蔡氏调周法对肥胖型多囊卵巢综合征患者脂代谢及血清瘦素、脂联素水平的影响
Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome
- 上海中医药杂志 2021年55卷第7期 页码：50-54
- 作者机构：
1.上海市第一人民医院中医科（上海 200080）
2.上海中医药大学龙华临床医学院（上海 200032）
3.上海中医药大学附属龙华医院妇科（上海 200032）
4.同济大学附属东方医院妇产科（上海 200120）
- 作者简介：
许华云，女，硕士，主治医师，主要从事中医药防治妇科内分泌疾病的临床研究工作
付金荣，主任医师，博士研究生导师；E-mail：fujinrong2006@sina.com
- 基金信息：上海市科委科研计划项目(16401934500);上海市“杏林新星”计划项目(ZY〔2018-2020〕-RCPY-3006);上海市卫健委进一步加快中医药事业发展三年行动计划项目(ZY3-CCCX-1-1006)
DOI：10.16305/j.1007-1334.2021.1912011
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许华云, 孔世露, 付金荣, 等. 蔡氏调周法对肥胖型多囊卵巢综合征患者脂代谢及血清瘦素、脂联素水平的影响[J]. 上海中医药杂志, 2021,55(7):50-54.
Huayun XU, Shilu KONG, Jinrong FU, et al. Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(7):50-54.
许华云, 孔世露, 付金荣, 等. 蔡氏调周法对肥胖型多囊卵巢综合征患者脂代谢及血清瘦素、脂联素水平的影响[J]. 上海中医药杂志, 2021,55(7):50-54. DOI： 10.16305/j.1007-1334.2021.1912011.
Huayun XU, Shilu KONG, Jinrong FU, et al. Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(7):50-54. DOI： 10.16305/j.1007-1334.2021.1912011.
摘要
目的,2,观察蔡氏调周法对肥胖型多囊卵巢综合征（PCOS）患者脂代谢及血清瘦素（LEP）、脂联素（ADP）水平的影响。,方法,2,纳入67例肥胖型PCOS患者，随机分为治疗组33例和对照组34例。治疗组给予蔡氏调周法治疗，对照组给予二甲双胍片口服，两组治疗周期均为3个月。治疗前后，计算并比较两组患者的腰臀比（WHR）、体质量指数（BMI）；检测两组患者的脂代谢相关指标水平，包括三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、游离脂肪酸（FFA）及LEP、ADP的水平；检测两组患者的血清黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）水平，计算LH/FSH比值。,结果,2,①治疗后，两组患者的TC、LDL水平较治疗前均降低（,P,<,0.05），但组间比较差异无统计学意义（,P,>,0.05）。②治疗后，两组患者的LEP水平均降低（,P,<,0.05）、ADP水平均升高（,P,<,0.05），但组间比较差异均无统计学意义（,P,>,0.05）。③治疗后，两组患者的WHR、BMI均明显降低（,P,<,0.05，,P,<,0.01），但组间比较差异均无统计学意义（,P,>,0.05）。④治疗后，两组患者的T、LH水平及LH/FSH比值较治疗前均降低（,P,<,0.05，,P,<,0.01），且治疗组患者的LH水平及LH/FSH比值低于对照组（,P,<,0.05）。,结论,2,蔡氏调周法能有效调节肥胖型PCOS患者的脂代谢紊乱，较好地改善其性激素水平，降低LEP水平及WHR、BMI，升高ADP水平，且无明显毒副反应。
Abstract
Objective,2,To observe the influence of Cai’s menstruation periodic treatment on lipid metabolism and the levels of serum leptin(LEP) and adiponectin(ADP) in obese patients with polycystic ovary syndrome (PCOS).,Methods,2,A total of 67 obese patients with PCOS were included and randomly divided into the treatment group (33 cases) and control group (34 cases). The patients in the treatment group were treated with Cai’s menstruation periodic treatment, and the patients in the control group were orally treated with metformin tablets. The treatment course of the two groups was 3 months. Before and after treatment, the waist-hip-ratio (WHR) and body mass index (BMI) of the two groups were calculated and compared; the levels of lipid metabolism indexes including triacylglycerol (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and free fatty acid (FFA), and the levels of LEP and ADP in the two groups were detected; the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) were detected, and the LH/FSH ratio was calculated.,Results,2,①After treatment, the levels of TC and LDL in the two groups were decreased compared with those before treatment (,P,<,0.05), but with no significantly statistical differences between the two groups (,P,>,0.05). ②After treatment, the level of LEP in the two groups was decreased (,P,<,0.05) and the level of ADP was increased (,P,<,0.05), but with no significantly statistical differences between the two groups (,P,>,0.05). ③After treatment, the WHR and BMI of the two groups were significantly decreased (,P,<,0.05,P,<,0.01), but with no significantly statistical differences between the two groups (,P,>,0.05). ④After treatment, the levels of T and LH and the LH/FSH ratio in the two groups were decreased compared with those before treatment (,P,<,0.05,P,<,0.01), and the level of LH and the LH/FSH ratio in the treatment group were lower than those in the control group (,P,<,0.05).,Conclusion,2,Cai’s menstruation periodic treatment can effectively regulate the lipid metabolism disorder in obese patients with PCOS, better improve the sex hormone levels, decrease the LEP level, WHR and BMI, and increase the level of ADP, without obvious toxic and side effects.
