Objective,2,The correlation between different thermodynamic distribution characteristics in various regions of the body surface of patients and traditional Chinese medicine(TCM) syndromes of knee osteoarthritis was investigated to provide an innovative and objective method for the diagnosis of TCM syndromes of knee osteoarthritis.,Methods,2,Patients were divided into wind-cold-damp Bi syndrome group, wind-damp-heat Bi syndrome group and static blood blockage syndrome group after syndrome differentiation, with 20 cases in each group. Another 20 healthy volunteers were selected as the control group. By collecting the infrared thermograms and temperatures of each organ’s projection area of enrolled subjects, the differences in temperature and heat-cool deviation between the observation groups and the control group were compared.,Results,2,①Compared with the condition in the control group, the body surface temperatures of the stomach and epigastrium, left lower back and right lower back were significantly lower with a cool deviation in the wind-cold-damp Bi syndrome group, and the differences were statistically significant(,P,<,0.05); The body surface temperatures of the lower abdomen, left and right lateral lower abdomen were significantly higher with a heat deviation in the wind-damp-heat Bi syndrome group, and the differences were statistically significant(,P,<,0.05); The body surface temperature of Xuli(apex of heart) was significantly lower with a cool deviation, and the body surface temperatures of the left hypochondrium and right hypochondrium were significantly higher with a heat deviation, and the differences were statistically significant differences(,P,<,0.05). ②Based on qualitative analysis of the temperature changes, the body surface temperatures of the stomach and epigastrium, upper abdomen, left lower abdomen, right lower abdomen, left lower back and right lower back in the wind-cold-damp Bi syndrome group were significantly lower than those in the wind-damp-heat Bi syndrome group; the body surface temperature of Xuli in the wind-cold-damp Bi syndrome group was significantly higher than that in the static blood blockage syndrome group and the body surface temperatures of the left hypochondrium, right hypochondrium, stomach and epigastrium, left lower back and right lower back were significantly lower than those in the static blood blockage syndrome group; Compared with the condition in the static blood blockage syndrome group, the body surface temperatures of Xuli, the lower abdomen, left lateral lower abdomen and right lateral lower abdomen were significantly higher while the body surface temperature of the left hypochondrium and right hypochondrium were significantly lower in the wind-damp-heat Bi syndrome group.,Conclusion,2,Compared with those of healthy people, the thermodynamic characteristics of knee osteoarthritis patients with wind-cold-damp Bi syndrome, wind-damp-heat Bi syndrome, and static blood blockage syndrome are significantly different and these differences can be objectively assessed by infrared thermography, which can provide an innovative method and reference for objectified diagnosis of TCM syndromes of knee osteoarthritis.