氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展

汪晓露; 赵勇; 左新河; 谢敏; 付畅

doi:10.16305/j.1007-1334.2021.2101089

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氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展

综述 | 更新时间：2022-08-03

- 氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展
- Research progress on effect of oxidative stress in thyroid cancer and intervention of Chinese medicine monomer in vitro
- 上海中医药杂志 2021年55卷第10期页码：79-83
- 作者机构：
  
  1.湖北中医药大学中医临床学院（湖北　武汉　430061）
  2.湖北省中医院甲状腺疾病诊疗中心（湖北　武汉　430074）
  3.湖北中医药大学第一临床学院（湖北　武汉　430061）
- 作者简介：
  
  汪晓露，女，硕士研究生，主要从事中医药防治内分泌代谢及免疫性疾病的研究工作
  左新河，主任医师，博士研究生导师；E-mail：fl1976@163.com
- 基金信息：
  
  国家中医药管理局陈如泉全国名中医传承工作室建设项目(国中医药人教函〔2018〕119号);国家中医药管理局全国中医学术流派传承工作室第二轮建设项目(国中医药人教函〔2019〕62号)
- DOI：10.16305/j.1007-1334.2021.2101089
  中图分类号：
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汪晓露, 赵勇, 左新河, 等. 氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展[J]. 上海中医药杂志, 2021,55(10):79-83.

Xiaolu WANG, Yong ZHAO, Xinhe ZUO, et al. Research progress on effect of oxidative stress in thyroid cancer and intervention of Chinese medicine monomer in vitro[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(10):79-83.
汪晓露, 赵勇, 左新河, 等. 氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展[J]. 上海中医药杂志, 2021,55(10):79-83. DOI： 10.16305/j.1007-1334.2021.2101089.

Xiaolu WANG, Yong ZHAO, Xinhe ZUO, et al. Research progress on effect of oxidative stress in thyroid cancer and intervention of Chinese medicine monomer in vitro[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(10):79-83. DOI： 10.16305/j.1007-1334.2021.2101089.

摘要

综述氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展。氧化应激以矛盾的方式影响甲状腺癌的进程，既参与肿瘤的形成与发展，亦可导致癌细胞死亡；活性氧的累积参与甲状腺癌的发生和进展，亦可导致癌细胞的迁移与侵袭。小白菊内酯、淫羊藿苷、雷公藤甲素、藏红花素、青蒿琥酯、姜黄素、丹酚酸B、葛根素、紫草素等中药单体能引起体外甲状腺癌细胞内氧化性物质堆积，减少抗氧化酶生成，以此诱导甲状腺癌细胞凋亡等，从而发挥其治疗作用。

Abstract

The research progress on the effect of oxidative stress in thyroid cancer and intervention of Chinese medicine monomer in vitro were reviewed. Oxidative stress affected the process of thyroid cancer in a paradoxical way, it not only participated in the formation and development of tumors, but also led to the death of cancer cells; the accumulation of reactive oxygen species was involved in the occurrence and progression of thyroid cancer, which could also lead to the migration and invasion of cancer cells. There were some Chinese medicine monomers such as parthenolide, icariin, triptolide, crocin, artesunate, curcumin, salvianolic acid B, puerarin and shikonin could cause the accumulation of oxidative substances in thyroid cancer cells in vitro, reduce the production of antioxidant enzymes, thereby inducing the apoptosis of thyroid cancer cells, etc., so as to exert its therapeutic effect.

关键词

氧化应激甲状腺癌细胞凋亡中药单体综述

Keywords

oxidative stressthyroid cancercell apoptosisChinese medicine monomerreview

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