中药干预巨噬细胞抗动脉粥样硬化机制的研究进展

刘超; 高嘉良

doi:10.16305/j.1007-1334.2021.2008119

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中药干预巨噬细胞抗动脉粥样硬化机制的研究进展

综述 | 更新时间：2022-08-03

- 中药干预巨噬细胞抗动脉粥样硬化机制的研究进展
- Research progress on mechanism of Chinese medicine regulating the macrophages against atherosclerosis
- 上海中医药杂志 2021年55卷第12期页码：94-99
- 作者机构：
  
  1.中国中医科学院广安门医院心血管科（北京　100053）
  2.北京中医药大学研究生院（北京　100029）
- 作者简介：
  
  刘超，男，博士研究生，主要从事中西医结合心血管疾病临床研究工作
  高嘉良，主治医师；E-mail: lianggaonmg@163.com
- 基金信息：
  
  国家自然科学基金面上项目(81673847)
- DOI：10.16305/j.1007-1334.2021.2008119
  中图分类号：
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刘超, 高嘉良. 中药干预巨噬细胞抗动脉粥样硬化机制的研究进展[J]. 上海中医药杂志, 2021,55(12):94-99.

Chao LIU, Jialiang GAO. Research progress on mechanism of Chinese medicine regulating the macrophages against atherosclerosis[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(12):94-99.
刘超, 高嘉良. 中药干预巨噬细胞抗动脉粥样硬化机制的研究进展[J]. 上海中医药杂志, 2021,55(12):94-99. DOI： 10.16305/j.1007-1334.2021.2008119.

Chao LIU, Jialiang GAO. Research progress on mechanism of Chinese medicine regulating the macrophages against atherosclerosis[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(12):94-99. DOI： 10.16305/j.1007-1334.2021.2008119.

摘要

综述中药干预巨噬细胞抗动脉粥样硬化（AS）机制的研究进展。巨噬细胞的黏附聚集和脂质代谢调节是AS形成的关键，巨噬细胞的极化和自噬调控AS的进展，巨噬细胞的凋亡和炎症反应加速AS的发生。活血化痰中药可调节巨噬细胞的黏附聚集和脂质代谢，扶正补虚中药可调节巨噬细胞的极化和自噬，清热解毒中药可调节巨噬细胞的凋亡和炎症反应。

Abstract

This paper reviewed the research progress on the mechanism of Chinese medicine regulating macrophages against atherosclerosis(AS). The adhesion and aggregation of macrophages and the regulation of lipid metabolism in macrophages were the key factors in the formation of AS. The polarization and autophagy of macrophages regulated the progression of AS. The apoptosis and inflammation of macrophages accelerated the occurrence of AS. Chinese medicine of activating blood and eliminating phlegm could regulate the adhesion and aggregation of macrophages and lipid metabolism in macrophages. Chinese medicine of reinforcing deficiency could regulate macrophages polarization and autophagy. Chinese medicine of clearing away heat and toxic materials could regulate macrophages apoptosis and inflammation.

关键词

中药巨噬细胞动脉粥样硬化机制综述

Keywords

traditional Chinese herbal medicinemacrophagesatherosclerosismechanismreview

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