1.海军军医大学附属长征医院中医科(上海 200003)
王晓炜,男,硕士,主治医师,主要从事消化系统疾病的中西医结合治疗工作
刘煊,博士,副主任医师;E-mail:18616630816@163.com
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王晓炜,张慈安,修丽娟等.316例结直肠癌前病变患者中医证型分布规律及肠镜下切除术后转归的回顾性研究[J].上海中医药杂志,2022,56(02):30-33.
WANG Xiaowei,ZHANG Ci’an,XIU Lijuan,et al.A retrospective study on the distribution of TCM syndromes and prognosis after colonoscopic resection in 316 patients with colorectal precancerous lesions[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(02):30-33.
王晓炜,张慈安,修丽娟等.316例结直肠癌前病变患者中医证型分布规律及肠镜下切除术后转归的回顾性研究[J].上海中医药杂志,2022,56(02):30-33. DOI: 10.16305/j.1007-1334.2022.2109124.
WANG Xiaowei,ZHANG Ci’an,XIU Lijuan,et al.A retrospective study on the distribution of TCM syndromes and prognosis after colonoscopic resection in 316 patients with colorectal precancerous lesions[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(02):30-33. DOI: 10.16305/j.1007-1334.2022.2109124.
目的,2,探析结直肠癌前病变患者的中医证型分布规律,随访其再发情况和癌变情况。,方法,2,以2010年1月至2015年12月海军军医大学附属长征医院收治的结直肠癌前病变患者为研究对象,回顾性分析其基线情况(病理类型、性别、年龄、腺瘤位置、瘤体大小等)、中医辨证分型、再发率、癌变率等。,结果,2,①本研究期间,最终共收集有效病例316例。其中,低级别上皮内瘤变(LGIN)217例,高级别上皮内瘤变(HGIN)99例;男性(58.54%)占比略多于女性(41.46%);患者年龄以40~60岁为多见(65.82%);癌前病变好发于左半结肠(73.42%);瘤体大小,多数在2 cm以下(86.08%)。②患者中,脾虚气滞证73例,湿热蕴结证86例,痰浊壅盛证85例,阳虚寒凝证37例,血瘀证35例。③中医辨证结果显示,湿热蕴结证和痰浊壅盛证占比较高,分别为27.22%和26.90%,其次是脾虚气滞证,占比23.10%。在LGIN组中,脾虚气滞证和湿热蕴结证居多,二者占比均为27.65%;在HGIN组中,痰浊壅盛证占比最高,为32.32%,其次是湿热蕴结证,占比26.26%。④在LGIN组中,湿热蕴结证患者的5年再发率最高,为61.67%;阳虚寒凝证、痰浊壅盛证和脾虚气滞证患者的5年再发率分别为58.33%、56.60%、40.00%,血瘀证患者的5年再发率最低,为35.00%。在HGIN组中,血瘀证患者的5年再发率最高,为80.00%,湿热蕴结证、痰浊壅盛证患者的5年再发率分别为69.23%、62.50%,脾虚气滞证与阳虚寒凝证患者的5年再发率均为53.85%。⑤在癌变情况方面,痰浊壅盛证、湿热蕴结证、血瘀证组中均有发生癌变的患者,癌变率分别为9.38%、6.67%、3.85%。,结论,2,在结直肠癌前病变患者中,湿热蕴结证、痰浊壅盛证及脾虚气滞证是临床主要中医证型。对于本病而言,痰浊、湿热、血瘀不仅是病理产物,也是致病因素,是导致本病复发、进展的重要病理因素,临床中应予重点关注。
Objective,2,To explore the distribution of traditional Chinese medicine (TCM) syndromes in patients with colorectal precancerous lesions, and follow up their recurrence rate and canceration rate.,Methods,2,The patients with colorectal precancerous lesions admitted to Changzheng Hospital affiliated to Naval Military Medical University from January 2010 to December 2015 were enrolled as the research objects, and their baseline conditions (pathological type, gender, age, adenoma location and size, etc.), TCM syndrome differentiation, recurrence rate and canceration rate were analyzed retrospectively.,Results,2,①In the course of study, a total of 316 effective cases were collected. Among them, there were 217 cases of low-grade intraepithelial neoplasia (LGIN) and 99 cases of high-grade intraepithelial neoplasia (HGIN); there were slightly more males (58.54%) than females (41.46%); the age range of most patients was from the age of 40 to 60 (65.82%); precancerous lesions mostly occurred in the left colon (73.42%); most tumors were less than 2 cm in size (86.08%). ②There were 73 cases of spleen deficiency and qi stagnation syndrome, 86 cases of damp-heat accumulation and binding syndrome, 85 cases of excessive phlegm-turbidity stagnation syndrome, 37 cases of yang deficiency and cold coagulation syndrome, and 35 cases of blood stasis syndrome. ③The results of TCM syndrome differentiation showed that the cases with damp-heat accumulation and binding syndrome and excessive phlegm-turbidity stagnation syndrome accounted for 27.22% and 26.90% respectively, followed by cases with spleen deficiency and qi stagnation syndrome (23.10%). In the LGIN group, the cases with spleen deficiency and qi stagnation syndrome (27.65%) and damp-heat accumulation and binding syndrome (27.65%) were in the majority; In the HGIN group, the cases with excessive phlegm-turbidity stagnation syndrome accounted for 32.32%, which was the highest proportion, followed by the cases with damp-heat accumulation and binding syndrome, which accounted for 26.26%. ④In the LGIN group, cases with the damp-heat accumulation and binding syndrome had the highest 5-year recurrence rate (61.67%), followed by the cases with yang deficiency and cold coagulation syndrome (58.33%), excessive phlegm-turbidity stagnation syndrome (56.6%) and spleen deficiency and qi stagnation syndrome (40.00%), and cases with blood stasis syndrome had the lowest 5-year recurrence rate (35.00%). In the HGIN group, cases with the blood stasis syndrome had the highest 5-year recurrence rate (80.00%), followed by cases with damp-heat accumulation and binding syndrome (69.23%), excessive phlegm-turbidity stagnation syndrome (62.50%), spleen deficiency and qi stagnation syndrome (53.85%) and yang deficiency and cold coagulation syndrome (53.85%). ⑤In terms of canceration rate, patients with canceration usually had excessive phlegm-turbidity stagnation syndrome, damp-heat accumulation and binding syndrome or blood stasis syndrome, and the canceration rates of each syndrome were 9.38%, 6.67% and 3.85% respectively.,Conclusions,2,Patients with colorectal precancerous lesions mostly have damp-heat accumulation and binding syndrome, excessive phlegm-turbidity stagnation syndrome or spleen deficiency and qi stagnation syndrome. Phlegm-turbidity, damp-heat and blood stasis are not only pathological products, but also important pathogenic factors leading to the recurrence and canceration of colorectal precancerous lesions, which should be paid special attention to in clinical practice.
结直肠癌癌前病变腺瘤性息肉肠镜下切除术后中医证型复发预后转归
colorectal cancerprecancerous lesionadenomatous polypafter colonoscopic resectionTCM syndromerecurrenceprognostic outcome
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