This paper introduces professor Li Yan’s experience in the treatment of brain tumor with common couplet drugs. Professor Li can cautiously grasp pathogenesis, flexibly treat with syndrome differentiation and is skilled in using couplet drugs to treat brain tumors. For instance,Radix Astragali, and ,Rhizoma Atractylodis Macrocephalae, are commonly used to strengthen spleen and replenish qi; ,Rhizoma Amorphophalli, and ,Rhizoma Pinelliae, are commonly used to resolve phlegm and soften hard masses. ,Rhizoma Sparganii, and ,Rhizoma Curcumae, are commonly used to improve blood circulation and disperse stasis. ,Fructus Lycii, and ,Fructus Ligustri Lucidi, are commonly used to tonify kidney and nourish yin. ,Semen Cuscutae, and ,Semen Astragali Complanati, are commonly used to tonify kidney and support yang. ,Edible Tulip, and ,Radix Semiaquilegiae, are commonly used to clear away heat and toxic material. ,Scorpio, and ,Scolopendra, are commonly used to relieve convulsion and spasm.