龙葵抗肿瘤成分及其作用机制研究进展
Research progress on antitumor components and mechanism of
Solanumnigrum L.- 上海中医药杂志 2021年55卷第2期 页码：101-104
- 作者机构：
1.上海中医药大学附属龙华医院中医肿瘤研究所（上海 200032）
- 作者简介：
陈雷，男，硕士研究生，主要从事中西医结合肿瘤基础与临床研究工作
胡兵，研究员，主任医师，博士研究生导师；E-mail：beearhu@hotmail.com
- 基金信息：上海市科委科研项目(19401933400);上海中医药大学附属龙华医院科技创新项目(CX202004)
DOI：10.16305/j.1007-1334.2021.2007176
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陈雷, 彭骁, 胡兵. 龙葵抗肿瘤成分及其作用机制研究进展[J]. 上海中医药杂志, 2021,55(2):101-104.
Lei CHEN, Xiao PENG, Bing HU. Research progress on antitumor components and mechanism of
Solanumnigrum L.[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(2):101-104.陈雷, 彭骁, 胡兵. 龙葵抗肿瘤成分及其作用机制研究进展[J]. 上海中医药杂志, 2021,55(2):101-104. DOI： 10.16305/j.1007-1334.2021.2007176.
Lei CHEN, Xiao PENG, Bing HU. Research progress on antitumor components and mechanism of
Solanumnigrum L.[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(2):101-104. DOI： 10.16305/j.1007-1334.2021.2007176.
摘要
龙葵是治疗肿瘤的常用中药，含有多种抗肿瘤活性成分，如龙葵碱、澳洲茄边碱、龙葵酸、澳洲茄碱、澳洲茄胺、去半乳糖替告皂苷、槲皮素、薯蓣皂苷元等，可治疗胃癌、肺癌、大肠癌、乳腺癌、膀胱癌、肝癌、骨肉瘤、前列腺癌等恶性肿瘤。其抗肿瘤作用及机制主要包括抑制增殖生长、阻滞细胞周期、诱导细胞凋亡、抑制上皮-间质转化和转移、逆转耐药、增强放化疗和靶向治疗疗效等。
Abstract
Solanumnigrum, L.is a Chinese medicine commonly used in tumor treatment, which contains a variety of anti-tumor active ingredients, such as solanine, solamargine, solaoiacid, solasonine, solasodine, degalactotigonin, quercetin, diosgenin and so on.It can be used to treat gastric cancer, lung cancer, colorectal cancer, breast cancer, bladder cancer, liver cancer, osteosarcoma, prostate cancer and other malignant tumors.Its anti-tumor mechanisms include inhibition of proliferation and growth, arrest of cell cycle, induction of apoptosis, inhibition of epithelial-stromal transformation and metastasis, reversal of drug resistance, enhancement of radiotherapy, chemotherapy and targeted therapy.
关键词
龙葵活性成分抗肿瘤作用作用机制综述
Keywords
Solanumnigrum L.active ingredientsantitumor effectsmechanismreview
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