Objective,2,To investigate Shanghai residents’ acceptance of traditional Chinese medicine （TCM） for combating novel coronavirus disease （“COVID-19”） pandemic.,Methods,2,Convenience and volunteer sampling methods were used to investigate the acceptance of TCM to combat the COVID-19 among medical personnel， community volunteers and residents in Shanghai.,Results,2,①A total of 662 valid questionnaires were collected. Among the 662 respondents， 41.1% were male， the age ranged from 20 to 60 years， and 29.2% were engaged in the medical profession. The results of univariate analysis showed that gender， age， occupation， education level， and personal monthly income had no significant effect on the acceptance of TCM. ②In this survey， 639 respondents believed in TCM treatment， accounting for 96.5% of the total. Among them， 584 respondents had used TCM before， accounting for 91.4%； 600 respondents showed their willingness to recommend others to use TCM for the pandemic prevention and control， accounting for 93.9%； and 500 respondents recommended TCM prescriptions alone to fight against the COVID-19， accounting for 78.2%. ③Compared with respondents who had never used TCM， those who had used TCM before were more likely to recommend others to use TCM for the pandemic prevention and control （,P,=0.004）； those who had used TCM before were more concerned about the flavor and other issues of TCM （,P,=0.054， ,P,=0.003）， and those who had not used TCM before were more concerned about effectiveness and safety of TCM （,P,=0.005，,P,=0.045）. ④Residents in Shanghai showed a wide range of demands for TCM， and the strongest ones were ranked in descending order： TCM treatment， TCM prevention and TCM science popularization， with a frequency of 452， 443， and 424， respectively.,Conclusions,2,Shanghai residents have a high level of acceptance of TCM and its use in the prevention and treatment of COVID-19 pandemic. Therefore， it is recommended to further the application of TCM in the pandemic prevention and control in response to the realistic demands.