Objective,2,To observe the clinical effect of Sini Decoction combined with western medicine on lower extremity arteriosclerosis obliterans (ASO).,Methods,2,A total of 100 patients with lower extremity ASO were randomly divided into control group (,n,=50) and treatment group (,n,=50). The control group was administered with conventional western medicine, while the treatment group was administered with Sini Decoction besides the conventional western medicine of the control group. The course of treatment in both groups lasted 28 days. The clinical effect was observed, and the changes in the quantitative scores of the symptoms and signs as well as the ankle-brachial index (ABI) were compared.,Results,2,①Finally, 95 patients completed the trial including 48 patients in the treatment group and 47 patients in the control group. ②The total effective rates of the treatment group and the control group were 79.2% and 57.4%, respectively. The clinical effect of the treatment group was significantly better than that of the control group (,P,<,0.05). ③The intra-group comparison before and after treatment showed that there were significant differences in the module scores of skin temperature perception, skin color, pain, ABI, intermittent claudication distance and intermittent claudication remission time in both groups (,P,<,0.05). According to the inter-group comparison after treatment, there were significant differences in the module scores of skin temperature perception, skin color, pain and ABI between the two groups (,P,<,0.05), but the module scores of intermittent claudication distance and intermittent claudication remission time showed no significant difference (,P,>,0.05). ④The intra-group comparison indicated that ABI differed significantly before and after treatment in both groups (,P,<,0.05), while the inter-group comparison indicated that the difference in ABI between the two groups after treatment was not significant (,P,>,0.05).,Conclusion,2,Compared with the single use of western medicine, the combined use of Sini Decoction with western medicine has better clinical effect on the treatment of lower extremity ASO, which can better improve the clinical symptoms and signs of patients.