabolomics approach for the differentiation of cultivation ages of mountain cultivated ginseng leaves using UHPLC/QTOF-MS[J]. J Pharmaceut Biomed, 2017, 141(15): 108-122.
CHEN Y J, ZHAO Z Z, CHEN H B, et al. Chemical differentiation and quality evaluation of commercial Asian and American ginsengs based on a UHPLC-QTOF/MS/MS metabolomics approach[J]. Phytochemical Anal, 2015, 26(2): 145-160.
PACE R, MARTINELLI E M, SARDONE N, et al. Metabolomic evaluation of ginsenosides distribution in Panax genus(Panax ginseng and Panax quinquefolius) using multivariate statistical analysis[J]. Fitoterapia, 2015, 101: 80-91.
PARK H W, IN G, KIM J H, et al. Metabolomic approach for discrimination of processed ginseng genus( Panax ginseng and Panax quinquefolius ) using UPLC-QTOF-MS[J]. J Ginseng Res, 2014, 38(1): 59-65.
QIAN M, BAI M, XU J D, et al. Discrimination of leaves of Panax ginseng and P. quinquefolius by ultra high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics approach[J]. J Pharm Biomed Anal, 2014, 97: 129-140.
刘丹. 气相色谱-质谱联用鉴别园参、移山参及伪山参[J]. 广东化工,2020, 47(20): 111-112.
贾丽. 基于离线三维色谱-高分辨质谱与代谢组学技术的人参花、西洋参花、三七花系统物质基础及其差异比较研究[D]. 天津:天津中医药大学,2020.
张春霞. 人参皂苷系统表征多技术比较与人参属多品种中药同时鉴别研究[D]. 天津:天津中医药大学,2020.
常相伟,李德坤,王彤,等. 基于UHPLC-QTOF/MS的植物代谢组学技术鉴别林下山参的不同部位[J].药学学报,2016, 51(10): 1609-1615.
LIU J, LIU Y, WANG Y, et al. The integration of GC-MS and LC-MS to assay the metabolomics profiling in Panax ginseng and Panax quinquefolius reveals a tissue- and species-specific connectivity of primary metabolites and ginsenosides accumulation[J]. J Pharm Biomed Anal, 2017, 135: 176-185.
LIU J, LIU Y, WANG Y, et al. GC-MS metabolomic analysis to reveal the metabolites and biological pathways involved in the developmental stages and tissue response of Panax ginseng[J]. Molecules, 2017, 22(3): 496.
CHEN Q L, CHEN Y J, ZHOU S S, et al. Laser microdissection hyphenated with high performance gel permeation chromatography-charged aerosol detector and ultra performance liquid chromatography-triple quadrupole mass spectrometry for histochemical analysis of polysaccharides in herbal medicine: Ginseng, a case study[J]. Int J Biol Macromol, 2018, 107(Pt A):332-342.
李林媛,屈玟珊,戴全宽,等. 不同生境人参的化学成分比较研究进展[J]. 广东药科大学学报,2018, 34(6): 803-807.
XU X F, CHENG X L, LIN Q H, et al. Identification of mountain-cultivated ginseng and cultivated ginseng using UPLC/oa-TOF MSE with a multivariate statistical sample-profiling strategy[J]. J Ginseng Res, 2016, 40(4): 344-350.
PARK S Y, LEE J G, CHO H S, et al. Metabolite profiling approach for assessing the effects of colored light-emitting diode lighting on the adventitious roots of ginseng(Panax ginseng C. A. Mayer)[J]. Plant Omics, 2013, 6(3): 224-230.
MIN J E, LONG N P, HONG J Y, et al. The dehiscence process in Panax ginseng seeds and the stigmasterol biosynthesis pathway in terms of metabolomics[J]. J Ginseng Res, 2022, 46(2): 225-234.
陈泽炎,赖长江生,魏旭雅,等. 中药材生长年限鉴定方法的研究进展[J]. 中国中药杂志,2021, 46(6): 1357-1367.
常相伟,赵颖,李德坤,等. 林下山参化学成分及鉴别评价研究进展[J]. 中草药,2016, 47(11): 1982-1991.
张艳欣. 基于LC-MS技术对林下山参鉴别及生长年限判定的研究[D]. 上海:上海中医药大学,2019.
张博,孙秀丽,郭云龙,等. 液质联用技术分析不同产地不同年限人参的化学成分[J]. 中国实验方剂学杂志,2020, 26(8): 206-212.
常相伟,王博然,王彤,等. 基于UPLC-Q-TOF/MS的植物代谢组学技术鉴别林下山参的生长年限[J]. 中国中药杂志,2016, 41(19): 3609-3614.
汪静静. 不同产地和年限人参样品皂苷类成分的比较研究[D]. 合肥:安徽中医药大学,2015.
LEE M Y, SEO H S, SINGH D, et al. Unraveling dynamic metabolomes underlying different maturation stages of berries harvested from Panax ginseng[J]. J Ginseng Res, 2020, 44(3): 413-423.
ZHANG H M, LI S L, ZHANG H, et al. Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach[J]. J Pharm Biomed Anal, 2012, 62: 258-273.
李震宇,何盼,秦雪梅. 代谢组学技术在中药材商品规格研究中的应用思考[J]. 中草药,2015, 46(7): 943-948.
