1.上海中医药大学附属曙光医院肾病科(上海 201203)
2.上海市闵行区梅陇社区卫生服务中心全科(上海 201101)
3.上海中医药大学中医肾病研究所(上海 201203)
4.肝肾疾病病证教育部重点实验室(上海 201203)
5.上海市中医临床重点实验室(上海 201203)
徐飞鹏,男,硕士研究生,主要从事中西医结合诊治慢性肾脏病临床研究工作
沈沛成,主任医师,硕士研究生导师; E-mail:Spc111215@163.com
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徐飞鹏,张亚君,沈沛成等.基于伏邪理论探讨肠-肾轴对慢性肾脏病的影响[J].上海中医药杂志,2022,56(05):36-38.
XU Feipeng,ZHANG Yajun,SHEN Peicheng,et al.To explore effect of intestine⁃kidney axis on chronic kidney disease based on theory of hidden pathogen[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(05):36-38.
徐飞鹏,张亚君,沈沛成等.基于伏邪理论探讨肠-肾轴对慢性肾脏病的影响[J].上海中医药杂志,2022,56(05):36-38. DOI: 10.16305/j.1007-1334.2022.2108019.
XU Feipeng,ZHANG Yajun,SHEN Peicheng,et al.To explore effect of intestine⁃kidney axis on chronic kidney disease based on theory of hidden pathogen[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(05):36-38. DOI: 10.16305/j.1007-1334.2022.2108019.
基于伏邪理论探讨肠-肾轴对慢性肾脏病的影响。慢性肾脏病的发病具有隐匿性,与中医伏邪有相似之处;肠道菌群紊乱产生的内毒素及微炎症对肾脏的损伤与伏邪致病具有类似之处;当肠黏膜发生免疫炎症时会导致慢性肾脏病的加重,这与伏邪的外发与化火类似。
To explore the effect of intestinal-kidney axis on chronic kidney disease based on the theory of hidden pathogen. The onset of chronic kidney disease was occult, which was similar to the hidden pathogen in traditional Chinese medicine. The damage of kidney caused by endotoxin and micro-inflammation on account of intestinal flora disturbance was similar to that caused by hidden pathogens. When the immune inflammation of intestinal mucosa occurred, it could lead to the aggravation of chronic kidney disease, which was similar to the external occurrence of hidden pathogen and hidden pathogen transforming into fire.
伏邪肠-肾轴肠道菌群慢性肾脏病
hidden pathogenintestine-kidney axisintestinal florachronic kidney disease
RITZ E. Intestinal-renal syndrome: mirage or reality?[J]. Blood Purif, 2011, 31(1-3):70-76.
LEHTO M, GROOP P H. The gut-kidney axis: putative interconnections between gastrointestinal and renal disorders[J]. Front Endocrinol (Lausanne), 2018 (9): 1-11.
李经纬,余瀛鳌,蔡景峰,等. 中医大辞典[M]. 北京:人民卫生出版社,1995: 526.
赵明芬,安冬青,汪建萍. 试论伏邪理论的源流及发展[J]. 中医杂志,2016, 57(3): 189-192.
江顺奎,李雷,侯敏. 试论伏邪疾病的治疗规律[J]. 中医杂志,2012, 53(13): 1160-1162.
吴雄志. 吴述温病研究·伏邪[M]. 沈阳:辽宁科学技术出版社,2017: 26-29.
赵洁,史伟,樊均明,等. 从伏邪论治IgA肾病的理论探讨[J]. 中华中医药杂志,2019, 34(10): 4709-4712.
陈楠. 慢性肾炎分子遗传新机制和临床诊治新策略[J]. 上海医学,2018, 41(12): 739-741.
王珏,刘军莉,赵敬杰. HLA-DRB1基因多态性与慢性肾小球肾炎相关性[J]. 山东大学学报(医学版),2008, 46(8): 759-762.
毛君来. 慢性肾炎急性发作的治疗探究[J]. 吉林医学,2012, 33(18): 3961-3962.
李雯雯,黄迪,沈沛成,等. 益气固本调免方治疗气阴两虚型IgA肾病热结咽喉证[J].中国实验方剂学杂志,2016, 22(1): 166-170.