关键词
多囊卵巢综合征肥胖蔡氏调周法中药脂代谢瘦素脂联素
Keywords
polycystic ovary syndromeobesityCai’s menstruation periodic treatmenttroditional Chinese herbal medicinelipid metabolismleptinadiponectin
references
FAUSER B C J M, TARLATZIS B C, REBAR R W, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J]. Fertil Steril, 2012, 97(1): 28-38.
DIAMANTI-KANDARAKIS E, CHRISTAKOU C D, KANDARAKI E, et al. Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome[J]. Eur J Endocrinol, 2010, 162(2): 193-212.
RAUTIO K, TAPANAINEN J S, RUOKONEN A, et al. Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study[J]. Hum Reprod, 2006, 21(6): 1400-1407.
OVALLE F, AZZIZ R. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus[J]. Fertil Steril, 2002, 77(6): 1095-1105.
胡敏，李威，吴效科. 肥胖对多囊卵巢综合征患者生殖内分泌功能的影响[J]. 医学研究生学报，2008, 21(11): 1207-1210.
贾丽娜，王兴娟. 不同方药对多囊卵巢综合征高瘦素血症的影响[J]. 复旦学报（医学版），2008, 35(4): 601-604.
VRBÍKOVÁ J, DVORÁKOVÁ K, HILL M, et al. Determinants of circulating adiponectin in women with polycystic ovary syndrome[J]. Gynecol Obstet Invest, 2005, 60(3): 155-161.
丰有吉，沈铿. 妇产科学[M]. 北京：人民卫生出版社，2005: 252-256.
李洋，傅华. 肥胖的重新定义和处理[J]. 上海预防医学，2001, 13(4): 161-162.
GOURGARI E, LODISH M, SHAMBUREK R, et al. Lipoprotein particles in adolescents and young women with PCOS provide insights into their cardiovascular risk[J]. J Clin Endocrinol Metab, 2015, 100(11): 4291-4298.
陈丽，郝丽娟. 脂代谢异常与多囊卵巢综合征[J]. 生殖医学杂志，2019, 28(7): 836-839.
SENN J J, KLOVER P J, NOWAK I A. Interleukin-6 induces cellular insulin resistance in hepatocytes[J]. Diabetes, 2002, 51(12): 3391-3399.
MORAN L J, MUNDRA P A, TEEDE H J, et al. The association of the lipidomic profile with features of polycystic ovary syndrome[J]. J Mol Endocrinol, 2017, 59(1): 93-104.
FULGHESU A M, SANNA F, UDA S, et al. IL-6 serum levels and production is related to an altered immune response in polycystic ovary syndrome girls with insulin resistance[J]. Mediators Inflamm, 2011(2011): 389317.
POURGHASSEM G B, HOUJEGHANI S, FARZADI L, et al. Relationship between serum leptin, ghrelin and dietary macronutrients in women with polycystic ovary syndrome[J]. Int J Fertil Steril, 2015, 9(3): 313-321.
LAGALY D V, AAD P Y, GRADO-AHUIR J A, et al. Role of adiponectin in regulating ovarian theca and granulosa cell function[J]. Mol Cell Endocrinol, 2008, 284(1-2): 38-45.
丁芳，易晓芳. 脂联素、抵抗素及瘦素在生殖领域的研究进展[J]. 中国现代医学杂志，2019, 29(14): 49-53.
范林霄，杨燕生，郝敏. 二甲双胍治疗多囊卵巢综合征合并高胰岛素血症患者的临床研究[J]. 生殖医学杂志，2004, 13(4): 237-239.
张莉，高旭峰，王玉环. 多囊卵巢综合征并胰岛素抵抗大鼠高分子脂联素表达及二甲双胍的影响[J]. 中国生育健康杂志，2019, 30(1): 72-76.
俞瑾. 多囊卵巢综合征的中西医治疗[J]. 中国实用妇科与产科杂志，2002, 18(11): 651-653.
文川，徐浩，黄启福，等. 活血中药对ApoE基因缺陷小鼠血脂及动脉粥样硬化斑块炎症反应的影响[J].中国中西医结合杂志，2005, 25(4): 345-349.
谈珍瑜，邹芝香，尤昭玲，等. 补肾活血方对PCO大鼠瘦素、胰岛素和睾酮影响的实验研究[J]. 新中医，2006, 38(12): 87-88.
李艳，于涛，苗明三. 淫羊藿的化学、药理与临床应用分析[J]. 中医学报，2017, 32(4): 619-622.
徐彩生，罗丽莉，曾如辉. 淫羊藿总黄酮对多囊卵巢综合征大鼠性激素水平的影响[J]. 重庆医科大学学报，2013, 38(2): 147-150.
刘忠平，李质馨，田洪艳，等. 肉苁蓉对生殖系统影响的研究进展[J]. 上海中医药杂志，2015, 49(12): 84-86.
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