1.黑龙江中医药大学药学院(黑龙江 哈尔滨 150000)
张具斌,男,硕士研究生,主要从事中药血清药物化学及药效物质基础研究工作
吴修红,教授,博士研究生导师; E-mail:wxh8088@qq.com
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张具斌,朴成玉,刘婷婷等.中药调控NF⁃κB相关信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2022,56(05):98-101.
ZHANG Jubin,PIAO Chengyu,LIU Tingting,et al.Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(05):98-101.
张具斌,朴成玉,刘婷婷等.中药调控NF⁃κB相关信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2022,56(05):98-101. DOI: 10.16305/j.1007-1334.2022.2111043.
ZHANG Jubin,PIAO Chengyu,LIU Tingting,et al.Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(05):98-101. DOI: 10.16305/j.1007-1334.2022.2111043.
综述中药调控核因子-κB(NF-κB)相关信号通路防治糖尿病肾病(DN)的研究进展。研究表明,DN的发生伴有NF-κB相关信号通路的异常活化,中药单体(毛蕊异黄酮、小檗碱、雷公藤红素等)及中药复方(芪丹地黄汤、黄芪汤、益肾胶囊等)可通过靶向调控NF-κB相关信号通路有效防治DN。
This paper reviewed the research progress on Chinese medicine in the prevention and treatment of diabetic nephropathy (DN)by interfering with nuclear factor-kappa B (NF-κB) related signaling pathways. Studies had been confirmed that DN was accompanied with abnormal activation of NF-κB related signaling pathways. Chinese medicine monomer (calycosin, berberine, tripterine, etc.) and Chinese medicine compound prescriptions(Qidan Dihuang Decoction, Huangqi Decoction, Yishen Capsule, etc.) could effectively prevent DN by interfering with NF-κB related signaling pathways.
核因子-κB信号通路糖尿病肾病中药综述
NF-κB signaling pathwaydiabetic nephropathytraditional Chinese herbal medicinereview
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