This paper introduces the understanding and clinical application of Wumei Wan by the representative successors of Longsha Medical School. Huang Huang believes that Wumei Wan mainly treats diseases characterized by vomiting， restlessness， cold limbs， pain， and chronic dysentery. Gu Zhishan believes that Wumei Wan mainly treats patients with diseases due to dysfunction of Jueyin Pivot， disconnection of yin qi and yang qi， cold and heat complex， and some of the diseases appeared or aggravated in the second half of the night. And three proven medical cases are presented.