This paper discusses the clinical experience of using classical prescriptions in differential treatment of sweating syndrome combined with 5 cases. It is considered that sweating syndrome is the syndrome of abnormal sweat leakage, and it is a kind of pathological sweating, mainly caused by the imbalance of yin and yang, the disharmony between nutrient qi and defensive qi, and the abnormal opening and closing of pores. As the key pathogenesis of sweating syndrome is the disharmony between nutrient qi and defensive qi, the main prescription for the syndrome is Guizhi Decoction combined with Chaihu prescriptions and Baihu prescriptions.