马桶花有效部位抗炎镇痛和利胆作用的研究
Anti-inflammatory, analgesic and choleretic effects of active fraction of
Incavillea arguta (Royle) Royle- 上海中医药杂志 2021年55卷第1期 页码：72-77
- 作者机构：
1.贵州省遵义市中医院药剂科（贵州 遵义 563000）
2.贵州省绥阳县人民医院手术室（贵州 遵义 563000）
- 作者简介：
潘泰，男，硕士，主管药师，主要从事临床药学（抗感染）研究工作
- 基金信息：贵州省遵义市红花岗区科技局资助项目(遵红科合社字（2019）22号);贵州省遵义市科联合项目(（2018）147号)
DOI：10.16305/j.1007-1334.2021.1907050
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潘泰, 饶丹丹. 马桶花有效部位抗炎镇痛和利胆作用的研究[J]. 上海中医药杂志, 2021,55(1):72-77.
Tai PAN, Dandan RAO. Anti-inflammatory, analgesic and choleretic effects of active fraction of
Incavillea arguta (Royle) Royle[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(1):72-77.潘泰, 饶丹丹. 马桶花有效部位抗炎镇痛和利胆作用的研究[J]. 上海中医药杂志, 2021,55(1):72-77. DOI： 10.16305/j.1007-1334.2021.1907050.
Tai PAN, Dandan RAO. Anti-inflammatory, analgesic and choleretic effects of active fraction of
Incavillea arguta (Royle) Royle[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(1):72-77. DOI： 10.16305/j.1007-1334.2021.1907050.
摘要
目的,2,研究马桶花有效部位（MTH）是否具有抗炎镇痛和利胆作用，且观察其效果是否优于马桶花初提物。,方法,2,采用小鼠甩尾实验、甲醛致痛实验研究MTH和马桶花初提物对小鼠的镇痛情况，进一步采用二甲苯致小鼠耳郭肿胀、角叉菜胶致大鼠足肿胀研究MTH和马桶花初提取物对小鼠的抗炎作用，最后通过小鼠胆囊重量实验和收集到的临床患者结石标本进行溶石实验，研究其利胆溶石作用。,结果,2,①镇痛实验：与模型组比较，MTH高剂量组、中剂量组在30 min后能明显提高小鼠痛阈值（,P,<,0.05）；MTH中、高剂量组在第Ⅰ时相和第Ⅱ时相能够降低甲醛致痛评分值（,P,<,0.05，,P,<,0.01），且镇痛效果优于马桶花初提物。②抗炎实验：与对照组比较，MTH高、中、低剂量组对二甲苯致耳郭肿胀均有抑制作用，抑制率分别为45.21%、41.89%、23.83%（,P,<,0.01、,P,<,0.01、,P,<,0.05），然而马桶花初提物的抑制率为16.64%，低于MTH中、高剂量组（,P,<,0.05）；MTH中、高剂量组均能抑制小鼠足趾肿胀（,P,<,0.01，,P,<,0.01）。③利胆溶石实验：与蒸馏水组比较，MTH高、中、低剂量组和马桶花初提物组均能减轻胆囊重量，促进胆汁排泄（,P,<,0.01），且MTH的利胆作用优于马桶花初提物；MTH高、中、低剂量组和马桶花初提物组均能有效溶解胆囊结石（,P,<,0.01）。,结论,2,MTH具有明显的镇痛、抗炎和利胆作用，且效果优于马桶花初提物。
Abstract
Objective,2,To study whether MTH, the active fraction of ,Incavillea arguta, (Royle) Royle, has anti-inflammatory, analgesic and choleretic effects and to observe whether its effect is better than that of the crude extract of ,Incavillea arguta,.,Methods,2,The mice formaldehyde pain test and mice hot plate test were used to study the analgesic condition of MTH and the crude extract of ,Incavillea arguta, (Royle) Royle, and the models of xylene-induced ear edema and the carrageenan-induced paw edema of mice were used to study the anti-inflammatory effect of MTH and the crude extract of ,Incavillea arguta, (Royle) Royle, and finally the gallbladder weight test in the mice and the gallstone samples collected from clinical patient were carried out to study its choleretic and stone-dissolving effect.,Results,2,①The analgesic test: compared with the model group, at 30 min, in hot plate test, medium and high dose groups of MTH could enhance the rate of pain threshold efficiency in mice (,P,<,0.05) ; and in mice formaldehyde pain test, medium and high dose of MTH could reduce the formaldehyde-induced pain score in the