Objective,2,To study the effects of Pingchuan Recipe on high mobility group protein B1/Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB）， airway remodeling related factors IκB kinase family （IKKs） and transforming growth factor-β1 （TGF-β1） in asthmatic mice.,Methods,2,Thirty-two male Balb/c mice were randomly divided into 4 groups： blank group， model group， dexamethasone group， and Pingchuan Recipe group， with 8 mice in each group. The asthma model was established by intraperitoneal injection of ovalbumin （OVA） with aluminum hydroxide and aerosolized inhalation of 5% OVA. One hour after atomization on the same day， Pingchuan Recipe was administered by gavage for 14 days. Serum， bronchoalveolar lavage fluid （BALF） and lung tissues were collected from mice in each group after the last administration. HE staining was used to observe the histopathological changes in the lungs of mice. Immunohistochemical staining was used to observe the expression of HMGB1， TLR4 and NF-κB. The content of HMGB1， TLR4， TGF-β1 and IKKs in BALF and peripheral blood was determined by ELISA. The expression of HMGB1， TLR4， NF-κB and IKKs mRNA in lung tissues was detected by RT-PCR. The expression of HMGB1 and TLR4 proteins in lung tissues was detected by Western blot.,Results,2,Compared with the condition of the blank group， the model group had severe airway remodeling， increased expression of HMGB1， TLR4 and NF-κB， increased HMGB1， TLR4， TGF-β1 and IKKs secretion （,P,<,0.05）， increased ,HMGB1,， ,TLR4,， ,NF⁃κB, and ,IKKs, mRNA expression （,P,<,0.05）， and increased HMGB1 and TLR4 protein expression （,P,<,0.05）. Compared with the condition of the model group， Pingchuan Recipe group had alleviated airway remodeling， significantly lower HMGB1， TLR4， TGF-β1 and IKKs secretion （,P,<,0.05）， reduced ,HMGB1,， ,TLR4,， ,NF⁃κB, and ,IKKs, mRNA expression （,P,<,0.05）， and decreased HMGB1 and TLR4 protein expression （,P,<,0.05）.,Conclusion,2,Pingchuan Recipe can reduce ,HMGB1,， ,TLR4,， ,NF,-,κB ,and ,IKKs, mRNA expression， decrease IKKs and TGF-β1 secretion， lower HMGB1 and TLR4 protein expression， alleviate the inflammation of lung tissues， and improve the pathological changes of lung tissues in asthmatic model mice.