中药抗哮喘气道炎症机制的研究进展
Research progress of anti-inflammation mechanism in asthmatic airway with traditional Chinese medicine
- 上海中医药杂志 2021年55卷第3期 页码：98-104
- 作者机构：
1.上海中医药大学附属普陀医院呼吸与危重症医学科（上海 200062）
- 作者简介：
朱林筠，女，博士研究生，主治医师，主要从事慢性气道炎症性疾病研究工作
王雄彪，主任医师，博士研究生导师。E-mail：xiongbiao6@yahoo.com
- 基金信息：上海市科委资助项目(18140904000、17401970900);上海市普陀区中心医院“培英计划”项目(2017206A)
DOI：10.16305/j.1007-1334.2021.2007053
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朱林筠, 孙亦鹏, 王雄彪. 中药抗哮喘气道炎症机制的研究进展[J]. 上海中医药杂志, 2021,55(3):98-104.
Linyun ZHU, Yipeng SUN, Xiongbiao WANG. Research progress of anti-inflammation mechanism in asthmatic airway with traditional Chinese medicine[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(3):98-104.
朱林筠, 孙亦鹏, 王雄彪. 中药抗哮喘气道炎症机制的研究进展[J]. 上海中医药杂志, 2021,55(3):98-104. DOI： 10.16305/j.1007-1334.2021.2007053.
Linyun ZHU, Yipeng SUN, Xiongbiao WANG. Research progress of anti-inflammation mechanism in asthmatic airway with traditional Chinese medicine[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(3):98-104. DOI： 10.16305/j.1007-1334.2021.2007053.
摘要
综述近年来中药治疗哮喘气道炎症机制的研究进展。中药复方或单味中药及其提取物可通过适应性免疫调节、抑制抗原呈递、固有免疫调节、抑制氧化应激、提高抗氧化能力、抑制NLRP3炎症小体形成、抑制炎症反应通路等，实现治疗哮喘的抗炎效应。同时通过网络药理学、高效液相色谱、基因组学、蛋白质组学等研究显示有效成分间的相互作用，进一步揭示中药多靶点多通路治疗哮喘气道炎症的机制。
Abstract
Thsi paper sumarizes the research progress about the mechanism of traditional Chinese medicine in treating asthmatic airway inflammation in recent years.Compound or single traditional Chinese medicine and its extracts can treat asthmatic airway inflammation through adaptive immune regulation, inhibition of antigen presentation, innate immune regulation, inhibition of oxidative stress, improvement of antioxidant capacity, inhibition of NLRP3 inflammasome formation, and inhibition of inflammatory response pathways.At the same time, studies on network pharmacology, high performance liquid chromatography, genomics, proteomics and other studies have shown the interaction between active ingredients, and further revealed the mechanism of multi-target and multi-channel treatment of asthma airway inflammation by traditional Chinese medicine.
关键词
哮喘抗炎中药慢性气道炎症综述
Keywords
asthmaanti-inflammationmedicine traditional Chinesechronic airway inflammationreview
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