first phase and the second phase (,P,<,0.05,P,<,0.01) , and the analgesic effects were better than that of the crude extract of ,Incavillea arguta, (Royle) Royle. ②The anti-inflammatory test: compared with the control group, high, medium and low dose groups of MTH significantly inhibited xylene-induced ear edema in mice, and the inhibition rates were respectively 45.21%, 41.89%, 23.83% (,P,<,0.01,P,<,0.01,P,<,0.05) , and the inhibition rates of the crude extract of ,Incavillea arguta, (Royle) Royle was 16.64%, lower than that of the high and medium dose groups of MTH (,P,<,0.05) . Both medium and high dose groups of MTH could inhibit toe swelling in mice (,P,<,0.01,P,<,0.01).③The choleretic test: compared with distilled water group, high, medium and low dose groups of MTH and the crude extract of ,Incavillea arguta, (Royle) Royle could reduce the gallbladder weight of mice, promote bile excretion (,P,<,0.01) and choleretic effect of MTH was better than that of the crude extract of ,Incavillea arguta, (Royle) Royle, and high, medium and low dose groups of MTH and the crude extract of ,Incavillea arguta, (Royle) Royle could effectively dissolve cholecystolithiasis (,P,<,0.01) .,Conclusion,2,MTH has obvious analgesic, anti-inflammatory and choleretic effects, and the effect is better than that of the crude extract of ,Incavillea arguta, (Royle) Royle.
关键词
马桶花镇痛抗炎利胆小鼠
Keywords
Incavillea arguta (Royle) Royleanalgesicanti-inflammatorycholereticmice
references
李志坚，管开云，李景秀.角蒿和铁线莲的矮化试验[J].广西植物，2003,23(3):264-266.
张志勇，徐洪，陈琳.黔产毛子草的资源分布及民族用药经验调查整理[J].中国民族民间医药杂志，2015,24(17):155-156.
左爱学，杨艳，朱萍，等.两头毛的化学成分和药理作用研究进展[J].现代药物与临床，2014,29(1):105-109.
余正文，朱海燕，杨小生，等.结石草化学成分及其促PC-12细胞的分化作用研究Ⅰ[J].中国中药杂志，2006,30(17):1335-1338.
黄良月，雷玉兰，刘常五，等.马桶花提取物的抗炎作用[J].中国中药杂志，1987,12(2):54-56.
曾万玲，林敏，喻微，等.龙香散镇痛作用及作用机制[J].中药药理与临床，2014,30(2):14-18.
匡淼，杨巧丽，王林林，等.蒿蓝感冒颗粒抗炎、镇痛、镇咳及解热作用研究[J].中药药理与临床，2013,29(6):144-147.
徐叔云，卞如濂，陈修，等.药理实验方法学[M].3 版.北京：人民卫生出版社，2002:1331.
缪云萍，叶小弟，程敏，等.通灵颗粒利尿及体外溶石作用的实验研究[J].中国中医药科技，2006,13(3):155-156.
田德安，张学松，刘南植.自制复方溶石剂的体外溶石作用及毒性的初步研究[J].中华肝胆外科杂志，2003,9(12):754-756.
张相君，夏同衍.贵州省中药材、民族药材质量标准[M].贵阳：贵州科技出版社，2003:92.
田德安，张学松，刘南植.自制复方溶石剂的体外溶石作用及毒性的初步研究[J].中华肝胆外科杂志，2003,9(12):754-756.
AL-GHAMDI M S.The anti-inflammatory，analgesic and antipyretic activity of Nigella sativa[J].J Ethnopharmacol，2001,76(1):45-48.
IWALEWA E O，IWALEWA O J，ADEBOYE J O.Analgesic，antipyretic，anti-inflammatory effects of methanol，chloroform and ether extracts of Vernonia cinerea less leaf[J].J Ethnopharmacol，2003,86(2):229-234.
ELDAHSHAN O A，ABDEL-DAIM M M.Phytochemical study，cytotoxic，analgesic，antipyretic and anti-inflammatory activities of Strychnos nux-vomica[J].Cytotechnology，2015,67(5):831-844.
张晨光.利胆汤对胆囊结石胆囊炎的治疗作用[D].北京：北京中医药大学，2010.
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