1.上海中医药大学康复医学院(上海 201203)
2.上海沪东医院中医科(上海 200129)
3.上海沪东医院康复科(上海 200129)
王健,男,博士,副教授,主要从事老年病的中医药防治与康复工作
张辉,主任医师;E-mail:15001921900@163.com
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王健,金蕾,汪六运,等.穴位按摩结合常规认知康复训练治疗卒中后认知障碍的临床观察[J].上海中医药杂志,2022,56(1):71-74.
WANG Jian,JIN Lei,WANG Liuyun,et al.Clinical observation on acupressure combined with cognitive rehabilitation training for cognitive impairment after stroke[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(1):71-74.
王健,金蕾,汪六运,等.穴位按摩结合常规认知康复训练治疗卒中后认知障碍的临床观察[J].上海中医药杂志,2022,56(1):71-74. DOI: 10.16305/j.1007-1334.2022.2108131.
WANG Jian,JIN Lei,WANG Liuyun,et al.Clinical observation on acupressure combined with cognitive rehabilitation training for cognitive impairment after stroke[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(1):71-74. DOI: 10.16305/j.1007-1334.2022.2108131.
目的,2,观察基于中医神明理论的穴位按摩结合常规认知康复训练对卒中后认知障碍患者认知功能、日常生活能力及血浆,β,淀粉样蛋白1-42(A,β,1-42,)水平的影响。,方法,2,将66例卒中后认知障碍患者随机分为对照组和治疗组,每组33例。对照组采用常规认知康复训练,治疗组在对照组基础上加用基于中医神明理论的穴位按摩。两组疗程均为12周,观察蒙特利尔认知评估量表(MoCA)、日常生活能力(ADL)评分和血浆A,β,1-42,水平的变化情况。,结果,2,治疗前后组内比较,两组MoCA评分值升高(,P,<0.05),ADL评分值、血浆A,β,1-42,水平降低(,P,<0.05);组间治疗后比较,治疗组MoCA评分高于对照组(,P,<0.05),血浆A,β,1-42,水平低于对照组(,P,<0.05),ADL评分差异无统计学意义(,P,>0.05)。,结论,2,与单纯采用认知康复训练相比,联合使用基于中医神明理论的穴位按摩治疗卒中后认知障碍疗效满意,能更好地改善患者的认知功能,提高日常生活能力,降低血浆A,β,1-42,水平。
Objective,2,To observe the effects of acupressure based on the Shen-Ming theory of traditional Chinese medicine (TCM) combined with conventional cognitive rehabilitation training on cognitive function, activities of daily living and plasma concentrations of ,β,-amyloid 1-42 (A,β,1-42,) in patients with post-stroke cognitive impairment.,Methods,2,Sixty-six patients with post-stroke cognitive impairment were randomly divided into a control group (,n,=33) and a treatment group (,n,=33). The control group was administered with conventional cognitive rehabilitation training, and the treatment group was additionally administered with TCM Shen-Ming theory-based acupressure besides the treatment measures of the control group. The course of treatment of the two groups lasted 12 weeks, and the changes of Montreal Cognitive Assessment (MoCA) score, activities of daily living (ADLs) scale score and plasma concentrations of A,β,1-42, were observed and compared.,Results,2,According to the intra-group comparison before and after treatment, MoCA scores increased (,P,<,0.05) and ADL scores and the plasma concentrations of A,β,1-42, decreased (,P,<,0.05) in both groups. According to the inter-group comparison after treatment, MoCA score was higher in the treatment group than that in the control group (P,<,0.05), the plasma concentrations of A,β,1-42, in the treatment group were lower than the concentrations in the control group (,P,<,0.05), and there was no significant difference in ADL score between two groups (,P,>,0.05).,Conclusion,2,Compared with the single use of cognitive rehabilitation training, the combined use of TCM Shen-Ming theory-based acupressure and cognitive rehabilitation training has achieved satisfactory results in treating post-stroke cognitive impairment, which can better improve patients’ cognitive function, facilitate activities of daily living and lower plasma concentrations of A,β,1-42,.
卒中后认知障碍认知功能穴位按摩β淀粉样蛋白1-42神明理论中西医结合疗法
post-stroke cognitive impairmentcognitive functionacupressureβ⁃amyloid 1-42Shen-Ming theoryintegrated traditional Chinese and western medicine therapy
中国卒中学会血管性认知障碍分会. 卒中后认知障碍管理专家共识2021[J]. 中国卒中杂志,2021, 16(4): 376-389.
