清热化瘀中药对子宫腺肌病患者高强度聚焦超声术后炎症的影响
Effect of clearing heat and removing blood stasis traditional Chinese medicine on inflammation of patients with adenomyosis after operation of HIFU
- 上海中医药杂志 2021年55卷第5期 页码：58-62
- 作者机构：
1.上海中医药大学附属曙光医院（上海 200021）
2.上海市第一妇婴保健院海扶中心（上海 200040）
3.上海市第一妇婴保健院中西医结合科（上海 200040）
- 作者简介：
张茜，女，硕士，规培医师，主要从事中西医结合治疗妇科病临床研究工作
张勤华，主任医师，博士研究生导师；E-mail：shumeier@163.com
艾星子·艾里，主任医师，硕士研究生导师；E-mail：1819483078@qq.com。
- 基金信息：上海市卫计委进一步加快中医药事业发展三年行动计划项目(ZY〔2018-2020〕-FWTX-3003);上海市科委科研计划项目(18401971900)
DOI：10.16305/j.1007-1334.2021.2005055
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张茜, 林彬, 马娟娟, 等. 清热化瘀中药对子宫腺肌病患者高强度聚焦超声术后炎症的影响[J]. 上海中医药杂志, 2021,55(5):58-62.
Xi ZHANG, Bin LIN, Juanjuan MA, et al. Effect of clearing heat and removing blood stasis traditional Chinese medicine on inflammation of patients with adenomyosis after operation of HIFU[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(5):58-62.
张茜, 林彬, 马娟娟, 等. 清热化瘀中药对子宫腺肌病患者高强度聚焦超声术后炎症的影响[J]. 上海中医药杂志, 2021,55(5):58-62. DOI： 10.16305/j.1007-1334.2021.2005055.
Xi ZHANG, Bin LIN, Juanjuan MA, et al. Effect of clearing heat and removing blood stasis traditional Chinese medicine on inflammation of patients with adenomyosis after operation of HIFU[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(5):58-62. DOI： 10.16305/j.1007-1334.2021.2005055.
摘要
目的,2,观察清热化瘀中药对子宫腺肌病患者高强度聚焦超声（HIFU）术后炎症的影响。,方法,2,纳入行HIFU治疗术后的子宫腺肌病患者60例，随机分为对照组和治疗组，每组30例。对照组患者在HIFU术后第1天予以促性腺激素释放激素类似物（GnRH-a）皮下注射，治疗组患者在对照组治疗基础上，自术后第1天起服用清热化瘀中药，疗程为7 d。于HIFU术后第1天（治疗前）及术后第10天（治疗后），比较两组患者的中医证候积分，评价两组患者的中医证候疗效；检测并比较两组患者的癌抗原125（CA125）、血管内皮生长因子（VEGF）、可溶性血管细胞黏附分子-1（sVCAM-1）及相关炎症因子白介素-1（IL-1）、白介素-6（IL-6）、前列腺素E,2,（PGE,2,）水平。,结果,2,①治疗后，治疗组的中医证候疗效总有效率为96.7%，对照组为83.3%，治疗组的疗效优于对照组（,P,<,0.05）。②治疗后，两组患者的中医证候总积分均明显下降（,P,<,0.05），且治疗组患者的积分低于对照组（,P,<,0.05）；两组患者的各项症状积分均明显下降（,P,<,0.05），且治疗组患者的腹部胀痛、尾骶部不适症状积分低于对照组（,P,<,0.05）。③治疗后，两组患者的VEGF、sVCAM-1水平均明显降低（,P,<,0.05），对照组患者的CA125水平升高（,P,<,0.05）；且治疗组患者的VEGF、sVCAM-1水平低于对照组（,P,<,0.05）。④治疗后，治疗组患者的IL-6、PGE,2,水平均降低（,P,<,0.05），对照组患者的IL-1水平升高（,P,<,0.05）；且治疗组患者的IL-1水平低于对照组（,P,<,0.05）。,结论,2,清热化瘀中药治疗子宫腺肌病HIFU术后患者，可改善患者的中医证候，降低炎症因子水平，控制血管异常增生，从而改善HIFU术后炎症。
Abstract
Objective,2,To observe the effect of clearing heat and removing blood stasis traditional Chinese medicine on the inflammation of patients with adenomyosis after operation of high intensity focused ultrasound (HIFU).,Methods,2,Sixty patients with adenomyosis treated by HIFU were included and randomly divided into the control group and the treatment group, 30 cases in each group. The patients in the control group were treated with subcutaneous injection of gonadotropin releasing hormone analogue (GnRH-a) on the first day after operation; the patients in the treatment group were treated with clearing heat and removing blood stasis traditional Chinese medicine based on the treatment of the control group from the first day after operation with a course of 7 days. On the first day after operation (before treatment) and the tenth day after operation (after treatment), the scores of Chinese medical syndrome of the two groups were compared, and the effect of Chinese medical syndrome in both groups were evaluated; the levels of cancer antigen125 (CA125), vascular endothelial growth factor (VEGF), soluble vascular cell adhesion molecule-1 (sVCAM-1) and the inflammatory factors including interleukin (IL)-1, IL-6 and prostaglandin E,2, (PGE,2,) in both groups were tested and compared.,Results,2,①After treatment, the total effective rates of the treatment group and the control group were 96.7% and 83.3% respectively, and the effect of the treatment group was superior to the control group (,P,<,0.05). ②After treatment, the total scores of Chinese medical syndrome in both groups were significantly decreased (,P,<,0.05), and the score of the treatment group was lower than that of the control group (,P,<,0.05); the scores of all the symptoms in both groups were significantly decreased (,P,<,0.05), and the scores of abdominal pain and sacrum discomfort symptoms in the treatment group were lower than those in the control group (,P,<,0.05). ③After treatment, the levels of VEGF and sVCAM-1 in both groups were significantly decreased (,P,<,0.05), the level of CA125 in the control group was increased (,P,<,0.05), and the levels of VEGF and sVCAM-1 in the treatment group were lower than those in the control group (,P,<,0.05). ④After treatment, the levels of IL-6 and PGE,2, in the treatment group were decreased (,P,<,0.05), the level of IL-1 in the control group was increased (,P,<,0.05), and the level of IL-1 in the treatment group was lower than that in the control group (,P,<,0.05).,Conclusion,2,Clearing heat and removing blood stasis traditional Chinese medicine can improve the Chinese medical syndrome, reduce the levels of inflammatory factors and control the abnormal proliferation of blood vessels in patients with adenomyosis after operation of HIFU, thus improve the inflammation after operation of HIFU.
关键词
子宫腺肌病炎症因子高强度聚焦超声清热化瘀
Keywords
adenomyosisinflammatory factorhigh intensity focused ultrasoundclearing heat and removing blood stasis
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