Objective,2,To analyze the characteristics of traditional Chinese medicine (TCM) syndromes and manifestations of primary biliary cholangitis (PBC) and explore the corresponding distribution rules.,Methods,2,TCM four-diagnosis information of 260 PBC cases was collected, factor analysis of selected items was conducted by using the principal component analysis (PCA), the characteristics of PBC TCM syndrome elements were determined based on the criteria of syndrome elements, and items were then clustered according to system cluster analysis method for the purpose of exploring the distribution rules of PBC TCM syndromes.,Results,2,①PBC patients mostly had qi deficiency or yin deficiency manifestations such as mental fatigue, lassitude, epigastric and hypochondriac fullness, dull pain in hypochondriac region, dry eyes, insomnia and dreaminess, inadequate appetite, dizziness, dry mouth, red tongue, and thin pulse, etc. ②The main syndrome elements of PBC disease property were yin deficiency, qi depression, damp-heat, blood stasis and qi deficiency, while the syndrome elements of PBC disease location mainly involved liver, kidney, spleen and gallbladder. ③The results of cluster analysis showed that the majority of PBC cases belonged to deficiency of liver and kidney yin syndrome (32.3%), and the rest belonged to blood stasis blocking collaterals syndrome (23.5%), liver depression and spleen deficiency syndrome (22.3%), damp-heat of liver and gallbladder syndrome (13.1%) and spleen qi deficiency syndrome (8.8%).,Conclusion,2,The disease location of PBC involves liver, kidney, spleen and gallbladder, resulting in deficiency-excess complex syndromes in TCM. Clinically, there are liver and kidney yin deficiency syndrome, blood stasis blocking collaterals syndrome, liver depression and spleen deficiency syndrome, liver and gallbladder damp-heat syndrome and spleen qi deficiency syndrome, of which liver and kidney yin deficiency syndrome and blood stasis blocking collaterals syndrome account for a relatively higher proportion.