1.上海中医药大学附属龙华医院脑病科(上海 200032)
余阳洋,女,硕士,主治医师,主要从事中西医结合治疗脑病临床研究工作
袁灿兴,主任医师,博士研究生导师;E-mail:18917763103@163.com
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余阳洋, 顾超, 王春旭, 等. 癫痫患者功能性肠病与焦虑、抑郁状态的关系及中医证候分布规律研究[J]. 上海中医药杂志, 2021,55(11):23-26.
Yangyang YU, Chao GU, Chunxu WANG, et al. Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(11):23-26.
余阳洋, 顾超, 王春旭, 等. 癫痫患者功能性肠病与焦虑、抑郁状态的关系及中医证候分布规律研究[J]. 上海中医药杂志, 2021,55(11):23-26. DOI: 10.16305/j.1007-1334.2021.2107078.
Yangyang YU, Chao GU, Chunxu WANG, et al. Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(11):23-26. DOI: 10.16305/j.1007-1334.2021.2107078.
目的,2,探讨癫痫患者功能性肠病(FBD)与焦虑、抑郁状态的关系及中医证型分布规律。,方法,2,将306例癫痫患者根据FBD的患病情况分为伴FBD组(172例)、不伴FBD组(134例),收集病例资料,分析比较两组一般情况(性别、年龄、病程、脑电图、认知功能)、焦虑状态自评量表(SAS)评分、抑郁状态自评量表(SDS)评分及中医证候分布情况,采用logistic回归分析癫痫FBD的影响因素。,结果,2,①伴FBD组年龄大于不伴FBD组,病程长于不伴FBD组,脑电图异常率高于不伴FBD组(,P,<,0.001,,P,<,0.05)。②伴FBD组SAS、SDS评分高于不伴FBD组(,P,<,0.001),SAS、SDS评分异常率高于不伴FBD组(,P,<,0.001)。③logistic回归分析结果显示,癫痫患者的病程、年龄、SAS评分为癫痫伴发FBD的影响因素(,P,<,0.05),其中SAS评分异常的癫痫患者伴发FBD的可能性是SAS评分正常者的6.104倍 [,OR,=6.104,95%,CI,(3.416~10.906),,P,<,0.001]。④伴FBD组患者心脾两虚证最多见(27.91%),不伴FBD组患者瘀阻脑络证最多见(41.79%);痰、虚、瘀三大中医证型分布显示,伴FBD组患者虚证最多见(44.19%),不伴FBD组患者痰证最多见(52.24%)。,结论,2,与不伴FBD比较,伴FBD的癫痫患者焦虑、抑郁情绪更加严重,癫痫病程、患者年龄、焦虑状态均为癫痫患者发生FBD的影响因素;癫痫伴FBD患者以虚证多见,其中占比最高的为心脾两虚证。
Objective,2,To explore the relationship between functional bowel disorder (FBD) and anxiety and depressive states in patients with epilepsy and the distribution of traditional Chinese medicine (TCM) syndromes., Methods,2,A total of 306 patients with epilepsy were divided into the group with FBD (,n,=172) and the group without FBD (,n,=134) according to the disease status of FBD. The case data were collected and analyzed to compare the general conditions (gender, age, disease duration, EEG, cognitive function), Self-rating Anxiety Scale (SAS) scores, Self-rating Depression Scale (SDS) scores and the distribution of TCM symptoms between the two groups. Logistic regression was used to analyze the factors influencing FBD in epileptic patients.,Results,2,①Compared with the conditions in the group without FBD, the age was higher, the disease duration was longer and the EEG abnormality rate was higher in the group with FBD (,P,<,0.001,P,<,0.05). ②SAS and SDS scores were higher in the group with FBD than the scores in the group without FBD (,P,<,0.001), and the abnormal rates of SAS and SDS scores were higher than those in the group without FBD (,P,<,0.001). ③According to the results of logistic regression analysis, the disease duration, age, and SAS scores were influencing factors of FBD in epileptic patients (,P,<,0.05), and epileptic patients with abnormal SAS scores were 6.104 times more likely to have FBD than those with normal SAS scores [,OR,=6.104, 95% ,CI, (3.416-10.906),P,<,0.001]. ④The heart and spleen dual deficiency syndrome was the most common syndrome in the group with FBD (27.91%), and the stasis blocking brain collaterals syndrome was most common syndrome in the group without FBD (41.79%). The distribution of TCM syndromes of phlegm, deficiency and stasis showed that most cases in the group with FBD had deficiency syndomes (44.19%) and most cases in the group without FBD had phlegm syndromes (52.24%).,Conclusion,2,Compared with conditions in the group without FBD, epileptic patients with FBD had more severe anxiety and depression. The disease duration, age, and anxiety and depressive states are all influencing factors in the occurrence of FBD in patients with epilepsy. Epileptic patients with FBD are more likely to have deficiency syndromes, and the heart and spleen dual deficiency syndrome has the highest proportion.
癫痫功能性肠病焦虑状态抑郁状态中医证型
epilepsyfunctional bowel disorderanxiety statedepressive statetraditional Chinese medicine syndrome
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