Objective,2,To observe the clinical effect of Huosu Yangwei Syrup combined with SOX chemotherapy regimen in the treatment of advanced gastric cancer (AGC).,Methods,2,A total of 72 AGC patients were randomly divided into treatment group (,n,=36) and control group (,n,=36). The control group was administered with SOX chemotherapy regimen alone, while the treatment group was administered with Huosu Yangwei Syrup besides SOX chemotherapy regimen. Both groups were treated for two courses of treatment, with 21 days as one course of treatment. The clinical efficacy and the incidence of adverse reactions were observed. The changes of TCM syndrome scores and the EORTC Core Quality of Life questionnaire (EORTC QLQ-C30) scores were compared.,Results,2,①During the trial, there were 2 drop-out cases in the treatment group and 1 drop-out case in the control group. A total of 69 patients finally completed the trail, including 34 cases in the treatment group and 35 cases in the control group. ②The total effective rates of the treatment group and the control group were 64.71% and 14.29% respectively, and the clinical efficacy of the treatwent group was significantly better than that of the control group(,P,<,0.05).③According to the intra-group comparison before and after treatment, the TCM syndrome scores in the treatment group decreased after treatment (,P,<,0.05), but there was no significant difference in the TCM syndrome scores in the control group (,P,>,0.05); According to the inter-group comparison before and after treatment, the differences in the TCM syndrome scores were statistically significant (,P,<,0.05). ④The improvement of fatigue, nausea, vomiting and loss of appetite in the treatment group was better than that in the control group (,P,<,0.05) according to the EORTC QLQ-C30 scores. ⑤The incidence of anemia was 47.06% in the treatment group and 71.43% in the control group, and the incidence of nausea and vomiting was 8.82% in the treatment group and 54.29% in the control group. There was statistically significant difference in the incidence of anemia, nausea and vomiting after chemotherapy between the two groups (,P,<,0.05).,Conclusion,2,Compared with the single use of SOX chemotherapy regimen, the combined use of Huosu Yangwei Syrup and Sox regimen in the treatment of advanced gastric cancer shows a more satisfactory result, as it can better improve patients’ clinical symptoms and the quality of life, and reduce the incidence of adverse reactions (anemia, nausea and vomiting) of chemotherapeutic drugs.