平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退的临床观察
Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome
- 上海中医药杂志 2021年55卷第8期 页码：71-74
- 作者机构：
1.上海市奉贤区中医医院脑病科（上海 201499）
2.上海中医药大学附属市中医医院神志病科（上海 200071）
- 作者简介：
凌蕴玉，女，硕士，主治医师，主要从事中医内科临床工作
许良，主任医师，硕士研究生导师；E-mail：18116013392@163.com
- 基金信息：上海市卫计委中医药科研课题(2018LP030)
DOI：10.16305/j.1007-1334.2021.2007171
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凌蕴玉, 许良. 平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退的临床观察[J]. 上海中医药杂志, 2021,55(8):71-74.
Yunyu LING, Liang XU. Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(8):71-74.
凌蕴玉, 许良. 平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退的临床观察[J]. 上海中医药杂志, 2021,55(8):71-74. DOI： 10.16305/j.1007-1334.2021.2007171.
Yunyu LING, Liang XU. Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(8):71-74. DOI： 10.16305/j.1007-1334.2021.2007171.
摘要
目的,2,观察平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退的临床疗效。,方法,2,将72例肝郁痰热型不寐伴记忆力减退患者随机分为治疗组和对照组，每组36例。对照组予舒肝解郁胶囊治疗，治疗组予平肝豁痰方治疗。两组疗程均为8周，观察临床疗效，比较中医证候积分、改良SPIEGEL自评量表评分、事件相关电位（ERP）检测中P300潜伏期和波幅的变化情况。,结果,2,①试验过程中，对照组脱落3例、治疗组脱落2例，最终完成试验者67例，其中对照组33例、治疗组34例。②治疗组、对照组总有效率分别为88.23%、63.64%，治疗组临床疗效优于对照组（,P,<,0.05）。③随着治疗时间的延长，两组中医证候积分、改良SPIEGEL自评量表评分均逐渐降低（,P,<,0.001）；治疗4周、6周、8周组间比较，治疗组中医证候积分、改良SPIEGEL自评量表评分低于对照组（,P,<,0.05）。④治疗前后组内比较，治疗组P300潜伏期缩短、波幅增大（,P,<,0.05），对照组P300潜伏期缩短（,P,<,0.05）；组间治疗后比较，P300潜伏期及波幅差异有统计学意义（,P,<,0.05）。,结论,2,平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退疗效满意，能显著改善患者的失眠、记忆力减退症状及中医证候。
Abstract
Objective,2,To observe the clinical effect of Pinggan Huotan Decoction on insomnia with hypomnesia of liver depression and phlegm heat syndrome.,Methods,2,Totally 72 patients with insomnia and hypomnesia of liver depression and phlegm heat syndrome were randomly divided into treatment group (,n,=36) and control group (,n,=36). The control group was administered with Shugan Jieyu Capsule, while the treatment group was administered with Pinggan Huotan Decoction. The course of treatment in both groups was 8 weeks. We observed the clinical efficacy, and compared the changes of TCM syndrome scores, modified Spiegel criteria scores, and P300 latency and amplitude in event-related potential (ERP) detection.,Results,2,①During the clinical trial, there were 3 drop-out cases in the control group and 2 drop-out cases in the treatment group, and 67 cases finally completed the trail, including 33 cases in the control group and 34 cases in the treatment group. ②The total effective rates of the treatment group and the control group were 88.23% and 63.64%, respectively. The clinical effect of the treatment group was better than that of the control group (,P,<,0.05). ③With the prolongation of treatment time, TCM syndrome scores and modified Spiegel criteria scores of both groups gradually decreased (,P,<,0.001); According to the inter-group comparison after 4 weeks, 6 weeks and 8 weeks of treatment, the TCM syndrome scores and modified Spiegel criteria scores of the treatment group were lower than those of the control group (,P,<,0.05). ④According to the intra-group comparison before and after treatment, the latency of P300 became shorter and the amplitude increased in the treatment group after treatment (,P,<,0.05), and the latency of P300 became shorter in the control group after treatment (,P,<,0.05); According to the inter-group comparison after treatment, there were significant differences in latency and amplitude of P300 between the two groups (,P,<,0.05).,Conclusion,2,Pinggan Huotan Decoction is effective in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome as it can significantly improve patients’ symptoms of insomnia, hypomnesis and TCM syndromes.
关键词
失眠不寐记忆力减退平肝豁痰方事件相关电位
Keywords
insomniasleeplessnesshypomnesisPinggan Huotan Decoctionevent-related potential
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