Objective,2,To observe the clinical efficacy of Feiyanning Granule in treating the intermediate and advanced stage lung squamous cell carcinoma （LSCC） of male patients with essence and qi deficiency syndrome.,Methods,2,Sixty male patients with intermediate and advanced stage LSCC of essence and qi deficiency syndrome were randomly divided into a treatment group （,n,=30） and a control group （,n,=30）. The treatment group was treated with Feiyanning Granule， while the control group was treated with Feiyanning Granule simulant. The course of treatment of both groups lasted 2 months. We observed the clinical efficacy， and compared the changes of Traditional Chinese Medicine （TCM） syndrome score， Karnofsky Performance Status （KPS） score， serum tumor markers and related immune indexes.,Results,2,①After treatment， the disease control rate of the treatment group was 80.0% and that of the control group was 56.7%. The clinical efficacy of the treatment group was better than that of the control group （,P,<,0.05）. ②According to the intra-group comparison before and after treatment， the scores of fatigue， cough， hemoptysis， pain and insomnia in the treatment group decreased （,P,<,0.05）， while there was no significant difference in the above-mentioned TCM syndrome scores in the control group （,P,>,0.05）. After treatment， the scores of fatigue， cough， hemoptysis， pain and insomnia in the treatment group were lower than those in the control group （,P,<,0.05）. ③The KPS score of the treatment group was better than that of the control group （,P,<,0.05）. ④The intra-group comparison before and after treatment showed that the levels of cancer antigen 12-5 （CA12-5）， cytokeratin 19 fragment antigen 21-1 （CYFRA21-1） and squamous cell cancinoma associated antigen（SCC） in the treatment group decreased （,P,<,0.05）； there was no significant difference in the level of tumor markers in the control group （,P,>,0.05）； after treatment， the levels of CA125， CYFRA21-1 and SCC in the treatment group were lower than those in the control group （,P,<,0.05）. ⑤There was no significant difference in the immune indexes between the two groups before and after treatment （,P,>,0.05）； After treatment， the levels of CD4, +, and NK cells in the treatment group were higher than those in the control group （,P,<,0.05）.,Conclusion,2,Feiyanning Granule is effective in the treatment of intermediate and advanced stage lung squamous cell carcinoma of male patients with essence and qi deficiency syndrome， as it can effectively improve the clinical symptoms and immune function， enhance the quality of life， reduce serum levels of tumor markers and inhibit tumor growth.