Objective,2,To observe the clinical efficacy and safety of Wumen Qingre Huazhuo Formula combined with external application of golden plaster in the treatment of acute gouty arthritis.,Methods,2,A total of 62 patients with acute gouty arthritis were randomly divided into treatment group and control group，31 cases in each group. The patients in the treatment group were treated with Wumen Qingre Huazhuo Decoction and external application of golden plaster， while the patients in the control group were treated with oral etoricoxib and external application of Sodium aescinate gel. After persistent treatment for 1 week， the pain VAS score， degree of swelling， temperature of skin， leukocyte， C-reactive protein and serum uric acid， as well as the incidence of adverse drug reactions were compared between the two groups.,Results,2,Compared with the control group， the VAS score of the treatment group had no significant change at 6 h after treatment（,P,>,0.05）， but the VAS scores decreased significantly at 1 day and 7 days after treatment （,P,<,0.05）. Compared with the control group， swelling score， skin temperature score and C-reactive protein levels of the affected limbs in the treatment group decreased significantly at 7 days after treatment （,P,<,0.05）， while the levels of leukocyte and serum uric acid had no significant change （,P,>,0.05）. The incidence of adverse drug reactions was 9.68% in the treatment group and 12.90% in the control group， the difference was not statistically significant （,P,>,0.05）.,Conclusion,2,Wumen Qingre Huazhuo Formula combined with external application of golden plaster can better relieve the acute symptoms of gouty arthritis， improve joint function， reduce inflammation， and do not increase the incidence of adverse drug reactions in the treatment of acute gouty arthritis.