THAISA M C J, DANIELE M F, LUISA M D S, et al. Polysaccharides from prunes: Gastroprotective activity and structural elucidation of bioactive pectins[J]. Food Chem, 2014, 128(146): 492-499.
LUCIMARA M C C, VANESSA D F R, CRISTIANE H B, et al. Arabinan and arabinan-rich pectic polysaccharides from quinoa (Chenopodium quinoa) seeds: Structure and gastroprotective activity[J]. Food Chem, 2012, 130(4): 937-944.
YU C, WANG Z, TAN S, et al. Chronic kidney disease induced intestinal mucosal barrier damage associated with intestinal oxidative stress injury[J]. Gastroenterol Res Pract, 2016(9): 76-85.
CANI P D, POSSEMIERS S, WIELE T V D, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2- driven improvement of gut permeability[J]. Gut, 2009, 58(8): 1091-1103.
RAUTAVA S, LUOTO R, SALMINEN S, et al. Microbial contact during pregnancy, intestinal colonization and human disease[J]. Nat Rev Gastroenterol Hepatol, 2012, 9(10): 565-576.
王娟利,王俭勤.慢性肾衰竭微炎症状态的研究进展[J].中国医学创新,2012, 9(10): 160-162.
金友平,李诗国,李武峰.参芪山腊梅叶汤对慢性肾功能衰竭患者微炎症因子的影响[J].天津中医药,2017, 34(6): 380-381.
李罗德,李永刚,晏子友,等.肾衰竭微炎症状态的中医病机及治疗探讨[J].四川中医,2012, 30(12): 22-23.
LI F, YANG N, ZHANG L, et al. Increased expression of toll-like receptor 2 in rat diabetic nephropathy[J]. Am J Nephrol, 2010, 32(2): 179-186.
杨孟雪,甘华,沈清. 脂多糖对2型糖尿病肾病患者单核细胞TLR4水平及NF-κB, Notch1表达的影响[J]. 中南大学学报(医学版),2012, 37(6): 578-585.
SCHINDLER R. Causes and therapy of microinflammation in renal failure[J]. Nephrol Dial Transplant, 2004, 19 (suppl 5) : 34-40.
HOBBY G P, KARADUTA O, DUSIO G F, et al. Chronic kidney disease and the gut microbiome[J]. Am J Physiol Renal Physiol, 2019, 316(6): F1211-F1217.
邱丽瑛. 柳宝诒《温热逢源》主要学术思想探要[J]. 江西中医药,1988, 37(3): 38-40.
COPPO R. The intestine-renal connection in IgA nephropathy[J]. Nephrol Dial Transplant, 2015, 30 (3) : 360-366.
MCCARTHY D D, KUJAWA J, WILSON C, et al. Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy[J]. J Clin Invest, 2011, 121 (10) : 3991-4002.
刘翔,任红旗. 肠肾连接与IgA肾病[J].中国中西医结合肾病杂志,2015, 16(9) :842-844.
WELANDER A, SUNDELIN B, FORED M, et al. Increased risk of IgA nephropathy among individuals with celiac disease[J]. J Clin Gastroenterol, 2013, 4799(8): 678-683.
钟瑜萍,郑作亮,李海燕,等. 大黄-黄芪不同剂量配比对慢性肾功能衰竭大鼠肠黏膜和肠道菌群移位的影响[J]. 中药药理与临床,2017, 33(2): 130-133.
姚东升,徐琳,兰天鹰,等. 肾衰Ⅱ号方对肾功能衰竭大鼠肠通透性及微炎症的影响[J].中国中医药信息杂志,2021, 28(1): 67-72.
戴铭卉,孔薇. 基于肠肾轴理论探讨通腑泄浊方调节肠道菌群清除慢性肾脏病模型大鼠尿毒症毒素的机制[J]. 中国中医基础医学杂志,2018, 24(8): 1073-1076, 1140.
李成曦,王颖异,王雨萌,等. 白皮杉醇调控肠道菌群减轻慢性肾病模型小鼠并发系统性炎症[J/OL]. 药学学报,2021[2021-08-03]. https://doi.org/10.16438/j.0513-4870.2021-0990https://doi.org/10.16438/j.0513-4870.2021-0990.
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