ZUO T T, ZHANG C X, LI W W, et al. Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling four-dimensional separation and characterization of the multicomponents from white ginseng and red ginseng[J]. J Pharm Biomed Anal, 2020, 10(6): 597-609.
CHEN X P, LIN Y P, HU Y Z, et al. Phytochemistry, Metabolism, and Metabolomics of Ginseng[J]. Chin Herb Med, 2015, 7(2): 98-108.
郑惠婷,李克宁,陈驰,等. 基于1H-NMR人参煎治疗2型糖尿病大鼠的胰腺代谢组学研究[J]. 中国中药杂志,2018, 43(14): 3012-3017.
杨银平,律广富,张乔,等. 基于细胞代谢组学技术的人参皂苷Rb1对SH-SY5Y细胞保护机制研究[J].分析化学,2019, 47(1): 49-58.
曹东敏,关琴笑,刘雅莉,等. 基于1H-NMR的人参总皂苷治疗缺血性脑中风的血清代谢组学研究[J]. 中国中药杂志,2020, 45(5): 1142-1148.
唐孟秋,林卫东,贤明华,等. 基于1H-NMR的人参煎治疗2型糖尿病的血清和尿液代谢组学研究[J]. 中国中药杂志,2020, 45(9): 2186-2192.
范自全,周明眉,邢丽娜,等. 人参皂苷对昼夜颠倒应激大鼠能量代谢干预作用的代谢组学研究[J]. 世界科学技术-中医药现代化,2012, 14(6): 2154-2160.
那丽莎,刘夕琳,李想,等. 基于生物分子网络的人参皂苷Rg1的生物效应[J]. 黑龙江医药科学,2015, 38(3): 30-32.
王妮,张娜,李铁,等. 人参干预脾气虚体质的非靶向代谢组学研究[J].中国中药杂志,2020, 45(2): 398-404.
林贺,皮子凤,门丽慧,等. 非靶向代谢组学用于藜芦妨害人参治疗脾气虚的机制研究[J]. 分析化学,2016, 44(11): 1755-1762.
郭丽娜,郑茜. 基于GC/TOF-MS代谢组学方法的人参反藜芦研究[J]. 山西医科大学学报,2019, 50(12): 1738-1744.
YOON D, KIM Y J, LEE W K, et al. Metabolic changes in serum metabolome of beagle dogs fed Black Ginseng[J]. Metabolites, 2020, 10(12): 517.
SUN Y, CHEN S WEI R, et al. Metabolome and gut microbiota variation with long-term intake of Panax ginseng extracts on rats[J]. Food Funct, 2018, 9(6): 3547-3556.
YANG L, YU Q T, GE Y Z, et al. Distinct urine metabolome after Asian ginseng and American ginseng intervention based on GC-MS metabolomics approach[J]. Sci Rep, 2016, 6: 39045.
WANG H, HUANG R, LI H, et al. Serum metabolomic analysis of the anti-diabetic effect of Ginseng berry in type Ⅱ diabetic rats based on ultra high-performance liquid chromatography-high resolution mass spectrometry[J]. J Pharm Biomed Anal, 2021, 196: 113897.
LIN H, PI Z, MEN L, et al. Urinary metabonomic study of Panax ginseng in deficiency of vital energy rat using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry[J]. J Ethnopharmacol, 2016, 184: 10-17.
包芳,李羽涵,杨志刚. 甘草代谢组学的研究进展[J]. 中草药,2018, 49(19): 4662-4669.
陈宵,孙承业. 代谢组学在天然产物毒性评价和毒理学研究中的应用进展[J]. 中草药,2019, 50(5): 1244-1257.
STEINBECK C, CONESA P, HAUG K, et al. MetaboLights: towards a new COSMOS of metabolomics data management[J]. Metabolomics, 2012, 8(5): 757-760.
SMELTER A, MOSELEY H N B. A Python library for FAIRer access and deposition to the Metabolomics Workbench Data Repository[J]. Metabolomic, 2018, 14(5): 64.
刘佳. 运用代谢组和转录组解析人参皂苷组织和发育特异性的代谢差异[D]. 哈尔滨:东北林业大学,2017.
XIAO Y, LI H, LI Y, et al. A review of microbial metabolomics in soil environment research[J]. Adv Appl Microbiol, 2017, 6(4): 116-123.
LEE Y S, PARK H S, LEE D K, et al. Integrated transcriptomic and metabolomic analysis of five Panax ginseng cultivars reveals the dynamics of ginsenoside biosynthesis[J]. Front Plant Sci, 2017, 8:1048.
LEE Y S, PARK H S, LEE D K, et al. Comparative analysis of the transcriptomes and primary metabolite profiles of adventitious roots of five Panax ginseng cultivars[J]. J Ginseng Res, 2017, 41(1): 60-68.
BIAN X B, ZHAO Y, XIAO S Y, et al. Metabolome and transcriptome analysis reveals the molecular profiles underlying the ginseng response to rusty root symptoms[J]. BMC Plant Biol, 2021, 21(1): 215.
吕尚,杨世林,饶毅,等. 代谢组学及其相关技术在中药研发领域的应用进展[J]. 中国中药杂志,2018, 43(21): 4182-4191.
0
浏览量
1340
下载量
0
CSCD
0
CNKI被引量
关联资源
相关文章
相关作者
相关机构