The study and exploration of ,Treatise on Cold Pathogenic Diseases, has gradually formed multiple systems for the interpretation of the book, such as text system, annotation system, disease and syndrome system, treatment and prescription system and clinical diagnosis and treatment system. These systems have made their own breakthroughs, but further in-depth digging on their own and also holistic explorations are expected. Interpreting both ancient and modern literatures would be beneficial for the comprehensive understanding of ,Treatise on Cold Pathogenic Diseases,.