Objective,2,To explore the medication rules of retention enema with traditional Chinese medicine (TCM) in treating anal sinusitis based on the ancient and modern medical case cloud platform (V2.3.8)., Methods,2,Related literatures of retention enema with TCM in the treatment of anal sinusitis published from the establishment of the databases to March 4, 2021 were retrieved from CNKI, VIP, WanFang Data, VIP, China Biomedical Literature Service Platform (CBM). A database of traditional Chinese medicine prescriptions was established based on the ancient and modern medical case cloud platform (V2.3.8). The "data mining analysis" module was used for the analysis of traditional Chinese herbal medicines (TCHMs) use frequency, nature, taste, tropism and correlation rules, and the "multidimensional analysis" module was used for the core drug analysis and cluster analysis.,Results,2,①Finally 58 articles were included, involving 58 prescriptions and 108 TCHMs. ②TCHMs with high use frequency were Phellodendron chinense Schneid, Coptis Rhizoma, Rhei Radix et Rhizoma, Sophorae Flavescentis Radix and Lonicerae Japonicae Flos, which have cold and warm properties, bitter, pungent and sweet tastes, and enter the liver, stomach, heart, spleen, large intestine and lung meridians. ③Fourteen TCHM combinations were obtained through correlation analysis, and the TCHM pairs with high use frequency were Sophorae Flavescentis Radix-Phellodendron chinense Schneid, Lonicerae Japonicae Flos-Phellodendron chinense Schneid, and Sanguisorbae Radix-Phellodendron chinense Schneid. ④The core medication network was composed of 18 TCHMs, and the core compatibility network was composed of 2 groups of TCHMs. There were 3 categories of TCHMs obtained through cluster analysis.,Conclusion,2,The application of retention enema with TCM to the treatment of anal sinusitis stresses the combined use of cold and warm medicines, and simultaneous regulation of the liver and spleen. The TCHMs used are mainly heat-clearing and detoxifying medicinals, heat-clearing and dampness-drying medicinals, heat-clearing and blood-cooling medicinals, and blood-activating and pain-relieving medicinals, reflecting the pathological characteristics of anal sinusitis: "dampness, heat, toxicity and stasis" .