张通,王强. 卒中后认知障碍的康复治疗[J]. 华西医学,2019, 34(5): 481-486.
中国卒中学会卒中后认知障碍研究圆桌会议专家组. 中国卒中后认知障碍防治研究专家共识[J]. 中国卒中杂志,2020, 15(2): 158-166.
王辉,邹愉龙,蔡素芳. 留置头皮针下作业治疗对脑卒中后认知障碍的疗效[J]. 神经病学与神经康复学杂志,2021, 17(1): 19-25.
刘婷,李川,谷令,等. 有氧运动联合高压氧治疗对脑卒中后认知障碍的疗效及氧化应激的影响[J]. 中华物理医学与康复杂志,2021, 43(7): 623-627..
中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国各类主要脑血管病诊断要点2019[J]. 中华神经科杂志,2019, 52(9): 710-715.
中华医学会神经病学分会,中华医学会神经病学分会神经康复学组,中华医学会神经病学分会脑血管病学组. 中国脑卒中早期康复治疗指南[J]. 中华神经科杂志,2017, 50(6): 405-412.
NASREDDINE Z S, PHILLIPS N A, BEDIRIANV, et al. The Montreal Cognitive Assessment,MoCA:a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc, 2005, 53(4): 695-699.
许贤豪. 神经心理量表检测指南[M]. 北京:中国协和医科大学出版社,2007: 66-67.
林水淼,王健,周如倩,等. 从心肾论治阿尔茨海默病的临床效果[J]. 中国临床康复,2006, 10(11): 162-164.
王健,林水淼. “心肾同治”阿尔茨海默病的思考[J]. 上海中医药杂志,2011, 45(9): 22-23.
ZHANG Y, CONG D, LIU P, et al. Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain-intestine interaction in the treatment of insomnia[J]. Medicine, 2021, 100(19): e25854.
沈翠玲,刘芳,姚立群. 穴位按摩改善认知功能障碍的研究进展[J]. 中国老年学杂志,2019, 39(2): 498-500.
WANG M, LIU L, ZHANG C S, et al. Mechanism of traditional Chinese medicine in treating knee osteoarthritis[J]. J Pain Res, 2020(13): 1421-1429.
EGGART M, QUERI S, MÜLLER-OERLINGHAUSEN B. Are the antidepressive effects of massage therapy mediated by restoration of impaired interoceptive functioning? A novel hypothetical mechanism[J]. Med Hypotheses,2019(128): 28-32.
LIU F, SHEN C, YAO L, et al. Acupoint massage for managing cognitive alterations in older adults: A systematic review and meta-analysis[J]. J Altern Complement Med, 2018, 24(6): 532-540.
施海金,周丹丹,王安琪. 穴位按摩对脑卒中患者运动功能日常生活能力以及认知功能的干预效果观察[J]. 中国中医药科技,2019, 26(2): 251-252.
罗颖,胡慧. 穴位按摩干预痴呆症及轻度认知障碍患者的研究进展[J]. 湖北中医杂志,2021, 43(2): 64-66.
ISHIMARU H, ISHIKAWA K, HAGA S, et al. Accumulation of apolipoprotein E and beta-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death[J]. Neuroreport, 1996, 7(18): 3063-3067.
顾杨,王宏,李军明,等. 血清可溶性CD40配体、β淀粉样蛋白1-42水平对卒中后认知功能障碍的诊断效能[J]. 山东医药,2017, 57(43): 49-51.
THIEL A, CECHETTO D F, HEISS W D, et al. Amyloid burden, neuroinflammation, and links to cognitive decline after ischemic stroke[J]. Stroke, 2014, 45(9): 2825-2829.
李朝远,刘春红,杨涵伟,等. 血清β淀粉样蛋白和Tau蛋白与急性脑梗死伴认知功能障碍及脑白质高信号相关性研究[J]. 医学食疗与健康,2020, 18(3): 21-22,33.
VERBERK I M W, SLOT R E, VERFAILLIE S C J, et al. Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes[J]. Ann Neurol, 2018, 84(5): 648-658.
李薇薇,徐亚丽,沈盈盈,等. 阿尔茨海默病血液标志物与淀粉样蛋白PET诊断的相关性研究[J]. 阿尔茨海默病及相关病杂志,2018, 1(1): 12-17.
毛蕾. 血浆Aβ1-42、tau蛋白及甲状腺激素水平对缺血性卒中后认知障碍发生的预测价值[D]. 上海:海军军医大学,2020.
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