桔梗皂苷D对非小细胞肺癌作用机制的研究进展

刘悦涵; 李璐; 赵堃鹏; 陈启龙

doi:10.16305/j.1007-1334.2021.1912073

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桔梗皂苷D对非小细胞肺癌作用机制的研究进展

综述 | 更新时间：2022-08-03

- 桔梗皂苷D对非小细胞肺癌作用机制的研究进展
- Research progress on mechanisms of platycodin D on non-small cell lung cancer
- 上海中医药杂志 2021年55卷第4期页码：92-96
- 作者机构：
  
  1.上海中医药大学交叉科学研究院中医复杂系统研究中心（上海　201203）
- 作者简介：
  
  刘悦涵，女，硕士研究生，主要从事中医病证关系及网络药理学研究工作
  陈启龙，研究员，教授，硕士研究生导师；E-mail：cqlw1975@126.com
- 基金信息：
  
  上海市科委科研计划项目(19ZR1452100)
- DOI：10.16305/j.1007-1334.2021.1912073
  中图分类号：
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刘悦涵, 李璐, 赵堃鹏, 等. 桔梗皂苷D对非小细胞肺癌作用机制的研究进展[J]. 上海中医药杂志, 2021,55(4):92-96.

Yuehan LIU, Lu LI, Kunpeng ZHAO, et al. Research progress on mechanisms of platycodin D on non-small cell lung cancer[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(4):92-96.
刘悦涵, 李璐, 赵堃鹏, 等. 桔梗皂苷D对非小细胞肺癌作用机制的研究进展[J]. 上海中医药杂志, 2021,55(4):92-96. DOI： 10.16305/j.1007-1334.2021.1912073.

Yuehan LIU, Lu LI, Kunpeng ZHAO, et al. Research progress on mechanisms of platycodin D on non-small cell lung cancer[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(4):92-96. DOI： 10.16305/j.1007-1334.2021.1912073.

摘要

综述桔梗皂苷D（PD）对非小细胞肺癌（NSCLC）作用机制的研究进展。PD可通过阻滞细胞生长周期，诱导细胞凋亡、自噬及抑制细胞转移，发挥治疗NSCLC的作用；同时对PD的生物学特性、抗癌活性、毒副作用加以总结，为其在NSCLC治疗中的科学研究和临床应用提供思路。

Abstract

The research progress on the mechanisms of platycodin D (PD) on non-small cell lung cancer (NSCLC) was reviewed. PD could treat NSCLC by blocking cell growth cycle, inducing apoptosis, autophagy and inhibiting cell metastasis. At the same time, the biological characteristics, anticancer activity and side effects of PD were summarized, so as to provide ideas for its scientific research and clinical application in the treatment of NSCLC.

关键词

桔梗皂苷D非小细胞肺癌细胞凋亡自噬转移作用机制综述

Keywords

platycodin DNSCLCapoptosisautophagymetastasismechanismreview

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