1.上海中医药大学附属龙华医院肛肠科(上海 200032)
2.上海市嘉定区中医医院肛肠科(上海 201800)
3.上海市普陀区中医医院肛肠科(上海 200062)
孙琰婷,女,博士研究生,主要从事良性肛肠疾病的中西医结合诊疗工作
陆金根,主任医师,教授,博士研究生导师; E-mail:jingen.lu@shutcm.edu.cn
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孙琰婷,厉越,陈倚,等.基于数据挖掘的陆金根治疗功能性便秘组方用药规律研究[J].上海中医药杂志,2022,56(11):21-28.
SUN Yanting,LI Yue,CHEN Yi,et al.Data mining⁃based research on Professor Lu Jingen’s prescription regularity in treating functional constipation[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):21-28.
孙琰婷,厉越,陈倚,等.基于数据挖掘的陆金根治疗功能性便秘组方用药规律研究[J].上海中医药杂志,2022,56(11):21-28. DOI: 10.16305/j.1007-1334.2022.2203029.
SUN Yanting,LI Yue,CHEN Yi,et al.Data mining⁃based research on Professor Lu Jingen’s prescription regularity in treating functional constipation[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):21-28. DOI: 10.16305/j.1007-1334.2022.2203029.
目的,2,借助数据挖掘方法分析陆金根教授治疗功能性便秘的用药经验与组方规律,总结治疗原则。,方法,2,收集2018年1月至2021年1月,陆金根教授在上海中医药大学附属龙华医院门诊诊治的功能性便秘的病例资料,用Microsoft Excel软件录入处方信息,借助R语言数据分析平台进行数据挖掘,分析中药使用频次、关联规则以及聚类情况,并进行相关分析。,结果,2,①共纳入中药处方261首,涉及中药129味,用药总频次4 748次;其中使用频次>200次的中药共14味,使用频次>30次的中药以补虚药、清热药、活血化瘀药、化痰药、润下药、行气药为主。②关联规则和聚类分析得出2个基础处方,即黄芪、白术、玄参、地黄、麦冬、南沙参、北沙参,以及当归、枳实、丹参、瓜蒌、火麻仁、莱菔子、桔梗、甘草;得出2个常用药对,即苦杏仁-郁李仁,以及红花-桃仁;得出2个药物组合,即百合-知母-玫瑰花-石菖蒲,以及大枣-淮小麦-炙甘草-灵芝-太子参。③相关分析得出高度相关的药对如下:红花-桃仁、南沙参-北沙参、百合-知母、大枣-淮小麦、玫瑰花-石菖蒲。,结论,2,陆金根教授治疗功能性便秘时以益气养阴、宣肺清化为总则,结合行气、活血、润下、宁神之法,临证以益气开秘方为基础进行加减,着重使用具有益气、养阴、补脾功效的中药,为功能性便秘的临床诊疗提供了思路。
Objective,2,To use data mining methods to analyze Professor Lu Jingen’s medication experience and prescription pattern of traditional Chinese medicine (TCM) in treating functional constipation and summarize treatment principles.,Methods,2,The cases of functional constipation treated by Professor Lu Jingen in Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine from January 2018 to January 2021 were collected. The prescription information was extracted with Microsoft Excel software, and data mining was performed with R language data analysis platform to analyze the use frequency, association rules and clustering of traditional Chinese herbal medicines (TCHMs), and the correlation analysis was also performed.,Results,2,①A total of 261 TCM prescriptions were included, involving 129 TCHMs with a total frequency of 4,748 times. Fourteen TCHMs were used over 200 times, and TCHMs used more than 30 times were mainly categorized into deficiency-tonifying medicines, heat-clearing medicines, blood-activating and stasis-removing medicines, phlegm-resolving medicines, bowel-moistening medicines and qi-promoting medicines. ②Based on association rules and clustering analysis, two basic formulas were obtained, i.e., formula No.1 was composed of Huangqi (Astragali Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), Xuanshen (Scophulariae Radix), Dihuang (Rehmanniae Radix), Maidong (Ophiopogonis Radix), Nanshashen (Adenophorae Radix) and Beishashen (Glehniae Radix), and formula No. 2 was composed of Danggui (Angelicae Sinensis Radix), Zhishi (Aurantii Fructus Immaturus), Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Gualou (Trichosanthis Fructus), Huomaren (Cannabis Fructus), Laifuzi (Raphani Semen), Jiegeng (Platycodonis Radix) and Gancao (Glycyrrhizae Radix et Rhizoma); Two couplet medicines were obtained, i.e., Kuxingren (Armeniacae Semen Amarum) – Yuliren (Pruni Semen), and Honghua (Carthami Flos) – Taoren (Persicae Semen); And two combinations of medicines were obtained, i.e., Baihe (Lilii Bulbus) – Zhimu (Anemarrhenae Rhizoma) – Meiguihua (Rosae Rugosae Flos) – Shichangpu (Acori Tatarinowii Rhizoma), and Dazao (Jujubae Fructus) – Huaixiaomai (Triticum aestivum L.) – Zhigancao (Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) – Lingzhi (Ganoderma) – Taizishen (Pseudostellariae Radix). ③The correlation analysis showed that the highly correlated couplet medicines were as follows: Honghua (Carthami Flos) – Taoren (Persicae Semen), Nanshashen (Adenophorae Radix) – Beishashen (Glehniae Radix), Baihe (Lilii Bulbus) – Zhimu (Anemarrhenae Rhizoma), Dazao (Jujubae Fructus) – Huaixiaomai (Triticum aestivum L.), and Meiguihua (Rosae Rugosae Flos) – Shichangpu (Acori Tatarinowii Rhizoma).,Conclusions,2,When treating functional constipation, Professor Lu Jingen takes invigorating qi and nourishing yin, dispersing lung and resolving turbidity as the general principles flexibly, chooses the methods of moving qi, activating blood, moistening bowels and calming mind, modifies individual prescription on the basis of “Yiqi Kaimi Formula” in clinical practice, and focuses on the use of TCHMs with the effects of supplementing qi, nourishing yin and invigorating spleen. Professor Lu’s clinical experience can provide ideas for clinical diagnosis and treatment of functional constipation.
功能性便秘中医药疗法名医经验数据挖掘用药规律
functional constipationtraditional Chinese medicine therapyfamous doctor’s experiencedata miningmedication pattern
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