Objective,2,To observe the clinical efficacy of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period.,Methods,2,Ninety patients with CKD3-4 period were randomly divided into treatment group and control group,45 patients in each group. All the patients were treated with basic therapy. In addition, the treatment group was given Xiao Chaihu Decoction combined Zhibai Dihuang Decoction. The treatment course was 8 weeks in both group. The clinical efficacy, relevant laboratory indicators (Scr, BUN, Ccr)and TCM syndrome scores were observed.,Results,2,The total effective rate of the treatment group and the control group were 93.33% and 66.66% respectively, and the clinical efficacy of the treatment group was better than that of the control group( ,P,<,0.05). After treatment, the level of Scr, BUN, Ccr, and the TCM syndrome scores were significantly improved in both groups ( ,P,<,0.05) and they were significantly better in the treatment group than those in the control group ( ,P,<,0.05).,Conclusions,2,Xiao Chaihu Decoction combined Zhibai Dihuang Decoction could improve clinical symptoms and renal function of patients with CKD3-4 period. The clinical efficacy was satisfactory.