The syndrome differentiation methods of exogenous febrile diseases include six meridians syndrome differentiation, Wei-Qi-Ying-Xue syndrome differentiation and triple energizers syndrome differentiation. The syndrome differentiation methods of endogenous miscellaneous diseases include syndrome differentiation based on zang-fu organs and meridians, and syndrome differentiation based on qi, blood and body fluids. There are differences between syndrome differentiation methods of exogenous febrile diseases and those of endogenous miscellaneous diseases. Exogenous febrile diseases tend to formulate a treatment plan according to individual conditions, while endogenous miscellaneous diseases aim at universally applicable methods. As more complicated clinical situation is faced by modern TCM physicians nowadays, attention should be paid to seeking common ground while reserving differences in various syndrome differentiation methods to summarize simpler and more universally applicable methods.