Objective,2,To observe the effect of Feiliu Xiaoji Formula on adverse reactions of chemotherapy in patients with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome.,Methods,2,Totally 100 cases with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome were randomly divided into treatment group (,n,=50) and control group (,n,=50). Both groups were administered with conventional chemotherapy. The control group was treated with anti-vomiting, liver protection and stomach protection as appropriate, while the treatment group was additionally administered with Feiliu Xiaoji Formula besides symptomatic treatment. The course of treatment in both groups was 4 chemotherapy cycles. The clinical effect and incidence of adverse reactions of chemotherapy were observed, and the changes of TCM syndrome scores and Quality of Life Questionnaire Core 30 of EORTC (EORTC QLQ-C30) scores were compared.,Results,2,①The total effective rate of the treatment group was 86.00%, which was significantly higher than that of the control group (68.00%) (,P,<,0.05). ②The number of cases of bone marrow suppression (grade 0), digestive tract reaction, alopecia, liver and kidney function damage and peripheral neurotoxicity in the treatment group was more than that in the control group, but the number of cases with above adverse reactions (grade 3-4) in the treatment group was less than that in the control group, and the difference was statistically significant (,P,<,0.05). ③The TCM syndrome scores of both groups decreased after treatment (,P,<,0.05) and the TCM syndrome scores of the treatment lower than the scores of the control group (,P,<, 0.05). ④By comparing the QLQ-C30 scores of the two groups before and after treatment, we found that in both groups the scores of overall quality of life, physical function and emotional function in the functional part increased after treatment (,P,<,0.05), the scores of fatigue, nausea, vomiting, pain, sleep disorder, anorexia, constipation and diarrhea in the symptom part decreased after treatment (,P,<,0.05), and the differences in above mentioned scores were significant between the two groups after treatment (,P,<,0.05).,Conclusion,2,Feiliu Xiaoji Formula has synergistic effect with chemotherapy as it can increase the clinical effect on the treatment of non-small cell lung cancer of intermingled phlegm and blood stasis syndrome, improve the quality of life of patients, and reduce adverse reactions of chemotherapy.